Multitasking of helix-loop-helix proteins in lymphopoiesis

Advances in Immunology

Volumn 84, Issue , 2004, Pages 43-77

  Sun, Xiao Hong ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD28 ANTIGEN; CD3 ANTIGEN; COMPLEMENTARY DNA; CYCLIC AMP; DNA; DNA FRAGMENT; GAMMA INTERFERON; HELIX LOOP HELIX PROTEIN; I KAPPA B; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN M; INHIBITOR OF DIFFERENTIATION 2; INTERLEUKIN 3; INTERLEUKIN 7; LIPOPOLYSACCHARIDE; PROTEIN; PROTEIN E; PROTEIN P16; PROTEIN P21; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR PAX5; TRICHOSTATIN A; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ACETYLATION; ANTIBODY RESPONSE; APOPTOSIS; B LYMPHOCYTE; BONE MARROW; BREAST CANCER; CARCINOGENESIS; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL FRACTIONATION; CELL FUNCTION; CELL GROWTH; CELL MATURATION; CELL POPULATION; CELL PROLIFERATION; CHROMATIN; CONCENTRATION RESPONSE; DIMERIZATION; DNA BINDING; DNA TRANSCRIPTION; DOWN REGULATION; FIBROBLAST; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC CODE; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; LEUKEMIA; LYMPHOID CELL; LYMPHOPOIESIS; MOLECULAR CLONING; MUSCLE DEVELOPMENT; NEUROBLASTOMA CELL; NICK END LABELING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REPORTER GENE; REVIEW; SIGNAL TRANSDUCTION; SOMATIC HYPERMUTATION; STAINING; STEM CELL; T CELL LYMPHOMA; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMOCYTE; THYMUS; TRANSGENIC MOUSE; TUMOR CELL; UBIQUITINATION;

EID: 3042773155     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2776(04)84002-1     Document Type: Article

References (184)

1. Alani R.M., Young A.Z., Shifflett C.B. Id1 regulation of cellular senescence through transcriptional repression of p16Ink4a. Proc. Natl. Acad. Sci. USA. 98:2001;7812-7816
2. Allman D., Punt J.A., Izon D.J., Aster J.C., Pear W.S. An invitation to T and more: Notch signaling in lymphopoiesis. Cell. 109:(Suppl.):2002;S1-S11
3. Aronheim A., Shiran R., Rosen A., Walker M.D. The E2A gene product contains two separable and functionally distinct transcription activation domains. Proc. Natl. Acad. Sci. USA. 90:1993;8063-8067
4. Baer R. TAL1, TAL2 and LYL1: A family of basic helix-loop-helix proteins implicated in T cell acute leukaemia. Semin. Cancer Biol. 4:1993;341-347
5. Bain G., Robanus Maandag E.C., Izon D.J., Amsen D., Kruisbeek A.M., Weintraub B., Krop I., Schlissel M.S., Feeney A.J., van Roon M., van der Valk M., te Riele H.P.J., Berns A., Murre C. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell. 79:1994;885-892
6. Bain G., Engel I., Robanus Maandag E.C., te Riele H.P., Voland J.R., Sharp L.L., Chun J., Huey B., Pinkel D., Murre C. E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. Mol. Cell. Biol. 17:1997a;4782-4791
7. Bain G., Robanus Maandag E.C., te Riele H.P., Feeney A.J., Sheehy A., Schlissel M., Shinton S.A., Hardy R.R., Murre C. Both E12 and E47 allow commitment to the B cell lineage. Immunity. 6:1997b;145-154
8. Bain G., Quong M.W., Soloff R.S., Hedrick S.M., Murre C. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47. J. Exp. Med. 190:1999;1605-1616
9. Bain G., Cravatt C.B., Loomans C., Alberola-Ila J., Hedrick S.M., Murre C. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat. Immunol. 2:2001;165-171
10. Barndt R., Dai M.F., Zhuang Y. A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. J. Immunol. 163:1999;3331-3343
11. Barndt R.J., Dai M., Zhuang Y. Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. Mol. Cell. Biol. 20:2000;6677-6685
12. Barone M.V., Pepperkok R., Peverali F.A., Philipson L. Id proteins control growth induction in mammalian cells. Proc. Natl. Acad. Sci. USA. 91:1994;4985-4988
13. Becker-Herman S., Lantner F., Shachar I. Id2 negatively regulates B cell differentiation in the spleen. J. Immunol. 168:2002;5507-5513
14. Begley C.G., Aplan P.D., Denning S.M., Haynes B.F., Waldmann T.A., Kirsch I.R. The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. Proc. Natl. Acad. Sci. USA. 86:1989;10128-10132
15. Bellavia D., Campese A.F., Alesse E., Vacca A., Felli M.P., Balestri A., Stoppacciaro A., Tiveron C., Tatangelo L., Giovarelli M., Gaetano C., Ruco L., Hoffman E.S., Hayday A.C., Lendahl U., Frati L., Gulino A., Screpanti I. Constitutive activation of NF-kappaB and T-cell leukemialymphoma in Notch3 transgenic mice. EMBO J. 19:2000;3337-3348
16. Bellavia D., Campese A.F., Checquolo S., Balestri A., Biondi A., Cazzaniga G., Lendahl U., Fehling H.J., Hayday A.C., Frati L., von Boehmer H., Gulino A., Screpanti I. Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc. Natl. Acad. Sci. USA. 99:2002;3788-3793
17. Benezra R., Davis R.L., Lockshon D., Turner D.L., Weintraub H. The protein Id: A negative regulator of helix-loop-helix DNA binding proteins. Cell. 61:1990;49-59
18. Bettini M., Xi H., Milbrandt J., Kersh G.J. Thymocyte development in early growth response gene 1-deficient mice. J. Immunol. 169:2002;1713-1720
19. Blom B., Heemskerk M.H., Verschuren M.C., van Dongen J.J., Stegmann A.P., Bakker A.Q., Couwenberg F., Res P.C., Spits H. Disruption of alphabeta but not of gammadelta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. EMBO J. 18:1999;2793-2802
20. Bradney C., Hjelmeland M., Komatsu Y., Yoshida M., Yao T.P., Zhuang Y. Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J. Biol. Chem. 278:2003;2370-2376
21. Callahan R., Raafat A. Notch signaling in mammary gland tumorigenesis. J. Mammary Gland. Biol. Neoplasia. 6:2001;23-36
22. Chen Q., Cheng J.T., Taub R., Schneider N., Buchanan G., Carroll A., Crist W., Ozanne B., Siciliano M.J., Baer R. The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J. 9:1990;415-424
23. Cheng J.T., Hsu H.L., Hwang L.Y., Baer R. Products of the TAL1 oncogene: Basic helix-loop-helix proteins phosphorylated at serine residues. Oncogene. 8:1993;677-6836
24. Choi J.K., Shen C.P., Radomska H.S., Eckhardt L.A., Kadesch T. E47 activates the Ig-heavy chain and TdT loci in non-B cells. EMBO J. 15:1996;5014-5021
25. Christy B.A., Sanders L.K., Lau L.F., Copeland N.G., Jenkins N.A., Nathans D. An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc. Natl. Acad. Sci. USA. 88:1991;1815-1819
26. Deed R.W., Hara E., Atherton G.T., Peters G., Norton J.D. Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation. Mol. Cell. Biol. 17:1997;6815-6821
27. Deng C.P., Zhang P., Haper J.W., Elledge S.J., Leder P. Mice lacking p21CIP1WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 82:1995;675-684
28. Eckner R., Yao T.P., Oldread E., Livingston D.M. Interaction and functional collaboration of p300CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev. 10:1996;2478-2490
29. Engel I., Johns C., Bain G., Rivera R.R., Murre C. Early thymocyte development is regulated by modulation of E2A protein activity. J. Exp. Med. 194:2001;733-745
30. Engel I., Murre C. The function of E- and Id proteins in lymphocyte development. Nat. Rev. Immunol. 1:2001;193-199
31. Engel I., Murre C. Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice. Proc. Natl. Acad. Sci. USA. 99:2002;11322-11327
32. Fehling H.J., Krotkova A., Saint-Ruf C., von Boehmer H. Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Nature. 375:1995;795-798
33. Frasca D., Nguyen D., Riley R.L., Blomberg B.B. Decreased E12 andor E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice. J. Immunol. 170:2003;719-726
34. Fukuma M., Okita H., Hata J., Umezawa A. Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWSets protein in Ewing sarcoma. Oncogene. 22:2003;1-9
35. Fukuyama S., Hiroi T., Yokota Y., Rennert P.D., Yanagita M., Kinoshita N., Terawaki S., Shikina T., Yamamoto M., Kurono Y., Kiyono H. Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Immunity. 17:2002;31-40
36. Gisler R., Sigvardsson M. The human V-preB promoter is a target for coordinated activation by early B cell factor and E47. J. Immunol. 168:2002;5130-5138
37. Goebel P., Janney N., Valenzuela J.R., Romanow W.J., Murre C., Feeney A.J. Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells. J. Exp. Med. 194:2001;645-656
38. Goldfarb A.N., Flores J.P., Lewandowska K. Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switching. Mol. Immunol. 33:1996;947-956
39. Gong S., Nussenzweig M.C. Regulation of an early developmental checkpoint in the B cell pathway by Ig beta. Science. 272:1996;411-414
40. Greenbaum S., Zhuang Y. Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system. Proc. Natl. Acad. Sci. USA. 99:2002;15030-15035
41. Grumont R.J., Rasko J.E., Strasser A., Gerondakis S. Activation of the mitogen-activated protein kinase pathway induces transcription of the PAC-1 phosphatase gene. Mol. Cell. Biol. 16:1996;2913-2921
42. Hacker C., Kirsch R.D., Ju X.S., Hieronymus T., Gust T.C., Kuhl C., Jorgas T., Kurz S.M., Rose-John S., Yokota Y., Zenke M. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat. Immunol. 4:2003;380-386
43. Han H., Tanigaki K., Yamamoto N., Kuroda K., Yoshimoto M., Nakahata T., Ikuta K., Honjo T. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int. Immunol. 14:2002;637-645
44. Hara E., Hall M., Peters G. Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors. EMBO J. 16:1997;332-342
45. Hara E., Uzman J.A., Dimri G.P., Nehlin J.O., Testori A., Campisi J. The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts. Dev. Genet. 18:1996;161-172
46. 1 progression and are repressed in senescent human fibroblasts. J. Biol. Chem. 269:1994;2139-2145
47. Hardy R.R., Carmack C.E., Shinton S.A., Kemp J.D., Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1991;1213-1225
48. Heemskerk M.H., Blom B., Oda K., Stegmann A.P., Bakker A.Q., Weijer K., Res P.C., Spits H. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3. J. Exp. Med. 186:1997;1597-1602
49. Henthorn P., Kiledjian M., Kadesch T. Two distinct transcription factors that bind the immunoglobin enhancer μE5κE2 motif. Science. 247:1990;467-470
50. Herblot S., Aplan P.D., Hoang T. Gradient of E2A activity in B-cell development. Mol. Cell. Biol. 22:2002;886-900
51. Hollnagel A., Oehlmann V., Heymer J., Ruther U., Nordheim A. Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J. Biol. Chem. 274:1999;19838-19845
52. Honjo T., Kinoshita K., Muramatsu M. Molecular mechanism of class switch recombination: Linkage with somatic hypermutation. Annu. Rev. Immunol. 20:2002;165-196
53. Hsu H.L., Huang L., Tsan J.T., Funk W., Wright W.E., Hu J.S., Kingston R.E., Baer R. Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins. Mol. Cell. Biol. 14:1994a;1256-1265
54. Hsu H.L., Wadman I., Tsan J.T., Baer R. Positive and negative transcriptional control by the TAL1 helix-loop-helix protein. Proc. Natl. Acad. Sci. USA. 91:1994b;5947-5951
55. Hsu L.Y., Lauring J., Liang H.E., Greenbaum S., Cado D., Zhuang Y., Schlissel M.S. A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. Immunity. 19:2003;105-117
56. Hu J.S., Olson E.N., Kingston R.E. HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors. Mol. Cell. Biol. 12:1992;1031-1042
57. Hu Y.C., Lam K.Y., Law S., Wong J., Srivastava G. Identification of differentially expressed genes in esophageal squamous cell carcinoma (ESCC) by cDNA expression array: Overexpression of Fra-1, Neogenin, Id-1, and CDC25B genes in ESCC. Clin. Cancer Res. 7:2001;2213-2221
58. Huang S., Brandt S.J. mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor. Mol. Cell. Biol. 20:2000;2248-2259
59. Iavarone A., Garg P., Lasorella A., Hsu J., Israel M.A. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev. 8:1994;1270-1284
60. Igarashi H., Gregory S.C., Yokota T., Sakaguchi N., Kincade P.W. Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity. 17:2002;117-130
61. Ishiguro A., Spirin K., Shiohara M., Tobler A., Norton J.D., Rigolet M., Shimbo T., Koeffler H.P. Expression of Id2 and Id3 mRNA in human lymphocytes. Leuk. Res. 19:1995;989-996
62. Jaleco A.C., Stegmann A.P., Heemskerk M.H., Couwenberg F., Bakker A.Q., Weijer K., Spits H. Genetic modification of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3. Blood. 94:1999;2637-2646
63. Jarriault S., Brou C., Logeat F., Schroeter E.H., Kopan R., Israel A. Signalling downstream of activated mammalian Notch. Nature. 377:1995;355-358
64. Kageyama R., Ohtsuka T. The Notch-Hes pathway in mammalian neural development. Cell Res. 9:1999;179-188
65. Kaneta M., Osawa M., Sudo K., Nakauchi H., Farr A.G., Takahama Y. A role for pref-1 and HES-1 in thymocyte development. J. Immunol. 164:2000;256-264
66. Katagiri T., Imada M., Yanai T., Suda T., Takahashi N., Kamijo R. Identification of a BMP-responsive element in Id1, the gene for inhibition of myogenesis. Genes Cells. 7:2002;949-960
67. Kebebew E., Treseler P.A., Duh Q.Y., Clark O.H. The helix-loop-helix transcription factor, Id-1, is overexpressed in medullary thyroid cancer. Surgery. 128:2000;952-957
68. Kee B.L., Bain G., Murre C. IL-7Ralpha and E47: Independent pathways required for development of multipotent lymphoid progenitors. EMBO J. 21:2002;103-113
69. Kelliher M.A., Seldin D.C., Leder P. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase II alpha 3. EMBO J. 15:1996;949-960
70. Kim D., Peng X.C., Sun X.H. Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice. Mol. Cell. Biol. 19:1999;5160-5166
71. Kim D., Xu M., Nie L., Peng X.C., Jimi E., Voll R.E., Nguyen T., Ghosh S., Sun X.H. Helix-loop-helix proteins regulate pre-TCR and TCR signaling through modulation of RelNF-kappaB activities. Immunity. 16:2002;8240-8253
72. Kincade P.W., Igarashi H., Medina K.L., Kouro T., Yokota T., Rossi M.I., Owen J.J., Garrett K.P., Sun X.H., Sakaguchi N. Lymphoid lineage cells in adult murine bone marrow diverge from those of other blood cells at an early, hormone-sensitive stage. Semin. Immunol. 14:2002;385-394
73. Kitamura D., Kudo A., Schaal S., Muller W., Melchers F., Rajewsky K. A critical role of lambda 5 protein in B cell development. Cell. 69:1992;823-831
74. Kitamura D., Roes J., Kuhn R., Rajewsky K. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature. 350:1991;423-426
75. Korchynskyi O., ten Dijke P. Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J. Biol. Chem. 277:2002;4883-4891
76. Lam L.T., Bresnick E.H. Identity of the beta-globin locus control region binding protein HS2NF5 as the mammalian homolog of the notch-regulated transcription factor suppressor of hairless. J. Biol. Chem. 273:1998;24223-24231
77. Langlands K., Yin X., Anand G., Prochownik E.V. Differential interactions of Id proteins with basic helix-loop-helix transcription factors. J. Biol. Chem. 272:1997;19785-19793
78. Lasorella A., Iavarone A., Israel M.A. Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. Mol. Cell. Biol. 16:1996;2570-2578
79. Lasorella A., Noseda M., Beyna M., Yokota Y., Iavarone A. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. Nature. 407:2000;592-598
80. Lasorella A., Boldrini R., Dominici C., Donfrancesco A., Yokota Y., Inserra A., Iavarone A. Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma. Cancer Res. 62:2002;301-306
81. Lenardo M., Pierce J.W., Baltimore D. Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science. 236:1987;1573-1577
82. Lin C.Q., Singh J., Murata K., Itahana Y., Parrinello S., Liang S.H., Gillett C.E., Campisi J., Desprez P.Y. A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells. Cancer Res. 60:2000;1332-1340
83. Lin H., Grosschedl R. Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature. 376:1995;263-267
84. Lopez-Rovira T., Chalaux E., Massague J., Rosa J.L., Ventura F. Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene. J. Biol. Chem. 277:2002;3176-3185
85. Ma L., Hu B., Kenter A.L. Ig S gamma-specific DNA binding protein SNAP is related to the helix-loop-helix transcription factor E47. Int. Immunol. 9:1997;1021-1029
86. MacDonald H.R., Wilson A., Radtke F. Notch1 and T-cell development: Insights from conditional knockout mice. Trends Immunol. 22:2001;155-160
87. Maruyama H., Kleeff J., Wildi S., Friess H., Buchler M.W., Israel M.A., Korc M. Id-1 and Id-2 are overexpressed in pancreatic cancer and in dysplastic lesions in chronic pancreatitis. Am. J. Pathol. 155:1999;815-822
88. Massari M.E., Grant P.A., Pray-Grant M.G., Berger S.L., Workman J.L., Murre C. A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Mol. Cell. 4:1999;63-73
89. Massari M.E., Jennings P.A., Murre C. The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells. Mol. Cell. 16:1996;121-129
90. Massari M.E., Murre C. Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms. Mol. Cell. Biol. 20:2000;429-440
91. Massari M.E., Rivera R.R., Voland J.R., Quong M.W., Breit T.M., van Dongen J.J., de Smit O., Murre C. Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes. Mol. Cell. Biol. 18:1998;3130-3139
92. Mellentin J.D., Smith S.D., Cleary M.L. Lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. Cell. 58:1989;77-83
93. Michael N., Shen H.M., Longerich S., Kim N., Longacre A., Storb U. The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Immunity. 19:2003;235-242
94. Mombaerts P., Iacomini J., Johnson R.S., Herrup K., Tonegawa S., Papaioannou V.E. RAG-1 deficient mice have no mature B and T lymphocytes. Cell. 68:1992;869-877
95. Morrow M.A., Mayer E.W., Perez C.A., Adlam M., Siu G. Overexpression of the helix-loop-helix protein Id2 blocks T cell development at multiple stages. Mol. Immunol. 36:1999;491-503
96. Mui A.L., Wakao H., Kinoshita T., Kitamura T., Miyajima A. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: Role of Stat5 in proliferation. EMBO J. 15:1996;2425-2433
97. Murre C., McCaw P.S., Baltimore D. A new DNA binding and dimerization motif in immunoglobin enhancer binding, daughterless, MyoD and myc proteins. Cell. 56:1989;777-783
98. Nagata Y., Shoji W., Obinata M., Todokoro K. Phosphorylation of helix-loop-helix proteins ID1, ID2 and ID3. Biochem. Biophys. Res. Commun. 207:1995;916-926
99. Nickoloff B.J., Chaturvedi V., Bacon P., Qin J.Z., Denning M.F., Diaz M.O. Id-1 delays senescence but does not immortalize keratinocytes. J. Biol. Chem. 275:2000;27501-27504
100. Nie L., Xu M., Vladimirova A., Sun X.-H. Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J. 22:2003;. (in press).
101. Nishimori H., Sasaki Y., Yoshida K., Irifune H., Zembutsu H., Tanaka T., Aoyama T., Hosaka T., Kawaguchi S., Wada T., Hata J., Toguchida J., Nakamura Y., Tokino T. The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors. Oncogene. 21:2002;8302-8309
102. O'Neil J., Ventura J.J., Cusson N., Kelliher M.A. NF-{kappa}B activation in premalignant mouse tal-1scl thymocytes and tumors. Blood. 102:2003;2593-2596
103. O'Riordan M., Grosschedl R. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity. 11:1999;21-31
104. Ohsako S., Hyer J., Panganiban G., Oliver I., Caudy M. Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation. Genes Dev. 8:1994;2743-2755
105. Ohtani N., Zebedee Z., Huot T.J., Stinson J.A., Sugimoto M., Ohashi Y., Sharrocks A.D., Peters G., Peters G., Hara E. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature. 409:2001;1067-1070
106. Ono Y., Fukuhara N., Yoshie O. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol. Cell. Biol. 18:1998;6939-6950
107. Ouyang X.S., Wang X., Lee D.T., Tsao S.W., Wong Y.C. Over expression of ID-1 in prostate cancer. J. Urol. 167:2002;2598-2602
108. Pan L., Sato S., Frederick J.P., Sun X.-H., Zhuang Y. Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene. Mol. Cell. Biol. 19:1999;5969-5980
109. Park S.T., Sun X.H. The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition. J. Biol. Chem. 273:1998;7030-7037
110. Park S.T., Nolan G.P., Sun X.-H. Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukemia cells. J. Exp. Med. 189:1999;501-508
111. Paroush Z., Finley R.L. Jr., Kidd T., Wainwright S.M., Ingham P.W., Brent R., Ish-Horowicz D. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell. 79:1994;805-815
112. Pear W.S., Aster J.C., Scott M.L., Hasserjian R.P., Soffer B., Sklar J., Baltimore D. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J. Exp. Med. 183:1996;2283-2291
113. Peverali F.A., Ramqvist T., Saffrich R., Pepperkik R., Barone M.V., Philipson L. Regulation of G1 progression by E2A and Id helix-loop-helix proteins. EMBO J. 13:1994;4291-4301
114. Prabhu S., Ignatova A., Park S.T., Sun X.-H. Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and ID proteins. Mol. Cell. Biol. 17:1997;5888-5896
115. Pui J.C., Allman D., Xu L., DeRocco S., Karnell F.G., Bakkour S., Lee J.Y., Kadesch T., Hardy R.R., Aster J.C., Pear W.S. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity. 11:1999;299-308
116. Qi, Z., and Sun, X.-H. Hyper-response to TCR signals leads to apoptosis in Id1 transgenic T cells. Submitted.
117. Qiu Y., Sharma A., Stein R. p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol. Cell. Biol. 18:1998;2957-2964
118. Quesenberry P.J., Iscove N.N., Cooper C., Brady G., Newburger P.E., Stein G.S., Stein J.S., Reddy G.P., Pearson-White S. Expression of basic helix-loop-helix transcription factors in explant hematopoietic progenitors. J. Cell Biochem. 61:1996;478-488
119. Quong M.W., Harris D.P., Swain S.L., Murre C. E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination. EMBO J. 18:1999;6307-6318
120. Quong M.W., Massari M.E., Zwart R., Murre C. A new transcriptional- activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells. Mol. Cell. Biol. 13:1993;792-800
121. Radtke F., Wilson A., Stark G., Bauer M., van Meerwijk J., MacDonald H.R., Aguet M. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity. 10:1999;547-558
122. Rascle A., Johnston J.A., Amati B. Deacetylase activity is required for recruitment of the basal transcription machinery and transactivation by STAT5. Mol. Cell. Biol. 23:2003;4162-4173
123. Reizis B., Leder P. The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes. J. Exp. Med. 194:2001;979-990
124. Riechmann V., van Cruchten I., Sablitzky F. The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3. Nucl. Acids Res. 22:1994;749-755
125. Rivera R.R., Johns C.P., Quan J., Johnson R.S., Murre C. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3. Immunity. 12:2000;17-26
126. Robb L., Begley C.G. The SCLTAL1 gene: roles in normal and malignant haematopoiesis. Bioessays. 19:1997;607-613
127. Romanow W.J., Langerak A.W., Goebel P., Wolvers-Tettero I.L., van Dongen J.J., Feeney A.J., Murre C. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells. Mol. Cell. 5:2000;343-353
128. Rudin C.M., Storb U. Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors. Mol. Cell. Biol. 12:1992;309-320
129. Saisanit S., Sun X.H. A novel enhancer, the pro-B enhancer, regulates Id1 gene expression in progenitor B cells. Mol. Cell. Biol. 15:1995;1513-1521
130. Saisanit S., Sun X.H. Regulation of the pro-B-cell-specific enhancer of the Id1 gene involves the CEBP family of proteins. Mol. Cell. Biol. 17:1997;844-850
131. Sasai Y., Kageyama R., Tagawa Y., Shigemoto R., Nakanishi S. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and enhancer of split. Genes Dev. 6:1992;2620-2634
132. Sato Y., Kobayashi Y., Sasaki H., Toyama T., Kondo S., Kiriyama M., Fujii Y. Expression of Id2 mRNA in neuroblastoma and normal ganglion. Eur. J. Surg. Oncol. 29:2003;284-287
133. Sawada S., Littman D.R. A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Mol. Cell. Biol. 13:1993;5620-5628
134. Sayegh C.E., Quong M.W., Agata Y., Murre C. E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nat. Immunol. 4:2003;586-593
135. Schindl M., Oberhuber G., Obermair A., Schoppmann S.F., Karner B., Birner P. Overexpression of Id-1 protein is a marker for unfavorable prognosis in early-stage cervical cancer. Cancer Res. 61:2001;5703-5706
136. Schindl M., Schoppmann S.F., Strobel T., Heinzl H., Leisser C., Horvat R., Birner P. Level of Id-1 protein expression correlates with poor differentiation, enhanced malignant potential, and more aggressive clinical behavior of epithelial ovarian tumors. Clin. Cancer Res. 9:2003;779-785
137. Schlissel M., Voronova A., Baltimore D. Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line. Genes Dev. 5:1991;1367-1376
138. Schoppmann S.F., Schindl M., Bayer G., Aumayr K., Dienes J., Horvat R., Rudas M., Gnant M., Jakesz R., Birner P. Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer. Int. J. Cancer. 104:2003;677-682
139. Shaffer A.L., Lin K.I., Kuo T.C., Yu X., Hurt E.M., Rosenwald A., Giltnane J.M., Yang L., Zhao H., Calame K., Staudt L.M. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity. 17:2002;51-62
140. Sherwood E.M., Blomberg B.B., Xu W., Warner C.A., Riley R.L. Senescent BALBc mice exhibit decreased expression of lambda5 surrogate light chains and reduced development within the pre-B cell compartment. J. Immunol. 161:1998;4472-4475
141. Sherwood E.M., Xu W., King A.M., Blomberg B.B., Riley R.L. The reduced expression of surrogate light chains in B cell precursors from senescent BALBc mice is associated with decreased E2A proteins. Mech. Ageing Dev. 118:2000;45-59
142. Shinkai Y., Rathbun G., Lam K.P., Oltz E.M., Stewart V., Mendelsohn M., Charron J., Datta M., Young F., Stall A.M., Alt F.W. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68:1992;855-867
143. Sigvardsson M. Overlapping expression of early B-cell factor and basic helix-loop-helix proteins as a mechanism to dictate B-lineage-specific activity of the lambda5 promoter. Mol. Cell. Biol. 20:2000;3640-3654
144. Sigvardsson M., Clark D.R., Fitzsimmons D., Doyle M., Akerblad P., Breslin T., Bilke S., Li R., Yeamans C., Zhang G., Hagman J. Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter. Mol. Cell. Biol. 22:2002;8539-8551
145. Sigvardsson M., O'Riordan M., Grosschedl R. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. Immunity. 7:1997;25-36
146. Singh J., Murata K., Itahana Y., Desprez P.Y. Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1RbHDAC-1 transcription repressor complex. Oncogene. 21:2002;1812-1822
147. Skerjanc I.S., Truong J., Filion P., McBurney M.W. A splice variant of the ITF-2 transcript encodes a transcription factor that inhibits MyoD activity. J. Biol. Chem. 271:1996;3555-3561
148. Smith E.M., Gisler R., Sigvardsson M. Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression. J. Immunol. 169:2002;261-270
149. Spicer D.B., Rhee J., Cheung W.L., Lassar A.B. Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist. Science. 272:1996;1476-1480
150. Strasser A., Whittingham S., Vaux D.L., Bath M.L., Adams J.M., Cory S., Harris A.W. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci. USA. 88:1991;8661-8665
151. Sugai M., Gonda H., Kusunoki T., Katakai T., Yokota Y., Shimizu A. Essential role of Id2 in negative regulation of IgE class switching. Nat. Immunol. 4:2003;25-30
152. Sun X.-H. Constitutive expression of the Id1 gene impairs mouse B cell development. Cell. 79:1994;893-900
153. Sun X.-H., Baltimore D. An inhibitory domain of E12 prevents DNA binding in E12 homodimers but not in E12 heterodimers. Cell. 64:1991;459-470
154. Sun X.-H., Copeland N.G., Jenkins N.A., Baltimore D. Id proteins, Id1 and Id2, selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol. Cell. Biol. 11:1991;5603-5611
155. Takai N., Miyazaki T., Fujisawa K., Nasu K., Miyakawa I. Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma. Cancer Lett. 165:2001;185-193
156. Takeuchi A., Yamasaki S., Takase K., Nakatsu F., Arase H., Onodera M., Saito T. E2A and HEB activate the pre-TCR alpha promoter during immature T cell development. J. Immunol. 167:2001;2157-2163
157. Tamura K., Taniguchi Y., Minoguchi S., Sakai T., Tun T., Furukawa T., Honjo T. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappaSu(H). Curr. Biol. 5:1995;1416-1423
158. Tang J., Gordon G.M., Nickoloff B.J., Foreman K.E. The helix-loop-helix protein id-1 delays onset of replicative senescence in human endothelial cells. Lab. Invest. 82:2002;1073-1079
159. Tomita K., Hattori M., Nakamura E., Nakanishi S., Minato N., Kageyama R. The bHLH gene Hes1 is essential for expansion of early T cell precursors. Genes Dev. 13:1999;1203-1210
160. Tournay O., Benezra R. Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1. Mol. Cell. Biol. 16:1996;2418-2430
161. Tudor K.S., Payne K.J., Yamashita Y., Kincade P.W. Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events. Immunity. 12:2000;335-345
162. Ulgiati D., Pham C., Holers V.M. Functional analysis of the human complement receptor 2 (CR2CD21) promoter: Characterization of basal transcriptional mechanisms. J. Immunol. 168:2002;6279-6285
163. Urbanek P., Wang Z.Q., Fetka I., Wagner E.F., Busslinger M. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5BSAP. Cell. 79:1994;901-912
164. Vandeputte D.A., Troost D., Leenstra S., Ijlst-Keizers H., Ramkema M., Bosch D.A., Baas F., Das N.K., Aronica E. Expression and distribution of id helix-loop-helix proteins in human astrocytic tumors. Glia. 38:2002;329-338
165. Vandesompele J., Edsjo A., De Preter K., Axelson H., Speleman F., Pahlman S. ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value. Oncogene. 22:2003;456-460
166. Voll R.E., Jimi E., Phillips R.J., Barber D.F., Rincon M., Hayday A.C., Flavell R.A., Ghosh S. NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity. 13:2000;677-689
167. Wadman I.A., Osada H., Grutz G.G., Agulnick A.D., Westphal H., Forster A., Rabbitts T.H. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1NLI proteins. EMBO J. 16:1997;3145-3157
168. Wang Q., Hii G., Shusterman S., Mosse Y., Winter C.L., Guo C., Zhao H., Rappaport E., Hogarty M.D., Maris J.M. ID2 expression is not associated with MYCN amplification or expression in human neuroblastomas. Cancer Res. 63:2003;1631-1635
169. Wang X., Xu K., Ling M.T., Wong Y.C., Feng H.C., Nicholls J., Tsao S.W.
170. Weintraub H., Dwarki V.J., Verma I., Davis R., Hollenberg S., Snider L., Lassar A., Tapscott S.J. Muscle-specific transcriptional activation by MyoD. Genes Dev. 5:1991;1377-1386
171. Wice B.M., Gordon J.I. Forced expression of Id-1 in the adult mouse small intestinal epithelium is associated with development of adenomas. J. Biol. Chem. 273:1998;25310-25319
172. Wilson J.W., Deed R.W., Inoue T., Balzi M., Becciolini A., Faraoni P., Potten C.S., Norton J.D. Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index. Cancer Res. 61:2001;8803-8810
173. Wilson R.B., Kiledjian M., Shen C.P., Benezra R., Zwollo P., Dymecki S.M., Desiderio S.V., Kadesch T. Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: Implications for B-lymphoid-cell development. Mol. Cell. Biol. 11:1991;6185-6191
174. Xia Y., Brown L., Yang C.Y.C., Tsan J.T., Siciliano M.J., Espinosa R., Le Beau M.M., Baer R. TAL2, a helix-loop-helix gene activated by the t(7;9)(q34;q32) translocation in human T cell leukemia. Proc. Natl. Acad. Sci. USA. 88:1991;11416-11420
175. Xu M., Nie L., Kim S.H., Sun X.H. STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of CEBPbeta. EMBO J. 22:2003;893-904
176. Xu Y., Davidson L., Alt F.W., Baltimore D. Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus. Proc. Natl. Acad. Sci. USA. 93:1996;2169-2173
177. Yan W., Young A.Z., Soares V.C., Kelley R., Benezra R., Zhuang Y. High incidence of T-cell tumors in E2A-null mice and E2AId1 double-knockout mice. Mol. Cell. Biol. 17:1997;7317-7327
178. Yokota Y., Mansouri A., Mori S., Sugawara S., Adachi S., Nishikawa S., Gruss P. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature. 397:1999;702-706
179. Yokota T., Kouro T., Hirose J., Igarashi H., Garrett K.P., Gregory S.C., Sakaguchi N., Owen J.J.T., Kincade P.W. Unique properties of fetal lymphoid progenitors identified according to RAG1 gene expression. Immunity. 19:2003;365-375
180. Yucel R., Karsunky H., Klein-Hitpass L., Moroy T. The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4CD8 lineage decision in the thymus. J. Exp. Med. 197:2003;831-844
181. Zhao F., Vilardi A., Neely R.J., Choi J.K. Promotion of cell cycle progression by basic helix-loop-helix E2A. Mol. Cell. Biol. 21:2001;6346-6357
182. Zhuang Y., Barndt R.J., Pan L., Kelley R., Dai M. Functional replacement of the mouse E2A gene with a human HEB cDNA. Mol. Cell. Biol. 18:1998;3340-3349
183. Zhuang Y., Cheng P., Weintraub H. B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol. Cell. Biol. 16:1996;2898-2905
184. Zhuang Y., Soriano P., Weintraub H. The helix-loop-helix gene E2A is required for B cell differentiation. Cell. 79:1994;875-884