Thymocyte maturation is regulated by the activity of the helix-loop- helix protein, E47

Journal of Experimental Medicine

Volumn 190, Issue 11, 1999, Pages 1605-1616

  Bain, Gretchen ^a   Quong, Melanie W ^a   Soloff, Rachel S ^a   Hedrick, Stephen M ^a   Murre, Cornelis ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

E2A; Helix loop helix; Positive selection; Thymocyte development

Indexed keywords

HELIX LOOP HELIX PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL MATURATION; CELL VIABILITY; CONTROLLED STUDY; FLOW CYTOMETRY; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; THYMOCYTE;

ANIMALS; BETA 2-MICROGLOBULIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; DNA-BINDING PROTEINS; FLOW CYTOMETRY; GENE DOSAGE; HELIX-LOOP-HELIX MOTIFS; LYMPHOCYTE ACTIVATION; LYMPHOMA, T-CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES; TCF TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033405692     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.11.1605     Document Type: Article

References (44)

1. Jameson, S., and M. Bevan. 1998. T-cell selection. Curr. Opin. Immunol. 10:214-219.
2. Kisielow, P., and H. von Boehmer. 1995. Development and selection of T cells: facts and puzzles. Adv. Immunol. 58:87-209.
3. Robey, E., and B. Fowlkes. 1994. Selective events in T cell development. Annu. Rev. Immunol. 12:675-705.
4. Bain, G., E. Robanus-Maandag, D. Izon, D. Amsen, A. Kruisbeek, B. Weintraub, I. Krop, M. Schlissel, A. Feeney, M. van Roon, et al. 1994. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell. 79:885-892.
5. Murre, C., P.S. McCaw, and D. Baltimore. 1989. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell. 56:777-783.
6. Murre, C., P.S. McCaw, H. Vaessin, M. Caudy, L.Y. Jan, Y.N. Jan, C.V. Cabrera, J.N. Buskin, S.D. Hauschka, A.B. Lassar, H. Weintraub, and D. Baltimore. 1989. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell. 58:537-544.
7. Bain, G., I. Engel, E. Robanus-Maandag, H. te Riele, J. Voland, L. Sharp, J. Chun, B. Huey, D. Pinkel, and C. Murre. 1997. E2A deficiency leads to abnormalities in αβ T cell development and to the rapid development of T cell lymphomas. Mol. Cell. Biol. 17:4782-4791.
8. Sigvardsson, M., M. O'Riordan, and R. Grosschedl. 1997. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. Immunity. 7:25-36.
9. Schlissel, M., A. Voronova, and D. Baltimore. 1991. Helix loop helix transcription factor-E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line. Genes Dev. 5:1367-1376.
10. Kee, B., and C. Murre. 1998. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12. J. Exp. Med. 188:699-713.
11. Blom, B., M.H. Heemskerk, M.C. Verschuren, J.J. van Dongen, A.P. Stegmann, A.Q. Bakker, F. Couwenberg, P.C. Res, and H. Spits. 1999. Disruption of αβ but not γδ T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. EMBO (Eur. Mol. Biol. Organ.) J. 18:2793-2802.
12. Zhuang, Y., P. Soriano, and H. Weintraub. 1994. The helix-loop-helix gene E2A is required for B cell formation. Cell. 79:875-884.
13. Bain, G., W.J. Romanow, K. Albers, W.L. Havran, and C. Murre. 1999. Positive and negative regulation of V(D)J recombination by the E2A proteins. J. Exp. Med. 189:289-300.
14. Heemskerk, M., B. Blom, G. Nolan, A. Stegmann, A. Bakker, K. Weijer, P. Res, and H. Spits. 1997. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3. J. Exp. Med. 186:1597-1602.
15. Bain, G., E. Robanus-Maandag, H. te Riele, A. Feeney, A. Sheehy, M. Schlissel, S. Shinton, R. Hardy, and C. Murre. 1997. Both E12 and E47 allow commitment to the B cell lineage. Immunity. 6:145-154.
16. Tough, D., and J. Sprent. 1994. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179:1127-1135.
17. Kinsella, T., and G. Nolan. 1996. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum. Gene Ther. 7:1405-1413.
18. Engel, I., and C. Murre. 1999. Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas. Proc. Natl. Acad. Sci. USA. 96:996-1001.
19. Bain, G., S. Gruenwald, and C. Murre. 1993. E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins. Mol. Cell. Biol. 13:3522-3529.
20. Ohashi, P., H. Pircher, K. Buerki, R. Zinkernagel, and H. Hengartner. 1990. Distinct sequence of negative or positive selection implied by thymocyte T cell receptor densities. Nature. 346:861-863.
21. Dutz, J., C. Ong, J. Marth, and H.-S. Teh. 1995. Distinct differentiative stages of CD4+CD8+ thymocyte development defined by lack of coreceptor binding in positive selection. J. Immunol. 154:2588-2599.
22. Bendelac, A., P. Matzinger, R.A. Seder, W.E. Paul, and R.H. Schwartz. 1992. Activation events during thymic selection. J. Exp. Med. 175:731-742.
23. Swat, W., M. Dessing, H. von Boehmer, and P. Kisielow. 1993. CD69 expression during selection and maturation of CD4+CD8+ thymocytes. Eur. J. Immunol. 23:739-746.
24. Yamashita, I., T. Nagata, T. Tada, and T. Nakayama. 1993. CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection. Int. Immunol. 5:1139-1150.
25. Swat, W., M. Dessing, A. Baron, P. Kisielow, and H. von Boehmer. 1992 Phenotypic changes accompanying positive selection of CD4+ CD8+ thymocytes. Eur. J. Immunol. 22: 2367-2372.
26. Kaye, J., M.-L. Hsu, M.-E. Sauron, S.C. Jameson, N.R.J. Gascoigne, and S.M. Hedrick. 1989. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature. 341:746-749.
27. Kisielow, P., H. Bluthmann, U. Staerz, M. Steinmetz, and H. von Boehmer. 1988. Tolerance in T cell receptor transgenic mice involves deletion of non-mature CD4+CD8+ thymocytes. Nature. 333:742-746.
28. Teh, H., P. Kisielow, B. Scott, H. Kishi, Y. Uematsu, H. Bluthmann, and H. von Boehmer. 1988. Thymic major histocompatibility complex antigens and the αβ T cell receptor determine the CD4/CD8 phenotype of T cells. Nature. 335: 229-233.
29. Borgulya, P., H. Kishi, Y. Uematsu, and H. von Boehmer. 1992. Exclusion and inclusion of α and β T cell receptor alleles. Cell. 69:529-537.
30. Teh, H., H. Kishi, B. Scott, P. Borgulya, H. von Boehmer, and P. Kisielow. 1990. Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice. Dev. Immunol. 1:1-10.
31. + cytolytic T cells. Nature. 344:742-747.
32. + T cells. Science. 248:1227-1230.
33. Jameson, S., K. Hogquist, and M. Bevan. 1995. Positive selection of thymocytes. Annu. Rev. Immunol. 13:93-126.
34. Lucas, B., and R.N. Germain. 1996. Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation. Immunity. 5:461-477.
35. Linette, G.P., M.J. Grusby, S.M. Hedrick, T.H. Hansen, L.H. Glimcher, and S.J. Korsmeyer. 1994. Bcl-2 is upregulated at the CD4+CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity. 1:197-205.
36. Sentman, C.L., J.R. Shutter, D. Hockenbery, O. Kanagawa, and S.J. Korsmeyer. 1991. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell. 67: 879-888.
37. Siegel, R.M., M. Katsumata, T. Miyashita, D.C. Louie, M.I. Greene, and J.C. Reed. 1992. Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice. Proc. Natl. Acad. Sci. USA. 89:7003-7007.
38. Strasser, A., A.W. Harris, and S. Cory. 1991. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell. 67:889-899.
39. Deftos, M.L., Y.-W. He, E.W. Ojala, and M.J. Bevan. 1998. Correlating notch signaling with thymocyte maturation. Immunity. 9:777-786.
40. Robey, E., D. Chang, A. Itano, D. Cado, H. Alexander, D. Lans, G. Weinmaster, and P. Salmon. 1996. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell. 87:483-492.
41. Ordentlich, P., A. Lin, C.-P. Shen, C. Blaumueller, K. Matsuno, S. Artavanis-Tsakonas, and T. Kadesch. 1998. Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol. Cell. Biol. 18:2230-2239.
42. Matechak, E.O., N. Killeen, S.M. Hedrick, and B.J. Fowlkes. 1996. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity. 4:337-347.
43. Itano, A., P. Salmon, D. Kioussis, M. Tolaini, P. Corbella, and E. Robey. 1996. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J. Exp. Med. 183:731-741.
44. Turka, L., D. Schatz, M. Oettinger, J. Chun, C. Gorka, K. Lee, W. McCormack, and C. Thompson. 1991. Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science. 253:778-781.