The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins

EMBO Journal

Volumn 16, Issue 11, 1997, Pages 3145-3157

  Wadman, Isobel A ^c   Osada, Hirotaka ^a,c   Grütz, Gerald G ^c   Agulnick, Alan D ^b   Westphal, Heiner ^b   Forster, Alan ^c   Rabbitts, Terence H ^c  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Haematopoiesis; Ldb1; LIM; Rbtn2; Transcription

Indexed keywords

DNA BINDING PROTEIN; OLIGOMER; TRANSACTIVATOR PROTEIN; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CHROMOSOME TRANSLOCATION; ERYTHROID CELL; HEMATOPOIESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; T CELL LEUKEMIA; TRANSACTIVATION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; CONSENSUS SEQUENCE; COS CELLS; DNA-BINDING PROTEINS; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; GENES, REPORTER; HEMATOPOIESIS; METALLOPROTEINS; MODELS, GENETIC; NUCLEAR PROTEINS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; TCF TRANSCRIPTION FACTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0030999645     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.11.3145     Document Type: Article

References (51)

1. Agulnick, A.D., Taira, M., Breen, J.J., Tanaka, T., Dawid, I.B. and Westphal, H. (1996) Functional and physical interaction of Ldb1, a novel LIM domain binding factor, with the LIM homeodomain protein Lhx1/Xlim-1. Nature, 384, 270-272.
2. Baer, R. (1993) TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia. Semin. Cancer Biol., 4, 341-347.
3. Begley, C.G., Aplan, P.D., Denning, S.M., Haynes, B.F., Waldmann, T.A. and Kirsch, I.R. (1989) The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. Proc. Natl Acad. Sci. USA, 86, 10128-10132.
4. Blackwell, T.K., Kretzner, L., Blackwood, E.M., Eisenman, R.N. and Weintraub, H. (1990) Sequence-specific DNA binding by the c-Myc protein. Science, 250, 1149-1151.
5. Boehm, T., Foroni, L., Kaneko, Y., Perutz, M.P. and Rabbitts, T.H. (1991) The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc. Natl Acad. Sci. USA, 88, 4367-4371.
6. Carroll, A.J., Crist, W.M., Link, M.P., Amylon, M.D., Pullen, D.J., Ragab, A.H., Buchanan, G.R., Wimmer, R.S. and Vietti, T.J. (1990) The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Blood, 76, 1220-1224.
7. Chen, Q. et al. (1990) The tal gene undergoes chromosome translocation in T cell leukaemia and potentially encodes a helix-loop-helix protein. EMBO J., 9, 415-424.
8. Cheng, J.-T., Cobb, M.H. and Baer, R. (1993a) Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1. Mol. Cell. Biol., 13, 801-808.
9. Cheng, J.T., Hsu, H.-L., Hwang, L.-Y. and Baer, R. (1993b) Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues. Oncogene, 8, 667-683.
10. Crossley, M. and Orkin, S.H. (1994) Phosphorylation of the erythroid transcription factor GATA-1. J. Biol. Chem., 269, 16589-16596.
11. Crossley, M., Merika, M. and Orkin, S.H. (1995) Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains. Mol. Cell. Biol., 15, 2448-2456.
12. Feuerstein, R., Wang, X., Song, D., Cooke, N.E. and Liebhaber, S.A. (1994) The LIM/double zinc-finger motif functions as a protein dimerisation domain. Proc. Natl Acad. Sci. USA, 91, 10655-10659.
13. Finger, L.R., Kagan, J., Christopher, G., Kurtzberg, J., Hershfield, M.S., Nowell,P.C. and Croce, C.M. (1989) Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc. Natl Acad. Sci. USA, 86, 5039-5043.
14. Foroni, L. et al. (1992) The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. J. Mol. Biol., 226, 747-761.
15. Funk, W.D. and Wright, W.E. (1992) Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor. Proc. Natl Acad. Sc.i USA, 89, 9484-9488.
16. Hsu, H.-L., Cheng, J.-T., Chen, Q. and Baer, R. (1991) Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins. Mol. Cell Biol., 11, 3037-3042.
17. Hsu, H.-L., Huang, L., Tsan, J.T., Funk, W., Wright, W.E., Hu, J.-S., Kingston, R.E. and Baer, R. (1994a) Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins. Mol. Cell. Biol., 14, 1256-1265.
18. Hsu, H.-L., Wadman, I. and Baer, R. (1994b) Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. Proc. Natl Acad. Sci. USA, 91, 3181-3185.
19. Hsu, H.-L., Wadman, I., Tsan, J.T. and Baer, R. (1994c) Positive and negative transcriptional control by the TAL1 helix-loop-helix protein. Proc. Natl Acad. Sci. USA, 91, 5947-5951.
20. Jurata, L.W., Kenny, D.A. and Gill, G.N. (1996) Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc. Natl Acad. Sci. USA, 93, 11693-11698.
21. Karlsson, O., Thor, S., Norberg, T., Ohlsson, H. and Edlund, T. (1990) Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a cys-his domain. Nature, 344, 879-882.
22. Larson, R.C., Lavenir, I., Larson, T.A., Baer, R., Warren, A.J., Wadman, I., Nottage, K. and Rabbitts, T.H. (1996) Protein dimerisation between Lmo2 (Rbtn2) and Tall alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. EMBO J., 15, 1021-1027.
23. Lee, K.A.W., Bindereif, A. and Green, M.R. (1988) A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing. Gene Anal. Technol., 5, 22-31.
24. Merika, M. and Orkin, S.H. (1995) Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol. Cell. Biol., 15, 2437-2447.
25. Murre, C., McCaw, P.S. and Baltimore, D. (1989) A new DNA binding and dimerisation motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell, 56, 777-783.
26. Omichinski, J.G., Clore, G.M., Schaad, O., Felsenfeld, G., Trainor, C., Appella, E., Stahl, S.J. and Gronenborn, A.M. (1993) NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. Science, 261, 438-446.
27. Osada, H., Grutz, G., Axelson, H., Forster, A. and Rabbitts, T.H. (1995) Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc. Natl Acad. Sci. USA, 92, 9585-9589.
28. Perez-Alvarado, G.C., Miles, C., Michelsen, J.W., Louis, H.A., Winge, D.R., Beckerle, M.C. and Summers, M.F. (1994) Structure of the carboxyterminal LIM domain from the cysteine rich protein CRP. Nature Struct. Biol., 1, 388-398.
29. Pevny, L., Simon, M.C., Robertson, E., Klein, W.H., Tsai, S.-F., D'Agati, V., Orkin, S.H. and Costantini, F. (1991) Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature, 349, 257-260.
30. Pollock, R. and Treisman, R. (1990) A sensitive method for the determination of protein-DNA binding specificities. Nucleic Acid Res., 18, 6197-6204.
31. Porcher, C., Swat, W., Rockwell, K., Fujiwara, Y., Alt, F.W. and Orkin, S.H. (1996) The T cell leukemia oncoprotein SC1/tal-1 is essential for development of all hematopoietic lineages. Cell, 86, 47-57.
32. Rabbitts, T.H. (1994) Chromosomal translocations in human cancer. Nature, 372, 143-149.
33. Robb, L., Lyons, I., Li, R., Hartley, L., Kontgen, F., Harvey, R.P., Metcalf, D. and Begley, C.G. (1995) Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc. Natl Acad. Sci. USA, 92, 7075-7079.
34. Robb, L., Elwood, N.J., Elefanty, A.G., Kontgen, F., Li, R., Barnet, L.D. and Begley, C.G. (1996) The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. EMBO J., 15, 4123-4129.
35. Roberts, V.J., Steenbergen, R. and Murre, C. (1993) Localization of E2A mRNA expression in developing and adult rat tissues. Proc. Natl Acad. Sci. USA, 90, 7583-7587.
36. Royer-Pokora, B., Loos, U. and Ludwig, W.-D. (1991) TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene, 6, 1887-1893.
37. Sanchez-Garcia, J. and Rabbitts, T.H. (1993) LIM domain proteins in leukaemia and development. Semin. Cancer Biol., 4, 349-358.
38. Sanchez-Garcia, I., Axelson, H. and Rabbitts, T.H. (1995) Functional diversity of LIM proteins: amino-terminal activation domains in the oncogenic proteins RBTN1 and RBTN2. Oncogene, 10, 1301-1306.
39. Schmeichel, K.L. and Beckerle, M.C. (1994) The LIM domain is a modular protein-binding interface. Cell, 79, 211-219.
40. Shivdasani, R.A., Mayer, E. and Orkin, S.H. (1995) Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature, 373, 432-434.
41. Sun, X.-H. and Baltimore, D. (1991) An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers. Cell, 64, 459-470.
42. Tsai, S.-F., Martin, D.I.K., Zon, L.I., D'Andrea, A.D., Wong, G.G. and Orkin, S.H. (1989) Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature, 339, 446-451.
43. Tsai, F.-Y., Keller, G., Kuo, F.C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F.W. and Orkin, S.H. (1994) An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature, 371, 221-226.
44. Valge-Archer, V.E., Osada, H., Warren, A.J., Forster, A., Li, J., Baer, R. and Rabbitts, T.H. (1994) The LIM protein RBTN2 and the bHLH protein TAL1 are present in a complex in erythroid cells. Proc. Natl Acad. Sci. USA, 91, 8617-8621.
45. Wadman, I., Li, J., Bash, R.O., Forster, A., Osada, H., Rabbitts, T.H. and Baer, R. (1994) Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukaemia. EMBO J., 13, 4831-4839.
46. Warren, A.J., Colledge, W.H., Carlton, M.B.L., Evans, M.J., Smith, A.J.H. and Rabbitts, T.H. (1994) The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell, 78, 45-58.
47. Weiss, M.J. and Orkin, S.H. (1995) GATA transcription factors: key regulators of hematopoiesis. Exp. Hematol., 23, 99-107.
48. Weiss, M.J., Keller, G. and Orkin, S.H. (1994) Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. Genes Dev., 8, 1184-1197.
49. Wright, W. E. and Funk, W.D. (1993) CASTing for multicomponent DNA-binding complexes. Trends Biochem. Sci., 18, 77-80.
50. Wright, W.E., Binder, M. and Funk, W. (1991) Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site. Mol. Cell. Biol., 11, 4104-4110.
51. Yang, H.-Y. and Evans, T. (1995) Homotypic interactions of chicken GATA-1 can mediate transcriptional activation.