Comparative biology of mouse versus human cells: Modelling human cancer in mice

Nature Reviews Cancer

Volumn 3, Issue 12, 2003, Pages 952-959

  Rangarajan, Annapoorni ^a   Weinberg, Robert A ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; PROTEIN P53; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN;

BONE MARROW CELL; BREEDING METHOD; CANCER; CANCER SUSCEPTIBILITY; CARCINOGENESIS; COMPARATIVE STUDY; DISEASE MODEL; DNA MODIFICATION; GENE DELETION; GENE TARGETING; HUMAN; KARYOTYPE; LABORATORY; MOLECULAR CLONING; NF1 GENE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPECIES DIFFERENCE; TUMOR SUPPRESSOR GENE; ANIMAL; CHEMICAL STRUCTURE; METABOLISM; MOUSE; NEOPLASM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; MICE; MODELS, MOLECULAR; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 1342288971     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1235     Document Type: Review

References (66)

1. Van Dyke, T. & Jacks, T. Cancer modeling in the modern era: progress and challenges. Cell 108, 135-144 (2002).
2. Herzig, M. & Christofori, G. Recent advances in cancer research: mouse models of tumorigenesis. Biochim. Biophys. Acta 1602, 97-113 (2002).
3. Jonkers, J. & Berns, A. Conditional mouse models of sporadic cancer. Nature Rev. Cancer 2, 251-265 (2002).
4. Ames, B. N., Saul, R. L. Schwiers, E., Adelman, R. & Cathcart, R. in Molecular Biology of Ageing (eds Sohal, R. S., Birnbam, L. S. & Cutler, R. G.) 137-144 (Raven Press, New York, 1985).
5. Holliday, R. Neoplastic transformation: the contrasting stability of human and mouse cells. Cancer Surv. 28, 103-115 (1996).
6. Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57-70 (2000).
7. Ames, B. N., Shigenaga, M. K. & Hagen, T. M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl Acad. Sci. USA 90, 7315-7322 (1993).
8. Adelman, R., Saul, R. L. & Ames, B. N. Oxidative damage to DNA: relation to species metabolic rate and life span. Proc. Natl Acad. Sci. USA 85, 2706-2708 (1988).
9. Schwartz, A. G. & Moore, C. J. Inverse correlation between species life span and capacity of cultured fibroblasts to bind 7, 12-dimethylbenz(a) anthracene to DNA. Exp. Cell Res. 109, 448-450 (1977).
10. DePinho, R. A. The age of cancer. Nature 408, 246-254 (2000).
11. Blasco, M. A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25-34 (1997).
12. Lee, H. W. et al. Essential role of mouse telomerase in highly proliferative organs. Nature 392, 569-574 (1998).
13. Artandi, S. E. et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 408, 641-645 (2000).
14. Atkin, N.B. Lack of reciprocal translocations in carcinomas. Cancer Genet. Cytogenet. 21, 275-278 (1986).
15. Heyer, J., Yang, K., Lipkin, M., Edelmann, W. & Kucherlapati, R. Mouse models for colorectal cancer. Oncogene 18, 5325-5333 (1999).
16. Newbold, R. F., Overell, R. W. & Connell, J. R. Induction of immortality is an earty event in malignant transformation of mammalian cells by carcinogens. Nature 299, 633-635 (1982).
17. Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621 (1961).
18. Shay, J. W., Wright, W. E. & Werbin, H. Defining the molecular mechanisms of human cell immortalization. Biochim. Biophys. Acta 1072, 1-7 (1991).
19. Harley, C. B. et al. Telomerase, cell immortality, and cancer. Cold Spring Harb. Symp. Quant. Biol. 59, 307-315 (1994).
20. Prowse, K. R. & Greider, C. W. Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl Acad. Sci. USA 92, 4818-4822 (1995).
21. Kim, N. W. et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015 (1994).
22. Vaziri, H. & Benchimol, S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8, 279-282 (1998).
23. Sherr, C. J. The INK4a/ARF network in tumour suppression. Nature Rev. Mol. Cell Biol. 2, 731-737 (2001).
24. Pamnello, S. et al. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nature Cell Biol. 5, 741-747 (2003).
25. Sherr, C. J. & DePinho, R. A. Cellular senescence: mitotic clock or culture shock? Cell 102, 407-410 (2000).
26. INK4a. Cell 88, 593-602 (1997).
27. Zindy, F. et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 12, 2424-2433 (1998).
28. ARF. Cell 91, 649-659 (1997).
29. Harvey, M. et al. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 8, 2457-2467 (1993).
30. Pantoja, C. & Serrano, M. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. Oncogene 18, 4974-4982 (1999).
31. Art predisposes mice to tumorigenesis. Nature 413, 86-91 (2001).
32. Sage, J. et al. Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev. 14, 3037-3050 (2000).
33. ink4a confers susceptibility to metastatic melanoma in mice. Nature 413, 83-86 (2001).
34. Dannenberg, J. H., van Rossum, A., Schuijff, L. & te Riele, H. Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev. 14, 3051-3064 (2000).
35. Peeper, D. S., Dannenberg, J. H., Douma, S., te Riele, H. & Bernards, R. Escape from premature senescence is not sufficient for oncogenic transformation by Ras. Nature Cell Biol. 3, 198-203 (2001).
36. ARF in replicative and induced senescence of human fibroblasts. Mol. Cell Biol. 21, 6748-6757 (2001).
37. INK4a-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol. Cell Biol. 20, 1436-1447 (2000).
38. INK4A(-) human mammary epithelial cells. Proc. Natl Acad. Sci. USA 98, 4498-4503 (2001).
39. INK4a confer resistance to Ras-and Ets-induced senescence in human diploid fibroblasts. Mol Cell Biol 22, 8135-43 (2002).
40. INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts. Mol. Cell Biol. 15, 4745-4753 (1995).
41. CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277, 831-834 (1997).
42. Rodriguez-Viciana, P. et al. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89, 457-467 (1997).
43. Campbell, S. L., Khosravi-Far, R., Rossman, K. L., Clark, G. J. & Der, C. J. Increasing complexity of Ras signaling. Oncogene 17, 1395-1413 (1998).
44. Morales, C. P. et al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nature Genet. 21, 115-118 (1999).
45. Hahn, W. C. et al. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol. Cell Biol. 22, 2111-2123 (2002).
46. Hahn, W. C. et al. Creation of human tumour cells with defined genetic elements. Nature 400, 464-468 (1999).
47. Janssens, V. & Goris, J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353, 417-439 (2001).
48. Zhao, J. J. et al. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell 3, 483-495 (2003).
49. Lazarov, M. et al. CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis. Nature Med. 8, 1105-1114 (2002).
50. Seger, Y. R. et al. Transformation of normal human cells in the absence of telomerase activation. Cancer Cell 2, 401-413 (2002).
51. Oldham, S. M., Clark, G. J., Gangarosa, L. M., Coffey, R. J. Jr. & Der, C. J. Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells. Proc. Natl Acad. Sci. USA 93, 6924-6928 (1996).
52. Hamad, N. M. et al. Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev. 16, 2045-2057 (2002).
53. Robanus-Maandag, E. et al. p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev. 12, 1599-1609 (1998).
54. Giovannini, M. et al. Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev. 14, 1617-1630 (2000).
55. Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363-9367 (1995).
56. Chin, L. et al. Essential role for oncogenic Ras in tumour maintenance. Nature 400, 468-472 (1999).
57. Zhu, Y., Ghosh, P., Charnay, P., Burns, D. K. & Parada, L. F. Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science 296, 920-922 (2002).
58. Lyden, D. et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth Nature Med. 7, 1194-1201 (2001).
59. Coussens, L. M. et al. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev. 13, 1382-1397 (1999).
60. Rabbany, S. Y., Heissig, B., Hattori, K. & Rafil, S. Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization. Trends Mol. Med. 9, 109-117 (2003).
61. Pompei, F., Polkanov, M. & Wilson, R. Age distribution of cancer in mice: the incidence turnover at old age. Toxicol. Ind. Health 17, 7-16 (2001).
62. Bayani, J. et al. Parallel analysis of sporadic primary ovarian carcinomas by spectral karyotyping, comparative genomic hybridization, and expression microarrays. Cancer Res. 62, 3466-3476 (2002).
63. Shibata, H. et al. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science 278, 120-123 (1997).
64. Xu, X. et al. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nature Genet. 22, 37-43 (1999).
65. Jonkers, J. et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nature Genet. 29, 418-425 (2001).
66. Reilly, K. M., Loisel, D. A., Bronson, R. T., McLaughlin, M. E. & Jacks, T. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nature Genet. 26, 109-113 (2000).