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Volumn 15, Issue 6, 2004, Pages 337-347

The role of TGF-β in epithelial malignancy and its relevance to the pathogenesis of oral cancer (part II)

Author keywords

Cancer; Epithelial; Oral; TGF

Indexed keywords

BETA CAROTENE; FENRETINIDE; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; DNA BINDING PROTEIN; TRANSACTIVATOR PROTEIN;

EID: 28744453728     PISSN: 10454411     EISSN: None     Source Type: Journal    
DOI: 10.1177/154411130401500603     Document Type: Review
Times cited : (54)

References (164)
  • 1
    • 0029853786 scopus 로고    scopus 로고
    • The somatic mutation frequency of the transforming growth factor-β receptor type II gene varies widely among different cancers with microsatellite instability
    • Abe T, Ouyang H, Migita T, Kato Y, Kimura M, Shiba K, et al. (1996). The somatic mutation frequency of the transforming growth factor-β receptor type II gene varies widely among different cancers with microsatellite instability. Eur J Surg Oncol 22:474-477.
    • (1996) Eur J Surg Oncol , vol.22 , pp. 474-477
    • Abe, T.1    Ouyang, H.2    Migita, T.3    Kato, Y.4    Kimura, M.5    Shiba, K.6
  • 2
    • 0034676340 scopus 로고    scopus 로고
    • Inhibition of farnesyltransferase increases TGF-β type II receptor expression and enhances the responsiveness of human cancer cells to TGF-β
    • Adnane J, Bizouarn FA, Chen Z, Ohkanda J, Hamilton AD, Munoz-Antonia T, et al. (2000). Inhibition of farnesyltransferase increases TGF-β type II receptor expression and enhances the responsiveness of human cancer cells to TGF-β. Oncogene 19:5525-5533.
    • (2000) Oncogene , vol.19 , pp. 5525-5533
    • Adnane, J.1    Bizouarn, F.A.2    Chen, Z.3    Ohkanda, J.4    Hamilton, A.D.5    Munoz-Antonia, T.6
  • 3
    • 0037038684 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitor (L-744,832) restores TGF-β type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2
    • Alcock RA, Dey S, Chendil D, Inayat MS, Mohiuddin M, Hartman G, et al. (2002). Farnesyltransferase inhibitor (L-744,832) restores TGF-β type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2. Oncogene 21:7883-7890.
    • (2002) Oncogene , vol.21 , pp. 7883-7890
    • Alcock, R.A.1    Dey, S.2    Chendil, D.3    Inayat, M.S.4    Mohiuddin, M.5    Hartman, G.6
  • 4
    • 0010607277 scopus 로고
    • The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers
    • The Alpha-Tocepherol Beta Carotene Cancer Prevention Study
    • The Alpha-Tocepherol Beta Carotene Cancer Prevention Study (1994). The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330:1029-1035.
    • (1994) N Engl J Med , vol.330 , pp. 1029-1035
  • 5
    • 0032500010 scopus 로고    scopus 로고
    • Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development
    • Amendt C, Schirmacher P, Weber H, Blessing M (1998). Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development. Oncogene 17:25-34.
    • (1998) Oncogene , vol.17 , pp. 25-34
    • Amendt, C.1    Schirmacher, P.2    Weber, H.3    Blessing, M.4
  • 6
    • 0036674213 scopus 로고    scopus 로고
    • P38 mitogen activated protein kinase is required for TGF-β-mediated fibroblastic transdifferentiation and cell migration
    • Bakin AV, Rinehart C, Tomlinson AK, Arteage CL (2002). P38 mitogen activated protein kinase is required for TGF-β-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 115:3193-3206.
    • (2002) J Cell Sci , vol.115 , pp. 3193-3206
    • Bakin, A.V.1    Rinehart, C.2    Tomlinson, A.K.3    Arteage, C.L.4
  • 8
    • 0037326569 scopus 로고    scopus 로고
    • The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: A comparison with Snail and E47 repressors
    • Bolos V, Peinado H, Perez-Moreno MA, Fraga MF, Esteller M, Cano A (2002). The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 116:499-511.
    • (2002) J Cell Sci , vol.116 , pp. 499-511
    • Bolos, V.1    Peinado, H.2    Perez-Moreno, M.A.3    Fraga, M.F.4    Esteller, M.5    Cano, A.6
  • 9
    • 0025277164 scopus 로고
    • Suppression of glomerulonephritis by antiserum against transforming growth factor-β1
    • Border WA, Okuda S, Languino LR, Sporn MB, Ruoslahti E (1990). Suppression of glomerulonephritis by antiserum against transforming growth factor-β1. Nature 346:371-374.
    • (1990) Nature , vol.346 , pp. 371-374
    • Border, W.A.1    Okuda, S.2    Languino, L.R.3    Sporn, M.B.4    Ruoslahti, E.5
  • 10
    • 0034630912 scopus 로고    scopus 로고
    • Retinoic acid resistance at late stages of papillomavirus type 16-mediated transformation of human keratinocytes arises despite intact retinoid signaling and is due to loss of sensitivity to transforming growth factor-β
    • Borger DR, Mi Y, Geslani G, Zyzack LL, Batova A, Engin TSW, et al. (2000). Retinoic acid resistance at late stages of papillomavirus type 16-mediated transformation of human keratinocytes arises despite intact retinoid signaling and is due to loss of sensitivity to transforming growth factor-β. Virology 270:397-407.
    • (2000) Virology , vol.270 , pp. 397-407
    • Borger, D.R.1    Mi, Y.2    Geslani, G.3    Zyzack, L.L.4    Batova, A.5    Engin, T.S.W.6
  • 11
    • 0031441041 scopus 로고    scopus 로고
    • Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor β receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]- anthracene
    • Bottinger EP, Jakubczak JL, Haines DC, Bagnall K, Wakefield LM (1997). Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor β receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene. Cancer Res 57:5564-5570.
    • (1997) Cancer Res , vol.57 , pp. 5564-5570
    • Bottinger, E.P.1    Jakubczak, J.L.2    Haines, D.C.3    Bagnall, K.4    Wakefield, L.M.5
  • 14
    • 0029101527 scopus 로고
    • Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-β1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype
    • Caulin C, Scholl FG, Frontelo P, Gamallo C, Quintanilla M (1995). Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-β1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype. Cell Growth Differ 6:1027-1035.
    • (1995) Cell Growth Differ , vol.6 , pp. 1027-1035
    • Caulin, C.1    Scholl, F.G.2    Frontelo, P.3    Gamallo, C.4    Quintanilla, M.5
  • 15
    • 0027250810 scopus 로고
    • Inactivation of type II receptor reveals two receptor pathways for the diverse TGF-β activities
    • Chen R-H, Ebner R, Derynck R (1993). Inactivation of type II receptor reveals two receptor pathways for the diverse TGF-β activities. Science 260:1335-1338.
    • (1993) Science , vol.260 , pp. 1335-1338
    • Chen, R.-H.1    Ebner, R.2    Derynck, R.3
  • 16
    • 0035452460 scopus 로고    scopus 로고
    • Novel inactivating mutations of transforming growth factor-β type I receptor gene in head-and-neck cancer metastases
    • Chen T, Yan W, Wells RG, Rimm DL, McNiff J, Leffell D, et al. (2001). Novel inactivating mutations of transforming growth factor-β type I receptor gene in head-and-neck cancer metastases. Int J Cancer 93:653-661.
    • (2001) Int J Cancer , vol.93 , pp. 653-661
    • Chen, T.1    Yan, W.2    Wells, R.G.3    Rimm, D.L.4    McNiff, J.5    Leffell, D.6
  • 17
  • 18
    • 0034964418 scopus 로고    scopus 로고
    • The two-handed e box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    • Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, et al. (2001). The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell 7:1267-1278.
    • (2001) Mol Cell , vol.7 , pp. 1267-1278
    • Comijn, J.1    Berx, G.2    Vermassen, P.3    Verschueren, K.4    Van Grunsven, L.5    Bruyneel, E.6
  • 19
    • 0038274163 scopus 로고    scopus 로고
    • Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads
    • Cordenonsi M, Dupont S, Maretto S, Insinga A, Imbriano C, Piccolo S (2003). Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads. Cell 113:301-314.
    • (2003) Cell , vol.113 , pp. 301-314
    • Cordenonsi, M.1    Dupont, S.2    Maretto, S.3    Insinga, A.4    Imbriano, C.5    Piccolo, S.6
  • 20
    • 0028051817 scopus 로고
    • Lack of TGF-β1 expression in benign skin tumors of p53 null mice is prognostic for a high risk of malignant conversion
    • Cui W, Kemp CJ, Duffie E, Balmain A, Akhurst RJ (1994). Lack of TGF-β1 expression in benign skin tumors of p53 null mice is prognostic for a high risk of malignant conversion. Cancer Res 54:5831-5836.
    • (1994) Cancer Res , vol.54 , pp. 5831-5836
    • Cui, W.1    Kemp, C.J.2    Duffie, E.3    Balmain, A.4    Akhurst, R.J.5
  • 21
    • 0030598681 scopus 로고    scopus 로고
    • TGF-β1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
    • Cui W, Fowlis DJ, Bryson S, Duffie E, Ireland H, Balmain A, et al. (1996). TGF-β1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86:531-542.
    • (1996) Cell , vol.86 , pp. 531-542
    • Cui, W.1    Fowlis, D.J.2    Bryson, S.3    Duffie, E.4    Ireland, H.5    Balmain, A.6
  • 22
    • 0027742864 scopus 로고
    • Immunocytochemical localization of secreted transforming growth factor-β1 to the advancing edge of primary tumors and to lymph node metastases of human mammary carcinoma
    • Dalal BI, Keown PA, Greenberg AH (1993). Immunocytochemical localization of secreted transforming growth factor-β1 to the advancing edge of primary tumors and to lymph node metastases of human mammary carcinoma. Am J Pathol 143:381-389.
    • (1993) Am J Pathol , vol.143 , pp. 381-389
    • Dalal, B.I.1    Keown, P.A.2    Greenberg, A.H.3
  • 23
    • 0030798673 scopus 로고    scopus 로고
    • Overexpression of autocrine TGF-β1 suppresses the growth of spindle epithelial cells in vitro and in vivo in the rat 4NQO model of oral carcinogenesis
    • Davies M, Prime SS, Stone AM, Heung Y-L, Huntley SP, Matthews JB, et al. (1997). Overexpression of autocrine TGF-β1 suppresses the growth of spindle epithelial cells in vitro and in vivo in the rat 4NQO model of oral carcinogenesis. Int J Cancer 73:68-74.
    • (1997) Int J Cancer , vol.73 , pp. 68-74
    • Davies, M.1    Prime, S.S.2    Stone, A.M.3    Heung, Y.-L.4    Huntley, S.P.5    Matthews, J.B.6
  • 24
    • 0033213421 scopus 로고    scopus 로고
    • Loss of differentiation of 4NQO-induced malignant oral rat keratinocytes correlates with metastatic dissemination and is associated with a reduced cellular response to TGF-β1 and an altered receptor profile
    • Davies M, Paterson IC, Stone A, Huntley S, Patel V, Curtis R, et al. (1999). Loss of differentiation of 4NQO-induced malignant oral rat keratinocytes correlates with metastatic dissemination and is associated with a reduced cellular response to TGF-β1 and an altered receptor profile. J Oral Path Med 28:397-405.
    • (1999) J Oral Path Med , vol.28 , pp. 397-405
    • Davies, M.1    Paterson, I.C.2    Stone, A.3    Huntley, S.4    Patel, V.5    Curtis, R.6
  • 25
    • 0034612789 scopus 로고    scopus 로고
    • Role of transforming growth factor-β signaling in cancer
    • de Caestecker MP, Piek E, Roberts AB (2000). Role of transforming growth factor-β signaling in cancer. J Natl Cancer Inst 92:1388-1402.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1388-1402
    • De Caestecker, M.P.1    Piek, E.2    Roberts, A.B.3
  • 26
    • 0034785348 scopus 로고    scopus 로고
    • TGF-β signaling in tumor suppression and cancer progression
    • Derynck R, Akhurst RJ, Balmain A (2001). TGF-β signaling in tumor suppression and cancer progression. Nature Genet 29:117-129.
    • (2001) Nature Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 27
    • 0037264633 scopus 로고    scopus 로고
    • Targeting Ras signaling pathways in cancer therapy
    • Downward J (2003). Targeting Ras signaling pathways in cancer therapy. Nature Rev Cancer 3:11-22.
    • (2003) Nature Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 28
    • 12244293337 scopus 로고    scopus 로고
    • The tumor microenvironment: A potential arbitrator of the tumor suppressive and promoting actions of TGF-β
    • Dumont N, Arteaga CL (2002). The tumor microenvironment: a potential arbitrator of the tumor suppressive and promoting actions of TGF-β. Differentiation 70:574-582.
    • (2002) Differentiation , vol.70 , pp. 574-582
    • Dumont, N.1    Arteaga, C.L.2
  • 29
    • 0037474223 scopus 로고    scopus 로고
    • Autocrine transforming growth factor-β signaling mediates Smad-independent motility in human cancer cells
    • Dumont N, Bakin AV, Arteaga CL (2003). Autocrine transforming growth factor-β signaling mediates Smad-independent motility in human cancer cells. J Biol Chem 278:3275-3285.
    • (2003) J Biol Chem , vol.278 , pp. 3275-3285
    • Dumont, N.1    Bakin, A.V.2    Arteaga, C.L.3
  • 30
    • 0035872426 scopus 로고    scopus 로고
    • Transforming growth factor β1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cells requiring extracellular signal-regulated kinase 2 activation
    • Ellenrieder V, Hendler SF, Boeck W, Seufferlein T, Menke A, Ruhland C, et al. (2001). Transforming growth factor β1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cells requiring extracellular signal-regulated kinase 2 activation. Cancer Res 61:4222-4228.
    • (2001) Cancer Res , vol.61 , pp. 4222-4228
    • Ellenrieder, V.1    Hendler, S.F.2    Boeck, W.3    Seufferlein, T.4    Menke, A.5    Ruhland, C.6
  • 31
    • 0033565626 scopus 로고    scopus 로고
    • Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
    • Engle SJ, Hoying JB, Boivin GP, Ormsby I, Gartside PS, Doelschman T (1999). Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res 59:3379-3386.
    • (1999) Cancer Res , vol.59 , pp. 3379-3386
    • Engle, S.J.1    Hoying, J.B.2    Boivin, G.P.3    Ormsby, I.4    Gartside, P.S.5    Doelschman, T.6
  • 32
    • 16044369574 scopus 로고    scopus 로고
    • MADR2 maps to 18q21 and encodes a TGF-β regulated MAD-related protein that is functionally mutated in colorectal carcinoma
    • Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, et al. (1996). MADR2 maps to 18q21 and encodes a TGF-β regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86:543-552.
    • (1996) Cell , vol.86 , pp. 543-552
    • Eppert, K.1    Scherer, S.W.2    Ozcelik, H.3    Pirone, R.4    Hoodless, P.5    Kim, H.6
  • 33
    • 0029784956 scopus 로고    scopus 로고
    • Dysregulation of autocrine TGF-β isoform production and ligand responses in human tumor-derived and Ha-ras-transfected keratinocytes and fibroblasts
    • Fahey MS, Paterson IC, Stone A, Collier AJ, Heung YLM, Davies M, et al. (1996). Dysregulation of autocrine TGF-β isoform production and ligand responses in human tumor-derived and Ha-ras-transfected keratinocytes and fibroblasts. Br J Cancer 74:1074-1080.
    • (1996) Br J Cancer , vol.74 , pp. 1074-1080
    • Fahey, M.S.1    Paterson, I.C.2    Stone, A.3    Collier, A.J.4    Heung, Y.L.M.5    Davies, M.6
  • 34
    • 0031034503 scopus 로고    scopus 로고
    • Evidence that loss of chromosome 18q is associated with tumor progression
    • Frank CJ, McClatchey KD, Devaney KO, Carey TE (1997). Evidence that loss of chromosome 18q is associated with tumor progression. Cancer Res 57:824-827.
    • (1997) Cancer Res , vol.57 , pp. 824-827
    • Frank, C.J.1    McClatchey, K.D.2    Devaney, K.O.3    Carey, T.E.4
  • 35
    • 0027131252 scopus 로고
    • Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival
    • Friess H, Yamanaka Y, Buchler M (1993). Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival. Gastroenterology 105:1846-1858.
    • (1993) Gastroenterology , vol.105 , pp. 1846-1858
    • Friess, H.1    Yamanaka, Y.2    Buchler, M.3
  • 36
    • 0025765115 scopus 로고
    • E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells
    • Frixen U, Behrens J, Sachs M, Eberle G, Voss B, Warda A, et al. (1991). E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113:173-185.
    • (1991) J Cell Biol , vol.113 , pp. 173-185
    • Frixen, U.1    Behrens, J.2    Sachs, M.3    Eberle, G.4    Voss, B.5    Warda, A.6
  • 37
    • 0022352890 scopus 로고
    • Tumor de-differentiation: An important step in tumor invasion
    • Gabbert H, Wagner R, Moll R, Gerharz CD (1985). Tumor de-differentiation: an important step in tumor invasion. Clin Exp Metastases 3:257-279.
    • (1985) Clin Exp Metastases , vol.3 , pp. 257-279
    • Gabbert, H.1    Wagner, R.2    Moll, R.3    Gerharz, C.D.4
  • 38
    • 0025860394 scopus 로고
    • Differentiation of malignant oral rat keratinocytes reflects changes in EGF and TGF-β receptor expression but not growth factor dependence
    • Game SM, Stone A, Matthews JB, Scully C, Prime SS (1991). Differentiation of malignant oral rat keratinocytes reflects changes in EGF and TGF-β receptor expression but not growth factor dependence. Carcinogenesis 12:409-416.
    • (1991) Carcinogenesis , vol.12 , pp. 409-416
    • Game, S.M.1    Stone, A.2    Matthews, J.B.3    Scully, C.4    Prime, S.S.5
  • 39
    • 0029114477 scopus 로고
    • Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells
    • Garrigue-Antar L, Munoz-Antonia T, Antonia SJ, Gesmonde J, Vellucci VF, Reiss M (1995). Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells. Cancer Res 55:3982-3987.
    • (1995) Cancer Res , vol.55 , pp. 3982-3987
    • Garrigue-Antar, L.1    Munoz-Antonia, T.2    Antonia, S.J.3    Gesmonde, J.4    Vellucci, V.F.5    Reiss, M.6
  • 41
    • 0032816746 scopus 로고    scopus 로고
    • Use of representational difference analysis to study the effect of TGF-β on the expression profile of a pancreatic cancer cell line
    • Geng MM, Ellenrieder V, Wallrapp C, Muller-Pillasch F, Sommer G, Adler G, et al. (1999). Use of representational difference analysis to study the effect of TGF-β on the expression profile of a pancreatic cancer cell line. Genes Chromosomes Cancer 26:70-79.
    • (1999) Genes Chromosomes Cancer , vol.26 , pp. 70-79
    • Geng, M.M.1    Ellenrieder, V.2    Wallrapp, C.3    Muller-Pillasch, F.4    Sommer, G.5    Adler, G.6
  • 43
    • 0027217314 scopus 로고
    • Loss of expression of TGF-β in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion
    • Glick AB, Kulkarni AB, Tennenbaum T, Hennings H, Flanders KC, O'Reilly M, et al. (1993). Loss of expression of TGF-β in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proc Natl Acad Sci USA 90:6076-6080.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6076-6080
    • Glick, A.B.1    Kulkarni, A.B.2    Tennenbaum, T.3    Hennings, H.4    Flanders, K.C.5    O'Reilly, M.6
  • 44
    • 0028171401 scopus 로고
    • Targeted deletion of the TGF-β1 gene causes rapid progression to squamous cell carcinoma
    • Glick AB, Lee MM, Darwiche N, Kulkarni AB, Karlsson S, Yuspa SH (1994). Targeted deletion of the TGF-β1 gene causes rapid progression to squamous cell carcinoma. Genes Dev 8:2429-2440.
    • (1994) Genes Dev , vol.8 , pp. 2429-2440
    • Glick, A.B.1    Lee, M.M.2    Darwiche, N.3    Kulkarni, A.B.4    Karlsson, S.5    Yuspa, S.H.6
  • 45
    • 0029784067 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 suppresses genomic instability independent of a G1 arrest, p53 and Rb
    • Glick AB, Weinberg WC, Wu IH, Quan W, Yuspa SH (1996). Transforming growth factor-beta1 suppresses genomic instability independent of a G1 arrest, p53 and Rb. Cancer Res 56:3645-3650.
    • (1996) Cancer Res , vol.56 , pp. 3645-3650
    • Glick, A.B.1    Weinberg, W.C.2    Wu, I.H.3    Quan, W.4    Yuspa, S.H.5
  • 46
    • 0034721099 scopus 로고    scopus 로고
    • Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFbetaRII
    • Go C, He W, Zhong L, Li P, Huang J, Brinkley BR, et al. (2000). Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFbetaRII. Oncogene 19:3623-3631.
    • (2000) Oncogene , vol.19 , pp. 3623-3631
    • Go, C.1    He, W.2    Zhong, L.3    Li, P.4    Huang, J.5    Brinkley, B.R.6
  • 47
    • 0032404111 scopus 로고    scopus 로고
    • Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas
    • Goggins M, Shekher M, Turnacioglu K, Yeo CJ, Hruban RH, Kern SE (1998). Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res 58:5329-5332.
    • (1998) Cancer Res , vol.58 , pp. 5329-5332
    • Goggins, M.1    Shekher, M.2    Turnacioglu, K.3    Yeo, C.J.4    Hruban, R.H.5    Kern, S.E.6
  • 48
    • 0037087507 scopus 로고    scopus 로고
    • Hepatocytes convert to a fibroblastoid phenotype through the co-operation of TGF-β and Ha-Ras: Steps towards invasiveness
    • Gotzmann J, Huber H, Thallinger C, Wolschek M, Jansen B, Schulte-Hermann R, et al. (2002). Hepatocytes convert to a fibroblastoid phenotype through the co-operation of TGF-β and Ha-Ras: steps towards invasiveness. J Cell Sci 115:1189-1202.
    • (2002) J Cell Sci , vol.115 , pp. 1189-1202
    • Gotzmann, J.1    Huber, H.2    Thallinger, C.3    Wolschek, M.4    Jansen, B.5    Schulte-Hermann, R.6
  • 49
    • 0033555627 scopus 로고    scopus 로고
    • Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers
    • Grady WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S, Lutterbaugh JD, et al. (1999). Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res 59:320-324.
    • (1999) Cancer Res , vol.59 , pp. 320-324
    • Grady, W.M.1    Myeroff, L.L.2    Swinler, S.E.3    Rajput, A.4    Thiagalingam, S.5    Lutterbaugh, J.D.6
  • 50
    • 0043172396 scopus 로고    scopus 로고
    • Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
    • Grunert S, Jechlinger M, Beug H (2003). Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nature Rev Mol Cell Biol 4:657-665.
    • (2003) Nature Rev Mol Cell Biol , vol.4 , pp. 657-665
    • Grunert, S.1    Jechlinger, M.2    Beug, H.3
  • 51
    • 0037131409 scopus 로고    scopus 로고
    • Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression
    • Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, et al. (2002). Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem 277:39209-39216.
    • (2002) J Biol Chem , vol.277 , pp. 39209-39216
    • Guaita, S.1    Puig, I.2    Franci, C.3    Garrido, M.4    Dominguez, D.5    Batlle, E.6
  • 52
    • 0042365388 scopus 로고    scopus 로고
    • Conditional loss of TGF-beta signaling leads to increased susceptibility to gastrointestinal carcinogenesis in mice
    • Hahm KB, Lee KM, Kim YB, Hong WS, Lee WH, Han SU, et al. (2002). Conditional loss of TGF-beta signaling leads to increased susceptibility to gastrointestinal carcinogenesis in mice. Aliment Pharmacol Ther 16:115-127.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 115-127
    • Hahm, K.B.1    Lee, K.M.2    Kim, Y.B.3    Hong, W.S.4    Lee, W.H.5    Han, S.U.6
  • 55
    • 1442332673 scopus 로고    scopus 로고
    • Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer
    • Han SK, Kim HT, Seong DH, Kim YS, Park YS, Bang YJ, et al. (2004). Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer. Oncogene 23:1333-1341.
    • (2004) Oncogene , vol.23 , pp. 1333-1341
    • Han, S.K.1    Kim, H.T.2    Seong, D.H.3    Kim, Y.S.4    Park, Y.S.5    Bang, Y.J.6
  • 56
    • 0032773710 scopus 로고    scopus 로고
    • Autocrine and paracrine motility factors and their involvement in invasiveness in a human oral carcinoma cell line
    • Hasina R, Matsumoto K, Matsumoto-Taniura N, Kato I, Sakuda M, Nakamura T (1999). Autocrine and paracrine motility factors and their involvement in invasiveness in a human oral carcinoma cell line. Br J Cancer 80:1708-1717.
    • (1999) Br J Cancer , vol.80 , pp. 1708-1717
    • Hasina, R.1    Matsumoto, K.2    Matsumoto-Taniura, N.3    Kato, I.4    Sakuda, M.5    Nakamura, T.6
  • 57
    • 0032713840 scopus 로고    scopus 로고
    • N-(4-hydroxyphenyl)retinamide activation of transforming growth factor-beta and induction of apoptosis in human breast cancer cells
    • Herbert BS, Sanders BG, Kline K (1999). N-(4-hydroxyphenyl)retinamide activation of transforming growth factor-beta and induction of apoptosis in human breast cancer cells. Nutr Cancer 34:121-132.
    • (1999) Nutr Cancer , vol.34 , pp. 121-132
    • Herbert, B.S.1    Sanders, B.G.2    Kline, K.3
  • 58
    • 0033545299 scopus 로고    scopus 로고
    • Cyclosporin induces cancer progression by a cell-autonomous mechanism
    • Hojo M, Morimot T, Maluccio M, Asano T, Morimoto K, Lagman M, et al. (1999). Cyclosporin induces cancer progression by a cell-autonomous mechanism. Nature 397:530-534.
    • (1999) Nature , vol.397 , pp. 530-534
    • Hojo, M.1    Morimot, T.2    Maluccio, M.3    Asano, T.4    Morimoto, K.5    Lagman, M.6
  • 59
    • 0033104577 scopus 로고    scopus 로고
    • Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo
    • Hoteiya T, Hayashi E, Satomura K, Kamata N, Nagayama M (1999). Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo. J Oral Path Med 28:107-111.
    • (1999) J Oral Path Med , vol.28 , pp. 107-111
    • Hoteiya, T.1    Hayashi, E.2    Satomura, K.3    Kamata, N.4    Nagayama, M.5
  • 60
    • 0028820153 scopus 로고
    • Transforming growth factor-β1 (TGF-β1) is an autocrine positive regulator of colon carcinoma U9 cells in vivo as shown by transfection of a TGF-β1 antisense expression plasmid
    • Huang F, Newman E, Theodorescu D, Kerbel RS, Friedman E (1995). Transforming growth factor-β1 (TGF-β1) is an autocrine positive regulator of colon carcinoma U9 cells in vivo as shown by transfection of a TGF-β1 antisense expression plasmid. Cell Growth Differ 6:1635-1642.
    • (1995) Cell Growth Differ , vol.6 , pp. 1635-1642
    • Huang, F.1    Newman, E.2    Theodorescu, D.3    Kerbel, R.S.4    Friedman, E.5
  • 61
    • 2342559112 scopus 로고    scopus 로고
    • Attenuated type II TGF-β receptor signalling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination
    • Huntley SP, Davies M, Matthews JB, Marshall J, Robinson CM, Eveson JW, et al. (2004). Attenuated type II TGF-β receptor signalling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination. Int J Cancer 110:170-176.
    • (2004) Int J Cancer , vol.110 , pp. 170-176
    • Huntley, S.P.1    Davies, M.2    Matthews, J.B.3    Marshall, J.4    Robinson, C.M.5    Eveson, J.W.6
  • 62
    • 0034710545 scopus 로고    scopus 로고
    • Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signaling pathway associated with progression to undifferentiated carcinomas
    • Iglesias M, Frontelo P, Gamallo C, Quintanilla M (2000). Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signaling pathway associated with progression to undifferentiated carcinomas. Oncogene 19:4134-4145.
    • (2000) Oncogene , vol.19 , pp. 4134-4145
    • Iglesias, M.1    Frontelo, P.2    Gamallo, C.3    Quintanilla, M.4
  • 63
    • 0035884192 scopus 로고    scopus 로고
    • Heterozygous mice for the transforming growth factor-β type II receptor gene have increased susceptibility to hepatocellular carcinogenesis
    • Im Y-H, Kim HT, Kim IY, Factor VM, Hahm K-B, Anzano M, et al. (2001). Heterozygous mice for the transforming growth factor-β type II receptor gene have increased susceptibility to hepatocellular carcinogenesis. Cancer Res 61:6665-6668.
    • (2001) Cancer Res , vol.61 , pp. 6665-6668
    • Im, Y.-H.1    Kim, H.T.2    Kim, I.Y.3    Factor, V.M.4    Hahm, K.-B.5    Anzano, M.6
  • 64
    • 0037148532 scopus 로고    scopus 로고
    • Ras and TGF-β cooperatively regulate epithelial cell plasticity and metastasis: Dissection of signaling pathways
    • Janda E, Lehmann K, Killisch I, Jechlinger M, Herzig M, Downward J, et al. (2002). Ras and TGF-β cooperatively regulate epithelial cell plasticity and metastasis: dissection of signaling pathways. J Cell Biol 156:299-313.
    • (2002) J Cell Biol , vol.156 , pp. 299-313
    • Janda, E.1    Lehmann, K.2    Killisch, I.3    Jechlinger, M.4    Herzig, M.5    Downward, J.6
  • 65
    • 0032882539 scopus 로고    scopus 로고
    • Autocrine TGF-β-regulated expression of adhesion receptors and integrin-linked kinase in HT-144 melanoma cells correlates with their metastatic phenotype
    • Janji B, Melchior C, Gouon V, Vallar L, Kieffer N (1999). Autocrine TGF-β-regulated expression of adhesion receptors and integrin-linked kinase in HT-144 melanoma cells correlates with their metastatic phenotype. Int J Cancer 83:255-262.
    • (1999) Int J Cancer , vol.83 , pp. 255-262
    • Janji, B.1    Melchior, C.2    Gouon, V.3    Vallar, L.4    Kieffer, N.5
  • 66
    • 0035909522 scopus 로고    scopus 로고
    • Regulation of the human transforming growth factor beta type II receptor gene promoter by novel Sp1 sites
    • Jennings R, Alsarraj M, Wright KL, Munoz-Antonia T (2001). Regulation of the human transforming growth factor beta type II receptor gene promoter by novel Sp1 sites. Oncogene 20:6899-6909.
    • (2001) Oncogene , vol.20 , pp. 6899-6909
    • Jennings, R.1    Alsarraj, M.2    Wright, K.L.3    Munoz-Antonia, T.4
  • 67
    • 8244221658 scopus 로고    scopus 로고
    • Frequent loss of heterozygosity on chromosome arm 18q in squamous cell carcinomas. Identification of 2 regions of loss - 18q11.1-q12.3 and 18q21.1-q23
    • Jones JW, Raval JR, Beals TF, Worsham MJ, Van Dyke DL, Esclamado RM, et al. (1997). Frequent loss of heterozygosity on chromosome arm 18q in squamous cell carcinomas. Identification of 2 regions of loss - 18q11.1-q12.3 and 18q21.1-q23. Arch Otolaryngol Head Neck Surg 123:610-614.
    • (1997) Arch Otolaryngol Head Neck Surg , vol.123 , pp. 610-614
    • Jones, J.W.1    Raval, J.R.2    Beals, T.F.3    Worsham, M.J.4    Van Dyke, D.L.5    Esclamado, R.M.6
  • 68
    • 0037025352 scopus 로고    scopus 로고
    • Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways
    • Kakonen SM, Selander KS, Chirgwin JM, Yin JJ, Burns S, Rankin WA, et al. (2002). Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways. J Biol Chem 277:24571-24578.
    • (2002) J Biol Chem , vol.277 , pp. 24571-24578
    • Kakonen, S.M.1    Selander, K.S.2    Chirgwin, J.M.3    Yin, J.J.4    Burns, S.5    Rankin, W.A.6
  • 69
    • 0000031048 scopus 로고    scopus 로고
    • Transcriptional repression of the transforming growth factor-beta type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer
    • Kang SH, Bang YJ, Im YH, Yang HK, Lee DA, Lee HS, et al. (1999). Transcriptional repression of the transforming growth factor-beta type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer. Oncogene 18:7280-7286.
    • (1999) Oncogene , vol.18 , pp. 7280-7286
    • Kang, S.H.1    Bang, Y.J.2    Im, Y.H.3    Yang, H.K.4    Lee, D.A.5    Lee, H.S.6
  • 70
    • 0035899396 scopus 로고    scopus 로고
    • Hepatocellular expression of a dominant-negative mutant TGF-beta type II receptor accelerates chemically induced hepatocarcinogenesis
    • Kanzler S, Meyer E, Lohse AW, Schirmacher P, Henninger J, Galle PR, et al. (2001). Hepatocellular expression of a dominant-negative mutant TGF-beta type II receptor accelerates chemically induced hepatocarcinogenesis. Oncogene 20:5015-5024.
    • (2001) Oncogene , vol.20 , pp. 5015-5024
    • Kanzler, S.1    Meyer, E.2    Lohse, A.W.3    Schirmacher, P.4    Henninger, J.5    Galle, P.R.6
  • 71
    • 0035883531 scopus 로고    scopus 로고
    • Predictive value of expression of TGF-beta(1) and its receptors in transitional cell carcinoma of the urinary bladder
    • Kim JH, Shariat SF, Kim IY, Menesses-Diaz A, Tokunaga H, Wheeler TM, et al. (2001). Predictive value of expression of TGF-beta(1) and its receptors in transitional cell carcinoma of the urinary bladder. Cancer 92:1475-1483.
    • (2001) Cancer , vol.92 , pp. 1475-1483
    • Kim, J.H.1    Shariat, S.F.2    Kim, I.Y.3    Menesses-Diaz, A.4    Tokunaga, H.5    Wheeler, T.M.6
  • 72
    • 0034027480 scopus 로고    scopus 로고
    • Molecular mechanisms of inactivation of TGF-beta receptors during carcinogenesis
    • Kim SJ, Im YH, Markowitz SD, Bang YJ (2000). Molecular mechanisms of inactivation of TGF-beta receptors during carcinogenesis. Cytokine Growth Factor Rev 11:159-168.
    • (2000) Cytokine Growth Factor Rev , vol.11 , pp. 159-168
    • Kim, S.J.1    Im, Y.H.2    Markowitz, S.D.3    Bang, Y.J.4
  • 73
    • 0033598408 scopus 로고    scopus 로고
    • The TGF-β signaling inhibitor Smad7 enhances tumori-genicity in pancreatic cancer
    • Kleeff J, Ishiwata T, Maruyama H, Friess H, Truong P, Buchler MW (1999). The TGF-β signaling inhibitor Smad7 enhances tumori-genicity in pancreatic cancer. Oncogene 18:5363-5672.
    • (1999) Oncogene , vol.18 , pp. 5363-5672
    • Kleeff, J.1    Ishiwata, T.2    Maruyama, H.3    Friess, H.4    Truong, P.5    Buchler, M.W.6
  • 74
    • 0035828188 scopus 로고    scopus 로고
    • Analysis of TGF-beta type I receptor for mutations and polymorphisms in head and neck cancers
    • Knobloch TJ, Lynch MA, Song H, DeGroff VL, Casto BC, Adams EM, et al. (2001). Analysis of TGF-beta type I receptor for mutations and polymorphisms in head and neck cancers. Mutat Res 479:131-139.
    • (2001) Mutat Res , vol.479 , pp. 131-139
    • Knobloch, T.J.1    Lynch, M.A.2    Song, H.3    Degroff, V.L.4    Casto, B.C.5    Adams, E.M.6
  • 75
    • 0027531528 scopus 로고
    • Transforming growth factor β null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni AB, Huh CG, Becker D, Geiser A, Lyght M, Flanders KC, et al. (1993). Transforming growth factor β null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 90:770-774.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 770-774
    • Kulkarni, A.B.1    Huh, C.G.2    Becker, D.3    Geiser, A.4    Lyght, M.5    Flanders, K.C.6
  • 76
    • 0032474868 scopus 로고    scopus 로고
    • The oncoprotein Evi-1 represses TGF-beta signaling by inhibiting Smad3
    • Kurokawa M, Mitani K, Irie K, Matsuyama T, Takahashi T, Chiba S, et al. (1998). The oncoprotein Evi-1 represses TGF-beta signaling by inhibiting Smad3. Nature 394:92-96.
    • (1998) Nature , vol.394 , pp. 92-96
    • Kurokawa, M.1    Mitani, K.2    Irie, K.3    Matsuyama, T.4    Takahashi, T.5    Chiba, S.6
  • 77
    • 0037448691 scopus 로고    scopus 로고
    • Fusion proteins of retinoid receptors antagonize TGF-β-induced growth inhibition of lung epithelial cells
    • La P, Morgan TA, Sykes SM, Mao H, Schnepp RW, Petersen CD, et al. (2003). Fusion proteins of retinoid receptors antagonize TGF-β-induced growth inhibition of lung epithelial cells. Oncogene 22:198-210.
    • (2003) Oncogene , vol.22 , pp. 198-210
    • La, P.1    Morgan, T.A.2    Sykes, S.M.3    Mao, H.4    Schnepp, R.W.5    Petersen, C.D.6
  • 78
    • 0036082554 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542
    • Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, et al. (2002). Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542. Mol Pharmacol 62:58-64.
    • (2002) Mol Pharmacol , vol.62 , pp. 58-64
    • Laping, N.J.1    Grygielko, E.2    Mathur, A.3    Butter, S.4    Bomberger, J.5    Tweed, C.6
  • 79
    • 0034666839 scopus 로고    scopus 로고
    • Raf induces TGF-β production while blocking its apoptotic but not invasive responses: A mechanism leading to increased malignancy in epithelial cells
    • Lehmann K, Janda E, Pierreux CE, Rytomaa M, Schulze A, McMahon M, et al. (2000). Raf induces TGF-β production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev 14:2610-2622.
    • (2000) Genes Dev , vol.14 , pp. 2610-2622
    • Lehmann, K.1    Janda, E.2    Pierreux, C.E.3    Rytomaa, M.4    Schulze, A.5    McMahon, M.6
  • 80
    • 0037947757 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 (TGF beta 1) expression in head and neck squamous cell carcinoma patients as related to prognosis
    • Logullo AF, Nonogaki S, Miguel RE, Kowalski LP, Nishimoto IN, Pasisni FS, et al. (2003). Transforming growth factor beta 1 (TGF beta 1) expression in head and neck squamous cell carcinoma patients as related to prognosis. J Oral Pathol Med 32:139-145.
    • (2003) J Oral Pathol Med , vol.32 , pp. 139-145
    • Logullo, A.F.1    Nonogaki, S.2    Miguel, R.E.3    Kowalski, L.P.4    Nishimoto, I.N.5    Pasisni, F.S.6
  • 81
    • 0033200361 scopus 로고    scopus 로고
    • The ski oncoprotein interacts with the Smad proteins to repress TGF-beta signaling
    • Luo K, Stroschein SL, Wang W, Chen D, Martens E, Zhou S, et al. (1999). The ski oncoprotein interacts with the Smad proteins to repress TGF-beta signaling. Genes Dev 13:2196-2206.
    • (1999) Genes Dev , vol.13 , pp. 2196-2206
    • Luo, K.1    Stroschein, S.L.2    Wang, W.3    Chen, D.4    Martens, E.5    Zhou, S.6
  • 82
    • 0033814963 scopus 로고    scopus 로고
    • Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease
    • Maitra A, Molberg K, Albores-Saavedra J, Lindberg G (2000). Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease. Am J Pathol 157:1105-1111.
    • (2000) Am J Pathol , vol.157 , pp. 1105-1111
    • Maitra, A.1    Molberg, K.2    Albores-Saavedra, J.3    Lindberg, G.4
  • 84
    • 0035968626 scopus 로고    scopus 로고
    • Squamous-cell cancer of the skin in patients given PUVA and cyclosporin: Nested cohort crossover study
    • Marcil I, Stern RS (2001). Squamous-cell cancer of the skin in patients given PUVA and cyclosporin: nested cohort crossover study. Lancet 358:1042-1045.
    • (2001) Lancet , vol.358 , pp. 1042-1045
    • Marcil, I.1    Stern, R.S.2
  • 85
    • 0029066689 scopus 로고
    • Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
    • Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, et al. (1995). Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268:1336-1338.
    • (1995) Science , vol.268 , pp. 1336-1338
    • Markowitz, S.1    Wang, J.2    Myeroff, L.3    Parsons, R.4    Sun, L.5    Lutterbaugh, J.6
  • 87
    • 0037779427 scopus 로고    scopus 로고
    • Repression of TGF-beta signaling by the oncogenic protein SKI in human melanomas: Consequences for proliferation, survival, and metastasis
    • Medrano EE (2003). Repression of TGF-beta signaling by the oncogenic protein SKI in human melanomas: consequences for proliferation, survival, and metastasis. Oncogene 22:3123-3129.
    • (2003) Oncogene , vol.22 , pp. 3123-3129
    • Medrano, E.E.1
  • 88
    • 0028603343 scopus 로고
    • TGF-β induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
    • Miettinen MJ, Ebner R, Lopez AR, Derynck R (1994). TGF-β induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 127:2021-2036.
    • (1994) J Cell Biol , vol.127 , pp. 2021-2036
    • Miettinen, M.J.1    Ebner, R.2    Lopez, A.R.3    Derynck, R.4
  • 89
    • 0034015947 scopus 로고    scopus 로고
    • K-ras mutation: Early detection in molecular diagnosis and risk assessment of colorectal, pancreas and lung cancers - A review
    • Minamoto T, Mai M, Ronai Z (2000). K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas and lung cancers - a review. Cancer Detect Prev 24:1-12.
    • (2000) Cancer Detect Prev , vol.24 , pp. 1-12
    • Minamoto, T.1    Mai, M.2    Ronai, Z.3
  • 90
    • 0033587156 scopus 로고    scopus 로고
    • Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis
    • Miyaki M, Iijima T, Konishi M, Sakai K, Ishii A, Yasuno M, et al. (1999). Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene 18:3098-3103.
    • (1999) Oncogene , vol.18 , pp. 3098-3103
    • Miyaki, M.1    Iijima, T.2    Konishi, M.3    Sakai, K.4    Ishii, A.5    Yasuno, M.6
  • 91
    • 0029902905 scopus 로고    scopus 로고
    • A mutation of the transforming growth factor type II receptor gene promoter associated with loss of gene expression
    • Munoz-Antonia T, Reiss M, Jackson R, Antonia S (1996). A mutation of the transforming growth factor type II receptor gene promoter associated with loss of gene expression. Cancer Res 56:4831-4835.
    • (1996) Cancer Res , vol.56 , pp. 4831-4835
    • Munoz-Antonia, T.1    Reiss, M.2    Jackson, R.3    Antonia, S.4
  • 93
  • 94
    • 0034901345 scopus 로고    scopus 로고
    • Defective transforming growth factor β signaling pathway in head and neck squamous cell carcinoma as evidenced by the lack of expression of activated Smad2
    • Muro-Cacho CA, Rosario-Ortiz K, Livingston S, Munoz-Antonia T (2001). Defective transforming growth factor β signaling pathway in head and neck squamous cell carcinoma as evidenced by the lack of expression of activated Smad2. Clin Cancer Res 7:1618-1626.
    • (2001) Clin Cancer Res , vol.7 , pp. 1618-1626
    • Muro-Cacho, C.A.1    Rosario-Ortiz, K.2    Livingston, S.3    Munoz-Antonia, T.4
  • 95
    • 0036281395 scopus 로고    scopus 로고
    • Smad4 and transforming growth factor β1 expression in patients with squamous cell carcinoma of the esophagus
    • Natsugoe S, Xiangming C, Matsumoto M, Okumura H, Nakashima S, Sakita H, et al. (2002). Smad4 and transforming growth factor β1 expression in patients with squamous cell carcinoma of the esophagus. Clin Cancer Res 8:1838-1842.
    • (2002) Clin Cancer Res , vol.8 , pp. 1838-1842
    • Natsugoe, S.1    Xiangming, C.2    Matsumoto, M.3    Okumura, H.4    Nakashima, S.5    Sakita, H.6
  • 96
    • 0029662049 scopus 로고    scopus 로고
    • TGF-β1 and Ha-ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • Oft M, Peli J, Rudaz C, Schwarz H, Beug H, Reichmann E (1996). TGF-β1 and Ha-ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev 10:2462-2477.
    • (1996) Genes Dev , vol.10 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3    Schwarz, H.4    Beug, H.5    Reichmann, E.6
  • 97
    • 0032547895 scopus 로고    scopus 로고
    • TGF-β signaling is necessary for carcinoma cell invasiveness and metastasis
    • Oft M, Heider K-H, Beug H (1998). TGF-β signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol 8:1243-1252.
    • (1998) Curr Biol , vol.8 , pp. 1243-1252
    • Oft, M.1    Heider, K.-H.2    Beug, H.3
  • 98
    • 0036304111 scopus 로고    scopus 로고
    • Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    • Oft M, Akhurst RJ, Balmain A (2002). Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol 4:487-494.
    • (2002) Nat Cell Biol , vol.4 , pp. 487-494
    • Oft, M.1    Akhurst, R.J.2    Balmain, A.3
  • 99
    • 0027530351 scopus 로고
    • Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis
    • Oka H, Shiozaki H, Kobayashi K, Inoue M, Tahara H, Kobayashi T, et al. (1993). Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res 53:1696-1701.
    • (1993) Cancer Res , vol.53 , pp. 1696-1701
    • Oka, H.1    Shiozaki, H.2    Kobayashi, K.3    Inoue, M.4    Tahara, H.5    Kobayashi, T.6
  • 100
    • 0027960437 scopus 로고
    • Overexpression of cyclin D1 reduces the transforming growth factor-beta (TGF-β) type II receptor and growth inhibition by TGF-β1 in an immortalised human oesophageal epithelial cell line
    • Okamoto A, Jiang W, Kim SJ, Spillare EA, Stoner G, Weinstein IB, et al. (1994). Overexpression of cyclin D1 reduces the transforming growth factor-beta (TGF-β) type II receptor and growth inhibition by TGF-β1 in an immortalised human oesophageal epithelial cell line. Proc Natl Acad Sci USA 91:11576-11580.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11576-11580
    • Okamoto, A.1    Jiang, W.2    Kim, S.J.3    Spillare, E.A.4    Stoner, G.5    Weinstein, I.B.6
  • 101
    • 9244262406 scopus 로고    scopus 로고
    • Effects of a combination of β-carotene and vitamin a on lung cancer and cardiovascular disease
    • Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, et al. (1996). Effects of a combination of β-carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334:1150-1155.
    • (1996) N Engl J Med , vol.334 , pp. 1150-1155
    • Omenn, G.S.1    Goodman, G.E.2    Thornquist, M.D.3    Balmes, J.4    Cullen, M.R.5    Glass, A.6
  • 102
    • 0029887265 scopus 로고    scopus 로고
    • Differential induction of apoptosis by all trans retinoic acid and N-(4-hydroxyphenyl)retinamide in human head and neck squamous cell carcinoma cell lines
    • Oridate N, Lotan D, Xu XC, Hong WK, Lotan R (1996). Differential induction of apoptosis by all trans retinoic acid and N-(4-hydroxyphenyl) retinamide in human head and neck squamous cell carcinoma cell lines. Clin Cancer Res 2:855-863.
    • (1996) Clin Cancer Res , vol.2 , pp. 855-863
    • Oridate, N.1    Lotan, D.2    Xu, X.C.3    Hong, W.K.4    Lotan, R.5
  • 103
    • 0035890776 scopus 로고    scopus 로고
    • Heterogeneous transforming growth factor (TGF)-β unresponsiveness and loss of TGF-β receptor type II expression caused by histone deacetylation in lung cancer cell lines
    • Osada H, Tatematsu Y, Masuda A, Saito T, Sugiyama M, Yanagisawa K, et al. (2001). Heterogeneous transforming growth factor (TGF)-β unresponsiveness and loss of TGF-β receptor type II expression caused by histone deacetylation in lung cancer cell lines. Cancer Res 61:8331-8339.
    • (2001) Cancer Res , vol.61 , pp. 8331-8339
    • Osada, H.1    Tatematsu, Y.2    Masuda, A.3    Saito, T.4    Sugiyama, M.5    Yanagisawa, K.6
  • 104
    • 0034214211 scopus 로고    scopus 로고
    • Mitogenic conversion of transforming growth factor-β1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer
    • Park B-J, Park J-I, Byun D-S, Park J-H, Chi S-G (2000). Mitogenic conversion of transforming growth factor-β1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer. Cancer Res 60:3031-3038.
    • (2000) Cancer Res , vol.60 , pp. 3031-3038
    • Park, B.-J.1    Park, J.-I.2    Byun, D.-S.3    Park, J.-H.4    Chi, S.-G.5
  • 105
    • 0030639334 scopus 로고    scopus 로고
    • Expression of antisense transforming growth factor-β1 transgene reduces tumorigenicity of EMT6 mammary tumor cells
    • Park JA, Wang E, Kurt RA, Schluter SF, Hersh EM, Akporiaye ET (1997). Expression of antisense transforming growth factor-β1 transgene reduces tumorigenicity of EMT6 mammary tumor cells. Cancer Gene Ther 4:42-50.
    • (1997) Cancer Gene Ther , vol.4 , pp. 42-50
    • Park, J.A.1    Wang, E.2    Kurt, R.A.3    Schluter, S.F.4    Hersh, E.M.5    Akporiaye, E.T.6
  • 106
    • 0034892562 scopus 로고    scopus 로고
    • Transforming growth factor beta1, urokinase-type plasminogen activator and urokinase plasminogen activator inhibitor-1 mRNA expression in head and neck squamous carcinoma and normal adjacent mucosa
    • Pasini FS, Brentani MM, Kowalski LP, Federico M (2001). Transforming growth factor beta1, urokinase-type plasminogen activator and urokinase plasminogen activator inhibitor-1 mRNA expression in head and neck squamous carcinoma and normal adjacent mucosa. Head Neck 23:725-732.
    • (2001) Head Neck , vol.23 , pp. 725-732
    • Pasini, F.S.1    Brentani, M.M.2    Kowalski, L.P.3    Federico, M.4
  • 107
    • 0028871322 scopus 로고
    • Effects of transforming growth factor beta-1 on growth regulatory genes in tumor-derived human oral keratinocytes
    • Paterson IC, Patel V, Sandy JR, Prime SS, Yeudall WA (1995). Effects of transforming growth factor beta-1 on growth regulatory genes in tumor-derived human oral keratinocytes. Br J Cancer 72:922-927.
    • (1995) Br J Cancer , vol.72 , pp. 922-927
    • Paterson, I.C.1    Patel, V.2    Sandy, J.R.3    Prime, S.S.4    Yeudall, W.A.5
  • 108
    • 0029937141 scopus 로고    scopus 로고
    • Molecular changes in oral cancer reflect ethnic origin and aetiology
    • Paterson IC, Eveson JW, Prime SS (1996). Molecular changes in oral cancer reflect ethnic origin and aetiology. Oral Oncol Eur J Cancer 32(B):150-153.
    • (1996) Oral Oncol Eur J Cancer , vol.32 , pp. 150-153
    • Paterson, I.C.1    Eveson, J.W.2    Prime, S.S.3
  • 109
    • 0035066199 scopus 로고    scopus 로고
    • Decreased expression of TGF-β cell surface receptors during progression of human oral squamous cell carcinoma
    • Paterson IC, Matthews JB, Huntley S, Robinson CM, Fahey M, Parkinson EK, et al. (2001). Decreased expression of TGF-β cell surface receptors during progression of human oral squamous cell carcinoma. J Pathol 193:458-467.
    • (2001) J Pathol , vol.193 , pp. 458-467
    • Paterson, I.C.1    Matthews, J.B.2    Huntley, S.3    Robinson, C.M.4    Fahey, M.5    Parkinson, E.K.6
  • 110
    • 0037185903 scopus 로고    scopus 로고
    • TGF-β acts as a tumor suppressor of human malignant keratinocytes independently of Smad4 expression and ligand-induced G1 arrest
    • Paterson IC, Davies M, Stone A, Huntley S, Smith E, Pring M, et al. (2002). TGF-β acts as a tumor suppressor of human malignant keratinocytes independently of Smad4 expression and ligand-induced G1 arrest. Oncogene 21:1616-1624.
    • (2002) Oncogene , vol.21 , pp. 1616-1624
    • Paterson, I.C.1    Davies, M.2    Stone, A.3    Huntley, S.4    Smith, E.5    Pring, M.6
  • 111
    • 0038756636 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 induces Snail transcription factor in epithelial cell lines. Mechanisms for epithelial mesenchymal transitions
    • Peinado H, Quintanilla M, Cano A (2003). Transforming growth factor beta 1 induces Snail transcription factor in epithelial cell lines. Mechanisms for epithelial mesenchymal transitions. J Biol Chem 278:21113-21123.
    • (2003) J Biol Chem , vol.278 , pp. 21113-21123
    • Peinado, H.1    Quintanilla, M.2    Cano, A.3
  • 112
    • 0031948084 scopus 로고    scopus 로고
    • A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor beta 1
    • Picon A, Gold LI, Wang J, Cohen A, Friedman E (1998). A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor beta 1. Cancer Epidemiol Biomarkers Prev 7:497-504.
    • (1998) Cancer Epidemiol Biomarkers Prev , vol.7 , pp. 497-504
    • Picon, A.1    Gold, L.I.2    Wang, J.3    Cohen, A.4    Friedman, E.5
  • 113
    • 0033377867 scopus 로고    scopus 로고
    • TGF-β type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
    • Piek E, Moustakas A, Kurisaki A, Heldin C-H, ten Dijke P (1999). TGF-β type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci 112:4557-4568.
    • (1999) J Cell Sci , vol.112 , pp. 4557-4568
    • Piek, E.1    Moustakas, A.2    Kurisaki, A.3    Heldin, C.-H.4    Ten Dijke, P.5
  • 115
    • 0031817391 scopus 로고    scopus 로고
    • Transforming growth factor β is essential for spindle cell conversion of mouse skin carcinoma in vivo: Implications for tumor invasion
    • Portella G, Cumming SA, Liddell J, Cui C, Ireland H, Akhurst R, et al. (1998). Transforming growth factor β is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Cell Growth Differ 9:393-404.
    • (1998) Cell Growth Differ , vol.9 , pp. 393-404
    • Portella, G.1    Cumming, S.A.2    Liddell, J.3    Cui, C.4    Ireland, H.5    Akhurst, R.6
  • 116
    • 0028179164 scopus 로고
    • TGF-β receptor regulation mediates the response to exogenous ligand but is independent of the degree of cellular differentiation in human oral keratinocytes
    • Prime SS, Matthews JB, Patel V, Game SM, Donnelly M, Stone A, et al. (1994). TGF-β receptor regulation mediates the response to exogenous ligand but is independent of the degree of cellular differentiation in human oral keratinocytes. Int J Cancer 56:406-412.
    • (1994) Int J Cancer , vol.56 , pp. 406-412
    • Prime, S.S.1    Matthews, J.B.2    Patel, V.3    Game, S.M.4    Donnelly, M.5    Stone, A.6
  • 117
    • 1342288971 scopus 로고    scopus 로고
    • Opinion: Comparative biology of mouse versus human cells: Modelling human cancer in mice
    • Rangarajan A, Weinberg RA (2003). Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice. Nature Rev Cancer 3:952-959.
    • (2003) Nature Rev Cancer , vol.3 , pp. 952-959
    • Rangarajan, A.1    Weinberg, R.A.2
  • 119
    • 0031031450 scopus 로고    scopus 로고
    • Fenretinide: Induction of apoptosis and endogenous transforming growth factor beta in PC-3 prostate cancer cells
    • Roberson KM, Penland SN, Padilla GM, Selvan RS, Kim CS, Fine RL, et al. (1997). Fenretinide: induction of apoptosis and endogenous transforming growth factor beta in PC-3 prostate cancer cells. Cell Growth Differ 8:101-111.
    • (1997) Cell Growth Differ , vol.8 , pp. 101-111
    • Roberson, K.M.1    Penland, S.N.2    Padilla, G.M.3    Selvan, R.S.4    Kim, C.S.5    Fine, R.L.6
  • 120
    • 0042307513 scopus 로고    scopus 로고
    • The two faces of transforming growth factor β in carcinogenesis
    • Roberts AB, Wakefield L (2003). The two faces of transforming growth factor β in carcinogenesis. Proc Natl Acad Sci USA 100:8621-8623.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8621-8623
    • Roberts, A.B.1    Wakefield, L.2
  • 121
    • 0035839552 scopus 로고    scopus 로고
    • Functional cloning of the prot-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor signaling
    • Rodriguez C, Huang LJ, Son JK, McKee A, Xiao Z, Lodish HF (2001). Functional cloning of the prot-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor signaling. J Biol Chem 276:30224-30230.
    • (2001) J Biol Chem , vol.276 , pp. 30224-30230
    • Rodriguez, C.1    Huang, L.J.2    Son, J.K.3    McKee, A.4    Xiao, Z.5    Lodish, H.F.6
  • 122
    • 0031595530 scopus 로고    scopus 로고
    • Assignment of the Smad7 gene (MADH7) to human chromosome 18q21.1 by fluorescence in situ hybridisation
    • Roijer E, Moren A, ten Dijke P, Stenman G (1998). Assignment of the Smad7 gene (MADH7) to human chromosome 18q21.1 by fluorescence in situ hybridisation. Cytogenet Cell Genet 81:189-190.
    • (1998) Cytogenet Cell Genet , vol.81 , pp. 189-190
    • Roijer, E.1    Moren, A.2    Ten Dijke, P.3    Stenman, G.4
  • 123
    • 0036050857 scopus 로고    scopus 로고
    • Soluble type II transforming growth factor-β receptor attenuates expression of metastases-associated genes and suppresses pancreatic cancer cell metastasis
    • Rowland-Goldsmith MA, Maruyama H, Matsuda K, Idezawa T, Ralli M, Ralli S, et al. (2002). Soluble type II transforming growth factor-β receptor attenuates expression of metastases-associated genes and suppresses pancreatic cancer cell metastasis. Mol Cancer Ther 1:161-167.
    • (2002) Mol Cancer Ther , vol.1 , pp. 161-167
    • Rowland-Goldsmith, M.A.1    Maruyama, H.2    Matsuda, K.3    Idezawa, T.4    Ralli, M.5    Ralli, S.6
  • 124
    • 0035800838 scopus 로고    scopus 로고
    • Oncogenic Ras represses transforming growth factor-beta/Smad signaling by degrading tumor suppressor Smad4
    • Saha D, Datta PK, Beauchamp RD (2001). Oncogenic Ras represses transforming growth factor-beta/Smad signaling by degrading tumor suppressor Smad4. J Biol Chem 276:29531-29537.
    • (2001) J Biol Chem , vol.276 , pp. 29531-29537
    • Saha, D.1    Datta, P.K.2    Beauchamp, R.D.3
  • 126
    • 0026322974 scopus 로고
    • E-cadherin expression in squamous cell carcinomas of the head and neck: Invasive correlation with tumor de-differentiation and lymph node metastasis
    • Schipper J, Frixen U, Behrens J, Unger A, Jahnke K, Birchmeier W (1991). E-cadherin expression in squamous cell carcinomas of the head and neck: invasive correlation with tumor de-differentiation and lymph node metastasis. Cancer Res 51:6328-6337.
    • (1991) Cancer Res , vol.51 , pp. 6328-6337
    • Schipper, J.1    Frixen, U.2    Behrens, J.3    Unger, A.4    Jahnke, K.5    Birchmeier, W.6
  • 127
    • 0029941913 scopus 로고    scopus 로고
    • In situ analysis of transforming growth factor-β (TGF-β1, TGF-β2, TGF-β3) and TGF-β type II receptor expression in basal cell carcinomas
    • Schmid P, Itin D, Rufli TH (1996). In situ analysis of transforming growth factor-β (TGF-β1, TGF-β2, TGF-β3) and TGF-β type II receptor expression in basal cell carcinomas. Br J Dermatol 134:1044-1051.
    • (1996) Br J Dermatol , vol.134 , pp. 1044-1051
    • Schmid, P.1    Itin, D.2    Rufli, T.H.3
  • 129
    • 0035501025 scopus 로고    scopus 로고
    • Identification of genetic alterations in the TGF-beta type II receptor gene promoter
    • Seijo ER, Song H, Lynch MA, Jennings R, Qong X, Lazaridis E, et al. (2001). Identification of genetic alterations in the TGF-beta type II receptor gene promoter. Mutat Res 483:19-26.
    • (2001) Mutat Res , vol.483 , pp. 19-26
    • Seijo, E.R.1    Song, H.2    Lynch, M.A.3    Jennings, R.4    Qong, X.5    Lazaridis, E.6
  • 130
    • 10744228797 scopus 로고    scopus 로고
    • Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-β signalling, as a target of the β-catenin pathway in colorectal tumor cells
    • Sekiya T, Adachi S, Kohu K, Yamada T, Higuchi O, Furukawa Y, et al. (2004). Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-β signalling, as a target of the β-catenin pathway in colorectal tumor cells. J Biol Chem 279:6840-6846.
    • (2004) J Biol Chem , vol.279 , pp. 6840-6846
    • Sekiya, T.1    Adachi, S.2    Kohu, K.3    Yamada, T.4    Higuchi, O.5    Furukawa, Y.6
  • 131
    • 0037115396 scopus 로고    scopus 로고
    • Suppression of tumor metastases by blockade of transforming growth factor β signaling in bone marrow cells through a retroviral-mediated gene therapy in mice
    • Shah AH, Tabayoyong WB, Kundu SD, Kim S-J, Parijs LV, Liu VC, et al. (2002). Suppression of tumor metastases by blockade of transforming growth factor β signaling in bone marrow cells through a retroviral-mediated gene therapy in mice. Cancer Res 62:7135-7138.
    • (2002) Cancer Res , vol.62 , pp. 7135-7138
    • Shah, A.H.1    Tabayoyong, W.B.2    Kundu, S.D.3    Kim, S.-J.4    Parijs, L.V.5    Liu, V.C.6
  • 132
    • 0030837455 scopus 로고    scopus 로고
    • Structural basis for mutational inactivation of the tumor suppressor Smad4
    • Shi Y, Hata A, Lo RS, Massagué J, Pavletich NP (1997). Structural basis for mutational inactivation of the tumor suppressor Smad4. Nature 388:87-93.
    • (1997) Nature , vol.388 , pp. 87-93
    • Shi, Y.1    Hata, A.2    Lo, R.S.3    Massagué, J.4    Pavletich, N.P.5
  • 133
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
    • Siegel PM, Massagué J (2003). Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nat Rev Cancer 3:807-819.
    • (2003) Nat Rev Cancer , vol.3 , pp. 807-819
    • Siegel, P.M.1    Massagué, J.2
  • 134
    • 0037816160 scopus 로고    scopus 로고
    • Transforming growth factor β signaling impairs neu-induced mammary tumorigenesis while promoting pulmonary metastases
    • Siegel PM, Shu W, Cardiff RD, Muller WJ, Massagué J (2003). Transforming growth factor β signaling impairs neu-induced mammary tumorigenesis while promoting pulmonary metastases. Proc Natl Acad Sci USA 100:8430-8435.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8430-8435
    • Siegel, P.M.1    Shu, W.2    Cardiff, R.D.3    Muller, W.J.4    Massagué, J.5
  • 135
    • 0026600577 scopus 로고
    • Transforming growth factor-β overproduction in prostate cancer: Effects on growth in vivo and in vitro
    • Steiner MS, Barrack ER (1992). Transforming growth factor-β overproduction in prostate cancer: effects on growth in vivo and in vitro. Mol Endocrinol 6:15-25.
    • (1992) Mol Endocrinol , vol.6 , pp. 15-25
    • Steiner, M.S.1    Barrack, E.R.2
  • 136
    • 0033595704 scopus 로고    scopus 로고
    • Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein
    • Stroschein SL, Wang W, Zhou S, Zhou Q, Luo K (1999). Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein. Science 286:771-774.
    • (1999) Science , vol.286 , pp. 771-774
    • Stroschein, S.L.1    Wang, W.2    Zhou, S.3    Zhou, Q.4    Luo, K.5
  • 137
    • 0036791030 scopus 로고    scopus 로고
    • Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator
    • Suganuma T, Kawabata M, Ohshima T, Ikeda M-A (2002). Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator. Proc Natl Acad Sci USA 99:13073-13078.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13073-13078
    • Suganuma, T.1    Kawabata, M.2    Ohshima, T.3    Ikeda, M.-A.4
  • 138
    • 2642614530 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 is a new form of tumor suppressor with true haploid insufficiency
    • Tang B, Bottinger EP, Jakolew SB, Bagnall KM, Mariano J, Anver MR, et al. (1998). Transforming growth factor beta 1 is a new form of tumor suppressor with true haploid insufficiency. Nat Med 4:802-807.
    • (1998) Nat Med , vol.4 , pp. 802-807
    • Tang, B.1    Bottinger, E.P.2    Jakolew, S.B.3    Bagnall, K.M.4    Mariano, J.5    Anver, M.R.6
  • 139
    • 0242285692 scopus 로고    scopus 로고
    • TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
    • Tang B, Vu M, Booker T, Santner S, Miller FR, Anver M, et al. (2003). TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. J Clin Invest 112:1116-1124.
    • (2003) J Clin Invest , vol.112 , pp. 1116-1124
    • Tang, B.1    Vu, M.2    Booker, T.3    Santner, S.4    Miller, F.R.5    Anver, M.6
  • 140
    • 0347626102 scopus 로고    scopus 로고
    • Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines
    • Tian F, DaCosta Byfield S, Parks WT, Yoo S, Felici A, Tang B, et al. (2003). Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines. Cancer Res 63:8284-8292.
    • (2003) Cancer Res , vol.63 , pp. 8284-8292
    • Tian, F.1    DaCosta Byfield, S.2    Parks, W.T.3    Yoo, S.4    Felici, A.5    Tang, B.6
  • 141
    • 0034704916 scopus 로고    scopus 로고
    • Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras
    • Tremain R, Marko M, Kinnimulki V, Ueno H, Bottinger E, Glick A (2000). Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras. Oncogene 19:1698-1709.
    • (2000) Oncogene , vol.19 , pp. 1698-1709
    • Tremain, R.1    Marko, M.2    Kinnimulki, V.3    Ueno, H.4    Bottinger, E.5    Glick, A.6
  • 143
    • 0035881295 scopus 로고    scopus 로고
    • Reversion of transcriptional repression of Sp1 by 5 aza-2′ deoxycytidine restores TGF-beta type II receptor expression in the pancreatic cancer cell line MIA PaCa-2
    • Venkatasubbarao K, Ammanamanchi S, Brattain MG, Mimari D, Freeman JW (2001). Reversion of transcriptional repression of Sp1 by 5 aza-2′ deoxycytidine restores TGF-beta type II receptor expression in the pancreatic cancer cell line MIA PaCa-2. Cancer Res 61:6239-6247.
    • (2001) Cancer Res , vol.61 , pp. 6239-6247
    • Venkatasubbarao, K.1    Ammanamanchi, S.2    Brattain, M.G.3    Mimari, D.4    Freeman, J.W.5
  • 145
    • 0030003483 scopus 로고    scopus 로고
    • Loss of human E-cadherin (ECD) correlated with invasiveness of transitional cell cancer in the renal pelvis, ureter and urinary bladder
    • Wakatsuki S-J, Watanabe R, Saito K, Saito T, Katagiri A, Sato S, et al. (1996). Loss of human E-cadherin (ECD) correlated with invasiveness of transitional cell cancer in the renal pelvis, ureter and urinary bladder. Cancer Lett 103:11-17.
    • (1996) Cancer Lett , vol.103 , pp. 11-17
    • Wakatsuki, S.-J.1    Watanabe, R.2    Saito, K.3    Saito, T.4    Katagiri, A.5    Sato, S.6
  • 146
    • 0031410093 scopus 로고    scopus 로고
    • Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck
    • Wang D, Song HJ, Evans JA, Lang JC, Schuller DE, Weghorst CM (1997). Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck. Carcinogenesis 18:2285-2290.
    • (1997) Carcinogenesis , vol.18 , pp. 2285-2290
    • Wang, D.1    Song, H.J.2    Evans, J.A.3    Lang, J.C.4    Schuller, D.E.5    Weghorst, C.M.6
  • 147
    • 11944255353 scopus 로고
    • Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential
    • Welch DR, Fabra A, Nakajima M (1990). Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential. Proc Natl Acad Sci USA 87:7678-7682.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7678-7682
    • Welch, D.R.1    Fabra, A.2    Nakajima, M.3
  • 148
    • 0027548803 scopus 로고
    • Repression of autocrine transforming growth factor β1 and β2 in quiescent CBS colon carcinoma cells leads to progression of tumorigenic properties
    • Wu SP, Sun LZ, Willson JK, Humphrey L, Kerbel R, Brattain MG (1993). Repression of autocrine transforming growth factor β1 and β2 in quiescent CBS colon carcinoma cells leads to progression of tumorigenic properties. Cell Growth Differ 4:115-123.
    • (1993) Cell Growth Differ , vol.4 , pp. 115-123
    • Wu, S.P.1    Sun, L.Z.2    Willson, J.K.3    Humphrey, L.4    Kerbel, R.5    Brattain, M.G.6
  • 149
    • 0037081179 scopus 로고    scopus 로고
    • Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: A tissue microarray study
    • Xie W, Mertens JC, Reiss DJ, Rimm DL, Camp RL, Haffty BG, et al. (2002). Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study. Cancer Res 62:497-505.
    • (2002) Cancer Res , vol.62 , pp. 497-505
    • Xie, W.1    Mertens, J.C.2    Reiss, D.J.3    Rimm, D.L.4    Camp, R.L.5    Haffty, B.G.6
  • 150
    • 0034712832 scopus 로고    scopus 로고
    • Mutations in the tumor suppressors of Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway
    • Xu J, Attisano L (2000). Mutations in the tumor suppressors of Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 97:4820-4825.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4820-4825
    • Xu, J.1    Attisano, L.2
  • 151
    • 0036714017 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-β signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGF-β type I receptor kinase
    • Yakymovych I, Engstrom U, Grimsby S, Heldin C-H, Souchelnytskyi S (2002). Inhibition of transforming growth factor-β signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGF-β type I receptor kinase. Biochemistry 41:11000-11007.
    • (2002) Biochemistry , vol.41 , pp. 11000-11007
    • Yakymovych, I.1    Engstrom, U.2    Grimsby, S.3    Heldin, C.-H.4    Souchelnytskyi, S.5
  • 152
    • 0034568227 scopus 로고    scopus 로고
    • Smad protein expression and activation in transforming growth factor-β refractory human squamous cell carcinoma cells
    • Yan W, Vellucci F, Reiss M (2000). Smad protein expression and activation in transforming growth factor-β refractory human squamous cell carcinoma cells. Oncol Res 12:157-167.
    • (2000) Oncol Res , vol.12 , pp. 157-167
    • Yan, W.1    Vellucci, F.2    Reiss, M.3
  • 153
    • 0035847018 scopus 로고    scopus 로고
    • Oncogenic Ki-ras confers a more aggressive colon cancer phenotype through modification of transforming growth factor-β receptor III
    • Yan Z, Deng X, Friedman E (2001). Oncogenic Ki-ras confers a more aggressive colon cancer phenotype through modification of transforming growth factor-β receptor III. J Biol Chem 276:1555-1563.
    • (2001) J Biol Chem , vol.276 , pp. 1555-1563
    • Yan, Z.1    Deng, X.2    Friedman, E.3
  • 154
    • 0035126895 scopus 로고    scopus 로고
    • Autocrine transforming growth factor beta suppresses telomerase activity and transcription of human telomerase reverse transcriptase in human cancer cells
    • Yang H, Kyo S, Takatura M, Sun L (2001). Autocrine transforming growth factor beta suppresses telomerase activity and transcription of human telomerase reverse transcriptase in human cancer cells. Cell Growth Differ 12:119-127.
    • (2001) Cell Growth Differ , vol.12 , pp. 119-127
    • Yang, H.1    Kyo, S.2    Takatura, M.3    Sun, L.4
  • 155
    • 0036087521 scopus 로고    scopus 로고
    • Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects
    • Yang YA, Dukhanina O, Tang B, Mamura M, Letterio JJ, MacGregor J, et al (2002). Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects. J Clin Invest 109:1607-1615.
    • (2002) J Clin Invest , vol.109 , pp. 1607-1615
    • Yang, Y.A.1    Dukhanina, O.2    Tang, B.3    Mamura, M.4    Letterio, J.J.5    MacGregor, J.6
  • 156
    • 0036668842 scopus 로고    scopus 로고
    • TGF-β1-mediated epithelial to mesenchymal transition is accompanied by invasion in the SiHa cell line
    • Yi JY, Hur KC, Lee E, Jin YJ, Arteaga CL, Son YS (2002). TGF-β1-mediated epithelial to mesenchymal transition is accompanied by invasion in the SiHa cell line. Eur J Cell Biol 81:457-468.
    • (2002) Eur J Cell Biol , vol.81 , pp. 457-468
    • Yi, J.Y.1    Hur, K.C.2    Lee, E.3    Jin, Y.J.4    Arteaga, C.L.5    Son, Y.S.6
  • 157
    • 0032918414 scopus 로고    scopus 로고
    • TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
    • Yin JJ, Selander K, Chirgwin JM, Dallas M, Grubbs BG, Wieser R, et al. (1999). TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest 103:197-206.
    • (1999) J Clin Invest , vol.103 , pp. 197-206
    • Yin, J.J.1    Selander, K.2    Chirgwin, J.M.3    Dallas, M.4    Grubbs, B.G.5    Wieser, R.6
  • 158
    • 0028845062 scopus 로고
    • Signaling by the transforming growth factor-β receptors
    • Yingling JM, Wang XF, Bassing CH (1995). Signaling by the transforming growth factor-β receptors. Biochim Biophys Acta 1242:115-136.
    • (1995) Biochim Biophys Acta , vol.1242 , pp. 115-136
    • Yingling, J.M.1    Wang, X.F.2    Bassing, C.H.3
  • 159
    • 0038744921 scopus 로고    scopus 로고
    • Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas
    • Yokoyama K, Kamata N, Fujimoto R, Tsutsumi S, Tomonari M, Taki M, et al. (2003). Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas. Int J Oncol 22:891-898.
    • (2003) Int J Oncol , vol.22 , pp. 891-898
    • Yokoyama, K.1    Kamata, N.2    Fujimoto, R.3    Tsutsumi, S.4    Tomonari, M.5    Taki, M.6
  • 160
    • 0035810944 scopus 로고    scopus 로고
    • Genetic programs of epithelial cell plasticity directed by transforming growth factor-β
    • Zavadil J, Bitzer M, Liang D, Yang Y-C, Massimi A, Kneitz S, et al. (2001). Genetic programs of epithelial cell plasticity directed by transforming growth factor-β. Proc Natl Acad Sci USA 98:6686-6691.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6686-6691
    • Zavadil, J.1    Bitzer, M.2    Liang, D.3    Yang, Y.-C.4    Massimi, A.5    Kneitz, S.6
  • 161
    • 0028856547 scopus 로고
    • Regulation of transforming growth factor beta receptors in H-ras oncogene transformed rat intestinal epithelial cells
    • Zhao J, Buick RN (1995). Regulation of transforming growth factor beta receptors in H-ras oncogene transformed rat intestinal epithelial cells. Cancer Res 55:61881-61888.
    • (1995) Cancer Res , vol.55 , pp. 61881-61888
    • Zhao, J.1    Buick, R.N.2
  • 162
    • 0038519756 scopus 로고    scopus 로고
    • Requirement for a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor β type II receptor expression in human pancreatic cancer cells
    • Zhao S, Venkatasubbarao K, Li S, Freeman JW (2003). Requirement for a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor β type II receptor expression in human pancreatic cancer cells. Cancer Res 63:2624-2630.
    • (2003) Cancer Res , vol.63 , pp. 2624-2630
    • Zhao, S.1    Venkatasubbarao, K.2    Li, S.3    Freeman, J.W.4
  • 163
    • 0032544448 scopus 로고    scopus 로고
    • Smad3 mutant mice develop metastatic colorectal cancer
    • Zhu Y, Richardson JA, Parada LF, Graff JM (1998). Smad3 mutant mice develop metastatic colorectal cancer. Cell 94:703-714.
    • (1998) Cell , vol.94 , pp. 703-714
    • Zhu, Y.1    Richardson, J.A.2    Parada, L.F.3    Graff, J.M.4
  • 164
    • 0035853883 scopus 로고    scopus 로고
    • Association between the T29 > C polymorphism in the transforming growth factor beta 1 gene and breast cancer among elderly white women: The study of osteoporotic women
    • Ziv E, Cauley J, Morin PA, Saiz R, Browner WS (2001). Association between the T29 > C polymorphism in the transforming growth factor beta 1 gene and breast cancer among elderly white women: the study of osteoporotic women. J Am Med Assoc 285:2859-2863.
    • (2001) J Am Med Assoc , vol.285 , pp. 2859-2863
    • Ziv, E.1    Cauley, J.2    Morin, P.A.3    Saiz, R.4    Browner, W.S.5


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