Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes

Nature Immunology

Volumn 3, Issue 5, 2002, Pages 469-476

  Guo, Jian ^a   Hawwari, Abbas ^a   Li, Hong ^a   Sun, Zuoming ^b,c   Mahanta, Sanjeev K ^b   Littman, Dan R ^b   Krangel, Michael S ^a   He, You Wen ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCL2L1 PROTEIN, MOUSE; CELL RECEPTOR; DNA; LYMPHOCYTE ANTIGEN RECEPTOR; ORPHAN NUCLEAR RECEPTOR ROR GAMMA; ORPHAN NUCLEAR RECEPTOR ROR-GAMMA; PROTEIN BCL 2; PROTEIN BCL X; RETINOIC ACID RECEPTOR; THYROID HORMONE RECEPTOR; CD4 ANTIGEN; CD8 ANTIGEN; CELL NUCLEUS RECEPTOR; PROTEIN BCL XL; T LYMPHOCYTE RECEPTOR ALPHA CHAIN;

ANIMAL; APOPTOSIS; ARTICLE; C57BL MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL SURVIVAL; CHEMISTRY; CHROMATIN; CYTOLOGY; FLOW CYTOMETRY; GENE REARRANGEMENT; GENETICS; GERMFREE ANIMAL; IMMUNOLOGY; ISOLATION AND PURIFICATION; MOUSE; POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL SELECTION; CONTROLLED STUDY; HELPER CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SUPPRESSOR CELL; THYMOCYTE;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL SURVIVAL; CHROMATIN; DNA; FLOW CYTOMETRY; GENE REARRANGEMENT, ALPHA-CHAIN T-CELL ANTIGEN RECEPTOR; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 0035999828     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni791     Document Type: Article

References (46)

1. Selecting and maintaining a diverse T-cell repertoire
2. Restricted onset of T cell receptor α gene rearrangement in fetal and neonatal thymocytes
3. T cell receptor gene recombination patterns and mechanisms: Cell death, rescue, and T cell production
4. α locus
5. Regulation of TCRα and β gene allelic exclusion during T-cell development
6. Multiple rearrangements in T cell receptor α chain genes maximize the production of useful thymocytes
7. α segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCRα chain gene and positive selection in the T cell repertoire formation
8. α rearrangement
9. T early α (TEA) regulates initial TCRVAJA rearrangements and leads to TCRJA coincidence
10. Ordered and coordinated rearrangement of the TCRα locus: Role of secondary rearrangement in thymic selection
11. Evidence for recombinatorial hot spots at the T cell receptor J α locus
12. Thymocyte expression of RAG-1 and RAG-2: Termination by T cell receptor cross-linking
13. Exclusion and inclusion of α and β T cell receptor alleles
14. Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression
15. The role of recombination activating gene (RAG) reinduction in thymocyte development in vivo
16. α following targeted deletion of T early α (TEA): Implications for TCRα locus accessibility
17. Function of the TCR α enhancer in αβ and γδ T cells
18. A role for histone acetylation in the developmental regulation of VDJ recombination
19. The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development
20. Role of the nuclear hormone receptor RORγ in transcriptional regulation, thymocyte survival, and lymphoid organogenesis
21. Requirement for RORγ in thymocyte survival and lymphoid organ development
22. Retinoid-related orphan receptor γ (RORγ) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis
23. Downregulation of the orphan nuclear receptor RORγt is essential for T lymphocyte maturation
24. RORγT, a thymus-specific isoform of the orphan nuclear receptor RORγ/TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter
25. RORγt, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells
26. α region: Assessment of regulatory function in vivo
27. Factors and forces controlling V(D)J recombination
28. Histone acetylation determines the developmentally regulated accessibility for T cell receptor γ gene recombination
29. Chromatin remodeling by the T cell receptor (TCR)-β gene enhancer during early T cell development: Implications for the control of TCR-β locus recombination
30. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes
31. Organization, structure, and function of 95 kb of DNA spanning the murine T-cell receptor Cα/Cδ region
32. Organization of the V gene segments in mouse T-cell antigen receptor α/δ locus
33. An HMG-box-containing T-cell factor required for thymocyte differentiation
34. A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during αβ thymopoiesis
35. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
36. Bclx regulates the survival of double-positive thymocytes
37. T-cell selection
38. L displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice
39. BCL-XL-regulated apoptosis in T cell development
40. + stage during positive selection and promotes thymocyte differentiation at several control points
41. α locus in its accessible configuration
42. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro
43. Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA
44. The human T-cell receptor TCRAC/TCRDC (Cα/Cδ) region: Organization, sequence, and evolution of 97.6 kb of DNA
45. CREB regulates MHC class II expression in a CIITA-dependent manner