The human V-preB promoter is a target for coordinated activation by early B cell factor and E47

Journal of Immunology

Volumn 168, Issue 10, 2002, Pages 5130-5138

  Gisler, Ramiro ^a   Sigvardsson, Mikael ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HELIX LOOP HELIX PROTEIN; PROTEIN VPREB; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E47; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; GENE TARGETING; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

EID: 0037093872     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.10.5130     Document Type: Article

References (48)

1. B-cell development: A comparison between mouse and man
2. Fates of human B-cell precursors
3. Flow cytometric analysis of human bone marrow. II. Normal B lymphocyte development
4. Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci
5. Surrogate light chain in B cell development
6. Immunoglobulin λ light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin ω light-chain protein
7. The immunoglobulin λ-like gene cluster (14.1, 16.1 and Fλ1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse λ 5 gene
8. Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species
9. Conservation of the organization of the pre-B cell specific VpreB1/VpreB2/λ5 loci in the genus Mus
10. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
11. The murine VpreB1 and VpreB2 genes both encode a protein of the surrogate light chain and are co-expressed during B cell development
12. The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice
13. A second gene, 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes
14. Organization of the murine Ig-related λ5 gene transcribed selectively in pre-B lymphocytes
15. A critical role of λ5 protein in B cell development
16. Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice
17. Mutations in the human λ5/14.1 gene result in B cell deficiency and agammaglobulinemia
18. Transgenic human λ5 rescues the murine λ5 nullizygous phenotype
19. The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci
20. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes
21. Failure of B-cell differentiation in mice lacking the transcription factor EBF
22. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
23. The helix-loop-helix gene E2A is required for B cell formation
24. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A
25. Cloning of human early B cell factor and identification of target genes suggest a conserved role for EBF in B cell development
26. Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells
27. Transcriptional regulation in B cell differentiation
28. Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes
29. Spi-C, a novel Ets protein that is temporally regulated during B lymphocyte development
30. Identification of a tissue-and differentiation stage-specific enhancer of the VpreB1 gene
31. Purification of early-B-cell factor and characterization of its DNA-binding specificity
32. A human Early B cell Factor (EBF) like protein participates in the regulation of the human CD19 promoter
33. Regulatory elements of the mb-I gene encoding the Ig-α component of the human B-cell antigen receptor
34. The promoter and 5′ flanking sequences controlling human B29 gene expression
35. Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms
36. The 14.1 surrogate light chain promoter has lineage- and stage-restricted activity
37. Identification and localization of a developmental stage-specific promoter activity from the murine λ5 gene
38. Physical location of the human immunoglobulin λ-like genes, 14.1, 16.1, and 16.2
39. The human VpreB gene is located on chromosome 22 near a cluster of Vλ gene segments
40. Regulation of an early developmental checkpoint in the B cell pathway by IgΒ
41. Aberrant B cell development and immune response in mice with a compromised BCR complex
42. Identification of the earliest B lineage stage in mouse bone marrow
43. Pre-B cell-specific λ5 gene expression due to suppression in non pre-B cells
44. Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression
45. The B29 (immunoglobulin β-chain) gene is a genetic target for early B-cell factor
46. Multiple motifs regulate the B-cell-specific promoter of the B29 gene
47. Heterogeneously initiated transcription from the pre-B- and B-cell-specific mb-1 promoter: Analysis of the requirement for upstream factor-binding sites and initiation site sequences
48. Pre-B lymphocyte-specific transcriptional control of the mouse VpreB gene