Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene

Nature Immunology

Volumn 3, Issue 5, 2002, Pages 489-496

  Gounari, Fotini ^a   Aifantis, Iannis ^a   Martin, Colin ^a   Fehling, Hans Joerg ^b   Hoeflinger, Sonja ^a   Leder, Philip ^c   von Boehmer, Harald ^a   Reizis, Boris ^c  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR; LYMPHOCYTE SURFACE MARKER; MESSENGER RNA; NOTCH RECEPTOR; STEM CELL FACTOR RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; THY 1 ANTIGEN;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL LINEAGE; CLONOGENIC ASSAY; CONTROLLED STUDY; GENE EXPRESSION; LYMPHOCYTE; LYMPHOID CELL; LYMPHOPOIESIS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; STEM CELL; THYMUS; TRANSGENIC MOUSE;

ANIMALS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HEMATOPOIESIS; HUMANS; LYMPHOCYTES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; RECEPTOR, NOTCH1; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, CELL SURFACE; RECEPTORS, INTERLEUKIN-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEM CELLS; TRANSCRIPTION FACTORS;

EID: 0036097258     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni778     Document Type: Article

References (42)

1. Purification and characterization of mouse hematopoietic stem cells
2. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
3. Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations
4. + stem cell compartment is accompanied by loss of self-renewal capacity
5. Identification of clonogenic common lymphoid progenitors in mouse bone marrow
6. Role of PU.I in hematopoiesis
7. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
8. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A
9. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus
10. Deficient T cell fate specification in mice with an induced inactivation of Notch1
11. Separation of Notch 1 promoted lineage commitment and expansion/transformation in developing T cells
12. Notch 1 expression in early lymphopoiesis influences B versus T lineage determination
13. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation
14. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein
15. Analysis and expression of a cloned pre-T cell receptor gene
16. Notch 1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
17. Direct induction of T lymphocyte specific gene expression by the mammalian Notch signaling pathway
18. Intra- and extra-thymic expression of the pre-T cell receptor α gene
19. A transgenic marker for mouse B lymphoid precursors
20. RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues
21. Continued RAG expression in late stages of B cell development and no apparent reinduction after immunization
22. The upstream enhancer is necessary and sufficient for the expression of the Pre-T cell receptor α gene in immature T lymphocytes
23. Expression of the mouse pre-T cell receptor α gene is controlled by an upstream region containing a transcriptional enhancer
24. Expression of functional interleukin-2 receptors in human light chain/Tac transgenic mice
25. Early T lymphocyte progenitors
26. Developmental potential of the earliest precursor cells from the adult mouse thymus
27. Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation
28. On the role of the pre-T cell receptor in αβ versus γδ T lineage commitment
29. Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5′ of RAG2
30. B cell development pathways
31. + cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors
32. Expression of pTα mRNA in a committed dendritic cell precursor in the human thymus
33. Commitment of common T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay
34. Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver
35. Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events
36. Mouse pre-immunocytes as non-proliferating multipotent precursors of macrophages, interferon-producing cells, CD8a+ and CD8a- dendritic cells
37. Mouse type 1 IFN-producing cells are immature APCs with plasmacytoid morphology
38. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus
39. Identification of a committed T cell precursor population in adult human peripheral blood
40. Haematopoietic cell fate decisions, chromatin regulation and Ikaros
41. Extrathymic maturation of αβ T cells from hemopoietic stem cells
42. Characterization of T cell precursor activity in the murine fetal thymus: Evidence for an input of T cell precursors between days 12 and 14 of gestation