A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells

Cancer Research

Volumn 60, Issue 5, 2000, Pages 1332-1340

  Lin, Claudia Qiao ^a,b,d   Singh, Jarnail ^b   Murata, Kenji ^b   Itahana, Yoko ^b   Parrinello, Simona ^b   Liang, Scott H ^b   Gillett, Cheryl E ^c   Campisi, Judith ^d   Desprez, Pierre Yves ^b  

^a BAYER AG   (Germany)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^c GUY S HOSPITAL   (United Kingdom)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY DNA; DNA; ESTROGEN; HELIX LOOP HELIX PROTEIN; MESSENGER RNA; PROGESTERONE; STEROID HORMONE; TRANSCRIPTION FACTOR;

ARTICLE; BREAST CANCER; CELL PROLIFERATION; CONTROLLED STUDY; HORMONE RESPONSE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; BREAST NEOPLASMS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELIX-LOOP-HELIX MOTIFS; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; MAMMARY GLANDS, ANIMAL; MICE; NEOPLASMS, HORMONE-DEPENDENT; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0034161969     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Riechmann, V., van Cruchten, I., and Sablitzky, F. The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3. Nucleic Acids. Res., 22: 749-755, 1994.
2. Riechmann, V., and Sablitzky, F. Mutually exclusive expression of two dominant-negative helix-loop-helix (dnHLH) genes, Id4 and Id3, in the developing brain of the mouse suggests distinct regulatory roles of these dnHLH proteins during cellular proliferation and differentiation of the nervous system. Cell Growth Differ., 6: 837-843, 1995.
3. Benezra, R., Davis, R. L., Lockshon, D., Turner, D. L., and Weintraub, H. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell, 61: 49-59. 1990.
4. Cross, J. C., Flannery, M. L., Blanar, M. A., Steingrimsson, E., Jenkins, N. A., Copeland, N. G., Rutter, W. J., and Wert, Z. Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development (Camb.), 121: 2513-2523, 1995.
5. Lister, J., Forrester, W. C., and Baron, M. H. Inhibition of an erythroid differentiation switch by the helix-loop-helix protein Id1. J. Biol. Chem., 270: 17939-17946, 1995.
6. Sun, X. H. Constitutive expression of the Id1 gene impairs mouse B cell development. Cell, 79: 893-900, 1994.
7. Wilson, R. B., Kiledjian, M., Shen, C. P., Benezra, R., Zwollo, P., Dymecki, S. M., Desiderio, S. V., and Kadesch, T. Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development. Mol. Cell. Biol., 11: 6185-6191, 1991.
8. Kreider, B. L., Benezra, R., Rovera, G., and Kadesch, T. Inhibition of myeloid differentiation by the helix-loop-helix protein Id. Science (Washington DC), 255: 1700-1702, 1992.
9. Desprez, P. Y., Hara E., Bissell, M. J., and Campisi, J. Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1. Mol. Cell. Biol., 15: 3398-3404, 1995.
10. Desprez, P. Y., Roskelley, C., Campisi, J., and Bissell, M. J. Isolation of functional cell lines from a mouse mammary epithelial cell strain: the importance of basement membrane and cell-cell interaction. Mol. Cell. Differ., 1: 99-110, 1993.
11. Desprez, P. Y., Lin, C. Q., Thomasset, N., Sympson, C. J., Bissell, M. J., and Campisi, J. A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1. Mol. Cell. Biol., 18: 4577-4588, 1998.
12. Dickson, R. B., Thompson, E. W., and Lippman, M. E. Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids. J. Steroid Biochem. Mol. Biol., 37: 305-316, 1990.
13. Clarke, C. L., and Sutherland, R. L. Progestin regulation of cellular proliferation. Endocr. Rev., 11: 266-301, 1990.
14. Horwitz, K. B. The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer? Endocr. Rev., 13: 146-163, 1992.
15. Horwitz, K. B. Mechanisms of hormone resistance in breast cancer. Breast Cancer Res Treat., 26: 119-130, 1993.
16. Webb, P., Lopez, G. N., Uht, R. M., and Kushner, P. J. Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens. Mol. Endocrinol., 9: 443-456, 1995.
17. Paech, K., Webb, P., Kuiper, G. G., Nilsson, S., Gustafsson, J., Kushner, P. J., and Scanlan, T. S. Differential ligand activation of estrogen receptors ERα and ERβ at API sites. Science (Washington DC), 277: 1508-1510, 1997.
18. 1 progression and are repressed in senescent human fibroblasts. J. Biol. Chem., 269; 2139-2145, 1994.
19. Morgenstern, J. P., and Land, H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res., 18: 3587-3596, 1990.
20. German, C. High efficiency gene transfer into mammalian cell. In: D. M. Glover (ed.), DNA Cloning, pp. 143-211. Oxford, United Kingdom: IRL, 1986.
21. Nehlin, J. O., Hara, E., Kuo, W. L., Collins, C., and Campisi, J. Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene. Biochem. Biophys. Res. Comm., 231: 628-634, 1997.
22. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
23. Maniatis, T., Fritsch, E. F., and Sambrook, J. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laborabory, 1989.
24. Albini, A., Iwamoto, Y., Kleinman, H. K., Martin, G. R., Aaronson, S. A., Kozlowski, J. M., and McEwan, R. N. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res., 47: 3239-3245, 1987.
25. Christy, B. A., Sanders, L. K., Lau, L. F., Copeland, N. G., Jenkins, N. A., and Nathans, D. An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc. Natl. Acad. Sci. USA. 88: 1815-1819, 1991.
26. Deed, R. W., Bianchi, S. M., Atherton, G. T., Johnston, D., Santibanez-Koref, M., Murphy, J. J., and Norton, J. D. An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types. Oncogene, 8: 599-607, 1993.
27. Tournay, O., and Benezra, R. Transcription of the dominant-negative helix-loop-helix protein Id 1 is regulated by a protein complex containing the immediate-early response gene Egr-1. Mol. Cell. Biol., 16: 2418-2430, 1996.
28. de Cremoux, P., Martin, E. C., Vincent-Salomon, A., Dieras, V., Barbaroux, C., Liva, S., Pouillart, P., Sastre-Garau, X., and Magdelenat, H. Quantitative PCR analysis of c-erh B-2 (HER2/neu) gene amplification and comparison with pl85(HER2/neu) protein expression on breast cancer drill biopsies. Int. J. Cancer, 83: 157-161, 1999.
29. Saisanit, S., and Sun, X. H. Regulation of the pro-B-cell specific enhancer of the Id1 gene involves the C/EBP family of proteins. Mol. Cell. Biol., 17: 844-850, 1997.
30. Kalkhoven, E., Kwakkenbos-Isbrucker, L., Mummery, C. L., de Laat, S. W., van den Eijnden-van Raaij, A. J., van der Saag, P. T., and van der Burg, B. The role of TGF-ß production in growth inhibition of breast-tumor cells by progestins. Int. J. Cancer, 61: 80-86, 1995.
31. Read, L. D., Snider, C. E., Miller, J. S., Greene, G. L., and Katzenellenbogen, B. S. Ligand-modulated regulation of progesterone receptor messenger ribonucleic acid and protein in human breast cancer cell lines. Mol. Endocrinol., 2: 263-271, 1988.
32. Wafl cyclin-dependent kinase inhibitor gene through Sp1 and CBP/p300. J. Biol. Chem., 273: 10696-10701, 1998.
33. Sablitzky, F., Moore, A., Bromley, M., Deed, R. W., Newton, J. S., and Norton, J. D. Stage- and subcellular-specific expression of Id proteins in male germ and Sertoli cells implicates distinctive regulatory roles for Id proteins during meiosis, spermatogenesis, and Sertoli cell function. Cell Growth Differ., 9, 1015-1024, 1998.
34. Maruyama, H., Kleeff, J., Wildi, S., Friess, H., Buchler, M. W., Israel, M. A., and Korc, M. Id-1 and Id-2 are overexpressed in pancreatic cancer and in dysplastic lesions in chronic pancreatitis. Am. J. Pathol., 155: 815-822, 1999.
35. Cippitelli, M., Sica, A., Viggiano, V., Ye, J., Ghosh, P., Birrer, M. J., and Young, H. A. Negative transcriptional regulation of the interferon-γ promoter by glucocorticoids and dominant negative mutants of c-Jun. J. Biol. Chem., 270: 12548-12556, 1995.
36. +, K(+)-ATPase α 1 gene expression through the interaction of aldosterone and cAMP-inducible transcriptional factors. Steroids, 60: 147-152, 1995.
37. Iavarone, A., Garg, P., Lasorella, A., Hsu, J., and Israel, M. A. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Develop., 8: 1270-1284, 1994.
38. Hara, E., Hall, M., and Peters, G. Cdk2-dependent phosphorylalion of Id2 modulates activity of E2A-related transcription factors. EMBO J., 16: 332-342, 1997.
39. Haslam, S. Z. The ontogeny of mouse mammary gland responsiveness to ovarian steroid hormones. Endocrinology, 125: 2766-2772, 1989.
40. Horwitz, K. B., Wei, L. L., Sedlacek, S. M., and D'Arville, C. N. Progestin action and progesterone receptor structure in human breast cancer: a review. Recent Prog. Horm. Res.. 41: 249-307, 1985.
41. Koga, M., Musgrove, E. A., and Sutherland, R. L. Modulation of the growth-inhibitory effects of progestins and the antiestrogen hydroxyclomiphene on human breast cancer cells by epidermal growth factor and insulin. Cancer Res., 49: 112-116, 1989.
42. Papa, V., Hartmann, K. K., Rosenthal, S. M., Maddux, B. A., Siiteri, P. K., and Goldfine I. D. Progestins induce down-regulation of insulin-like growth factor-I (IGF-I) receptors in human breast cancer cells: potential autocrine role of IGF-II. Mol. Endocrinol., 5: 709-717, 1991.
43. Reddy, K. B., Yee, D., Hilsenbeck, S. G., Coffey, R. J., and Osborne, C. K. Inhibition of estrogen-induced breast cancer cell proliferation by reduction in autocrine transforming growth factor α expression. Cell Growth Differ., 5: 1275-1282, 1994.
44. Pratt, M. A. C., Satkunaratnam, A., and Novosad, D. M. Estrogen activates raf-1 kinase and induces expression of Egr-1 in MCF-7 breast cancer cells. Mol. Cell. Biochem., 189: 119-125, 1998.
45. Norton, J. D., Deed, R. W., Craggs, G., and Sablitzky, F. Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol., 8: 58-65, 1998.
46. Musgrove, E. A., Swarbrick, A., Lee, C. S., Cornish, A. L., and Sutherland, R. L. Mechanisms of cyclin-dependent kinase inactivation by progestins. Mol. Cell. Biol., 18: 1812-1825, 1998.
47. Chung, M., Chang, H. R., Bland, K. I., and Wanebo, H. J. Younger women with breast carcinoma have a poorer prognosis than older women. Cancer (Phila.), 77: 97-103, 1996.
48. Lyden, D., Young, A. Z., Zagzag, D., Yan, W., Gerald, W., O'Reilly, R., Bader, B. L., Hynes, R. O., Zhuang, Y., Manova, K., and Benezra, R. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumor xenografts. Nature (Lond.), 401: 670-677, 1999.
49. Maniotis, A. J., Folberg, R., Hess, A., Seftor, E. A., Gardner, L. M. G., Pe'er, J., Trent, J. M., Meltzer, P. S., and Hendrix, M. J. C. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am. J. Pathol., 155: 739-752, 1999.