Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer

International Journal of Cancer

Volumn 104, Issue 6, 2003, Pages 677-682

  Schoppmann, Sebastian F ^a   Schindl, Monika ^a   Bayer, Guenther ^a   Aumayr, Klaus ^a   Dienes, Julia ^a   Horvat, Reinhard ^a   Rudas, Margaretha ^a   Gnant, Michael ^a   Jakesz, Raimund ^a   Birner, Peter ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Id 1 protein; Node negative breast cancer; Prognosis; Survival

Indexed keywords

CELL CYCLE PROTEIN; ESTROGEN RECEPTOR; INHIBITOR OF DIFFERENTIATION 1; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER HORMONE THERAPY; CANCER INHIBITION; CANCER SURVIVAL; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN INTERACTION; RECEPTOR DENSITY;

BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; CHEMOTHERAPY, ADJUVANT; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HELIX-LOOP-HELIX MOTIFS; HUMANS; IMMUNOENZYME TECHNIQUES; INHIBITOR OF DIFFERENTIATION PROTEIN 1; LYMPH NODES; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; REPRESSOR PROTEINS; SURVIVAL RATE; TRANSCRIPTION FACTORS; UP-REGULATION; UTERINE CERVICAL NEOPLASMS;

EID: 0345669748     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11009     Document Type: Article

References (42)

1. Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 1990;61:49-59.
2. Benezra R, Rafii S, Lyden D. The Id proteins and angiogenesis. Oncogene 2001;20:8334-41.
3. Chen CR, Kang Y, Massague J. Defective repression of c-myc in breast cancer cells: a loss at the core of the transforming growth factor beta growth arrest program. Proc Natl Acad Sci USA 2001;98:992-9.
4. Christy BA, Sanders LK, Lau LF, Copeland NG, Jenkins NA, Nathans D. An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc Natl Acad Sci USA 1991;88:1815-9.
5. Norton JD, Atherton GT. Coupling of cell growth control and apoptosis functions of Id proteins. Mol Cell Biol 1998;18:2371-81.
6. Lasorella A, Uo T, Iavarone A. Id proteins at the cross-road of development and cancer. Oncogene 2001;20:8326-33.
7. Lyden D, Young AZ, Zagzag D, Yan W, Gerald W, O'Reilly R, Bader BL, Hynes RO, Zhuang Y, Manova K, Benezra R. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 1999;401:670-7.
8. Arnold JM, Mok SC, Purdie D, Chenevix-Trench G. Decreased expression of the Id3 gene at 1p36.1 in ovarian adenocarcinomas. Br J Cancer 2001;84:352-9.
9. Schindl M, Oberhuber G, Obermair A, Schoppmann SF, Karner B. Birner P. Overexpression of Id-1 protein is a marker for unfavorable prognosis in early-stage cervical cancer. Cancer Res 2001:61:5703-6.
10. Schindl M, Schoppmann SF, Stroebel T, Heinzl H, Leisser C, Horvat R, Birner P. Level of Id-1 protein expression correlates with poor differentiation, enhanced malignant potential, and more aggressive clinical behavior of epithelial ovarian tumors. Clin Cancer Res 2003 (in press).
11. Alani RM, Hasskarl J, Grace M, Hernandez MC, Israel MA, Munger K. Immortalization of primary human keratinocytes by the helix-loophelix protein, Id-1. Proc Natl Acad Sci USA 1999;96:9637-41.
12. Woo PL, Cercek A, Desprez PY, Firestone GL. Involvement of the helix-loop-helix protein Id-1 in the glucocorticoid regulation of tight junctions in mammary epithelial cells. J Biol Chem 2000;275:28649-58.
13. Clement JH, Marr N, Meissner A, Schwalbe M, Sebald W, Kliche KO, Hoffken K, Wolfl S. Bone morphogenetic protein 2 (BMP-2) induces sequential changes of Id gene expression in the breast cancer cell line MCF-7. J Cancer Res Clin Oncol 2000;126:271-9.
14. Desprez PY, Hara E, Bissell MJ, Campisi J. Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1. Mol Cell Biol 1995;15:3398-404.
15. Desprez PY, Lin CQ, Thomasset N, Sympson CJ, Bissell MJ, Campisi J. A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1. Mol Cell Biol 1998;18:4577-88.
16. Lin CQ, Singh J, Murata K, Itahana Y, Parrinello S, Liang SH, Gillett CE, Campisi J, Desprez PY. A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells. Cancer Res 2000;60:1332-40.
17. Parrinello S, Lin CQ, Murata K, Itahana Y, Singh J, Krtolica A, Campisi J, Desprez PY. Id-1, ITF-2, and Id-2 comprise a network of helix-loop-helix proteins that regulate mammary epithelial cell proliferation, differentiation, and apoptosis. J Biol Chem 2001;276: 39213-9.
18. Singh J, Itahana Y, Parrinello S, Murata K, Desprez PY. Molecular cloning and characterization of a zinc finger protein involved in Id-1-stimulated mammary epithelial cell growth. J Biol Chem 2001; 276:11852-8.
19. Ouyang XS, Wang X, Ling MT, Wong HL, Tsao SW, Wong YC. Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathway. Carcinogenesis 2002;23:721-5.
20. Polsky D, Young, AZ, Busam KJ, Alani RM. The transcriptional repressor of p16/Ink4a, Id1, is up-regulated in early melanomas. Cancer Res 2001;61:6008-11.
21. Elston EW, Ellis IO. Method for grading breast cancer. J Clin Pathol 1993;46:189-90.
22. Maruyama H, Kleeff J, Wildi S, Friess H, Buchler MW, Israel MA, Korc M. Id-1 and Id-2 are overexpressed in pancreatic cancer and in dysplastic lesions in chronic pancreatitis. Am J Pathol 1999;155:815-22.
23. Langlands K, Down GA, Kealey T. Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma. Cancer Res 2000;60:5929-33.
24. Dorai H, Sampath TK. Bone morphogenetic protein-7 modulates genes that maintain the vascular smooth muscle cell phenotype in culture. J Bone Joint Surg Am 2001;83A:S70-8.
25. Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G. Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 2000;60:4693-6.
26. Aagaard L, Lukas J, Bartkova J, Kjerulff AA, Strauss M, Bartek J. Aberrations of p161nk4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines. Int J Cancer 1995;61:115-20.
27. Lee CT, Capodieci P, Osman I, Fazzari M, Ferrara J, Scher HI, Cordon-Cardo C. Overexpression of the cyclin-dependent kinase inhibitor p16 is associated with tumor recurrence in human prostate cancer. Clin Cancer Res 1999;5:977-83.
28. Jakesz R, Dittrich C, Hanusch J, Kolb R, Lenzhofer R, Moser K. Rainer H, Reiner G, Schemper M, Spona J, et al. Simultaneous and sequential determinations of steroid hormone receptors in human breast cancer. Influence of intervening therapy. Ann Surg 1985;201: 305-10.
29. Jakesz R, Hausmaninger H, Haider K, Kubista E, Samonigg H, Gnant M, Manfreda D, Tschurtschenthaler G, Kolb R, Stierer M, Fridrik M, Mlineritsch B, et al. Randomized trial of low-dose chemotherapy added to tamoxifen in patients with receptor-positive and lymph node-positive breast cancer. J Clin Oncol 1999;17:1701-9.
30. Reiner A, Neumeister B, Spona J, Reiner G, Schemper M, Jakesz R. Immunocytochemical localization of estrogen and progesterone receptor and prognosis in human primary breast cancer. Cancer Res 1990;50:7057-61.
31. Kaplan EL, Meier P. Non parametric estimation from incomplete observations. J Am Stat Assoc 1985;53:457-81.
32. Jakesz R, Hausmaninger H, Samonigg H, Kubista E, Haider K, Mlineritsch B, Schmid M, Tausch C, Reiner G, Renner K, Stierer M, Jatzko G, et al. [Therapy studies of the Austrian Breast Cancer Group (ABC)]. Zentralbl Chir 1998;123:28-32.
33. Ahmad M, Medford RM. Evidence for the regulation of Na+, K(+)-ATPase α1 gene expression through the interaction of aldosterone and cAMP-inducible transcriptional factors. Steroids 1995;60:147-52.
34. Cippitelli M, Sica A, Viggiano V, Ye J, Ghosh P, Birrer MJ, Young HA. Negative transcriptional regulation of the interferon-γ promoter by glucocorticoids and dominant negative mutants of c-Jun. J Biol Chem 1995;270:12548-56.
35. Dickson RB. Stimulatory and inhibitory growth factors and breast cancer. J Steroid Biochem Mol Biol 1990;37:795-803.
36. Dickson RB, Thompson EW, Lippman ME. Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids. J Steroid Biochem Mol Biol 1990;37:305-16.
37. Kalkhoven E, Kwakkenbos-Isbrucker L, Mummery CL, de Laat SW, van den Eijnden-van Raaij AJ, van der Saag PT, van der Burg B. The role of TGF-β production in growth inhibition of breast-tumor cells by progestins. Int J Cancer 1995;61:80-6.
38. Groshong SD, Owen GI, Grimison B, Schauer IE, Todd MC, Langan TA, Sclafani RA, Lange CA, Horwitz KB. Biphasic regulation of breast cancer cell growth by progesterone: role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1). Mol Endocrinol 1997;11: 1593-607.
39. Sitruk-Ware R, Plu-Bureau G. Progestins and cancer. Gynecol Endocrinol 1999;13(Suppl):3-9.
40. INK4a expression during cellular senescence. Nature 2001;409:1067-70.
41. INK4a messenger RNA is a marker of poor prognosis. Clin Cancer Res 2000;6:2777-87.
42. Norton JD, Deed RW, Craggs G, Sablitzky F. Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol 1998;8: 58-65.