The impact of pre-T-cell receptor signals on gene expression in developing T cells

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 64, Issue , 1999, Pages 283-289

  Von Boehmer, H ^a   Aifantis, I ^a   Azogui, O ^a   Saint Ruf, C ^a   Grassi, F ^a,b  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; CD3 ANTIGEN; CELL SURFACE PROTEIN; FLUORESCEIN ISOTHIOCYANATE; MITOGEN ACTIVATED PROTEIN KINASE 1;

ALLELISM; CONFERENCE PAPER; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE REARRANGEMENT; GENE SILENCING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ARTICLE; CELL MATURATION; CELL PROLIFERATION; CONFOCAL MICROSCOPY; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; HUMAN; IMMUNOFLUORESCENCE TEST; MRNA EXPRESSION ASSAY; POLYMERASE CHAIN REACTION; PRE T LYMPHOCYTE; PROTEIN EXPRESSION;

EUKARYOTA;

EID: 0033504906     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1999.64.283     Document Type: Conference Paper

References (55)

1. Aifantis I., Buer J., von Boehmer H., and Azogui O. 1997. Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor β locus (erratum appears in Immunity 7: 895.) Immunity 7: 601.
2. Aifantis I., Feinberg J., Fehling H.J., Di Santo J.P., and von Boehmer H. 1999a. Early T cell receptor β gene expression is regulated by the pre-T cell receptor-CD3 complex. J. Exp. Med. 190: 141.
3. Aifantis I., Azogui O., Feinberg J., Saint-Ruf C., Buer J., and von Boehmer H. 1998. On the role of the pre-T cell receptor in αβ versus 78 T lineage commitment. Immunity 9: 649.
4. Aifantis I., Pivniouk V., Gartner F., Feinberg J., Swat W., Alt F., von Boehmer H., and Geha R. 1999b. Surface expression of the pre-TCR but lack of TCR-β allelic exclusion in SLP-76 deficient mice. J. Exp. Med. 190: 1093.
5. Anderson S.J., Levin S.D., and Perlmutter R.M. 1993. Protein tyrosine kinase p561ck controls allelic exclusion of T-cell receptor β-chain genes. Nature 365: 552.
6. Barber D.F., Passoni L., Wen L., Geng L., and Hayday A.C. 1998. The expression in vivo of a second isoform of pTα: Implications for the mechanism of pTα action. J. Immunol. 161: 11.
7. Biro J., Wurch A., Potocnik A.J., Falk I., Mossmann H., and Eichmann K. 1999. Regulation of T cell receptor (TCR) β gene expression by CD3 complex signaling in immature thymocytes: Implications for TCR-β allelic exclusion. Proc. Natl. Acad. Sci. 96: 3882.
8. Blom B., Heemskerk M.H., Verschuren M.C., van Dongen J.J., Stegmann A.P., Bakker A.Q., Couwenberg F., Res P.C., and Spits H. 1999. Disruption of αβ but not of γδ T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. EMBO J. 18: 2793.
9. Brown K.E., Baxter J., Graf D., Merkenschlager M., and Fisher A.G. 1999. Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division. Mol. Cell 3: 207.
10. Brown K.E., Guest S.S., Smale S.T., Hahm K., Merkenschlager M., and Fisher A.G. 1997. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 91: 845.
11. Bruno L., Scheffold A., Radbruch A., and Owen M.J. 1999. Threshold of pre-T-cell-receptor surface expression is associated with αβ T-cell lineage commitment. Curr. Biol. 9: 559.
12. Buer J., Aifantis I., DiSanto J.P., Fehling H.J., and von Boehmer H. 1997. Role of different T cell receptors in the development of pre-T cells. J. Exp. Med. 185: 1541.
13. Burtrum D.B., Kim S., Dudley E.G., Hayday A.C., and Petrie H.T. 1996. TCR gene recombination and αβ-γδ lineage divergence: Productive TCR-β rearrangement is neither exclusive nor preclusive of γδ cell development. J. Immunol. 157: 4293.
14. Cheng A.M., Negishi I., Anderson S.J., Chan A.C., Bolen J., Loh D.Y., and Pawson T. 1997. The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc. Natl. Acad. Sci. 94: 9797.
15. Clements J.L., Boerth N.J., Lee J.R., and Koretzky G.A. 1999. Integration of T cell receptor-dependent signaling pathways by adapter proteins. Annu. Rev. Immunol. 17: 89.
16. Clements J.L., Yang B., Ross-Barta S.E., Eliason S.L., Hrstka R.F., Williamson R.A., and Koretzky G.A. 1998. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 281: 416.
17. Dave V.P., Cao Z., Browne C., Alarcon B., Fernandez-Miguel G., Lafaille J., de la Hera A., Tonegawa S., and Kappes D.J. 1997. CD3 δ deficiency arrests development of the αβ but not the γδ T cell lineage. EMBO J. 16: 1360.
18. Del Porto P., Bruno L., Mattei M.G., von Boehmer H., and Saint-Ruf C. 1995. Cloning and comparative analysis of the human pre-T-cell receptor α-chain gene. Proc. Natl. Acad. Sci. 92: 12105.
19. Di Santo J.P., Aifantis I., Rosmaraki E., Garcia C., Feinberg J., Fehling H.J., Fischer A., von Boehmer H., and Rocha B. 1999. The common cytokine receptor γ chain and the pre-T cell receptor provide independent but critically overlapping signals in early αβ T cell development. J. Exp. Med. 189: 563.
20. Dudley B.C., Girardi M., Owen M.J., and Hayday A.C. 1995. αβ and γδ T cells can share a late common precursor. Curr. Biol. 5: 659.
21. Fehling H.J., Krotkova A., Saint-Ruf C., and von Boehmer H. 1995a. Crucial role of the pre-T-cell receptor a gene in development of αβ but not γδ T cells (erratum appears in Nature 378: 419). Nature 375: 795-798.
22. Fehling H.J., Laplace C., Mattel M.G., Saint-Ruf C., and von Boehmer H. 1995b. Genomic structure and chromosomal location of the mouse pre-T-cell receptor a gene. Immunogenetics 42: 275.
23. -/- mice by anti-CD3ε antibody treatment or with transgenes encoding activated Lck or tailless pTα. Immunity 6: 703.
24. Garcia K.C., Degano M., Stanfield R.L., Brunmark A., Jackson M.R., Peterson P.A., Teyton L., and Wilson I.A. 1996. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex. Science 274: 209.
25. Gärtner F., Alt F., Monroe R., Chu M., Sleckman B.P., Davidson L., and Swat W. 1999. Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion. Immunity 10: 537.
26. Grassi F., Barbier E., Porcellini S., von Boehmer H., and Cazenave P.A. 1999. Surface expression and functional competence of CD3-independcnt TCR ζ-chains in immature thymocytes. J. Immunol. 162: 2589.
27. Groettrup M., Baron A., Griffiths G., Palacios R., and von Boehmer H. 1992. T cell receptor (TCR) β chain homodimers on the surface of immature but not mature α, γ, δ chain deficient T cell lines. EMBO J. 11: 2735.
28. Groettrup M., Ungewiss K., Azogui O., Palacios R., Owen M.J., Hayday A.C., and von Boehmer H. 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein. Cell 75: 283.
29. Groves T., Smiley P., Cooke M.P., Forbush K., Perlmutter R.M., and Guidos C.J. 1996. Fyn can partially substitute for Lck in T lymphocyte development. Immunity 5: 417.
30. Iritani B., Alberola-Ila J., Forbush K.A., and Perlmutter R.M. 1999. Distinct signals mediate maturation and allelic exclusion of lymphocyte progenitors. Immunity 10: 713.
31. Irving B.A., Alt F.W., and Killeen N. 1998. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science 280: 905.
32. Kang J., Baker J., and Raulet D.H. 1995. Evidence that productive rearrangements of TCR γ genes influence the commitment of progenitor cells to differentiate into αβ or γδ T cells. Eur. J. Immunol. 25: 2706.
33. Kang J., Coles M., Cado D., and Raulet D.H. 1998. The developmental fate of T cells is critically influenced by TCRγδ expression. Immunity 8: 427.
34. Kim J., Sif S., Jones B., Jackson A., Koipally J., Heller E., Winandy S., Viel A., Sawyer A., Ikeda T., Kingston R., and Georgopoulos K. 1999. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 10: 345.
35. Kishi H., Borgulya P., Scott B., Karjalainen K., Traunecker A., Kaufman J., and von Boehmer H. 1991. Surface expression of the β T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells. EMBO J. 10: 93.
36. Koipally J., Renold A., Kim J., and Georgopoulos K. 1999. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J. 18: 3090.
37. Krotkova A., von Boehmer H., and Fehling H.J. 1997. Allelic exclusion in pTα-deficient mice: No evidence for cell surface expression of two T cell receptor (TCR)-β chains, but less efficient inhibition of endogeneous Vβ→(D)Jβ rearrangements in the presence of a functional TCR-β transgene. J. Exp. Med. 186: 767.
38. Levelt C.N., Mombaerts P., Iglesias A., Tonegawa S., and Eichmann K. 1993. Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by trans-membrane signaling through CD3ε. Proc. Natl. Acad. Sci. 90: 11401.
39. Livak F., Petrie H.T., Crispe I.N., and Schatz D.G. 1995. Inframe TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision. Immunity 2: 617.
40. Malissen M., Gillet A., Ardouin L., Bouvier G., Trucy J., Ferrier P., Vivier E., and Malissen B. 1995. Altered T cell development in mice with a targeted mutation of the CD3ε gene. EMBO J. 14: 4641.
41. Mertsching E. and Ceredig R. 1996. T cell receptor-γδ-expressing fetal mouse thymocytes are generated without T cell receptor Vβ selection. Eur. J. Immunol. 26: 804.
42. O'Shea C.C., Thornell A.P., Rosewell I.R., Hayes B., and Owen M.J.. 1997. Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes. Immunity 7: 591.
43. Passoni L., Hoffman E.S., Kim S., Crompton T., Pao W., Dong M.Q., Owen M.J., and Hayday A.C. 1997. Intrathymic δ selection events in γδ cell development. Immunity 7: 83.
44. Pivniouk V., Tsitsikov E., Swinton P., Rathbun G., Alt F.W., and Geha R.S. 1998. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 94: 229.
45. Reizis B. and Leder P. 1999. Expression of the mouse pre-T cell receptor α gene is controlled by an upstream region containing a transcriptional enhancer. J. Exp. Med. 189: 1669.
46. Saint-Ruf C., Lechner O., Feinberg J., and von Boehmer H. 1998. Genomic structure of the human pre-T cell receptor a chain and expression of two mRNA isoforms. Eur. J. Immunol. 28: 3824.
47. Saint-Ruf C., Ungewiss K., Groettrup M., Bruno L., Fehling H.J., and von Boehmer H. 1994. Analysis and expression of a cloned pre-T cell receptor gene. Science 266: 1208.
48. ten Boekel E., Melchers F., and Rolink A.G. 1998. Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression. Immunity 8: 199.
49. van Oers N.S., von Boehmer H., and Weiss A. 1995. The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-ζ subunit. J. Exp. Med. 182: 1585.
50. van Oers N.S., Lowin-Kropf B., Finlay D., Connolly K., and Weiss A. 1996. αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity 5: 429.
51. von Boehmer, H. 1990. Developmental biology of T cells in T cell-receptor transgenic mice. Annu. Rev. Immnnol. 8: 531.
52. Wiest D.L., Burgess W.H., McKean D., Kearse K.P., and Singer A. 1995. The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes. EMBO J. 14: 3425.
53. Wurch A., Biro J., Potocnik A.J., Falk I., Mossmann H., and Eichmann K. 1998. Requirement of CD3 complex-associated signaling functions for expression of rearranged T cell receptor β VDJ genes in early thymic development. J. Exp. Med. 188: 1669.
54. Xu Y., Davidson L., Alt F.W., and Baltimore D. 1996. Function of the pre-T-cell receptor α chain in T-cell development and allelic exclusion at the T-cell receptor β locus. Proc. Natl. Acad. Sci. 93: 2169.
55. Zhang W., Sommers C.L., Burshtyn D.N., Stebbins C.C., DeJarnette J.B., Trible R.P., Grinberg A., Tsay H.C., Jacobs H.M., Kessler C.M., Long E.O., Love P.E., and Samelson L.E. 1999. Essential role of LAT in T cell development. Immunity 10: 323.