E47 activates the Ig-heavy chain and TdT loci in non-B cells

EMBO Journal

Volumn 15, Issue 18, 1996, Pages 5014-5021

  Choi, John Kim ^a   Shen, Chun Pyn ^a,b   Radomska, Hanna S ^c,d   Eckhardt, Laurel A ^c   Kadesch, Tom ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CITY UNIVERSITY OF NEW YORK   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

B lymphocytes; E2A proteins; E47; Immunoglobulin; Td; Transcription

Indexed keywords

HELIX LOOP HELIX PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; DNA BINDING; ENHANCER REGION; GENE CONTROL; HYBRID CELL; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING;

EID: 0029838632     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00881.x     Document Type: Article

References (55)

1. Bain, G. et al. (1994) E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell, 79, 885-892.
2. Baron, M.H. and Farrington, S.M. (1994) Positive regulators of the lineage-specific transcription factor GATA-1 in differentiating erythroid cells. Mol. Cell. Biol., 14, 3108-3114.
3. Beckmann, H., Su, L.-K. and Kadesch, T. (1990) TFE3: A helix-loop-helix protein that activates transcription through the immunoglobulin enhancer μE3 motif. Genes Dev., 4, 167-179.
4. Bergman, Y., Strich, B., Sharir, H., Ber, R. and Laskov, R. (1990) Extinction of Ig gene expression in myeloma×broblast somatic cell hybrids is accompanied by repression of the oct-2 gene encoding a B-cell specific transcription factor. EMBO J., 9, 849-855.
5. Burk, O., Mink, S., Ringwald, M. and Klempnauer, K.-H. (1993) Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors. EMBO J., 12, 2027-2038.
6. Chen, J., Young, F. Bottaro, A., Steward, V., Smith, R.K. and Alt, F.W. (1993) Mutations, of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of JH locus. EMBO J., 12, 4635-4645.
7. Cserjesi, P. and Olson, E.N. (1991) Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products. Mol. Cell. Biol., 11, 4854-4862.
8. Dorshkind, K. (1994) Transcriptional control points during lymphopoiesis. Cell, 79, 751-753.
9. El-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, E., Kinzler, K.W. and Vogelstein, B. (1993) WAFI, a potential mediator of p53 tumor suppression. Cell, 75, 817-825.
10. Emst, P. and Smale, S.T. (1995) Combinatorial regulation of transcription II: the immunoglobulin μ heavy chain gene. Immunity, 2, 427-438.
11. Fernex, C., Capone, M. and Ferrier, P. (1995) The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate. Mol. Cell. Biol., 15, 3217-3226.
12. Genetta, T., Ruezinsky, D. and Kadesch, T. (1994) Displacement of an E-box binding repressor by basic helix-loop-helix proteins: implication for B-cell specificity of the immunoglobulin heavy-chain enhancer. mol. Cell. Biol., 14, 6153-6163.
13. Graham, F.L. and van der Eb, A.J. (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology, 52, 456-467.
14. Gregor, P.D., Sawadogo, M. and Roeder, R.G. (1990) The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. Genes Dev., 4, 1730-1740.
15. Gstaiger, M., Knoepfel, L., Georgiev, D., Schaffner, W. and Hovens, C.M. (1995) A B-cell coactivator of octamer-binding transcription factors. Nature, 373, 360-362.
16. Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. and Elledge, S.J. (1993) The p21 cdk-interacting protein cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75, 805-816.
17. Henthorn, P., Kiledjian, M. and Kadesch, T. (1990) Two distinct transcription factors that bind the immunoglobulin enhancer μE5/kE2 motif. Science, 247, 467-470.
18. Junker, S., Pedersen, S., Schreiber, E. and Matthias, P. (1990) Extinction of an immunoglobulin promoter in cell hybrids is mediated by the octamer motif and correlates with suppression of Oct-2 expression. Cell, 61, 467-474.
19. Kemp, D., Harris, A. and Adams, J. (1980) Transcripts of the immunoglobulin Gμ gene vary in structure and splicing during lymphoid development. Proc. Natl Acad. Sci. USA, 77, 7400-7404.
20. König, H., Pfisterer, P., Corcoran, L.M. and Wirth, T. (1995) Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2. Genes Dev., 9, 1598-1607.
21. Li, Y.S., Hayakawa, K. and Hardy, R.R. (1993) The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med., 178, 951-960.
22. Lieberman, S.A., Hines, M.D., Bergsagel, P.L., Kuehl, W.M. and Eckhardt, L.A. (1993) Coordinate silencing of myelomaspecific genes in myeloma×T lymphoma hybrids. J. Immunol., 151, 2588-2600.
23. Lin, H. and Grosschedl, R. (1995) Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature, 376, 263-267.
24. Luo, Y. and Roeder, R.G. (1995) Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol. Cell. Biol., 15, 4115-4124.
25. Melchers, F., Rolink, A., Grawunder, U., Winkler, T.H., Karasuyama, H., Ghia, P. and Andersson, J. (1995) Positive and negative selection events during B lymphopoiesis. Curr. Opin. Immunol., 7, 214-227.
26. Melotti, P. and Calabretta, B. (1994) Ets-2 and c-myb act independently in regulating expression of the hematopoietic stem cell antigen CD34. J. Biol. Chem., 269, 25303-25309.
27. Molkentin, J.D., Black, B.L., Martin, J.F. and Olson, E.N. (1995) Cooperative activation of muscle gene expression by EF2 and myogenic bHLH proteins. Cell, 83, 1125-1136.
28. Murre, C., Schonleber McCaw, P. and Baltimore, D. (1989) A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell, 56, 777-783.
29. Nelson, K.J., Haimovich, J. and Perry, R.P. (1983) Characterization of productive and sterile transcripts form the immunoglobulin heavy-chain locus: processsing of μm and μs mRNA. Mol. Cell. Biol., 3, 1317-1332.
30. Ness, S. and Kowenz-Leutz, E. (1993) Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. Genes Dev., 7, 749-759.
31. Olson, E.N. and Klein, W.H. (1994) bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes Dev., 8, 1-8.
32. Peverali, F., Ramqvist, A.T., Saffrich, R., Pepperkok, R., Barone M.V. and Philipson, L. (1994) Regulation of G1 progression by E2A and Id helix-loop-helix proteins. EMBO J., 13, 4291-4301.
33. Quong, M.W., Massari, M.E., Zwart, R. and Murre, C. (1993) A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells. Mol. Cell. Biol., 13, 792-800.
34. Radomska, H.S., Shen, C.-P., Kadesch, T. and Eckhardt, L.A. (1994) Constitutively expressed Oct-2 prevents immunoglobulin gene silencing in myeloma×T cell hybrids. Immunity, 1, 623-634.
35. Schafer, B.W., Blakely, B.T., Darlington, G.J. and Blau, H.M. (1990) Effect of cell history on response of helix-loop-helix family of myogenic regulators. Nature, 344, 454-458.
36. Schlissel, M.S., Corcoran, L.M. and Baltimore, D. (1991a) Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription. J. Exp. Med., 173, 711-720.
37. Schlissel, M., Voronova, A. and Baltimore, D. (1991b) Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line. Genes Dev., 5, 1367-1376.
38. Scott, E., Simon, C., Anastasi, J. and Singh, H. (1994) Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science, 265, 1573-1577.
39. Serwe,M . and Sablitzky, F. (1993) V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J., 12, 2321-2327.
40. Shen, C.-P. and Kadesch, T. (1995) B-cell-specific DNA binding by an E47 homodimer. Mol. Cell. Biol., 15, 4518-4524.
41. Shen, L., Lieberman, S. and Eckhardt, L.A. (1993) The octamer/μE4 region of the immunoglobulin heavy-chain enhancer mediates gene repression in myeloma×T-lymphoma hybrids. Mol. Cell. Biol., 13, 3530-3540.
42. Singh, H. (1994) Genetic analysis of transcription factors implicated in B lymphocyte development. Immunol. Res., 13, 280-290.
43. Strubin, M., Newell, J.W. and Matthias, P. (1995) OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell, 80, 497-506.
44. Su, L.K. and Kadesch, T. (1990) The immunoglobuin heavy-chain enhancer functions as the promoter for the Iμ sterile transcription. Mol. Cell. Biol., 10, 2619-2624.
45. Sudo, T., Nishikawa, S., Ohno, N., Akiyama, N., Tamakoshi, M., Yoshida, H. and Nishikawa, S.I. (1993) Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl Acad. Sci. USA, 90, 9125-9129.
46. Sun, X.-H. and Baltimore, D. (1991) An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers. Cell, 64, 459-470.
47. Tapscott, S.J., Thayer, M.J., Weintraub, H. (1993) Deficiency in rhabdomyosarcomas of a factor required for MyoD activity and myogenesis. Science, 259, 1450-1453.
48. Tontonoz, P., Hu, E. and Spiegelman, B.M. (1994) Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell, 79, 1147-1156.
49. Wechsler, D.S., Papoulas, O., Dang, C.V. and Kingston, R.E. (1994) Differential binding of c-myc and max to nucleosomal DNA. Mol. Cell. Biol., 14, 4097-4107.
50. Weintraub, H., Genetta, T. and Kadesch, T. (1994) Tissue-specific gene activation by MyoD: determination of specificity by cis-acting repression elements. Genes Dev., 3, 2203-2211.
51. Wilson, R.B., Kiledjian, M., Shen, C.-P., Benezra, R., Zwollo, P., Dymecki, S.M., Desiderio, S.V. and Kadesch, T. (1991) Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: Implications for B-lymphoid-cell development. Mol. Cell. Biol., 11, 6185-6191.
52. Workman, J., Taylor, I.C.A. and Kingston, R.E. (1991) Activation domains of stably bound GAL4 derivatives alleviate repression of promoters by nucleosomes. Cell, 64, 533-544.
53. Wu, S., Xie, Y., Bucher, N.L.R. and Farmer, S.R. (1995) Conditional ectopic expression of C/EBPβ in NIH-3T3 cells induces PPARy and stimulates adipogenesis. Genes Dev., 9, 2350-2363.
54. Yu, H., Porton, B., Shen, L. and Eckhardt, L. (1989) Role of the octamer motif in hybrid cell extinction of immunoglobulin gene expression; extinction is dominant in a two enhancer system. Cell, 58, 441-448.
55. Zhuang, Y., Soriano, P. and Weintraub, H. (1994) The helix-loop-helix gene E2A is required for B cell formation. Cell, 79, 875-884.