Both E12 and E47 allow commitment to the B cell lineage

Immunity

Volumn 6, Issue 2, 1997, Pages 145-154

  Bain, Gretchen ^a   Robanus Maandag, Els C ^b   Te Riele, Hein P J ^b   Feeney, Ann J ^c   Sheehy, Ann ^e   Schlissel, Mark ^e   Shinton, Susan A ^d   Hardy, Richard R ^d   Murre, Cornelis ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d FOX CHASE CANCER CENTER   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; DEVELOPMENT; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; LYMPHOCYTE DIFFERENTIATION; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; TRANSGENIC MOUSE;

EID: 0031003914     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80421-5     Document Type: Article

References (43)

1. Alkema, M.J., van der Lugt, N.M.T., Bobeldijk, A., Berns, A., and van Lohuizen, M. (1995). Transformation of axial skeleton due to overexpression of bmi-1 transgenic mice. Nature 374, 724-727.
2. Alt, F.W., Yancopoulos, G.D., Blackwell, T.K., Wood, C., Thomas, E., Boss, M., Coffman, R., Rosenberg, N., Tonegawa, S., and Baltimore, D. (1984). Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J. 3, 1209-1219.
3. Alt, F.W., Oltz, E., Young, F., Gorman, J., and Taccioli, G. (1992). VDJ recombination. Immunol. Today 13, 306-314.
4. Aronheim, A., Shiran, R., Rosen, A., and Walker, M.D. (1993). The E2A gene product contains two separable and functionally distinct transcription activation domains. Proc. Natl. Acad. Sci. USA 90, 8063-8067.
5. Bain, G., Grunwald, S., and Murre, C. (1993). B-cell-specific E2-box DNA-binding proteins. Mol. Cell. Biol. 13, 3522-3529.
6. Bain, G., Robanus Maandag, E.C., Izon, D.J., Armsen, D., Kruisbeek, A.M., Weintraub, B.C., Krop, I., Schilssel, M.S., Feeney, A.J., van Roon, M., van der Valk, M., te Riele, H.P.J., Berns, A., and Murre, C. (1994). E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79, 885-892.
7. Barberis, A., Widenhorn, K., Vitelli, L., and Busslinger, M. (1990). A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation. Genes Dev. 4, 849-859.
8. Benezra, R. (1994). An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperature. Cell 79, 885-892.
9. Ehlich, A., Schaal, S., Gu, H., Kitamura, D., Muller, W., and Rajewsky, K. (1993). Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72, 695-704.
10. Feeney, A. (1991). Predominance of the prototypic T15 anti-phosphorylcholine junctional sequence in neonatal pre-B cells. J. Immunol. 147, 4343-4350.
11. H junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies. J. Immunol. 149, 222-229.
12. Grabstein, K.H., Waldschmidt, T.J., Finkelman, F.D., Hess, B.W., Alpert, A.R., and Boiani, N.E. (1995). Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J. Exp. Med. 178, 257-264.
13. Hagman, J., Belanger, C., Travis, A., Turck, C.W., and Grosschedl, R. (1993). Cloning and functional characterization of early B-cell factor, a regulator of lymphoid-specific gene expression. Genes Dev. 7, 760-773.
14. Hardy, R.R., Carmack, C.E., Shinton, S.A., Kemp, J.D., and Hayakawa, K. (1991). Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173, 1213-1225.
15. Henthorn, P., Kiledjian, M., and Kadesch, T. (1990). Two distinct transcription factors that bind the immunoglobulin enhancer μE5/ κE2 motif. Science 247, 467-470.
16. Jacobs, Y., Vierra, C., and Nelson, C. (1994). E2A expression, nuclear localization, and in vivo formation of DNA-and non-DNA-binding species during B-cell development. Mol. Cell. Biol. 13, 7321-7333.
17. Kee, B., and Paige, C. (1996). In vitro tracking of IL-7 responsiveness and gene expression during commitment of bipotent B-cell/macrophage progenitors. Curr. Biol. 6, 1159-1169.
18. Lassar, A.B., Davis, R.L., Wright, W.E., Kadesch, T., Murre, C., Voronova, A., Baltimore, D., and Weintraub, H. (1991). Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/ E47-like proteins in vivo. Cell 66, 305-315.
19. Lin, H., and Grosschedl, R. (1995). Failure of B cell differentiation in mice lacking the transcription factor EBF. Nature 376, 263-266.
20. Massari, M., Jennings, P.A., and Murre, C. (1996). The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells. Mol. Cell. Biol. 16, 121-129.
21. Murre, C., McCaw, P.S., and Baltimore, D. (1989a). A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56, 777-783.
22. Murre, C., McCaw, P.S., Vaessin, H., Caudy, M., Jan, L.Y., Jan, Y.N., Cabrera, C.V., Buskin, J.N., Hauschka, S.D., Lassar, A.B., Weintraub, H., and Baltimore, D. (1989b). Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58, 537-544.
23. Murre, C., Voronova, A., and Baltimore, D. (1991). B-cell-and myocyte-specific E2-box-binding factors contain E12/E47-like subunits. Mol. Cell. Biol. 11, 1156-1160.
24. Peschon, J., Morrissey, P.J., Grabstein, K.H., Ramsdell, F.J., Marakovsky, E., Gliniak, B.C., Park, L.S., Ziegler, S.F., Williams, D.E., Ware, C.B., Meyer, J.D., and Davison, B.L. (1994). Early lymphocyte expansion is severely impaired in interleukin-7 receptor deficient mice. J. Exp. Med. 180, 1955-1960.
25. Pongubala, J., and Atchison, M. (1991). Functional characterization of the developmentally controlled immunoglobulin κ 3′ enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors. Mol. Cell. Biol. 11, 1040-1047.
26. Quong, M.W., Massari, M.E., Zwart, R., and Murre, C. (1993). A new transcriptional activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells. Mol. Cell. Biol. 13, 792-800.
27. Rolink, A., ten Boekel, E., Melchers, F., Fearon, D.T., Krop, I., and Andersson, J. (1996). A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J. Exp. Med. 183, 187-194.
28. Sawada, S., and Littman, D.R. (1993). A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Mol. Cell Biol. 13, 5620-5628.
29. Schlissel, M.S., Voronova, A., and Baltimore, D. (1991a). Helix loop helix transcription factor-E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line. Genes Dev. 5, 1367-1376.
30. Schlissel, M.S., Corcoran, L.M., and Baltimore, D. (1991b). Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription. J. Exp. Med. 173, 711-720.
31. Shen, C.P., and Kadesch, T. (1995). B cell specific transcription by an E47 homodimer. Mol. Cell. Biol. 15, 4518-4524.
32. Spanopoulou, E., Roman, C.A.J., Corcoran, L.M., Schlissel, M.S., Silver, D.R., Nemazee, D., Nussenzweig, M.C., Shinton, S.A., Hardy, R.R., and Baltimore, D. (1994). Functional immunoglobulin trans-genes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8, 1030-1042.
33. Sudo, T., Ito, M., Ogawa, Y., Lizuka, M., Kodama, H., and Kunsada, T. (1989). Interleukin 7 production and function in stromal cell-dependent B cell development. J. Exp. Med. 170, 333-342.
34. Sun, X.H. (1994). Constitutive expression of the Id1 gene impairs mouse B cell development. Cell 79, 893-901.
35. Sun, X.H., and Baltimore, D. (1991). An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers. Cell 64, 459-470.
36. te Riele, H., Robanus-Maandag, E., and Berns, A. (1992). Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. Proc. Natl. Acad. Sci. USA 89, 5128-5132.
37. Thomas, K., and Capecchi, M. (1987). Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51, 503-512.
38. Urbanek, P., Wang, Z.Q., Fetka, I., Wagner, E.F., and Buslinger, M. (1994). Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax-5/BSAP. Cell 79, 901-913.
39. von Freeden-Jeffry, U., Vieira, P., Lucina, L., McNeil, T., Burdach, S.E.G., and Murray, R. (1995). Lymphopenia in interleukin-7 gene deleted mice identifies II-7 as a non-redundant cytokine. J. Exp. Med. 181, 1519-1526.
40. Xin, X.Q., Nelson, C., Collins, C., and Dorshkind, K. (1994). Kinetics of E2A HLH protein expression during myelopoiesis and primary B cell differentiation. J. Immunol. 152, 16351-16356.
41. Yancopoulos, G., and Alt, F.W. (1985). Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell 40, 271-281.
42. Young, F., Ardman, B., Shinkai, Y., Lansford, R., Blackwell, T.K., Mendelsohn, M., Rolink, A., Melchers, F., and Alt, F.W. (1994). Influence of immunoglobulin heavy-and light-chain expression on B-cell differentiation. Genes Dev. 8, 1043-1057.
43. Zhuang, Y., Soriano, P., and Weintraub, H. (1994). The helix-loop-helix gene E2A is required for B cell formation. Cell 79, 875-885.