Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells

Journal of Experimental Medicine

Volumn 194, Issue 1, 2001, Pages 99-106

  Allman, David ^a   Karnell, Fredrick G ^a   Punt, Jennifer A ^b   Bakkour, Sonia ^a   Xu, Lanwei ^a   Myung, Peggy ^a   Koretzky, Gary A ^a   Pui, John C ^a   Aster, Jon C ^c   Pear, Warren S ^a,d  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b HAVERFORD COLLEGE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d 611 BRB II/III ^*  (United States)

Author keywords

Development; Hematopoiesis; Leukemia; Lymphocyte; Stem cells

Indexed keywords

NOTCH RECEPTOR;

ADOLESCENT; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL LINEAGE; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T CELL LEUKEMIA; T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD44; BONE MARROW; CELL LINEAGE; DNA-BINDING PROTEINS; HEMATOPOIETIC STEM CELLS; LEUKEMIA, T-CELL; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; RECEPTOR, NOTCH1; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, CELL SURFACE; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND; TRANSCRIPTION FACTORS;

EID: 0035796488     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.1.99     Document Type: Article

References (36)

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5. Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5
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14. Impaired viability and profound block in thymocyte development in mice lacking the adapter protein SLP-76
15. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
16. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by Notch1
17. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
18. Signals transduced by CD3epsilon, but not by surface pre-TCR complexes, are able to induce maturation of an early thymic lymphoma in vitro
19. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice
20. -/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha
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23. + thymocytes by modulating TCR signal strength
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35. Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma
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