Thymocyte development in early growth response gene 1-deficient mice

Journal of Immunology

Volumn 169, Issue 4, 2002, Pages 1713-1720

  Bettini, Matthew ^a   Xi, Hongkang ^a   Milbrandt, Jeffrey ^a   Kersh, Gilbert J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; HELIX LOOP HELIX PROTEIN; PROTEIN BCL 2; ZINC FINGER PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MATURATION; CELL SELECTION; ENZYME ACTIVATION; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; T LYMPHOCYTE; THYMOCYTE; THYMUS;

EID: 0037103324     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.4.1713     Document Type: Article

References (46)

1. Selecting and maintaining a diverse T-cell repertoire
2. The Goldilocks conditions applied to T cell development
3. Disruption of T cell signaling networks and development by Grb2 haploid insufficiency
4. A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity
5. CD3δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection
6. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor
7. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization
8. Induction of the early growth response (Egr) family of transcription factors during thymic selection
9. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade
10. Early growth response (Egr)-1 gene induction in the thymus in response to TCR ligation during early steps in positive selection is not required for CD8 lineage commitment
11. Modulation of thymic selection by expression of an immediate-early gene, early growth response 1 (Egr-1)
12. Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A*
13. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)
14. TCR transgenic mice in which usage of transgenic α- and β-chains is highly dependent on the level of selecting ligand
15. - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression
16. T cell homeostasis: Thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors
17. + T cells
18. The influence of the MAPK pathway on T cell lineage commitment
19. T cell receptor antagonist peptides induce positive selection
20. Activation events during thymic selection
21. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity
22. Selective requirement for MAP kinase activation in thymocyte differentiation
23. Positive and negative selection invoke distinct signaling pathways
24. + thymocytes
25. Degree of ERK activation influences both positive and negative thymocyte selection
26. A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex
27. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47
28. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas
29. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3
30. + stage during positive selection and promotes thymocyte differentiation at several control points
31. + thymocytes in vitro induces early aspects of positive selection, but not apoptosis
32. Maturation versus death of developing double-positive thymocytes reflects competing effects on Bcl-2 expression and can be regulated by the intensity of CD28 costimulation
33. The action of Bax and bcl-2 on T cell selection
34. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
35. Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene
36. + thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus
37. + thymocytes
38. Pro-thymocyte expansion by c-kit and the common cytokine receptor γ chain is essential for repertoire formation
39. + distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase-activating gene-deficient background
40. + stage
41. Granulocyte-macrophage colony-stimulating factor and interleukin-3 signaling pathways converge on the CREB-binding site in the human egr-1 promoter
42. The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells
43. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
44. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
45. + thymocytes
46. Suppression of human fibrosarcoma cell growth by transcription factor, Egr-1, involves down-regulation of Bcl-2