A TCR α chain transgene induces maturation of CD4-CD8-αβ+ T cells from γδ T cell precursors

European Journal of Immunology

Volumn 28, Issue 3, 1998, Pages 828-837

  Fritsch, Maria ^a   Andersson, Åsa ^a   Petersson, Karin ^a   Ivars, Fredrik ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b INSTITUT PASTEUR   (France)

Author keywords

Maturation; Precursor; TCR; Transgenic mouse

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN;

ANIMAL CELL; ARTICLE; GENE REARRANGEMENT; IMMUNOPHENOTYPING; LYMPHOID ORGAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE; TRANSGENIC MOUSE;

ANIMALS; CELL DIFFERENTIATION; FLOW CYTOMETRY; GENE REARRANGEMENT, ALPHA-CHAIN T-CELL ANTIGEN RECEPTOR; GENE REARRANGEMENT, DELTA-CHAIN T-CELL ANTIGEN RECEPTOR; GENE REARRANGEMENT, GAMMA-CHAIN T-CELL ANTIGEN RECEPTOR; GENE REARRANGEMENT, T-LYMPHOCYTE; GENES, T-CELL RECEPTOR ALPHA; HYBRIDOMAS; IMMUNOPHENOTYPING; MICE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; TRANSGENES;

EID: 0031929363     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199803)28:03<828::AID-IMMU828>3.0.CO;2-X     Document Type: Article

References (44)

1. Fowlkes, B. J., Edison, L., Mathieson, B. J. and Chused, T. M., Early T-lymphocytes. Differentiation in vivo of adult intrathymic precursor cells. J. Exp. Med. 1985. 162: 802-822.
2. + T cells. Curr. Opin. Immunol. 1995. 7: 367-374.
3. Haas, W., Pereira, P. and Tonegawa, S., Gamma/delta T cells. Annu. Rev. Immunol. 1993. 11: 637-685.
4. + cells: new clues to their origin, specificity and function. J. Exp. Med. 1995. 182: 633-638.
5. + lymphocyte populations with different T cell receptors: A role for the gut epithelium in differentiation. J. Exp. Med. 1991. 173: 471-481.
6. Rocha, B., Vasalli, P. and Guy-Grand, D., Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice. J. Exp. Med. 1994. 180: 681-686.
7. Petrie, H. T., Scollay, R. and Shortman, K., Commitment to the T cell receptor-αβ or -γδ lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes. Eur. J. Immunol. 1992. 22: 2185-2188.
8. Dudley, E. C., Petrie, H. T., Shah, L. M., Owen, M. J. and Hayday, A. C., T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 1994. 1: 83-93.
9. Dudley, E. M., Girardi, M., Owen, M. J. and Hayday, A. C., αβ and γδ T cells can share a late common precursor. Curr. Biol. 1995. 5: 659-669.
10. Mombaerts, P., Clarke, A. R., Rudnicki, M. A., Iacomini, J., Itohara, S., Lafaille, J. J., Wang, L., Ichikawa, Y., Jaenisch, R., Hooper, M. L. and Tonegawa, S., Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 1992. 360: 225-231.
11. Livak, F., Petrie, H. T., Crispe, I. N. and Schatz, D. G., In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision. Immunity 1995. 2: 617-627.
12. Kang, J., Baker, J. and Raulet, D. H., Evidence that productive rearrangements of TCR γ genes influence the commitment of progenitor cells to differentiate into αβ or γδ T cells. Eur. J. Immunol. 1995. 25: 2706-2709.
13. Burtrum, D. B., Kim, S., Dudley, E. C., Hayday, A. C. and Petrie, H. T., TCR gene recombination and αβ-γδ lineage divergence. Productive TCR-β rearrangements is neither exclusive nor preclusive of γδ cell development. J. Immunol. 1996. 157: 4293-4296.
14. Bruno, L., Fehling, H. J. and von Boehmer, H., The αβ T cell receptor can replace the γδ receptor in the development of γδ lineage cells. Immunity 1996. 5: 343-352.
15. + thymocytes. Nature 1988. 333: 742-746.
16. Sha, W. C., Nelson, C. A., Newberry, R. D., Kranz, D. M., Russell, J. H. and Loh, D. Y., Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 1988. 336: 73-76.
17. Berg, L. J., Fazekas de St. Groth, B., Ivars, F., Goodnow, C. C., Gilfillan, S., Garchon, H.-J. and Davis, M. M., Expression of T-cell receptor alpha-chain genes in transgenic mice. Mol. Cell Biol. 1988. 8: 5459-5469.
18. Teh, H. S., Kishi, H., Scott, B. and von Boehmer, H., Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules. J. Exp. Med. 1989. 169: 795-806.
19. Russell, J. H., Meleedy-Rey, P., McCulley, D. E., Sha, W. S., Nelson, C. A. and Loh, D. Y., Evidence for CD8-independent T cell maturation in transgenic mice. J. Immunol. 1990. 144: 3318-3325.
20. Malissen, M., Trucy, J., Jouvin-Marche, E., Cazenave, P.-A., Scollay, R. and Malissen, B., Regulation of TCR α and β gene allelic exclusion during T-cell development. Immunol. Today 1992. 13: 315-322.
21. Kelly, K. A., Pircher, H., von Boehmer, H., Davis, M. M. and Scollay, R., Regulation of T cell production in T cell receptor transgenic mice. Eur. J. Immunol. 1993. 23: 1922-1928.
22. +) thymocytes in normal and genetically modified mice. J. Immunol. 1995. 154: 5103-5113.
23. Ivars, F., T-cell subset specific expression of antigen receptor β chains in α-chain transgenic mice. Eur. J. Immunol. 1992. 22: 635-639.
24. Fenton, R. G., Marrack, P., Kappler, J. W., Kanagawa, O. and Seidman, J. G., Isotypic exclusion of γδ T cell receptors in transgenic mice bearing a rearranged β-chain gene. Science 1988. 241: 1089-1092.
25. von Boehmer, H., Bonneville, M., Ishida, I., Ryser, S., Lincoln, G., Smith, R. T., Kishi, H., Scott, B., Kisielow, P. and Tonegawa, S., Early expression of a T-cell receptor β-chain transgene suppresses rearrangement of the Vγ4 gene segment. Proc. Natl. Acad. Sci. USA 1988. 85: 9729-9732.
26. Azuara, V., Lavraud, J. P., Lembezat, M. P. and Pereira, P., A novel subset of adult gamma delta thymocytes that secretes a distinct pattern of cytokines and expresses a very restricted T cell receptor repertoire. Eur. J. Immunol. 1997. 27: 544-553.
27. a-encoded antigens. Nature 1988. 332: 40-45.
28. von Boehmer, H., Kirberg, J. and Rocha, B., An unusual lineage of α/β T cells that contains autoreactive cells. J. Exp. Med. 1991. 174: 1001-1008.
29. Chien, Y., Iwashima, M., Wettstein, D. A., Kaplan, K. B., Elliott, J. F., Born, W. and Davis, M. M., T-cell receptor γ gene rearrangements in early thymocytes. Nature 1987. 330: 722-727.
30. Koop, B. F., Wilson, R. K., Wang, K., Vermoij, B., Zaller, D., Kuo, C. L., Seto, D., Toda, M. and Hood, L., Organization, structure and function of 95 kb of DNA spanning the murine T-cell receptor Cα/Cδ region. Genomics 1992. 13: 1209-1230.
31. + T cells. Eur. J. Immunol. 1997. 27: 1576-1579.
32. von Boehmer, H., Developmental biology of T cells in T cell receptor transgenic mice. Annu. Rev. Immunol. 1990. 8: 531-556.
33. DiSanto, J. P., Guy-Grand, D., Fisher, A. and Tarakhovsky, A., Critical role for the common cytokine receptor γ chain in intrathymic and peripheral T cell selection. J. Exp. Med. 1996. 183: 1111-1118.
34. Passoni, L., Hoffman, E. S., Kim, S., Crompton, T., Pao, W., Dong, M.-Q., Owen, M. J. and Hayday, A. C., Intrathymic δ selection events in γδ cell development. Immunity 1997. 7: 83-95.
35. Cochet, M., Pannetier, C., Regnault, A., Darche, S., Leclerc, C. and Kourilsky, P., Molecular detection and in vivo analysis of the specific T cell response to a protein antigen. Eur. J. Immunol. 1992. 22: 2639-2647.
36. Groettrup, M., Ungewiss, K., Azogui, O., Palacios, R., Owen, M. J., Hayday, A. C. and von Boehmer, H., A novel disulfide linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein. Cell 1993. 75: 283-294.
37. Hoffman, E. S., Passoni, L., Crompton, T., Leu, T. M. J., Schatz, D. G., Koff, A., Owen, M. J. and Hayday, A. C., Productive T-cell receptor β-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev. 1996. 10: 948-962.
38. Fehling, H. J., Krotkova, A., Saint-Ruf, C. an von Boehmer, H., Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature 1995. 375: 795-798.
39. Buer, J., Aifantis, I., DiSanto, J., Fehling, H. J. and von Boehmer, H., Role of different T cell receptors in the development of pre-T cells. J. Exp. Med. 1997. 185: 1541-1547.
40. + T cells in major histocompatibility complex class II-deficient mice. J. Exp. Med. 1995. 182: 993-1004.
41. Lauzurica, P. and Krangel, M. S., Temporal and lineage-specific control of T cell receptor α/δ gene rearrangements by T cell receptor α and δ enhancers. J. Exp. Med. 1994. 179: 1913-1921.
42. Openshaw, P., Murphy, E. E., Hosken, N. A., Maino, V., Davis, K. and O'Garra, A., Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 1995. 182: 1357-1367.
43. White, J., Blackman, M., Bill, J., Kappler, J., Marrack, P. and Bnorn, W., Two better cell lines for making hybridomas expressing specific T cell receptors. J. Immunol. 1989. 143: 1822-1825.
44. Lafaille, J. J., DeCloux, A., Bonneville, M., Takagaki, Y. and Tonegawa, S., Junctional sequences of T cell receptor γδ genes: implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining. Cell 1989. 59: 859-870.