Selection of the T-cell repertoire: Receptor-controlled checkpoints in T-cell development

Advances in Immunology

Volumn 84, Issue , 2004, Pages 201-238

  Von Boehmer, Harald ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; B LYMPHOCYTE RECEPTOR; BONE MORPHOGENETIC PROTEIN; CD4 ANTIGEN; CD8 ANTIGEN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NOTCH1 RECEPTOR; PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; BINDING AFFINITY; BONE MARROW CELL; CELL DEATH; CELL LINEAGE; CELL MATURATION; CELL SELECTION; CELL SUBPOPULATION; CELLULAR IMMUNITY; DNA METHYLATION; EFFECTOR CELL; GENE EXPRESSION; GENE MUTATION; GENE REARRANGEMENT; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MATURITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; SUPPRESSOR CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMOCYTE; THYMUS; TRANSGENE;

EID: 3042734665     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2776(04)84006-9     Document Type: Article

References (211)

1. Aguado E., Richelme S., Nunez-Cruz S., Miazek A., Mura A.M., Richelme M., Guo X.J., Sainty D., He H.T., Malissen B., Malissen M. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science. 296:2002;2036
2. Aifantis I., Azogui O., Feinberg J., Saint-Ruf C., Buer J., von Boehmer H. On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment. Immunity. 9:1998;649
3. 2+ mobilization and activation of NF-kappaB and NFAT. Nat. Immunol. 2:2001;403
4. Alam S.M., Gascoigne N.R. Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation. J. Immunol. 160:1998;3883
5. Alberola-lla J., Forbush K.A., Seger R., Krebs E.G., Perlmutter R.M. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature. 373:1995;620
6. Alberola-lla J., Hogquist K.A., Swan K.A., Bevan M.J., Perlmutter R.M. Positive and negative selection invoke distinct signaling pathways. J. Exp. Med. 184:1996;9
7. Aliahmad P., O'Flaherty E., Han P., Goularte O.D., Wilkinson B., Satake M., Molkentin J.D., Kaye J. TOX provides a link between calcineurin activation and CD8 lineage commitment. J. Exp. Med. 199:2004;1089-1099
8. Allman D., Karnell F.G., Punt J.A., Bakkour S., Xu L., Myung P., Koretzky G.A., Pui J.C., Aster J.C., Pear W.S. Separation of Notch1 promoted lineage commitment and expansiontransformation in developing T cells. J. Exp. Med. 194:2001;99
9. Allman D., Sambandam A., Kim S., Miller J.P., Pagan A., Well D., Meraz A., Bhandoola A. Thymopoiesis independent of common lymphoid progenitors. Nat. Immunol. 4:2003;168
10. Anderson A.C., Nicholson L.B., Legge K.L., Turchin V., Zaghouani H., Kuchroo V.K. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire. J. Exp. Med. 191:2000;761
11. Anderson M.S., Venanzi E.S., Klein L., Chen Z., Berzins S.P., Turley S.J., von Boehmer H., Bronson R., Dierich A., Benoist C., Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science. 298:2002;1395
12. Apostolou I., Sarukhan A., Klein L., von Boehmer H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:2002;756
13. Apostolou I., von Boehmer H. Specific tolerance by generation of antigen-specific suppressor cells from naive T cells. J. Exp. Med. 199:2004;1401-1408
14. Ashton-Rickardt P.G., Bandeira A., Delaney J.R., Van Kaer L., Pircher H.P., Zinkernagel R.M., Tonegawa S. Evidence for a differential avidity model of T cell selection in the thymus. Cell. 76:1994;651
15. + T cells in the thymus. Cell. 73:1993;1041
16. Babbitt B.P., Allen P.M., Matsueda G., Haber E., Unanue E.R. Binding of immunogenic peptides to la histocompatibility molecules. Nature. 317:1985;359
17. Bain G., Cravatt C.B., Loomans C., Alberola-lla J., Hedrick S.M., Murre C. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat. Immunol. 2:2001;165
18. Basson M.A., Zamoyska R. The CD4CD8 lineage decision: Integration of signalling pathways. Immunol. Today. 21:2000;509
19. Benacerraf B., McDevitt H.O. Histocompatibility-linked immune response genes. Science. 175:1972;273
20. Bendelac A., Rivera M.N., Park S.H., Roark J.H. Mouse CD1-specific NK1 T cells: Development, specificity, and function. Annu. Rev. Immunol. 15:1997;535
21. Benlagha K., Kyin T., Beavis A., Teyton L., Bendelac A. A thymic precursor to the NK T cell lineage. Science. 296:2002;553
22. Bennett C.L., Christie J., Ramsdell F., Brunkow M.E., Ferguson P.J., Whitesell L., Kelly T.E., Saulsbury F.T., Chance P.F., Ochs H.D. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27:2001;20
23. Benoist C., Mathis D. Positive selection of the T cell repertoire: Where and when does it occur? Cell. 58:1989;1027
24. Bensinger S.J., Bandeira A., Jordan M.S., Caton A.J., Laufer T.M. Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J. Exp. Med. 194:2001;427
25. Benveniste P., Cantin C., Hyam D., Iscove N.N. Hematopoietic stem cells engraft in mice with absolute efficiency. Nat. Immunol. 4:2003;708
26. Bergman Y., Fisher A., Cedar H. Epigenetic mechanisms that regulate antigen receptor gene expression. Curr. Opin. Immunol. 15:2003;176
27. Bettini M., Xi H., Milbrandt J., Kersh G.J. Thymocyte development in early growth response gene 1-deficient mice. J. Immunol. 169:2002;1713
28. Bevan M.J. In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature. 269:1977a;417
29. Bevan M.J. Killer cells reactive to altered-self antigens can also be alloreactive. Proc. Natl. Acad. Sci. USA. 74:1977b;2094
30. Binz H., Wigzell H. Antigen-binding, idiotypic receptors from T lymphocytes: An analysis of their biochemistry, genetics, and use as immunogens to produce specific immune tolerance. Cold Spring Harb. Symp. Quant. Biol. 41:(Pt 1):1977;275
31. Bjorkman P.J., Saper M.A., Samraoui B., Bennett W.S., Strominger J.L., Wiley D.C. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature. 329:1987;512
32. Borgulya P., Kishi H., Uematsu Y., von Boehmer H. Exclusion and inclusion of alpha and beta T cell receptor alleles. Cell. 69:1992;529
33. Borowski C., Li X., Aifantis I., Gounari F., von Boehmer H. Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development. J. Exp. Med. 2004;. (in press).
34. Brocker T. The role of dendritic cells in T cell selection and survival. J. Leukoc. Biol. 66:1999;331
35. Brown K.E., Guest S.S., Smale S.T., Hahm K., Merkenschlager M., Fisher A.G. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell. 91:1997;845
36. Brunkow M.E., Jeffery E.W., Hjerrild K.A., Paeper B., Clark L.B., Yasayko S.A., Wilkinson J.E., Galas D., Ziegler S.F., Ramsdell F. Disruption of a new forkheadwinged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27:2001;68
37. Bruno L., Fehling H.J., von Boehmer H. The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells. Immunity. 5:1996;343
38. Buch T., Rieux-Laucat F., Forster I., Rajewsky K. Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity. 16:2002;707
39. Bueno O.F., Brandt E.B., Rothenberg M.E., Molkentin J.D. Defective T cell development and function in calcineurin A beta-deficient mice. Proc. Natl. Acad. Sci. USA. 99:2002;9398
40. Buer J., Aifantis I., DiSanto J.P., Fehling H.J., von Boehmer H. Role of different T cell receptors in the development of pre-T cells. J. Exp. Med. 185:1997;1541
41. Burnet F.M. The clonal selection theory. 1959;Cambridge University Press, London
42. Buus S., Sette A., Colon S.M., Jenis D.M., Grey H.M. Isolation and characterization of antigen-la complexes involved in T cell recognition. Cell. 47:1986;1071
43. Calnan B.J., Szychowski S., Chan F.K., Cado D., Winoto A. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity. 3:1995;273
44. Canelles M., Park M.L., Schwartz O.M., Fowlkes B.J. The influence of the thymic environment on the CD4-versus-CD8 T lineage decision. Nat. Immunol. 4:2003;756
45. Cantor H., Boyse E.A. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen. J. Exp. Med. 141:1975;1376
46. Carrasco Y.R., Navarro M.N., Toribio M.L. A role for the cytoplasmic tail of the pre-T cell receptor (TCR) alpha chain in promoting constitutive internalization and degradation of the pre-TCR. J. Biol. Chem. 278:2003;14507
47. Casanova J.L., Romero P., Widmann C., Kourilsky P., Maryanski J.L. T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: Implications for T cell allelic exclusion and antigen-specific repertoire. J. Exp. Med. 174:1991;1371
48. Chi T.H., Wan M., Zhao K., Taniuchi I., Chen L., Littman D.R., Crabtree G.R. Reciprocal regulation of CD4CD8 expression by SWISNF-like BAF complexes. Nature. 418:2002;195
49. Ciofani M., Schmitt T.M., Ciofani A., Michie A.M., Çuburu N., Aublin A., Maryanski J.L., Zuñiga-pflücker J.C. Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J. Immunol. 172:2004;5230-5239
50. Dembic Z., Haas W., Weiss S., McCubrey J., Kiefer H., von Boehmer H., Steinmetz M. Transfer of specificity by murine alpha and beta T-cell receptor genes. Nature. 320:1986;232
51. Dembic Z., Haas W., Zamoyska R., Parnes J., Steinmetz M., von Boehmer H. Transfection of the CD8 gene enhances T-cell recognition. Nature. 326:1987;510
52. Derbinski J., Schulte A., Kyewski B., Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2:2001;1032
53. Di Santo J.P., Aifantis I., Rosmaraki E., Garcia C., Feinberg J., Fehling H.J., Fischer A., von Boehmer H., Rocha B. The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alphabeta T cell development. J. Exp. Med. 189:1999;563
54. Donda A., Schulz M., Burki K., De Libero G., Uematsu Y. Identification and characterization of a human CD4 silencer. Eur. J. Immunol. 26:1996;493
55. Douagi I., Colucci F., Di Santo J.P., Cumano A. Identification of the earliest prethymic bipotent TNK progenitor in murine fetal liver. Blood. 99:2002;463
56. Dower N.A., Stang S.L., Bottorff D.A., Ebinu J.O., Dickie P., Ostergaard H.L., Stone J.C. RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat. Immunol. 1:2000;317
57. Doyle C., Strominger J.L. Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature. 330:1987;256
58. Ellmeier W., Sunshine M.J., Maschek R., Littman D.R. Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity. 16:2002;623
59. Engel I., Murre C. The function of E- and Id proteins in lymphocyte development. Nat. Rev. Immunol. 1:2001;193
60. Fehling H.J., Iritani B.M., Krotkova A., Forbush K.A., Laplace C., Perlmutter R.M., von Boehmer H. Restoration of thymopoiesis in pT alpha - mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha. Immunity. 6:1997;703
61. Fisson S., Darrasse-Jeze G., Litvinova E., Septier F., Klatzmann D., Liblau R., Salomon B.L. Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J. Exp. Med. 198:2003;737
62. Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4:2003;330
63. Fritsch M., Andersson A., Petersson K., Ivars F. A TCR alpha chain transgene induces maturation of CD4- CD8- alpha beta+ T cells from gamma delta T cell precursors. Eur. J. Immunol. 28:1998;828
64. Garefalaki A., Coles M., Hirschberg S., Mavria G., Norton T., Hostert A., Kioussis D. Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences. Immunity. 16:2002;635
65. Gay D., Buus S., Pasternak J., Kappler J., Marrack P. The T-cell accessory molecule CD4 recognizes a monomorphic determinant on isolated la. Proc. Natl. Acad. Sci. USA. 85:1988;5629
66. Gibbons D., Douglas N.C., Barber D.F., Liu Q., Sullo R., Geng L., Fehling H.J., von Boehmer H., Hayday A.C. The biological activity of natural and mutant pTalpha alleles. J. Exp. Med. 194:2001;695
67. Girao C., Hu Q., Sun J., Ashton-Rickardt P.G. Limits to the differential avidity model of T cell selection in the thymus. J. Immunol. 159:1997;4205
68. Gong Q., Cheng A.M., Akk A.M., Alberola-Ila J., Gong G., Pawson T., Chan A.C. Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Nat. Immunol. 2:2001;29
69. Gounari F., Aifantis I., Khazaie K., Hoeflinger S., Harada N., Taketo M.M., von Boehmer H. Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development. Nat. Immunol. 2:2001;863
70. Gounari F., Aifantis I., Martin C., Fehling H.J., Hoeflinger S., Leder P., von Boehmer H., Reizis B. Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat. Immunol. 3:2002;489
71. Graf D., Nethisinghe S., Palmer D.B., Fisher A.G., Merkenschlager M. The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development. J. Exp. Med. 196:2002;163
72. Groettrup M., Ungewiss K., Azogui O., Palacios R., Owen M.J., Hayday A.C., von Boehmer H. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein. Cell. 75:1993;283
73. Guo J., Hawwari A., Li H., Sun Z., Mahanta S.K., Littman D.R., Krangel M.S., He Y.W. Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. Nat. Immunol. 3:2002;469
74. Haks M.C., Belkowski S.M., Ciofani M., Rhodes M., Lefebvre J.M., Trop S., Hugo P., Zuniga-Pflucker J.C., Wiest D.L. Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells. J. Immunol. 170:2003;2853
75. Haks M.C., Krimpenfort P., van den Brakel J.H., Kruisbeek A.M. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity. 11:1999;91
76. Han H., Tanigaki K., Yamamoto N., Kuroda K., Yoshimoto M., Nakahata T., Ikuta K., Honjo T. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int. Immunol. 14:2002;637
77. Hara M., Kingsley C.I., Niimi M., Read S., Turvey S.E., Bushell A.R., Morris P.J., Powrie F., Wood K.J. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol. 166:2001;3789
78. Hardy R.R., Hayakawa K. B cell development pathways. Annu. Rev. Immunol. 19:2001;595
79. Harker N., Naito T., Cortes M., Hostert A., Hirschberg S., Tolaini M., Roderick K., Georgopoulos K., Kioussis D. The CD8alpha gene locus is regulated by the Ikaros family of proteins. Mol. Cell. 10:2002;1403
80. Heath W.R., Carbone F.R., Bertolino P., Kelly J., Cose S., Miller J.F. Expression of two T cell receptor alpha chains on the surface of normal murine T cells. Eur. J. Immunol. 25:1995;1617
81. Hedrick S.M., Cohen D.I., Nielsen E.A., Davis M.M. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature. 308:1984a;149
82. Hedrick S.M., Nielsen E.A., Kavaler J., Cohen D.I., Davis M.M. Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature. 308:1984b;153
83. Heino M., Peterson P., Kudoh J., Nagamine K., Lagerstedt A., Ovod V., Ranki A., Rantala I., Nieminen M., Tuukkanen J., Scott H.S., Antonarakis S.E., Shimizu N., Krohn K. Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla. Biochem. Biophys. Res. Commun. 257:1999;821
84. Hernandez-Hoyos G., Sohn S.J., Rothenberg E.V., Alberola-lla J. Lck activity controls CD4CD8 T cell lineage commitment. Immunity. 12:2000;313
85. Hogquist K.A., Gavin M.A., Bevan M.J. Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J. Exp. Med. 177:1993;1469
86. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:2003;1057
87. Huesmann M., Scott B., Kisielow P., von Boehmer H. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell. 66:1991;533-540
88. Igarashi H., Gregory S.C., Yokota T., Sakaguchi N., Kincade P.W. Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity. 17:2002;117
89. Jaleco A.C., Neves H., Hooijberg E., Gameiro P., Clode N., Haury M., Henrique D., Parreira L. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J. Exp. Med. 194:2001;991
90. Jerne N.K. The natural selection theory of antibody formation. Proc. Natl. Acad. Sci. USA. 41:1955;849
91. Jerne N.K. Waiting for the end. Cold Spring Harb. Symp. Quant. Biol. 32:1967;591
92. Jerne N.K. The somatic generation of immune recognition. Eur. J. Immunol. 1:1971;1
93. Jerne N.K. The common sense of immunology. Cold Spring Harb. Symp. Quant. Biol. 41:(Pt 1):1977;1
94. Jolicoeur C., Hanahan D., Smith K.M. T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus. Proc. Natl. Acad. Sci. USA. 91:1994;6707
95. Jordan M.S., Riley M.P., von Boehmer H., Caton A.J. Anergy and suppression regulate CD4(+) T cell responses to a self peptide. Eur. J. Immunol. 30:2000;136
96. Jung D., Bassing C.H., Fugmann S.D., Cheng H.L., Schatz D.G., Alt F.W. Extrachromosomal recombination substrates recapitulate beyond 1223 restricted VDJ recombination in nonlymphoid cells. Immunity. 18:2003;65
97. Kappler J.W., Marrack P. The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression. J. Exp. Med. 148:1978;1510
98. Kappler J.W., Roehm N., Marrack P. T cell tolerance by clonal elimination in the thymus. Cell. 49:1987;273
99. Kappler J.W., Skidmore B., White J., Marrack P. Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition. J. Exp. Med. 153:1981;1198
100. Katz D.H., Benacerraf B. The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products. Transplant Rev. 22:1975;175
101. Katz D.H., Hamaoka T., Dorf M.E., Maurer P.H., Benacerraf B. Cell interactions between histoincompatible T and B lymphocytes. IV. Involvement of the immune response (Ir) gene in the control of lymphocyte interactions in responses controlled by the gene. J. Exp. Med. 138:1973;734
102. Kaye J., Hsu M.L., Sauron M.E., Jameson S.C., Gascoigne N.R., Hedrick S.M. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature. 341:1989;746
103. Khattri R., Cox T., Yasayko S.A., Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4:2003;337
104. Kim J., Sif S., Jones B., Jackson A., Koipally J., Heller E., Winandy S., Viel A., Sawyer A., Ikeda T., Kingston R., Georgopoulos K. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity. 10:1999;345
105. Kirberg J., Baron A., Jakob S., Rolink A., Karjalainen K., von Boehmer H. Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180:1994;25
106. Kisielow P., Bluthmann H., Staerz U.D., Steinmetz M., von Boehmer H. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature. 333:1988a;742
107. Kisielow P., Hirst J.A., Shiku H., Beverley P.C., Hoffman M.K., Boyse E.A., Oettgen H.F. Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse. Nature. 253:1975;219
108. Kisielow P., Teh H.S., Bluthmann H., von Boehmer H. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature. 335:1988b;730
109. Klein B., Kyewski B. Self-antigen presentation by thymic stromal cells: A subtle division of labor. Curr. Opin. Immun. 2000;. (in press).
110. Klein L., Khazaie K., von Boehmer H. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA. 2003;. (in press).
111. Klein L., Klein T., Ruther U., Kyewski B. CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium. J. Exp. Med. 188:1998;5
112. Klein L., Klugmann M., Nave K.A., Kyewski B. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6:2000;56
113. Koch U., Lacombe T.A., Holland D., Bowman J.L., Cohen B.L., Egan S.E., Guidos C.J. Subversion of the TB lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1. Immunity. 15:2001;225
114. Kondo M., Weissman I.L., Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 91:1997;661
115. Kouskoff V., Vonesch J.L., Benoist C., Mathis D. The influence of positive selection on RAG expression in thymocytes. Eur. J. Immunol. 25:1995;54
116. Krawinkel U., Cramer M., Berek C., Hammerling G., Black S.J., Rajewsky K., Eichmann K. On the structure of the T-cell receptor for antigen. Cold Spring Harb. Symp. Quant. Biol. 41:(Pt 1):1977;285
117. Kyewski B., Derbinski J., Gotter J., Klein L. Promiscuous gene expression and central T-cell tolerance: More than meets the eye. Trends Immunol. 23:2002;364
118. Lederberg J. Genes and antibodies: Do antigens bear instructions for antibody specificity or do they select cell lines that arise by mutation? Science. 129:1959;1649
119. Liston A., Lesage S., Wilson J., Peltonen L., Goodnow C.C. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4:2003;350
120. Livak F., Petrie H.T., Crispe I.N., Schatz D.G. In-frame TCR delta gene rearrangements play a critical role in the alpha betagamma delta T cell lineage decision. Immunity. 2:1995;617
121. Love P.E., Chan A.C. Regulation of thymocyte development: Only the meek survive. Curr. Opin. Immunol. 15:2003;199
122. Marsden V.S., Strasser A. Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu. Rev. Immunol. 21:2003;71
123. Martin C.H., Aifantis I., Scimone M.L., Von Andrian U.H., Reizis B., Von Boehmer H., Gounari F. Efficient thymic immigration of B220(+) lymphoid-restricted bone marrow cells with T precursor potential. Nat. Immunol. 4:2003;866
124. Martinic M.M., Rulicke T., Althage A., Odermatt B., Hochli M., Lamarre A., Dumrese T., Speiser D.E., Kyburz D., Hengartner H., Zinkernagel R.M. Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC. Proc. Natl. Acad. Sci. USA. 100:2003;1861
125. Matsuyama M., Wiadrowski M.N., Metcalf D. Autoradiographic analysis of lymphopoiesis and lymphocyte migration in mice bearing multiple thymus grafts. J. Exp. Med. 123:1966;559
126. Matzinger P. T cell response: Nature or nurture. Nature. 274:1978;840
127. Matzinger P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:1994;991
128. Matzinger P. The danger model: A renewed sense of self. Science. 296:2002;301
129. Miyazaki T., Lemonnier F.A. Modulation of thymic selection by expression of an immediate-early gene, early growth response 1 (Egr-1). J. Exp. Med. 188:1998;715
130. Nagy Z.A., Klein J. Macrophage or T cell: That is the question. Immunol. Today. 2:1981;228
131. Neilson J.R., Winslow M.M., Hur E.M., Crabtree G.R. Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity. 20:2004;255-266
132. Norment A.M., Salter R.D., Parham P., Engelhard V.H., Littman D.R. Cell-cell adhesion mediated by CD8 and MHC class I molecules. Nature. 336:1988;79
133. Opferman J.T., Letai A., Beard C., Sorcinelli M.D., Ong C.C., Korsmeyer S.J. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 426:2003;671
134. Pages G., Guerin S., Grall D., Bonino F., Smith A., Anjuere F., Auberger P., Pouyssegur J. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science. 286:1999;1374
135. Pai S.Y., Truitt M.L., Ting C.N., Leiden J.M., Glimcher L.H., Ho I.C. Critical roles for transcription factor GATA-3 in thymocyte development. Immunity. 19:2003;863
136. Panigada M., Porcellini S., Barbier E., Hoeflinger S., Cazenave P.A., Gu H., Band H., von Boehmer H., Grassi F. Constitutive endocytosis and degradation of the pre-T cell receptor. J. Exp. Med. 195:2002;1585
137. Passoni L., Hoffman E.S., Kim S., Crompton T., Pao W., Dong M.Q., Owen M.J., Hayday A.C. Intrathymic delta selection events in gammadelta cell development. Immunity. 7:1997;83
138. Pennisi E. Teetering on the brink of danger. Science. 271:1996;1665
139. Petrie H.T., Livak F., Schatz D.G., Strasser A., Crispe I.N., Shortman K. Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes. J. Exp. Med. 178:1993;615
140. Radtke F., Wilson A., Stark G., Bauer M., van Meerwijk J., MacDonald H.R., Aguet M. Deficient T cell fate specification in mice with an induced inactivation of Notch 1. Immunity. 10:1999;547
141. Ramsey C., Winqvist O., Puhakka L., Halonen M., Moro A., Kampe O., Eskelin P., Pelto-Huikko M., Peltonen L. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 11:2002;397
142. Raulet D.H., Garman R.D., Saito H., Tonegawa S. Developmental regulation of T-cell receptor gene expression. Nature. 314:1985;103
143. Rincon M., Whitmarsh A., Yang D.D., Weiss L., Derijard B., Jayaraj P., Davis R.J., Flavell R.A. The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes. J. Exp. Med. 188:1998;1817
144. Rodewald H.R., Fehling H.J. Molecular and cellular events in early thymocyte development. Adv. Immunol. 69:1998;1
145. Rodewald H.R., Ogawa M., Haller C., Waskow C., DiSanto J.P. Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formation. Immunity. 6:1997;265
146. Rolink A., ten Boekel E., Melchers F., Fearon D.T., Krop I., Andersson J. A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J. Exp. Med. 183:1996;187
147. Rosenthal A.S., Shevach E.M. Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes. J. Exp. Med. 138:1973;1194
148. Saint-Ruf C., Ungewiss K., Groettrup M., Bruno L., Fehling H.J., von Boehmer H. Analysis and expression of a cloned pre-T cell receptor gene. Science. 266:1994;1208
149. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1995;1151
150. Sawada S., Littman D.R. Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Mol. Cell. Biol. 11:1991;5506
151. Sawada S., Scarborough J.D., Killeen N., Littman D.R. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell. 77:1994;917
152. Schmitt T.M., Zuniga-Pflucker J.C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity. 17:2002;749
153. Scott B., Bluthmann H., Teh H.S., von Boehmer H. The generation of mature T cells requires interaction of the alpha beta T-cell receptor with major histocompatibility antigens. Nature. 338:1989;591
154. Shao H., Kono D.H., Chen L.Y., Rubin E.M., Kaye J. Induction of the early growth response (Egr) family of transcription factors during thymic selection. J. Exp. Med. 185:1997;731
155. Sharp L.L., Schwarz D.A., Bott C.M., Marshall C.J., Hedrick S.M. The influence of the MAPK pathway on T cell lineage commitment. Immunity. 7:1997;609
156. Shevach E.M. CD4+ CD25+ suppressor T cells: More questions than answers. Nat. Rev. Immunol. 2:2002;389
157. Shortman K., Jackson H. The differentiation of T lymphocytes. I. Proliferation kinetics and interrelationships of subpopulations of mouse thymus cells. Cell Immunol. 12:1974;230
158. Shortman K., Wu L. Early T lymphocyte progenitors. Annu. Rev. Immunol. 14:1996;29
159. Sicinska E., Aifantis I., Le Cam L., Swat W., Borowski C., Yu Q., Ferrando A.A., Levin S.D., Geng Y., von Boehmer H., Sicinski P. Requirement for cyclin D3 in lymphocyte development and T-cell leukemias. Cancer Cell. 4:2003;451
160. Simonsen M. The clonal selection hypothesis evaluated by grafted cells reacting against their host. Cold Spring Harb. Symp. Quant. Biol. 32:1968;517
161. Sitnicka E., Bryder D., Theilgaard-Monch K., Buza-Vidas N., Adolfsson J., Jacobsen S.E. Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool. Immunity. 17:2002;463
162. Smith F.I., Miller J.F. Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras. J. Exp. Med. 151:1980;246
163. Snodgrass H.R., Dembic Z., Steinmetz M., von Boehmer H. Expression of T-cell antigen receptor genes during fetal development in the thymus. Nature. 315:1985a;232
164. Snodgrass H.R., Kisielow P., Kiefer M., Steinmetz M., von Boehmer H. Ontogeny of the T-cell antigen receptor within the thymus. Nature. 313:1985b;592
165. Sommers C.L., Park C.S., Lee J., Feng C., Fuller C.L., Grinberg A., Hildebrand J.A., Lacana E., Menon R.K., Shores E.W., Samelson L.E., Love P.E. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science. 296:2002;2040
166. Sospedra M., Ferrer-Francesch X., Dominguez O., Juan M., Foz-Sala M., Pujol-Borrell R. Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens. J. Immunol. 161:1998;5918
167. Staal F.J., Clevers H.C. Wnt signaling in the thymus. Curr. Opin. Immunol. 15:2003;204
168. Starr T.K., Jameson S.C., Hogquist K.A. Positive and negative selection of T cells. Annu. Rev. Immunol. 21:2003;139
169. Stefanova I., Dorfman J.R., Germain R.N. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature. 420:2002;429
170. Sugawara T., Moriguchi T., Nishida E., Takahama Y. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes. Immunity. 9:1998;565
171. Sullivan B.A., Kraj P., Weber D.A., Ignatowicz L., Jensen P.E. Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin. Immunity. 17:2002;95
172. Swat W., Ignatowicz L., von Boehmer H., Kisielow P. Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells. Nature. 351:1991;150
173. Takagi T., Harada J., Ishii S. Murine Schnurri-2 is required for positive selection of thymocytes. Nat. Immunol. 2:2001;1048
174. Taniuchi I., Osato M., Egawa T., Sunshine M.J., Bae S.C., Komori T., Ito Y., Littman D.R. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell. 111:2002;621
175. Teh H.S., Kisielow P., Scott B., Kishi H., Uematsu Y., Bluthmann H., von Boehmer H. Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4CD8 phenotype of T cells. Nature. 335:1988;229
176. Terrence K., Pavlovich C.P., Matechak E.O., Fowlkes B.J. Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells. J. Exp. Med. 192:2000;537
177. Trop S., Rhodes M., Wiest D.L., Hugo P., Zuniga-Pflucker J.C. Competitive displacement of pT alpha by TCR-alpha during TCR assembly prevents surface coexpression of pre-TCR and alpha beta TCR. J. Immunol. 165:2000;5566
178. Uchida N., Weissman I.L. Searching for hematopoietic stem cells: Evidence that Thy-1. 1lo Lin-Sca-1+ cells are the only stem cells in C57BLKa-Thy-1.1 bone marrow. J. Exp. Med. 175:1992;175
179. Urdahl K.B., Sun J.C., Bevan M.J. Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells. PG-772-9. Nat. Immunol. 3:2002
180. Voll R.E., Jimi E., Phillips R.J., Barber D.F., Rincon M., Hayday A.C., Flavell R.A., Ghosh S. NF-kappaB activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity. 13:2000;677
181. von Boehmer H. The selection of the alpha, beta heterodimeric T-cell receptor for antigen. Immunol. Today. 7:1986;333
182. von Boehmer H. The development biology of T lymphocytes. Annu. Rev. Immunol. 6:1988;309
183. von Boehmer H. Developmental biology of T cells in T cell-receptor transgenic mice. Annu. Rev. Immunol. 8:1990;531
184. von Boehmer H. Positive selection of lymphocytes. Cell. 76:1994;219
185. von Boehmer H. CD4CD8 lineage commitment: Back to instruction? J. Exp. Med. 183:1996;713
186. von Boehmer H., Aifantis I., Azogui O., Saint-Ruf C., Grassi F. The impact of pre-T-cell receptor signals on gene expression in developing T cells. Cold Spring Harb. Symp. Quant. Biol. 64:1999;283
187. von Boehmer H., Aifantis I., Gounari F., Azogui O., Haughn L., Apostolou I., Jaeckel E., Grassi F., Klein L. Thymic selection revisited: How essential is it? Immunol. Rev. 191:2003;62
188. von Boehmer H., Haas W. Cytotoxic T lymphocytes recognise allogeneic tolerated TNP-conjugated cells. Nature. 261:1976;141
189. von Boehmer H., Haas W., Jerne N.K. Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice. Proc. Natl. Acad. Sci. USA. 75:1978;2439
190. von Boehmer H., Hengartner H., Nabholz M., Lernhardt W., Schreier M.H., Haas W. Fine specificity of a continuously growing killer cell clone specific for H-Y antigen. Eur. J. Immunol. 9:1979;592
191. von Boehmer H., Hudson L., Sprent J. Collaboration of histoincompatible T and B lymphocytes using cells from tetraparental bone marrow chimeras. J. Exp. Med. 142:1975;989
192. von Boehmer H., Kisielow P. How the immune system learns about self. Sci. Am. 265:1991;74
193. von Boehmer H., Teh H.S., Kisielow P. The thymus selects the useful, neglects the useless and destroys the harmful. Immunol. Today. 10:1989;57
194. Wagner H., Hardt C., Stockinger H., Pfizenmaier K., Bartlett R., Rollinghoff M. Impact of thymus on the generation of immunocompetence and diversity of antigen-specific MHC-restricted cytotoxic T-lymphocyte precursors. Immunol. Rev. 58:1981;95
195. + regulatory T cells in vivo. J. Exp. Med. 198:2003;249
196. Warren L.A., Rothenberg E.V. Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors. Curr. Opin. Immunol. 15:2003;166
197. Werlen G., Hausmann B., Palmer E. A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity. Nature. 406:2000;422
198. Wildin R.S., Ramsdell F., Peake J., Faravelli F., Casanova J.L., Buist N., Levy-Lahad E., Mazzella M., Goulet O., Perroni L., Bricarelli F.D., Byrne G., McEuen M., Proll S., Appleby M., Brunkow M.E. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 27:2001;18
199. Wilson A., MacDonald H.R., Radtke F. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J. Exp. Med. 194:2001;1003
200. Winandy S., Wu L., Wang J.H., Georgopoulos K. Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros. J. Exp. Med. 190:1999;1039
201. Wu C., Bassing C.H., Jung D., Woodman B.B., Foy D., Alt F.W. Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3′Dbeta1 recombination signal sequence. Immunity. 18:2003;75
202. Wu L.C., Tuot D.S., Lyons D.S., Garcia K.C., Davis M.M. Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature. 418:2002;552
203. Yamazaki S., Iyoda T., Tarbell K., Olson K., Velinzon K., Inaba K., Steinman R.M. Direct expansion of functional CD25+CD4+ regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198:2003;235
204. Yannoutsos N., Wilson P., Yu W., Chen H.T., Nussenzweig A., Petrie H., Nussenzweig M.C. The role of recombination activating gene (RAG) reinduction in thymocyte development in vivo. J. Exp. Med. 194:2001;471
205. Yasutomo K., Doyle C., Miele L., Fuchs C., Germain R.N. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate. Nature. 404:2000;506
206. Zinkernagel R.M. Virus-specific T-cell-mediated cytotoxicity across the H-2 barrier to virus-altered alloantigen. Nature. 261:1976;139
207. Zinkernagel R.M., Althage A., Callahan G., Welsh R.M. Jr. On the immunocompetence of H-2 incompatible irradiation bone marrow chimeras. J. Immunol. 124:1980;2356
208. Zinkernagel R.M., Althage A., Cooper S., Callahan G., Klein J. In irradiation chimeras, K or D regions of the chimeric host, not of the donor lymphocytes, determine immune responsiveness of antiviral cytotoxic T cells. J. Exp. Med. 148:1978a;805
209. Zinkernagel R.M., Callahan G.N., Althage A., Cooper S., Klein P.A., Klein J. On the thymus in the differentiation of "H-2 self-recognition" by T cells: Evidence for dual recognition? J. Exp. Med. 147:1978b;882
210. Zinkernagel R.M., Doherty P.C. Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis. Nature. 251:1974;547
211. Zou Y.R., Sunshine M.J., Taniuchi I., Hatam F., Killeen N., Littman D.R. Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat. Genet. 29:2001;332