E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells

Molecular Cell

Volumn 5, Issue 2, 2000, Pages 343-353

  Romanow, William J ^a   Langerak, Anton W ^c   Goebel, Peter ^b   Wolvers Tettero, Ingrid L M ^c   Van Dongen, Jacques J M ^c   Feeney, Ann J ^b   Murre, Cornelis ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINASE;

ARTICLE; B LYMPHOCYTE; EMBRYO CELL; GENE EXPRESSION; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; KIDNEY CELL CULTURE; REGULATOR GENE; T LYMPHOCYTE RECEPTOR GENE; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 0033871151     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80429-3     Document Type: Article

References (47)

1. Early B-cell factor (EBF) down-regulates immunoglobulin heavy chain intron enhancer function in a plasmacytoma cell line
2. E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins
3. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
4. Positive and negative regulation of V(D)J recombination by the E2A proteins
5. Conserved sequence elements in Kappa promoters from mice and humans: Implications for transcriptional regulation and repertoire expression
6. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the J(H) locus
7. E47 activates the Ig-heavy chain and TdT loci in non-B cells
8. A directory of human germ-line Vκ segments reveals a strong bias in their usage
9. Human cord blood κ repetoire
10. Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase
11. Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression
12. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12
13. Expression and hypermutation of human immunoglobulin k genes
14. Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1
15. Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations
16. Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility
17. Cell cycle regulation of the V(D)J recombination-activating protein RAG-2
18. Failure of B-cell differentiation in mice lacking the transcription factor EBF
19. Induced rearrangement of κ genes in the BLIN-1 human pre-B cell line correlates with germline J-Cκ and Vκ transcription
20. A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex
21. RAG-1-deficient mice have no mature B and T lymphocytes
22. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
23. Essential functions of Pax5 (BSAP) in pro-B cell development: Difference between fetal and adult lymphopoesis and reduced V-to-DJ recombination at the IgH locus
24. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
25. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A
26. Production of high-titer helper-free retroviruses by transient transfection
27. p300 mediates transcriptional stimulation by the basic helix-loop-helix factors of the insulin gene
28. Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1
29. The V D J recombination activating gene, RAG-1
30. The variable genes of the human immunoglobulin κ locus
31. Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line
32. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated
33. V D J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhacer
34. B-cell specific DNA binding by an E47 homodimer
35. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
36. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes
37. Accessibility control of antigen-receptor variable-region gene assembly: Role of cis-acting elements
38. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro
39. Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant D(H)6-19 and D(H)7-27 usage, can results in complete V-D-J rearrangements, and are rare in T-cell receptor α β lineage
40. Immunoglobulin κ light chain germ-line transcripts in human precursor B lymphocytes
41. Initiation of V(D)J recombination in a cell-free system
42. Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast
43. V(D)J recombination: Double-strand break repair gene products used in the joining mechanism
44. Evidence that the Vκ III gene usage is nonstochastic in both adult and newborn peripheral B cells and that peripheral CD5+ adult B cells are oligoclonal
45. Deletion of the Igκ light chain intronic enhancer/matrix attachment region impairs but does not abolish Vκ Jκ rearrangement
46. Developmentally controlled and tissue-specific expression of unrearranged V(H) gene segments
47. The helix-loop-helix gene E2A is required for B cell formation