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Volumn 15, Issue 2, 2003, Pages 166-175

Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 1;

EID: 0037375763     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(03)00011-6     Document Type: Review
Times cited : (58)

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    • Using a conditional knockout, the authors showed that CSL is essential for early T-cell differentiation in the thymus. The knockout also had the effect of inducing B lymphopoiesis in the thymus, again recapitulating the effects of a Notch knockout and supporting the central role of the CSL-Notch-ICN complex in regulating the B versus T lineage choice
    • Han H., Tanigaki K., Yamamoto N., Kuroda K., Yoshimoto M., Nakahata T., Ikuta K., Honjo T. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int. Immunol. 14:2002;637-645 Using a conditional knockout, the authors showed that CSL is essential for early T-cell differentiation in the thymus. The knockout also had the effect of inducing B lymphopoiesis in the thymus, again recapitulating the effects of a Notch knockout and supporting the central role of the CSL-Notch-ICN complex in regulating the B versus T lineage choice.
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    • Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway
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    • Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations
    • HES genes encode bHLH transcription factors that can act as repressors. HES-1 and HES-5 are directly upregulated by Notch via the CSL (here called CBF1) pathway. Transplantation of transgenic mouse bone-marrow tissue expressing either Hes family genes or Notch-ICN showed that, although constitutive Notch signaling leads to a complete block in B-lineage development, overexpression of HES-1 or HES-5 can produce a partial block. In a reporter gene assay, NotchIC, HES-1 and HES-5 (but not HES-2 or HES-3) were found to inhibit the transactivation potential of E2A, an E protein that plays a key role in B-lineage commitment. These experiments suggest that Notch could suppress the B-lineage fate in part through HES-mediated repression of the E2A gene
    • Kawamata S., Du C., Li K., Lavau C. Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations. Oncogene. 21:2002;3855-3863 HES genes encode bHLH transcription factors that can act as repressors. HES-1 and HES-5 are directly upregulated by Notch via the CSL (here called CBF1) pathway. Transplantation of transgenic mouse bone-marrow tissue expressing either Hes family genes or Notch-ICN showed that, although constitutive Notch signaling leads to a complete block in B-lineage development, overexpression of HES-1 or HES-5 can produce a partial block. In a reporter gene assay, NotchIC, HES-1 and HES-5 (but not HES-2 or HES-3) were found to inhibit the transactivation potential of E2A, an E protein that plays a key role in B-lineage commitment. These experiments suggest that Notch could suppress the B-lineage fate in part through HES-mediated repression of the E2A gene.
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    • This paper presents a comparison of hematopoietic cells recovered from the fetal thymus of wild-type and Id2-null mice, which revealed a sharp reduction in the number of cells expressing the NK cell marker CD122 (IL-2R) in the mutants. Overall thymocyte cellularity was about the same for mutant and wild type, which suggests that thymically-localized hematopoietic progenitors simply follow the T-lineage program in the absence of Id2. Buttressing this inference, Id2-null fetal thymic organ culture (FTOC) failed to produce mature NK cells but exhibited normal T-cell development, whereas RT-PCR analysis of wild-type progenitors fractionated on the basis of CD122 expression revealed a strong correlation between Id2 levels and NK-lineage commitment
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    • ••]. Here, Spi-B is also shown to be expressed normally in the plasmacytoid class of DCs, and its overexpression enhances the generation of these cells from hematopoietic precursors in a permissive culture system. These observations strengthen the link between the normal expression of Spi-B and PU.1, which continues through the early stages of T-cell development, and the ability of these early T-cell precursors to differentiate along the DC pathway.
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    • Lineage infidelity in myeloid cells with TCR gene rearrangement: A latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling
    • •], the loss of responsiveness coincides with the timing of endogenous PU.1 downregulation. These results emphasize the regulatory instability of precursors during the first stages of lymphoid differentiation, even while the cells are initiating expression of T-cell genes such as pTα
    • •], the loss of responsiveness coincides with the timing of endogenous PU.1 downregulation. These results emphasize the regulatory instability of precursors during the first stages of lymphoid differentiation, even while the cells are initiating expression of T-cell genes such as pTα.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.