Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development

Nature Immunology

Volumn 2, Issue 9, 2001, Pages 863-869

  Gounari, Fotini ^a   Aifantis, Iannis ^a   Khazaie, Khashayarsha ^a   Hoeflinger, Sonja ^a   Harada, Naomoto ^b   Taketo, Makoto M ^c   Von Boehmer, Harald ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

^c KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR; WNT PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SPECIFICITY; CELL SURVIVAL; CONTROLLED STUDY; GENE DELETION; MEMBRANE STABILIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SOMATIC MUTATION; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; APOPTOSIS; BETA CATENIN; CELL CYCLE; CYTOSKELETAL PROTEINS; EXONS; FLOW CYTOMETRY; LYMPHOCYTE ACTIVATION; MICE; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SEQUENCE DELETION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND; TRANS-ACTIVATORS;

EID: 0035554684     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni0901-863     Document Type: Article

References (34)

1. Early T lymphocyte progenitors
2. T cell lineage commitment and cytokine responses of thymic progenitors
3. The common cytokine receptor γ chain and the pre- T cell receptor provide independent but critically overlapping signals in early α/β T cell development
4. A novel disulfide-linked heterodimer on pre- T cells consists of the T cell receptor β chain and a 33 kd glycoprotein
5. Pleiotropic changes controlled by the pre- T cell receptor
6. Lymphocyte survival and lineage commitment through positive selection
7. Critical involvement of Tcf-I in expansion of thymocytes
8. Redundant regulation of T cell differentiation and TCRα gene expression by the transcription factors LEF-1 and TCF-1
9. LEF1 turns over a new leaf
10. Wnt signaling is required for thymocyte development and activates Tcf- 1 mediated transcription
11. Mechanisms of Wnt signaling in development
12. Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses
13. Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein
14. Intestinal polyposis in mice with a dominant stable mutation of the β-catenin gene
15. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
16. Role of different T cell receptors in the development of pre-T cells
17. 2+ mobilization and activation of NF-κB and NF-AT
18. Productive T cell receptor β-chain gene rearrangement: Coincident regulation of cell cycle and clonality during development in vivo
19. Developmental regulation of bcl-2 expression in the thymus
20. FADD/MORT1 regulates the pre- TCR check point and can function as a tumour suppressor
21. NF-κB activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development
22. −/− mice
23. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells
24. + stage during positive selection and promotes thymocyte differentiation at several control points
25. Mutations in T cell antigen receptor genes α and β block thymocyte development at different stages
26. Crucial role of the pre- T cell receptor α gene in development of α β but not γ δ T cells
27. RAG-1-deficient mice have no mature B and T lymphocytes
28. Pre- T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros
29. T cell-specific FADD-deficient mice: FADD is required for early T cell development
30. A role for FADD in T cell activation and development
31. Mutations in the p53 and SCID genes cooperate in tumorigenesis
32. + stage of thymocyte differentiation in the absence α β T cell receptor rearrangement
33. Role of Bcl-2 in α β T cell development in mice deficient in the common cytokine receptor γ-chain: The requirement for Bcl-2 differs depending on the TCR/MHC affinity
34. On the role of the pre- T cell receptor in αβ versus γδ T lineage commitment