Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: Amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein

Journal of Immunology

Volumn 162, Issue 1, 1999, Pages 486-493

  Higgins, Lisa M ^a   McDonald, Stuart A C ^a   Whittle, Nigel ^b   Crockett, Nigel ^b   Shields, John G ^b   MacDonald, Thomas T ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b Cantab Pharmaceuticals Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL INFILTRATION; ENTERITIS; FEMALE; IMMUNOREGULATION; LIGAND BINDING; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TARGET CELL;

ANIMALS; ANTIGENS, CD27; CHO CELLS; COLITIS; CONCANAVALIN A; CRICETINAE; CYTOKINES; EPITOPES, T-LYMPHOCYTE; FEMALE; HUMANS; IMMUNOGLOBULIN G; INFLAMMATORY BOWEL DISEASES; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-2; LIGANDS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, KNOCKOUT; OX40 LIGAND; RECEPTORS, OX40; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTORS;

EID: 0032955192     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Gruss, H. J., and S. K. Dower. 1995. Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. Blood 85:3378.
2. Smith, C. A., T. Farrah, and R. G. Goodwin. 1994. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 76:959.
3. Smith, C. A., H. J. Gruss, T. Davis, D. Anderson, T. Farrah, E. Baker, G. R. Sutherland, C. I. Brennan, N. G. Copeland, and N. A. Jenkins. 1993. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell 73:1349.
4. Banchereau, J., F. Bazan, D. Blanchard, F. Briere, J. P. Galizzi, C. van Kooten, Y. J. Liu, F. Rousset, and S. Saeland. 1994. The CD40 antigen and its ligand. Annu. Rev. Immunol. 12:881.
5. Al-Shamkhani, A., M. L. Birkeland, M. Puklavec, M. H. Brown, W. James, and A. N. Barclay. 1996. OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. Eur. J. Immunol. 26:1695.
6. + T blasts. Mol. Immunol. 24:1281.
7. Baum, P. R., R. B. Gayle III, F. Ramsdell, S. Srinivasan, R. A. Sorensen, M. L. Watson, M. F. Seldin, E. Baker, G. R. Sutherland, K. N. Clifford, M. R. Alderson, R. G. Goodwin, and W. C. Fanslow. 1994. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J. 13:3992.
8. + T cells with homology to tumor necrosis factor. J. Exp. Med. 180:757.
9. Imura, A., T. Hori, K. Imada, T. Ishikawa, Y. Tanaka, M. Maeda, S. Imamura, and T. Uchiyama. 1996. The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J. Exp. Med. 183:2185.
10. Ohshima, Y., Y. Tanaka, H. Tozawa, Y. Takahashi, C. Maliszewski, and G. Delespesse. 1997. Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 159:3838.
11. Arch, R. A., and C. B. Thompson. 1998. 4-1BB and OX40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that binds TNF receptor-associated factors and activates nuclear factor κB. Mol. Cell. Biol. 18:558.
12. Stüber, E., and W. Strober. 1996. The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response. J. Exp. Med. 183:979.
13. Imura, A., T. Hori, K. Imada, S. Kawamata, Y. Tanaka, S. Imamura, and T. Uchiyama. 1997. OX40 expresses on fresh leukemic cells from adult T-cell leukemia patients mediates cell adhesion to vascular endothelial cells: implication for the possible involvement of OX40 in leukemic cell infiltration. Blood 89: 2951.
14. MacDonald, T. T. 1990. The role of activated T lymphocytes in gastrointestinal disease. Clin. Exp. Allergy 20:247.
15. Raine, C. S. 1991. Multiple sclerosis: a pivotal role for the T cell in lesion development. Neuropathol. Appl. Neurobiol. 17:265.
16. Ianone, F., V. M. Corrigall, G. Kingsley, and G. Panayi. 1994. Evidence for continuous recruitment and activation of T cells into the joints of patients with rheumatoid arthritis. Eur. J. Immunol. 24:2706.
17. Gleichemann, E., S. T. Pals, A. C. Rolink, T. Radaszkiewics, and H. Gleichemann. 1994. Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases. Immunol. Today 5:324.
18. Weinberg, A. D., D. N. Bourdette, T. J. Sullivan, M. Lemon, J. J. Wallin, R. Maziarz, M. Davcy, F. Palida, W. Godfrey, E. Engelman, R. J. Fulton, H. Offner, and A. A. Vandenbark. 1996. Selective depletion of myelin-reactive T cells with the anti-OX40 antibody ameliorates autoimmune encephalomyelitis. Nat. Med. 2:183.
19. Neurath, M. F., I. Fuss, B. L. Kelsall, E. Stüber, and W. Strober. 1995. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1281.
20. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis in mice with a disrupted interleukin-2 gene. Cell 75:253.
21. McDonald, S. A. C., M. J. H. J. Palmen, E. P. Van Rees, and T. T. MacDonald. 1997. Characterization of the mucosal cell-mediated immune response in IL-2 knockout mice before and after the onset of colitis. Immunology 91:73.
22. Krawisz, J. E., P. Sharon, and W. F. Stenson. 1984. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Gastroenterology 87: 1344.
23. Eckmann, L., J. Fierer, and M. F. Kagnoff. 1996. Genetically resistant (ltyr) and susceptible (ltys) congenic mouse strains show similar cytokine responses following infection with Salmonella dublin. J. Immunol. 156:2894.
24. Viney, J., T. T. MacDonald, and P. J. Kilshaw. 1989. T cell receptor expression in intestinal intraepithelial lymphocyte subpopulations of normal and athymic mice. Immunology 66:583.
25. Kühn, R., J. Löhler, D. Rennick, K. Rajewsky, and W. Müller. 1993. Interleukin-10 deficient mice develop chronic enterocolitis. Cell 75:263.
26. Mombaerts, P., E. Mizoguchi, M. J. Grusby, L. H. Glimcher, A. K. Bahn, and S. Tonegawa. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75:275.
27. Rudolph, U., M. J. Finegold, S. S. Rich, G. R. Harriman, Y. Srinivasan, P. Brabert, G. Boulay, A. Bradley, and L. Birnbaumer. 1995. Ulcerative colitis and adenocarcinoma of the colon in Gα 12-deficient mice. Nat. Genet. 10:143.
28. Höllander, G. A., S. J. Simpson, E. Mizoguchi, A. Nichogiannopoulou, J. She, J. C. Gutierrez-Ramos, A. K. Bhan, S. J. Burakoff, B. Wang, and C. Terhorst, 1995. Severe colitis in mice with aberrant thymic selection. Immunity 3:27.
29. Watanabe, M., Y. Ueno, T. Yajima, S. Okamoto, T. Hayashi, M. Yamazaki, Y. Iwao, H. Ishii, S. Habu, M. Uehira, H. Nishimoto, H. Iahikawa, J. I. Hata, and T. Hibi. 1998. Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J. Exp. J. Med. 187:389.
30. Neurath, M. F., I. Fuss, M. Pasparakis, L. Alexopoulou, S. Haralambous, K. H. Meyer zum Büschenfelde, W. Strober, and G. Kollias. 1997. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. Eur. J. Immunol. 27:1743.
31. Ribbons, K. A., J. H. Thompson, X. Liu, K. Pennline, D. A. Clark, and M. J. S. Miller. 1997. Anti-inflammatory properties of interleukin-10 administration in hapten-induced colitis. Eur. J. Pharm. 323:245.
32. Neurath, M. F., S. Pettersson, K. H. Meyer zum Büschenfelde, and W. Strober. 1996. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice. Nat. Med. 2:998.
33. Stüber, E., W. Strober, and M. Neurath. 1996. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J. Exp. Med. 183:693.
34. Lenschow, D. J., Y. Zeng, J. R. Thistlethwaite, A. Montag, W. Brady, M. G. Gibson, P. S. Linsley, and J. A. Bluestone. 1992. Long term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg. Science 257:789.
35. Khoury, S. J., E. Akalin, A. Chandraker, L. A. Turka, P. S. Linsley, M. H. Sayegh, and W. W. Hancock. 1995. CD28-B7 costimulatory blockade by TLA4lg prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system. J. Immunol. 155:4521.