p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene

Molecular and Cellular Biology

Volumn 18, Issue 5, 1998, Pages 2957-2964

  Qiu, Y I ^a   Sharma, Arun ^a,b   Stein, Roland ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCUS; GENE MUTATION; GENE REPRESSION; HAMSTER; NERVE CELL DIFFERENTIATION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

EID: 0031943003     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.5.2957     Document Type: Article

References (76)

1. Abraham, S. E., S. Lobo, P. Yaciuk, H.-G. H. Wang, and E. Moran. 1993. p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes. Oncogene 8:1639-1647.
2. Arany, Z., D. Newsome, E. Oldread, D. M. Livingston, and R. Eckner. 1995. A family of transcriptional adapter proteins targeted by the E1A protein. Nature 374:81-84.
3. Aronheim, A., H. Ohlsson, C. W. Park, T. Edlund, and M. D. Walker. 1991. Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytes. Nucleic Acids Res. 19: 3893-3899.
4. Bannister, A. J., and T. Kouzarides. 1995. CBP-induced stimulation of c-Fos activity is abrogated by E1A. EMBO J. 14:4758-4762.
5. Bannister, A. J., T. Oehler, D. Wilhelm, P. Angel, and T. Kauzarides. 1995. Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11: 2509-2514.
6. Bannister, A. J., and T. Kouzarides. 1996. The CBP co-activator is a histone acetyltransferase. Nature 384:641-643.
7. Chrivia, J. C., R. P. S. Kwok, N. Lamb, M. Hagiwara, M. R. Montminy, and R. H. Goodman. 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365:855-859.
8. Cordle, S. R., E. Henderson, H. Masuoks, A. P. Weil, and R. Stein. 1991. Pancreatic β-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins. Mol. Cell. Biol. 11:1734-1738.
9. Crowe, D. T., and M.-J. Tsai. 1989. Mutagenesis of the rat insulin II 5′-flanking region defines sequences important for expression in HIT cells. Mol. Cell. Biol. 9:1784-1789.
10. Dai, P., H. Akimaru, Y. Tanaka, D.-X. Hou, T. Yasukawa, C. Kanei-Ishii, T. Talahashi, and S. Ishii. 1996. CBP as a transcriptional coactivator of c-Myb. Genes Dev. 10:528-540.
11. Dallas, P. B., P. Yaciuk, and E. Moran. 1997. Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes. J. Virol. 71:1726-1731.
12. De Wet, J. R., K. V. Wood, M. DeLuca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725-737.
13. Eckner, R., M. E. Ewen, D. Newsine, M. Gerdes, J. A. DeCaprio, J. B. Lawrenee, and D. M. Livingston. 1994. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adapter. Genes Dev. 8:869-884.
14. Eckner, R., T.-P. Yao, E. Oldread, and D. M. Livingston. 1996. Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev. 10:2478-2490.
15. Eckner, R. 1997. p300 and CBP as transcriptional regulators and targets of oncogenic. Biol. Chem. 377:685-688.
16. Edlund, T., M. D. Walker, P. J. Barr, and W. J. Rutter. 1985. Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5′-flanking sequences. Science 230:912-916.
17. German, M. S., M. A. Blanar, C. Nelson, L. G. Moss, and W. J. Rutter. 1991. Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer. Mol. Endocrinol. 5:292-299.
18. German, M. S., L. G. Moss, J. Wang, and W. J. Rutter. 1992. The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical β-cell nuclear complexes. Mol. Cell. Biol. 12: 1777-1788.
19. German, M. S., and J. Wang. 1994. The insulin gene contains multiple transcriptional elements that response to glucose. Mol. Cell. Biol. 14:4067-4075.
20. German, M. S., S. Ashcroft, K. Docherty, H. Edlund, T. Edlund, S. Goodison, H. Imura, G. Kennedy, O. Madsen, D. Melloul, L. Moss, K. Olson, M. A. Permutt, J. Philippe, R. P. Robertson, W. J. Rutter, P. Serup, R. Stein, D. Steiner, M.-J. Tsai, and M. D. Walker. 1995. The insulin promoter: a simplified nomenclature. Diabetes 44:1002-1004.
21. Gu, W., and R. C. Roeder. 1997. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90:595-606.
22. Gu, W., X.-L. Shi, and R. C. Roeder. 1997. Synergistic activation of transcription by CBP and p53. Nature 387:819-822.
23. Guz, Y., M. R. Montminy, R. Stein, J. Leonard, L. W. Gamer, C. V. E. Wright, and G. Teitelman. 1995. Expression of murine STF-1, a putative insulin gene transcription factor, in β-cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitor during ontogeny. Development 121:11-18.
24. Henderson, E., and R. Stein. 1994. c-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of control. Mol. Cell. Biol. 14:655-662.
25. Hwung, Y.-P., Y.-Z. Gu, and M.-J. Tsai. 1990. Cooperativity of sequence elements mediates tissue specificity of the rat insulin II gene. Mol. Cell. Biol. 10:1784-1788.
26. Jonsson, J., L. Carlsson, T. Edlund, and H. Edlund. 1994. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609.
27. Kamei, Y., L. Xu, T. Heinzel, J. Torchia, R. Kurokave, B. Gloss, S.-C. Lin, R. A. Heyman, D. W. Rose, C. K. Glass, and M. G. Rosenfeld. 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414.
28. Karlsson, O., T. Edlund, J. B. Moss, W. J. Rutter, and M. D. Walker. 1987. A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. Proc. Natl. Acad. Sci. USA 84:8819-8823.
29. Kwok, R. P. S., J. R. Lundblad, J. C. Chrivia, J. P. Richards, H. P. Bachinger, R. G. Brennan, S. G. E. Roberts, M. R. Green, and R. H. Goodman. 1994. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370:223-226.
30. Lee, J. E., S. M. Hollenberg, L. Snider, D. L. Turner, N. Lipnick, and H. Weintraub. 1995. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268:836-843.
31. Lee, J.-S., K. M. Galvin, R. H. See, R. Eckner, D. Livingston, E. Moran, and Y. Shi. 1995. Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. Genes Dev. 9:1188-1198.
32. Lee, J.-S., R. H. See, T. Deng, and Y. Shi. 1996. Adenovirus E1A downregulates c-Jun- and JunB-mediated transcription by targeting their coactivator p300. Mol. Cell. Biol. 16:4312-4326.
33. Leonard, J., B. Peers, T. Johnson, K. Ferrere, S. Lee, and M. Montminy. 1993. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cell. Mol. Endocrinol. 7:1275-1283.
34. Lill, N. L., S. R. Grossman, D. Ginsberg, J. DeCaprio, and D. M. Livingston. 1997. Binding and modulation of p53 by p300/CBP coactivators. Nature 387: 823-827.
35. Lillie, J. C., and M. R. Green. 1989. Transcription activation by adenovirus E1A protein. Nature 338:39-44.
36. Lundblad, J. R., R. P. S. Kwok, M. E. Laurance, M. L. Harter, and R. H. Goodman. 1995. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature 374:85-88.
37. Macfarlane, W. M., M. L. Read, M. Gilligan, I. Bujalska, and K. Docherty. 1994. Glucose modulates the binding activity of the β-cell transcription factor IUF1 in a phosphorylation-dependent manner. Biochem. J. 303:625-631.
38. Massari, M. E., P. A. Jennings, and C. Murre. 1996. The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells. Mol. Cell. Biol. 16:121-129.
39. Melloul, D., Y. Ben-Neriah, and E. Cerasi. 1993. Glucose regulates the binding of an islet-specific factor to a conserved sequence within the rat and the human insulin promoter. Proc. Natl. Acad. Sci. USA 90:3865-3869.
40. Miller, C. P., R. E. McGhee, Jr., and J. F. Habener. 1994. IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J. 13:1145-1156.
41. Murre, C., and D. Baltimore. 1992. The helix-loop-helix motif: structure and function, p. 861-879. In S. L. McKnight and K. R. Yamamoto (ed.), Transcriptional regulation. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
42. Mutoh, H., B. P. Fung, F. Naya, M.-J. Tsai, J. Nishitani, and A. B. Leiter. 1997. The basic helix-loop-helix transcription factor BETA2/NeuroD is expressed in mammalian enteroendocrine cells and activates secretin gene expression. Proc. Natl. Acad. Sci. USA 94:3560-3564.
43. Naya, F. J., H.-P. Huang, Y. Qiu, H. Mouth, F. J. DeMayo, A. B. Leiter, and M.-J. Tsai. 1997. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice. Genes Dev. 11:2323-2334.
44. Naya, F. J., C. M. M. Stellrecht, and M.-J. Tsai. 1995. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev. 9:1009-1019.
45. Nordeen, S. K., P. P. Green III, and D. M. Fowles. 1987. Laboratory methods. A rapid, sensitive, and inexpensive assay for chloramphenicol acetyltransferase. DNA 6:173-178.
46. Offield, M. F., T. L. Jetton, R. Stein, T. Labosky, R. Ray, M. Magnuson, B. Hogan, and C. V. E. Wright. 1996. PDX-1 is required for development of the pancreas and differentiation of the rostral duodenum. Development 122: 983-995.
47. Ogryzko, V. V., R. L. Schiltz, V. Russanova, B. H. Howard, and Y. Nakatani. 1996. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87:953-959.
48. Ohlsson, H., K. Karlsson, and T. Edlund. 1993. IPF-1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 12:4251-4259.
49. Parker, D., K. Ferreri, T. Nakajima, V. J. Lamorte, R. Evans, S. C. Koerber, C. Hoeger, and M. R. Montminy. 1996. Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. Mol. Cell. Biol. 16:694-703.
50. Peers, B., J. Leonard, S. Sharma, G. Teitelman, and M. R. Montminy. 1994. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol. Endocrinol. 8:1798-1806.
51. Peers, B., S. Sharma, T. Johnson, M. Kamps, and M. R. Montminy. 1995. The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain. Mol. Cell. Biol. 15:7091-7097.
52. Peshavaria, M., L. Gamer, E. Henderson, G. Teitelman, C. V. E. Wright, and R. Stein. 1994. XIHbox8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Mol. Endocrinol. 8:806-816.
53. Peshavaria, M., E. Henderson, A. Sharma, C. V. E. Wright, and R. Stein. 1997. Functional characterization of the transactivation properties of the PDX-1 homeodomain protein. Mol. Cell. Biol. 17:3987-3996.
54. Petersen, H. V., P. Serup, J. Leonard, B. K. Michelsen, and O. D. Madsen. 1994. Transcriptional regulation of the human insulin gene is dependent of the homeodomain proteins STF1/IPF1 acting through the CT boxes. Proc. Natl. Acad. Sci. USA 91:10465-10469.
55. Peyton, M., L. Moss, and M.-J. Tsai. 1994. Two distinct class A helix-loop-helix transcription factors, E2A and BETA1, form separate DNA-binding complexes on the insulin E-box. J. Biol. Chem. 269:25936-25941.
56. Puri, P. L., V. Sarorelli, X.-J. Yang, Y. Hamamori, V. V. Ogryzko, B. H. Howard, L. Kedes, Y. Y. Y. Wang, A. Graessmann, Y. Nakatani, and M. Levrero. 1997. Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol. Cell 1:35-45.
57. Quong, M. W., M. E. Massari, R. Zwart, and C. Murre. 1993. A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells. Mol. Cell. Biol. 13:792-800.
58. Robinson, G. L. W. G., E. Henderson, M. E. Massari, C. Murre, and R. Stein. 1995. c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene products. Mol. Cell. Biol. 15:1398-1404.
59. Sander, M., and M. S. German. 1997. The beta cell transcription factors and development of the pancreas. J. Mol. Med. 75:327-340.
60. Sartorelli, V., J. Huang, Y. Hamamori, and L. Kedes. 1997. Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol. Cell. Biol. 17:1010-1026.
61. Sharma, A., and R. Stein. 1994. Glucose-induced transcription of the insulin gene is mediated by factors required for β-cell-type-specific expression. Mol. Cell. Biol. 14:871-879.
62. Sharma, A., L. K. Olson, R. P. Rooertson, and R. Stein. 1995. The reduction of insulin gene transcription in HIT-T15 β cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression. Mol. Endocrinol. 9:1127-1134.
63. Sharma, A., E. Henderson, L. Gamer, Y. Zhuang, and R. Stein. 1997. Analysis of the role of E2A-encoded proteins in insulin gene transcription. Mol. Endocrinol. 11:1608-1617.
64. 63a. Sharma, A., and R. Stein. Unpublished data.
65. Shieh, S.-Y., and M.-J. Tsai. 1991. Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene. J. Biol. Chem. 266:16708-16714.
66. Shikama, N., J. Lyon, and N. B. La Thangue. 1997. The p300/CBP family: integrating signals with transcription factors and chromatin. Trends Cell Biol. 7:230-236.
67. Smith, C. L., S. A. Onate, M.-J. Tsai, and B. O'Malley. 1996. CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription. Biochemistry 93:8884-8888.
68. Song, C.-Z., P. M. Loewenstein, K. Toth, Q. Tang, A. Nishikawa, and M. Green. 1997. The adenovirus E1A repression domain disrupts the interaction between the TATA binding protein and the TATA box in a manner reversible by TFIIB. Mol. Cell. Biol. 17:2186-2193.
69. Stein, R. W., and J. Whelan. 1989. Insulin gene enhancer activity is inhibited by adenovirus 5 E1a gene products. Mol. Cell. Biol. 9:4531-4534.
70. Stein, R. W., M. Corrigan, P. Yaciuk, J. Whelan, and E. Moran. 1990. Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity. J. Virol. 64:4421-4427.
71. Stein, R. 1993. Regulation of insulin gene transcription. Trends Endocrinol. Metab. 4:96-101.
72. Stellrecht, C. M. M., F. J. DeMayo, M. J. Finegold, and M. J. Tsai. 1997. Tissue-specific and developmental regulation of the rat insulin II gene enhancer, RIPE3, in transgenic mice. J. Biol. Chem. 272:3567-3572.
73. Whelan, J., D. Poon, P. A. Weil, and R. Stein. 1989. Pancreatic β-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative transcriptional elements. Mol. Cell. Biol. 9:3253-3259.
74. Yang, X.-J., V. V. Ogryzko, J. Nishikawa, B. H. Howard, and Y. Nalatani. 1996. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382:319-324.
75. Yao, T.-P., G. Ku, N. Zhou, R. Scully, and D. M. Livingston. 1996. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc. Natl. Acad. Sci. USA 93:10626-10631.
76. Yuan, W., G. Condorelli, M. Caruso, A. Felsani, and A. Giordano. 1996. Human p300 protein is a coactivator for the transcription factor MyoD. J. Biol. Chem. 271:9009-9013.