Suppression of interleukin-3-induced gene expression by a C-terminal truncated stat5: Role of stat5 in proliferation

EMBO Journal

Volumn 15, Issue 10, 1996, Pages 2425-2433

  Mui, Alice L F ^a   Wakao, Hiroshi ^a,b   Kinoshita, Taisei ^a,b   Kitamura, Toshio ^a   Miyajima, Atsushi ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

c myc; Cell proliferation; Interleukin 3; Stat5

Indexed keywords

INTERLEUKIN 3; TRANSCRIPTION FACTOR;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; DNA SYNTHESIS; EARLY RESPONSE GENE; GENE EXPRESSION; GENE REPRESSION; HEMATOPOIETIC SYSTEM; HUMAN; ONCOGENE C FOS; ONCOGENE C MYC; ONCOGENE RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0029892399     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00600.x     Document Type: Article

References (44)

1. Arai,K., Lee,F. Miyajima,A., Miyatake,S., Arai,N. and Yokota,T. (1990) Cytokines: coordinators of immune and inflammatory responses. Annu. Rev. Biochem., 59, 783-836.
2. Azam,M., Erdument-Bormage,H., Krieder,B.L., Xia,M., Quelle,F., Basu,R., Saris,C., Tempst,P., Ihle,J.N. and Schindler,C. (1995) Interleukin-3 signals through multiple isoforms of Stat5. EMBO J., 14, 1402-1411.
3. Barahmand-pour,F., Meinke,A., Eilers,A., Gouilleux,F., Groner,B. and Decker,T. (1995) Colony-stimulating factors and interferon-gamma activate a protein related to MGF-Stat 5 to cause formation of the differentiation-induced factor in myeloid cells. FEBS Lett., 360, 29-33.
4. Bluyssen,A.A.R., Muzaffar,R., Vlieststra,R.J., Van der Made,A.C.J., Leung,S., Stark,G.R., Kerr,I.M., Trapman,J. and Levy,D.E. (1995) Combinatorial association and abundance of components of interferonstimulated gene factor 3 dictate the selectivity of interferon responses. Proc. Natl Acad. Sci. USA, 91, 5645-5649.
5. Damen,J.E., Wakao,H., Miyajima,A., Krosl,J., Humphries,R.K., Cutler,R.L. and Krystal,G. (1995) Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J., 14, 5557-5568.
6. Danial,N., Pernis,A. and Rothman,P. (1995) Jak-STAT signaling induced by the v-abl oncogene. Science. 269, 1875-1877.
7. Darnel,J.J., Kerr,I.M. and Stark,G.R. (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science, 264. 1415-1421.
8. Domen,J., van der Lugt,N.M., Laird,P.W., Sans,C.J., Clarke,A.R., Hooper,M.L. and Berns,A. (1993) Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells. Bland, 82, 1445-1452.
9. Eilers,A., Georgellis,D., Klose,G., Schindler,C., Ziemiecki,A., Harpur, A.G., Wilks,A.F. and Decker,T. (1995) Differentiation-regulated serine phosphorylation of STATI promotes GAP activation in macrophages. Mol Cell Biol., 15, 3579-3586.
10. Friedmann,M., Migone,T, Russell,S. and Leonard,W. (1995) Different IL2R beta tyrosines couple to at least two signalling pathways and synergistically mediate IL2 induced proliferation. Proc. Natl Acad. Sci. USA, 93, 2077-2082.
11. Fujii,H., Nakagawa,Y., Schindler,U., Kawahara,A., Mori,H., Gouilleux,F., Groner,B., Ihle,J.N., Minami,Y., Miyazaki,T. and Taniguchi,T. (1995) Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transduction, Proc. Natl Acad. Sci. USA, 92, 5482-5486.
12. Gossen,M. and Bujard,H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl Acad. Sci. USA, 89, 5547-5551.
13. Gouilleux,F, Wakao,H., Mundt,M. and Groner,B. (1994) Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J., 13, 4361-4369.
14. Gouilleux,F., Pallard,C. Dusanter,F.I., Wakao,H., Haldosen,L.A., Norstedt,G., Levy,D. and Groner,B. (1995) Prolactin, growth hormone. erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity. EMBO J., 14, 2005-2013.
15. Hara,E., Yamaguchi.T., Nojima,H., Ide,T., Campisi,J., Okayama,H. and Oda,K. (1994) Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. J. Biol. Chem., 269, 2139-2145.
16. Ho,A.S.-Y., Wei,S.H.-Y, Mui,A.L.-E, Miyajima,A. and Moore,K.W. (1995) Functional regions of the mouse interleukin-10 receptor cytoplasmic domain. Mol. Cell. Biol., 15, 5043-5053.
17. Hou,J., Schindler,U., Henzel,W.J.H., Ho,T., Brasseur,M. and McKnight,S. (1994) An interleukin-4-induced transcription factor: IL-4 Stat. Science, 1701-1706.
18. Ihle,J.N., Witthuhn,B.A., Quelle,F.W., Yamamoto,K., Thierfelder,W.E., Kreider,B. and Silvennoinen,O. (1994) Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Bitichem. Sci., 19, 222-227.
19. Kinoshita,T., Yokota,T., Arai,K. and Miyajima,A. (1995a) Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoielic cells. Oncogene, 10, 2207-2212.
20. Kinoshita,T., Yokota,T., Arai,K. and Miyajima,A. (1995b) Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors. EMBO J., 14, 266-275.
21. Lilly,M., Le,T., Holland,P. and Hendrickson,S.L. (1992) Sustained expression of the pim-1 kinase is specifically induced in myeloid cells by cytokines whose receptors are structurally related. Oncogene, 7, 727-732.
22. Lin,J.X. et al. (1995) The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, 1L-13, and IL-15, Immunity, 2, 331-339.
23. Migone,T., Lin,J., Cereseto,A., Mulloy,J., O'Shea,J., Franchini,G. and Leonard,W. (1995) Constitutively activated Jak-STAT pathways in T cells transformed wiht HTLV-I. Science, 269, 79-81.
24. Miyajima,A., Kitamura,T., Harada,N., Yokota,T. and Arai,K. (1992) Cytokine receptors and signal transduction. Anna. Rev. Immunol., 10, 295-331.
25. Miyajima,A., Mui,A.L.-F, Ogorochi,T. and Sakamaki,K. (1993) Receptors for granulocyte-macrophage colony-stimulating factor, interleukin 3 and interleukin 5. Blood, 82, 1960-1974.
26. Mui,A.L., Wakao,H., O'Farrell,A., Harada,N. and Miyajima,A. (1995) lnterleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 signals through two STAT5 homologs. EMBO J., 14, 1166-1175.
27. Quelle,F.W., Sato,N., Witthuhn,B.A., Inhorn,R.C., Eder,M., Miyajima,A., Griftin,J.D. and Ihle,J.N. (1994) JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol. Cell. Biol., 14, 4335-4341.
28. Quelle,F.W., Shimoda,K., Thierfelder,W., Fischer,C. Kim,A., Ruhen, S.M., Cleveland,J.L., Pierce,J.H., Keegan,A.D., Nelms,K., Paul,W.E. and Ihle,J.N. (1995) Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL4 and IL3 but are not required for mitogenesis. Mol. Cell. Biol., 15, 3336-3343.
29. Renz,M., Neuberg,M., Kurz,C, Bravo,R. and Muller,R. (1985) Regulation of c-fos transcription in mouse fibroblasts: identification of DNase 1-hypersensitive sites and regulatory upstream sequences. EMBO J., 4, 3711-3716.
30. Sakamaki,K., Miyajima,I., Kitamura,T. and Miyajima,A. (1992) Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J., 11, 3541-3549.
31. Samuels,M., Weber,J., Bishop,J. and McMahon,M. (1993) Conditional transformation of cells and rapid activation of the mitogen activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol. Cell. Biol. 13, 6241-6252.
32. Sato,N., Sakamaki,K., Terada,N., Arai,K. and Miyajima,A. (1993) Signal transduction by the high affinity GM-CSF receptor: two distinct cytoplasmic regions of the common β subunit responsible for differentiation. EMBO J., 12, 4181-1189.
33. Schmitt,N.M., Doppler,W., Ball,R.K. and Groner,B. (1991) Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor. Mol. Cell. Biol., 11, 3745-3755.
34. Treisman,R. (1986) Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors. Cell, 46, 567-574.
35. van Lohuizen,M., Verbeek,S., Krimpenfort,F, Domen,J., Saris,C., Radaszkiewicz,T. and Berns,A. (1989) Predisposition to lymphoma-genesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell, 56, 673-682.
36. Voronova,A.F. and Lee,F. (1994) The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation. Proc. Natl Acad. Sci. USA, 91, 5952-5956.
37. Wakao,H., Gouilleux,F. and Groner,B. (1994) Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J., 13, 2182-2191.
38. Wakao,H., Harada,N., Kitamura,T., Mui,A.L. and Miyajima,A. (1995) Interleukin-2 and erythropoietin activate STat5/MGF via distinct pathways. EMBO J., 14, 2527-2535.
39. Waxman,D.J., Ram,P.A., Park,S.H. and Choi,H.K. (1995) Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver expressed, Stat5-related DNA binding protein. J. Biol. Chem., 270, 13262-13270.
40. Yip-Schneider,M.T., Horie,M. and Broxmeyer,H.E. (1995) Transcriptional induction of pim-1 protein kinase gene expression by Interferon gamma and posttranscriptional effects on costimulation with steel factor. Blood, 85, 3494-3502.
41. Yoshimura,A., Ohkubo,T., Kiguchi,T., Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Hara,T. and Miyajima,A. (1995) A novel cytokineinducible gene CIS encodes an SH2-containing protein that binds to tyrosine phosphorylated interleukin 3 and erythropoietin receptors. EMBO J., 14, 2816-2826.
42. Yoshimura,A., Ichichara,M,. Kinjyo,I., Moriyama,M., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Hara,T. and Miyajima,A. (1996) Mouse oncoslatin M: an immediate early gene induced by multiple cytokines through a common JAK-STAT pathway. EMBO J., 15, 1055-1063.
43. Yu,C., Meyer,D., Campbell,G., Larner,A., Caner-Su,C., Schartz,J. and Jove,R. (1995) Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the src oncoprotein. Science, 269, 81-83.
44. Zhang,X., Blenis,J., Li,H., Schindler,C. and Chen-Kiang,S. (1995) Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science, 267, 1990-1994.