Competitive displacement of pTα by TCR-α during TCR assembly prevents surface coexpression of pre-TCR and αβ TCR

Journal of Immunology

Volumn 165, Issue 10, 2000, Pages 5566-5572

  Trop, S ^a   Rhodes, M ^a   Wiest, D L ^a   Hugo, P ^a   Zuniga Pflucker, J C ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GENE EXPRESSION REGULATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE; THYMOCYTE;

EID: 0034670045     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.10.5566     Document Type: Article

References (25)

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4. Multiple rearrangements in T cell receptor α chain genes maximize the production of useful thymocytes
5. Signals involved in thymocyte positive and negative selection
6. Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection
7. Limiting TCR expression leads to quantitative but not qualitative changes in thymic selection
8. The single positive T cells found in CD3-ζη(-/-) mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex
9. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains
10. Domains of the TCRβ-chain required for early thymocyte development
11. Intra- and extra-thymic expression of the pre-T cell receptor α gene
12. Analysis and expression of a cloned pre-T cell receptor gene
13. Expression of genes encoding the pre-TCR and CD3 complex during thymus development
14. Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3δ is physically associated but not functionally required
15. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
16. Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition
17. TCR-αβ-independent CD28 signaling and costimulation require non-CD4-associated Lck
18. Retroviral vectors for production of interleukin-12 in the bone marrow to induce a graft-versus-leukemia effect
19. A GFP reporter system to assess gene transfer and expression in viable human hematopoietic progenitors
20. The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos
21. The connecting peptide domain of pTα dictates weak association of the pre-T cell receptor with the TCR ζ subunit
22. Safe and efficient ecotropic and amphotropic packaging lines for use in gene transfer experiments
23. The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-ζ subunit
24. Subunit interactions within the T-cell antigen receptor: Clues from the study of partial complexes
25. Identification of a novel pre-TCR isoform in which the accessibility of the TCRβ subunit is determined by occupancy of the 'missing' V domain of pTα