Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin-proteasome pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 9, 2000, Pages 4820-4825

  Xu, Jing ^a   Attisano, Liliana ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEASOME; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN;

ARTICLE; CANCER GENETICS; GENE MUTATION; HUMAN; MALIGNANT NEOPLASTIC DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; ARGININE; CELL NUCLEUS; COLORECTAL NEOPLASMS; CONSERVED SEQUENCE; CYSTEINE ENDOPEPTIDASES; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; HUMANS; MULTIENZYME COMPLEXES; MUTATION, MISSENSE; PANCREATIC NEOPLASMS; PROMOTER REGIONS (GENETICS); PROTEASOME ENDOPEPTIDASE COMPLEX; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD4 PROTEIN; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; UBIQUITINS;

EID: 0034712832     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.9.4820     Document Type: Article

References (33)

1. Attisano, L. & Wrana, J. L. (2000) Curr. Op. Cell Biol. 12, 235-243.
2. Heldin, C.-H., Miyazono, K. & ten Dijke, P. (1997) Nature (London) 390, 465-471.
3. Massagué, J. (1998) Annu. Rev. Biochem. 67, 753-791.
4. Markowitz, S. D. & Roberts, A. B. (1996) Cytokine Growth Factor Rev. 7, 93-102.
5. Hata, A., Shi, Y. & Massague, J. (1998) Mol. Med. Today 6, 257-262.
6. Derynck, R., Zhang, Y. & Feng, X.-H. (1998) Cell 95, 737-740.
7. Eppert, K., Scherer, S. W., Ozcelik, H., Pirone, R., Hoodless, P., Kim, H., Tsui, L.-C., Bapat, B., Gallinger, S., Andrulis, I., et al. (1996) Cell 86, 543-552.
8. Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., et al. (1996) Science 271, 350-353.
9. Riggins, G. J., Thiagalingam, S., Rozenblum, E., Weinstein, C. L., Kern, S. E., Hamilton, S. R., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W. & Vogelstein, B. (1996) Nat. Genet. 13, 347-349.
10. Howe, J. R., Roth, S., Ringold, J. C., Summers, R. W., Jarvinen, H. J., Sistonen, P., Tomlinson, I. P. M., Houlston, R. S., Bevan, S., Mitros, F. A., et al. (1998) Science 280, 1086-1088.
11. Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M. F. & Taketo, M. M. (1998) Cell 92, 645-656.
12. Zhu, Y., Richardson, J. A., Parada, L. F. & Graff, J. M. (1998) Cell 94, 703-714.
13. Shi, Y., Hata, A., Lo, R. S., Massagué, J. & Pavletich, N. P. (1997) Nature (London) 388, 87-93.
14. Schutte, M., Hruban, R. H., Hedrick, L., Cho, K. R., Nadasdy, G. M., Weinstein, C. L., Bova, G. S., Isaacs, W. B., Cairns, P., Nawroz, H., et al. (1996) Cancer Res. 56, 2527-2530.
15. Macías-Silva, M., Abdollah, S., Hoodless, P. A., Pirone, R., Attisano, L. & Wrana, J. L. (1996) Cell 87, 1215-1224.
16. Labbé, E., Silvestri, C., Hoodless, P. A., Wrana, J. L. & Attisano, L. (1998) Mol. Cell 2, 109-120.
17. Hoodless, P. A., Haerry, T., Abdollah, S., Stapleton, M., O'Connor, M. B., Attisano, L. & Wrana, J. L. (1996) Cell 85, 489-500.
18. Gonen, H., Bercovich, B., Orian, A., Carrano, A., Takizawa, C., Yamanaka, K., Pagano, M., Iwai, K. & Ciechanover, A. (1999) J. Biol. Chem. 274, 14823-14830.
19. Chen, X., Weisberg, E., Fridmacher, V., Watanabe, M., Naco, G. & Whitman, M. (1997) Nature (London) 389, 85-89.
20. Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y.-Y., Grinnell, B. W., Richardson, M. A., Topper, J. N., Gimbrone, M. A., Jr., Wrana, J. L., et al. (1997) Cell 89, 1165-1173.
21. Liu, F., Pouponnot, C. & Massagué, J. (1997) Genes Dev. 11, 3157-3167.
22. Hata, A., Lo, R. S., Wotton, D., Lagna, G. & Massagué, J. (1997) Nature (London) 388, 82-87.
23. Dai, J. L., Turnacioglu, K. K., Schutte, M., Sugar, A. Y. & Kern, S. E. (1998) Cancer Res. 58, 4592-4597.
24. Song, C.-Z., Siok, T. E. & Gelehrter, T. D. (1998) J. Biol. Chem. 273, 29287-29290.
25. Hoodless, P. A., Tsukazaki, T., Nishimatsu, S.-i., Attisano, L., Wrana, J. L. & Thomsen, G. H. (1999) Dev. Biol. 207, 364-379.
26. Zhou, S., Zawel, L., Lengauer, C., Kinzler, K. W. & Vogelstein, B. (1998) Mol. Cell 2, 121-127.
27. Stroschein, S. L., Wang, W. & Luo, K. (1999) J. Biol. Chem. 274, 9431-9441.
28. Hershko, A. & Ciechanover, A. (1998) Annu. Rev. Biochem. 67, 425-479.
29. Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J. & Schreiber, S. L. (1995) Science 268, 726-731.
30. Shimizu, K. & Gurdon, J. B. (1999) Proc. Natl. Acad. Sci. USA 96, 6791-6796.
31. Shi, Y., Wang, Y.-F., Jayaraman, L., Yang, H., Massagué, J. & Pavletich, N. P. (1998) Cell 94, 585-594.
32. Lo, R. S. & Massagué, J. (1999) Nat. Cell Biol. 1, 472-478.
33. Zhu, H., Kavsak, P., Abdollah, S., Wrana, J. L. & Thomsen, G. H. (1999) Nature (London) 400, 687-693.