Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB

Molecular and Cellular Biology

Volumn 20, Issue 18, 2000, Pages 6677-6685

  Barndt, R J ^a   Dai, M ^a   Zhuang, Y ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; ENHANCER REGION; FLOW CYTOMETRY; GENE DISRUPTION; GENE FUNCTION; GENE LOCUS; GENE MUTATION; GENE REARRANGEMENT; KNOCKOUT MOUSE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; SOUTHERN BLOTTING; T LYMPHOCYTE; THYMOCYTE; TRANSCRIPTION REGULATION; TRANSGENE; WESTERN BLOTTING;

ALLELES; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINEAGE; DIMERIZATION; DNA NUCLEOTIDYLTRANSFERASES; DNA-BINDING PROTEINS; GENE DOSAGE; GENE EXPRESSION; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; GENES, T-CELL RECEPTOR; HELIX-LOOP-HELIX MOTIFS; HEMATOPOIESIS; HUMANS; LEUKOPOIESIS; MICE; MICE, INBRED C57BL; MUTAGENESIS; PHENOTYPE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES; TCF TRANSCRIPTION FACTORS; THYMUS GLAND; TRANSCRIPTION FACTORS; TRANSGENES; VDJ RECOMBINASES;

EID: 0033811622     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.18.6677-6685.2000     Document Type: Article

References (66)

1. E2A and E2-E2 are subunits of B-cell-specific E2-box DNA-binding proteins
2. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
3. Both El2 and E47 allow commitment to the B cell lineage
4. E2A deficiency leads to abnormalities in α/β T-cell development and to rapid development of T-cell lymphomas
5. A novel role for HEB downstream or parallel to the pre-TCR signal during alpha/beta thymopoiesis
6. The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
7. An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures
8. Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors
9. E47 activates the Ig-heavy chain and TdT loci in non-B cells
10. T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice
11. Early αβ T-cell development in the thymus of normal and genetically altered mice
12. The Ikaros gene is required for the development of all lymphoid lineages
13. A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression
14. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3
15. HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors
16. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein
17. Helix-loop-helix proteins in the regulation of immunoglobulin gene transcription
18. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
19. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12
20. Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice
21. Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH protein
22. Profound block in thymocyte development in mice lacking p56lck
23. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice
24. Overexpression of the helix-loop-helix protein Id2 blocks T cell development at multiple stages
25. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless. MyoD, and myc proteins
26. Interactions between heterodimeric helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
27. Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1
28. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76
29. Developmental regulation of VDJ recombination by the core fragment of the T cell receptor alpha enhancer
30. A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines
31. Helix-loop- scription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line
32. B-cell-specific DNA binding by an E47 homodimer
33. Restoration of T cell development to RAG-2-deficient mice by functional TCR transgenes
34. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes
35. Constitutive expression of the Id1 genes impairs mouse B cell development
36. Transcription factor GATA-3 is required for development of the T-cell lineage
37. Definition of a T-cell receptor β gene core enhancer of V(D)J recombination by transgenic mapping
38. T-cell specific rearrangement of T-cell receptor beta transgenes in mice
39. Alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases
40. An HMG-box-containing T-cell factor required for thymocyte differentiation
41. Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains
42. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation
43. The myoD gene family: Nodal point during specification of the muscle cell lineage
44. Essential role of LAT in T cell development
45. The helix-loop-helix gene E2A is required for B cell formation
46. B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-E2, and HEB
47. Functional replacement of the mouse E2A gene with a human HEB cDNA
48. Association of the TLX-2 homeodomain and 14-3-3 signaling proteins
49. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
50. Human cruciform binding protein belongs to the 14-3-3 family
51. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex
52. Identification of a new family of higher eukaryotic histone deacetylases
53. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
54. A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated SNF-2 superfamily ATPase
55. HDAC4, a human histone deacetylase related to yeast HDA1, is a potent transcriptional corepressor
56. Activators and repressors: Making use of chromatin to regulate transcription
57. Alteration of nucleosome structure as a mechanism of transcriptional regulation
58. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
59. The structural basis for 14-3-3: Phosphopeptide binding specificity
60. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3
61. Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family
62. Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 2
63. The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities
64. Analysis of the Nurd subunits reveals a histone deacetylase core complex and a connection with Dna methylation
65. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex
66. Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5