Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells

Journal of Immunology

Volumn 170, Issue 6, 2003, Pages 2853-2861

  Haks, Mariëlle C ^a   Belkowski, Stanley M ^a   Ciofani, Maria ^b   Rhodes, Michele ^a   Lefebvre, Juliette M ^a   Trop, Sebastién ^b   Hugo, Patrice ^c   Zúñiga Pflücker, Juan Carlos ^b   Wiest, David L ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; CD4 ANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CELL MEMBRANE; CONTROLLED STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE;

EID: 0037443414     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.6.2853     Document Type: Article

References (44)

1. Irving, B. A., F. W. Alt, and N. Killeen. 1998. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science 280:905.
2. Levelt, C. N., and K. Eichmann. 1995. Receptors and signals in early thymic selection. Immunity 3:667.
3. + precursors. Eur. J. Immunol. 18:2089.
4. Berger, M. A., V. Dave, M. R. Rhodes, G. C. Bosma, M. J. Bosma, D. J. Kappes, and D. L. Wiest. 1997. Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3δ is physically associated but not functionally required. J. Exp. Med. 186:1461.
5. Saint-Ruf, C., M. Panigada, O. Azogui, P. Debey, H. von Boehmer, and F. Grassi. 2000. Different initiation of pre-TCR and γδ5TCR signalling. Nature 406:524.
6. Xavier, R., T. Brennan, Q. Li, C. McCormack, and B. Seed. 1998. Membrane compartmentation is required for efficient T cell activation. Immunity 8:723.
7. Zhang, W., R. P. Trible, and L. E. Samelson. 1998. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 9:239.
8. Kabouridis, P. S., A. I. Magee, and S. C. Ley. 1997. S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J. 16:4983.
9. Kosugi, A., F. Hayashi, D. R. Liddicoat, K. Yasuda, S. Saitoh, and T. Hamaoka. 2001. A pivotal role of cysteine 3 of Lck tyrosine kinase for localization to glycolipid-enriched microdomains and T cell activation. Immunol. Lett. 76:133.
10. Aifantis, I., C. Borowski, F. Gounari, H. D. Lacorazza, J. Nikolich-Zugich, and H. von Boehmer. 2002. A critical role for the cytoplasmic tail of pTα in T lymphocyte development. Nat. Immun. 3:483.
11. -/- mice by anti-CD3ε antibody treatment or with transgenes encoding activated Lck or tailless pTα. Immunity 6:703.
12. Gibbons, D., N. C. Douglas, D. F. Barber, Q. Liu, R. Sullo, L. Geng, H. J. Fehling, H. von Boehmer, and A. C. Hayday. 2001. The biological activity of natural and mutant pTα alleles. J. Exp. Med. 194:695.
13. Montixi, C., C. Langlet, A. M. Bernard, J. Thimonier, C. Dubois, M. A. Wurbel, J. P. Chauvin, M. Pierres, and H. T. He. 1998. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J. 17:5334.
14. Buer, J., I. Aifantis, J. P. DiSanto, H. J. Fehling, and H. von Boehmer. 1997. Role of different T cell receptors in the development of pre-T cells. J. Exp. Med. 185:1541.
15. Berg, L. J., B. F. de St. Groth, A. M. Pullen, and M. M. Davis. 1989. Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection. Nature 340:559.
16. Haks, M. C., P. Krimpenfort, J. Borst, and A. M. Kruisbeek. 1998. The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages. EMBO J. 17:1871.
17. Trop, S., A. M. Steff, F. Denis, D. L. Wiest, and P. Hugo. 1999. The connecting peptide domain of pTα dictates weak association of the pre-T cell receptor with the TCRζ subunit. Eur. J. Immunol. 29:2187.
18. + stage. J. Immunol. 168:1649.
19. Berger, M. A., M. Carleton, M. Rhodes, J. M. Sauder, S. Trop, R. L. Dunbrack, P. Hugo, and D. L. Wiest. 2000. Identification of a novel pre-TCR isoform in which the accessibility of the TCR β subunit is determined by occupancy of the "missing" V domain of pre-Tα. Int. Immunol. 12:1579.
20. Carlyle, J. R., and J. C. Zuniga-Pflucker. 1998. Requirement for the thymus in αβ T lymphocyte lineage commitment. Immunity 9:187.
21. Michie, A. M., and J. C. Zuniga-Pflucker. 2000. Transfection and transcription of genes in developing thymocytes. Methods in Molecular Biology 134:55.
22. Fehling, H. J., A. Krotkova, C. Saint-Ruf, and H. von Boehmer. 1995. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. [Published erratum appears in 1995 Nature 378:419.] Nature 375:795.
23. Mertsching, E., A. Wilson, H. R. MacDonald, and R. Ceredig. 1997. T cell receptor a gene rearrangement and transcription in adult thymic γδ cells. Eur. J. Immunol. 27:389.
24. Mancini, S., S. M., Candeias, H. J. Fehling, H. von Boehmer, E. Jouvin-Marche, and P. N. Marche. 1999. TCR α-chain repertoire in pTα-deficient mice is diverse and developmentally regulated: implications for pre-TCR functions and TCRα gene rearrangement. J. Immunol. 163:6053.
25. Erman, B., L. Feigenbaum, J. E. Coligan, and A. Singer. 2002. Early TCRα expression generates TCRαγ complexes that signal the DN-to-DP transition and impair development. Nat. Immun. 3:564.
26. Vereb, G., J. Matko, G. Vamosi, S. M. Ibrahim, E. Magyar, S. Varga, J. Szollosi, A. Jenei, R. Gaspar, Jr., T. A. Waldmann, and S. Damjanovich. 2000. Cholesterol-dependent clustering of IL-2Rα and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts. Proc. Natl. Acad. Sci. USA 97:6013.
27. + thymocytes. Proc. Natl. Acad. Sci. USA 93:4683.
28. Iritani, B. M., J. Alberola-Ila, K. A. Forbush, and R. M. Perimutter. 1999. Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors, Immunity 10:713.
29. Michie, A. M., S. Trop, D. L. Wiest, and J. C. Zuniga-Pflucker. 1999. Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo. J. Exp. Med. 190:1647.
30. Bruno, L., A. Scheffold, A. Radbruch, and M. J. Owen. 1999. Threshold of pre-T-cell-receptor surface expression is associated with αβ T-cell lineage commitment. Curr. Biol. 9:559.
31. Kirchgessner, C. U., C. K. Patil, J. W. Evans, C. A. Cuomo, L. M. Fried, T. Carter, M. A. Oettinger, and J. M. Brown. 1995. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267:1178.
32. Blunt, T., N. J. Finnie, G. E. Taccioli, G. C. Smith, J. Demengeot, T. M. Gottlieb, R. Mizuta, A. J. Varghese, F. W. Alt, P. A. Jeggo, et al. 1995. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80:813.
33. Lewis, R. S. 2001. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 19:497.
34. Tuosto, L., I. Parolini, S. Schroder, M. Sargiacomo, A. Lanzavecchia, and A. Viola. 2001. Organization of plasma membrane functional rafts upon T cell activation. Eur. J. Immunol. 31:345.
35. 2+ mobilization and activation of NF-κB and NFAT. Nat. Immun. 2:403.
36. Simons, K., and D. Toomre. 2000. Lipid rafts and signal transduction. [Published erratum appears in 2001 Nat. Rev. Mol. Cell Biol. 2:216.] Nat. Rev. Mol. Cell Biol. 1:31.
37. Willumsen, B. M., A. D. Cox, P. A. Solski, C. J. Der, and J. E. Buss. 1996. Novel determinants of H-Ras plasma membrane localization and transformation. Oncogene 13:1901.
38. Resh, M. D. 1996. Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins. Cell. Signal. 8:403.
39. Azzam, H. S., A. Grinberg, K. Lui, H. Shen, E. W. Shores, and P. E. Love. 1998. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 188:2301.
40. + thymocytes and regulates positive selection. Immunity 15:457.
41. Lacorazza, H. D., C. Tucek-Szabo, L. V. Vasovic, K. Remus, and J. Nikolich-Zugich. 2001. Premature TCR αβ expression and signaling in early thymocytes impair thymocyte expansion and partially block their development. J. Immunol. 166:3184.
42. Terrence, K., C. P. Pavlovich, E. O. Matechak, and B. J. Fowlkes. 2000. Premature expression of T cell receptor (TCR)αβ suppresses TCRγδ gene rearrangement but permits development of γδ lineage T cells. J. Exp. Med. 192:537.
43. Abraham, K. M., S. D. Levin, J. D. Marth, K. A. Forbush, and R. M. Perlmutter. 1991. Delayed thymocyte development induced by augmented expression of p561ck. J. Exp. Med. 173:1421.
44. Diehl, N. L., H. Enslen, K. A. Fortner, C. Merritt, N. Stetson, C. Charland, R. A. Flavell, R. J. Davis, and M. Rincón. 2000. Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo. J. Exp. Med. 191:321.