Gradient of E2A activity in B-cell development

Molecular and Cellular Biology

Volumn 22, Issue 3, 2002, Pages 886-900

  Herblot, Sabine ^a   Aplan, Peter D ^a   Hoang, Trang ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; IMMUNOGLOBULIN M; PROTEIN P21; PROTEIN SCA; PROTEIN TAL1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2A; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL CYCLE; CELL LINEAGE; CELL MATURATION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; GENE DOSAGE; LEUKEMOGENESIS; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DNA BINDING;

ANIMALIA;

EID: 0036142364     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.3.886-900.2002     Document Type: Article

References (59)

1. An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice
2. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas
3. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
4. Both E12 and E47 allow commitment to the B cell lineage
5. The SCL gene: From case report to critical hematopoietic regulator
6. An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures
7. Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells
8. Lineage commitment in lymphopoiesis
9. Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: Parallels with E2A-deficient mice
10. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
11. Chromatin immunoselection defines a TAL-1 target gene
12. A stromal cell line from myeloid long-term bone marrow cultures can support myelopoiesis and B lymphopoiesis
13. Inhibition of cellular differentiation by the SCL/tal oncoprotein: Transcriptional repression by an Id-like mechanism
14. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
15. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
16. SCL and LMO1 alter thymocyte differentiation: Inhibition of E2A-HEB function and pre-Talpha chain expression
17. Opposing effects of the basic helix-loop-helix transcription factor SCL on erythroid and monocytic differentiation
18. The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation
19. Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia
20. Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins
21. Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells
22. Positive and negative transcriptional control by the TAL1 helix-loop-helix protein
23. E2A expression, nuclear localization, and in vivo formation of DNA- and non-DNA-binding species during B-cell development
24. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12
25. Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice
26. Protein dimerization between Lmo2 (Rbtn2) and Tall alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice
27. Identification of the earliest B lineage stage in mouse bone marrow
28. Oncogenic transcription factors in the human acute leukemias
29. Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL)
30. Two models of murine B lymphopoiesis: A correlation
31. Expression of tal-1 and GATA-binding proteins during human hematopoiesis
32. Intertwining proteins in thymocyte development and cancer
33. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
34. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3
35. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A
36. The Tall oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition
37. Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins
38. Target-dependent effect of phosphorylation on the DNA binding activity of the TAL1/SCL oncoprotein
39. Expression of TAL-1 proteins in human tissues
40. LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes
41. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene
42. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
43. A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines
44. Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line
45. Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription
46. B-cell-specific DNA binding by an E47 homodimer
47. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
48. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes
49. Phosphorylation of E47 as a potential determinant of B-cell-specific activity
50. Constitutive expression of the Id1 gene impairs mouse B cell development
51. Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events
52. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins
53. The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene
54. Long-term culture of B lymphocytes and their precursors from murine bone marrow
55. High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice
56. Promotion of cell cycle progression by basic helix-loop-helix E2A
57. B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2 and HEB
58. Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis
59. The helix-loop-helix gene E2A is required for B cell formation