Promotion of cell cycle progression by basic helix-loop-helix E2A

Molecular and Cellular Biology

Volumn 21, Issue 18, 2001, Pages 6346-6357

  Zhao, Fang ^a   Vilardi, Antonina ^a   Neely, Robert J ^a   Choi, John Kim ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D2; CYCLIN D3; HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR E2A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; HUMAN; HUMAN CELL; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE; CELL LINE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HELIX-LOOP-HELIX MOTIFS; HUMANS; TRANSCRIPTION FACTORS;

ANIMALIA; MURINAE;

EID: 0035725846     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.18.6346-6357.2001     Document Type: Article

References (71)

1. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
2. The E2A gene product contains two separable and functionally distinct transcription activation domains
3. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas
4. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
5. Cyclin D3: Requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation
6. An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures
7. The two isoforms of mouse terminal deoxynucleotidyl transferase differ in both the ability to add N regions and subcellular localization
8. Overexpression of cyclin A in the mammary glands of transgenic mice results in the induction of nuclear abnormalities and increased apoptosis
9. Functional analysis of the human cyclin D2 and cyclin D3 promoters
10. Fos family members induce cell cycle entry by activating cyclin D1
11. Daughterless is required for Drosophila photoreceptor cell determination, eye morphogenesis, and cell cycle progression
12. Selective utilization of basic helix-loop-helix-leucine zipper proteins at the immunoglobulin heavy-chain enhancer
13. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
14. Hybrid HIV/MSCV LTR enhances transgene expression of lentiviral vectors in human CD34+ hematopoietic cells
15. E47 activates the Ig-heavy chain and TdT loci in non-B cells
16. 1/S-regulatory genes
17. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
18. Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation
19. Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas
20. Natural and engineered disorders of lymphocyte development
21. Glucocorticoid-mediated destabilization of cyclin D3 mRNA involves RNA-protein interactions in the 3′-untranslated region of the mRNA
22. G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb
23. Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci
24. Mice lacking TdT: Mature animals with an immature lymphocyte repertoire
25. Identification of a highly conserved module in E proteins required for in vivo helix-loop-helix dimerization
26. Helix-loop-helix proteins in the regulation of immunoglobulin gene transcription
27. The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials
28. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12
29. A critical role of lambda 5 protein in B cell development
30. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene
31. Cyclin A is a functional target of retinoblastoma tumor suppressor protein-mediated cell cycle arrest
32. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes
33. Improved methods of retroviral vector transduction and production for gene therapy
34. Failure of B-cell differentiation in mice lacking the transcription factor EBF
35. A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex
36. RAG-1-deficient mice have no mature B and T lymphocytes
37. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
38. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene
39. Cyclin synthesis drives the early embryonic cell cycle
40. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
41. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
42. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A
43. Cyclin A is required at two points in the human cell cycle
44. Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth
45. Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukemia cells
46. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
47. Regulation of G1 progression by E2A and Id helix-loop-helix proteins
48. Abundance of cyclin B1 regulates gamma-radiation-induced apoptosis
49. Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins
50. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts
51. Expression of basic helix-loop-helix transcription factors in explant hematopoietic progenitors
52. A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells
53. Modulation of the IgH enhancer's cell type specificity through a genetic switch
54. Restricted expression of E2A protein in primary human tissues correlates with proliferation and differentiation
55. Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line
56. Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis
57. B-cell-specific DNA binding by an E47 homodimer
58. Cancer cell cycles
59. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes
60. Phosphorylation of E47 as a potential determinant of B-cell-specific activity
61. An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers
62. Selective usage of D-type cyclins in lymphoid malignancies
63. A dominant interfering Myb mutant causes apoptosis in T cells
64. Expression of cyclin D2 and D3 in lymphoid lesions
65. Characterization of the mouse cyclin D3 gene: Exon/intron organization and promoter activity
66. Tissue-specific gene activation by MyoD: Determination of specificity by cis-acting repression elements
67. Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: Implications for B-lymphoid-cell development
68. Kinetics of E2A basic helix-loop-helix-protein expression during myelopoiesis and primary B cell differentiation
69. High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice
70. Functional replacement of the mouse E2A gene with a human HEB cDNA
71. The helix-loop-helix gene E2A is required for B cell formation