Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activity in vitro

European Journal of Immunology

Volumn 31, Issue 4, 2001, Pages 1247-1254

  Stephens, Leigh A ^a   Mottet, Christian ^b   Mason, Don ^a   Powrie, Fiona ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Autoimmunity; Regulation; T cell; Tolerance

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; MITOGENIC AGENT; POLYCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BLOOD ANALYSIS; CELL CONTACT; CELL FUNCTION; CELL STIMULATION; CHILD; COLITIS; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE DEFICIENCY; IMMUNITY; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MIXED LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; RAT; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS;

ANTIGENS, CD4; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELL DIVISION; CELLS, CULTURED; COCULTURE TECHNIQUES; FLOW CYTOMETRY; HUMANS; IMMUNE TOLERANCE; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; IONOMYCIN; LYMPHOCYTE ACTIVATION; MITOGENS; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; THYMUS GLAND;

EID: 0035054606     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200104)31:4<1247::AID-IMMU1247>3.0.CO;2-M     Document Type: Article

References (27)

1. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
2. Auto-immune disease as a consequence of developmental abnormality of a T cell subpopulation
3. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
4. + regulatory T cells that control intestinal inflammation
5. + immunoregulatory T cells that control autoimmune diabetes
6. - subpopulations
7. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
8. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
9. + T cells: A population of T cells with immune regulatory activities in vitro
10. + T cell subset that inhibits this auto-immune potential
11. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients
12. Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells
13. + immunoregulatory T cells is antigen nonspecific
14. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
15. + thymocytes
16. Developmental stages in the human thymus
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18. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
19. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymhoid compartment
20. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
21. Potent immunostimulatory dendritic cells can be cultured in bulk from progenitors in normal infant and adult myasthenic human thymus
22. Cytokine regulation of T-cell function: Potential for therapeutic intervention
23. Cytokines induce the development of functionally heterogeneous T helper cell subsets
24. + T cells
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27. Preparation of lymphocyte subpopulations