E2A and HEB activate the pre-TCRα promoter during immature T cell development

Journal of Immunology

Volumn 167, Issue 4, 2001, Pages 2157-2163

  Takeuchi, A ^a   Yamasaki, S ^a   Takase, K ^a   Nakatsu, F ^a   Arase, H ^a   Onodera, M ^a   Saito, T ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; DNA PROTEIN COMPLEX; ENHANCER REGION; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE; THYMOCYTE;

EID: 0035881544     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.4.2157     Document Type: Article

References (27)

1. Analysis and expression of a cloned pre-T cell receptor gene
2. Structure and function of the pre-T cell receptor
3. Intra- and extra-thymic expression of the pre-T cell receptor α gene
4. Crucial role of the pre-T-cell receptor alpha gene in development of αβ but not γδ T cells
5. Helix-loop-helix (E2-5, HEB, TAL1 and Id1) protein interaction with the TCRαδ enhancers
6. A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines
7. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas
8. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47
9. A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during αβ thymopoiesis
10. Expression of the mouse pre-T cell receptor α gene is controlled by an upstream region containing a transcriptional enhancer
11. SCL and LMO1 alter thymocyte differentiation: Inhibition of E2A-HEB function and pre-Tα chain expression
12. Surface expression of a T cell receptor β (TCR-β) chain in the absence of TCR-α, -δ, and -γ proteins
13. Signals transduced by CD3ε, but not by surface pre-TCR complexes, are able to induce maturation of an early thymic lymphoma in vitro
14. T cell receptor (TCR) β chain homodimers on the surface of immature but not mature α, γ, δ chain deficient T cell lines
15. Epitopes associated with major histocompatibility complex (MHC) restriction site of T cells. IV. I-J epitopes on MHC-restricted cloned T cells
16. The fine specificity of antigen and 1a determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c
17. Pan: A transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs
18. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
19. Id helix-loop-helix proteins in cell growth and differentiation
20. Disruption of αβ but not of γδ T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors
21. Transcriptional control of T cell development
22. Helix-loop-helix proteins: Regulators of transcription in eukaryotic organisms
23. Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB
24. Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice
25. B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB
26. HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors
27. The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells