The CD4/CD8 lineage decision: Integration of signalling pathways

Immunology Today

Volumn 21, Issue 10, 2000, Pages 509-514

  Basson, M Albert ^a   Zamoyska, Rose ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; NOTCH RECEPTOR;

ANIMAL CELL; CELL FATE; CELL LINEAGE; CELL SURVIVAL; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE; THYMUS; TRANSCRIPTION REGULATION;

EID: 0033791575     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(00)01711-4     Document Type: Review

References (44)

1. Development and selection of T cells: Facts and puzzles
2. Positive selection of thymocytes
3. CD4/CD8 lineage commitment: Basic instruction
4. Molecular requirements for lineage commitment in the thymus-antibody-mediated receptor engagements reveal a central role for Lck in lineage decisions
5. Analysis of antigen receptor signalling using mouse gene targeting
6. Regulation of lineage commitment distinct from positive selection
7. Self-antigen presentation by thymic stromal cells: A subtle division of labor
8. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
9. + T cells in vivo
10. Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus
11. CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity
12. The CD8 coreceptor revisited: One chain good, two chains better
13. The role of CD8α in the CD4 versus CD8 lineage choice
14. Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and Lck signaling
15. Lck activity controls CD4/CD8 T cell lineage commitment
16. Inducible expression of a p56(Lck) transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes
17. Selection of the T cell repertoire
18. Early growth response (Egr)-1 gene induction in the thymus in response to T cell receptor ligation during early steps in positive selection is not required for CD8 lineage commitment
19. The influence of the MAPK pathway on T cell lineage commitment
20. Slow accumulation of active mitogen-activated protein kinase during thymocyte differentiation regulates the temporal pattern of transcription factor gene expression
21. Activation of the extracellular signal-related kinase/mitogen-ctivated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus
22. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
23. Selective requirement for MAP kinase activation in thymocyte differentiation
24. + T-cell lineage fate
25. Specificity of receptor tyrosine kinase signalling: Transient versus sustained extracellular signal-related kinase activation
26. Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor
27. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
28. Cross-antagonism of a T cell clone expressing two distinct T cell receptors
29. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
30. Correlating notch signaling with thymocyte maturation
31. Notch signaling in T cell development
32. Notch signaling: Cell fate control and signal integration in development
33. Emergent properties of networks of biological signaling pathways
34. Notch inhibition of E47 supports the existence of a novel signaling pathway
35. + stage during positive selection and promotes thymocyte differentiation at several control points
36. Bcl-XL and Bcl-2 repress a common pathway of cell death
37. Cutting edge: Protective effects of notch-1 on TCR-induced apoptosis
38. The regulation of CD4 and CD8 coreceptor gene expression during T cell development
39. Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells
40. Hierarchical interactions of control elements determine CD8α gene expression in subsets of thymocytes and peripheral T cells
41. Positive selection induces CD4 promoter and enhancer function
42. The notch pathway intermediate HES-1 silences CD4 gene expression
43. A role for pref-1 and HES-1 in thymocyte development
44. Subclass-specific nuclear localization of a novel CD4 silencer binding factor