Raf induces TGFβ production while blocking its apoptotic but not invasive responses: A mechanism leading to increased malignancy in epithelial cells

Genes and Development

Volumn 14, Issue 20, 2000, Pages 2610-2622

  Lehmann, Kerstin ^a   Janda, Elzbieta ^b   Pierreux, Christophe E ^a   Rytömaa, Marjatta ^a   Schulze, Almut ^a   McMahon, Martin ^c   Hill, Caroline S ^a   Beug, Hartmut ^b   Downward, Julian ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Raf; Ras; SMAD; TGF

Indexed keywords

COLLAGEN GEL; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; RAS PROTEIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; 4 HYDROXYTAMOXIFEN; 4-HYDROXYTAMOXIFEN; COLLAGEN; DNA BINDING PROTEIN; DRUG DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; RECOMBINANT PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TAMOXIFEN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL INVASION; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; EPITHELIUM CELL; GENE TRANSLOCATION; GROWTH INHIBITION; MALIGNANT TRANSFORMATION; MESENCHYME; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSACTIVATION; ANIMAL; CELL DIVISION; CELL LINE; DOG; DRUG EFFECT; GENETICS; MESODERM; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALIA;

ANIMALS; APOPTOSIS; CELL DIVISION; CELL LINE; COLLAGEN; DNA-BINDING PROTEINS; DOGS; EPITHELIAL CELLS; MESODERM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-RAF; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TAMOXIFEN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034666839     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.181700     Document Type: Article

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