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Volumn 3, Issue 1, 2003, Pages 11-22

Targeting RAS signalling pathways in cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; CANERTINIB; CETUXIMAB; CGP 69846A; ERLOTINIB; EVEROLIMUS; GEFITINIB; GROWTH FACTOR RECEPTOR; IMATINIB; ISIS 2503; L 778123; LAPATINIB; LONAFARNIB; PELITINIB; PHOSPHOTRANSFERASE INHIBITOR; PK 1116; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN KINASE B; RAS PROTEIN; SORAFENIB; TEMSIROLIMUS; TIPIFARNIB; TRASTUZUMAB; UNCLASSIFIED DRUG; ZANESTRA; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN;

EID: 0037264633     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc969     Document Type: Review
Times cited : (2672)

References (87)
  • 2
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos, J. L. Ras oncogenes in human cancer: a review. Cancer Res. 49, 4682-4689 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 5
    • 0031687777 scopus 로고    scopus 로고
    • Signal transduction via Ras
    • Wittinghofer, A. Signal transduction via Ras. Biol. Chem. 379, 933-937 (1998).
    • (1998) Biol. Chem. , vol.379 , pp. 933-937
    • Wittinghofer, A.1
  • 7
    • 0345135149 scopus 로고    scopus 로고
    • K-ras is an essential gene in the mouse with partial functional overlap with N-ras
    • Johnson, L. et al. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 11, 2468-2481 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 2468-2481
    • Johnson, L.1
  • 8
    • 0031970317 scopus 로고    scopus 로고
    • Membrane association and targeting of prenylated Ras-like GTPases
    • Seabra, M. C. Membrane association and targeting of prenylated Ras-like GTPases. Cell Signal. 10, 167-172 (1998).
    • (1998) Cell Signal. , vol.10 , pp. 167-172
    • Seabra, M.C.1
  • 9
    • 0030749458 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?
    • Cox, A. D. & Der, C. J. Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras? Biochim. Biophys. Acta 1333, F51-F71 (1997).
    • (1997) Biochim. Biophys. Acta , vol.1333
    • Cox, A.D.1    Der, C.J.2
  • 10
    • 0024406286 scopus 로고
    • All ras proteins are polyisoprenylated but only some are palmitoylated
    • Hancock, J. F., Magee, A. I., Childs, J. E. & Marshall, C. J. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57, 1167-1177 (1989).
    • (1989) Cell , vol.57 , pp. 1167-1177
    • Hancock, J.F.1    Magee, A.I.2    Childs, J.E.3    Marshall, C.J.4
  • 11
    • 0025013547 scopus 로고
    • A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
    • Hancock, J. F., Paterson, H. & Marshall, C. J. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell 63, 133-139 (1990). References 10 and 11 describe the original characterization of the modification of RAS by farnesylation and, in the case of HRAS and NRAS, but not KRAS, palmitoylation.
    • (1990) Cell , vol.63 , pp. 133-139
    • Hancock, J.F.1    Paterson, H.2    Marshall, C.J.3
  • 12
    • 0034104590 scopus 로고    scopus 로고
    • The Ras branch of small GTPases: Ras family members don't fall far from the tree
    • Reuther, G. W. & Der, C. J. The Ras branch of small GTPases: Ras family members don't fall far from the tree. Curr. Opin. Cell Biol. 12, 157-165 (2000).
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 157-165
    • Reuther, G.W.1    Der, C.J.2
  • 15
    • 0030044360 scopus 로고    scopus 로고
    • Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
    • Daub, H., Weiss, F. U., Wallasch, C. & Ullrich, A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379, 557-560 (1996).
    • (1996) Nature , vol.379 , pp. 557-560
    • Daub, H.1    Weiss, F.U.2    Wallasch, C.3    Ullrich, A.4
  • 16
    • 0036091925 scopus 로고    scopus 로고
    • Ras signalling on the endoplasmic reticulum and the Golgi
    • Chiu, V. K. et al. Ras signalling on the endoplasmic reticulum and the Golgi. Nature Cell Biol. 4, 343-350 (2002).
    • (2002) Nature Cell Biol. , vol.4 , pp. 343-350
    • Chiu, V.K.1
  • 17
    • 0032524389 scopus 로고    scopus 로고
    • RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
    • Ebinu, J. O. et al. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science 280, 1082-1086 (1998).
    • (1998) Science , vol.280 , pp. 1082-1086
    • Ebinu, J.O.1
  • 19
    • 0037075886 scopus 로고    scopus 로고
    • GTPase activating proteins: Critical regulators of intracellular signaling
    • Donovan, S., Shannon, K. M. & Bollag, G. GTPase activating proteins: critical regulators of intracellular signaling. Biochim. Biophys. Acta 1602, 23-45 (2002).
    • (2002) Biochim. Biophys. Acta , vol.1602 , pp. 23-45
    • Donovan, S.1    Shannon, K.M.2    Bollag, G.3
  • 20
    • 0028272507 scopus 로고
    • Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
    • Leevers, S. J., Paterson, H. F. & Marshall, C. J. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369, 411-414 (1994).
    • (1994) Nature , vol.369 , pp. 411-414
    • Leevers, S.J.1    Paterson, H.F.2    Marshall, C.J.3
  • 21
    • 0029006126 scopus 로고
    • Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation
    • Marais, R., Light, Y., Paterson, H. F. & Marshall, C. J. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J. 14, 3136-3145 (1995).
    • (1995) EMBO J. , vol.14 , pp. 3136-3145
    • Marais, R.1    Light, Y.2    Paterson, H.F.3    Marshall, C.J.4
  • 22
    • 0034684620 scopus 로고    scopus 로고
    • Signal transduction and the Ets family of transcription factors
    • Yordy, J. S. & Muise-Helmericks, R. C. Signal transduction and the Ets family of transcription factors. Oncogene 19, 6503-6513 (2000).
    • (2000) Oncogene , vol.19 , pp. 6503-6513
    • Yordy, J.S.1    Muise-Helmericks, R.C.2
  • 23
    • 0035964458 scopus 로고    scopus 로고
    • Ras and Rho regulation of the cell cycle and oncogenesis
    • Pruitt, K. & Der C. J. Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett. 171, 1-10 (2001).
    • (2001) Cancer Lett. , vol.171 , pp. 1-10
    • Pruitt, K.1    Der, C.J.2
  • 24
    • 0028074316 scopus 로고
    • Phosphatidylinositol-3-OH kinase as a direct target of Ras
    • Rodriguez-Viciana, P. et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370, 527-532 (1994).
    • (1994) Nature , vol.370 , pp. 527-532
    • Rodriguez-Viciana, P.1
  • 25
    • 0033635157 scopus 로고    scopus 로고
    • Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinaseγ
    • Pacold, M. E. et al. Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinaseγ. Cell 103, 931-943 (2000). This describes the three-dimensional structure of RAS in complex with one of its effectors, PI3K. The size of the interaction interface shows the difficulty that is likely to face the design of inhibitors of protein-protein interaction.
    • (2000) Cell , vol.103 , pp. 931-943
    • Pacold, M.E.1
  • 26
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta, S. R., Brunet, A. & Greenberg, M. E. Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 27
    • 0030913673 scopus 로고    scopus 로고
    • Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
    • Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P. H. & Downward, J. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16, 2783-2793 (1997).
    • (1997) EMBO J. , vol.16 , pp. 2783-2793
    • Khwaja, A.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 28
    • 0036051325 scopus 로고    scopus 로고
    • Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism
    • Lambert, J. M. et al. Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nature Cell Biol. 4, 621-625 (2002).
    • (2002) Nature Cell Biol. , vol.4 , pp. 621-625
    • Lambert, J.M.1
  • 29
    • 0037142034 scopus 로고    scopus 로고
    • Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours
    • Malliri, A. et al. Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature 417, 867-871 (2002).
    • (2002) Nature , vol.417 , pp. 867-871
    • Malliri, A.1
  • 30
    • 0035171566 scopus 로고    scopus 로고
    • Regulation of the Forkhead transcription factor AFX by Ra1-dependent phosphorylation of threonines 447 and 451
    • De Ruiter, N. D., Burgering, B. M. & Bos, J. L. Regulation of the Forkhead transcription factor AFX by Ra1-dependent phosphorylation of threonines 447 and 451. Mol. Cell. Biol. 21, 8225-8235 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 8225-8235
    • De Ruiter, N.D.1    Burgering, B.M.2    Bos, J.L.3
  • 32
    • 0033605482 scopus 로고    scopus 로고
    • Hyperactive Ras as a therapeutic target in neurofibromatosis type 1
    • Weiss, B., Bollag, G. & Shannon, K. Hyperactive Ras as a therapeutic target in neurofibromatosis type 1. Am. J. Med. Genet. 89, 14-22 (1999).
    • (1999) Am. J. Med. Genet. , vol.89 , pp. 14-22
    • Weiss, B.1    Bollag, G.2    Shannon, K.3
  • 33
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn, J. & Baselga, J. The EGF receptor family as targets for cancer therapy. Oncogene 19, 6550-6565 (2000).
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 34
    • 0034947649 scopus 로고    scopus 로고
    • EGF mutant receptor vIII as a molecular target in cancer therapy
    • Kuan, C. T., Wikstrand, C. J. & Bigner, D. D. EGF mutant receptor vIII as a molecular target in cancer therapy Endocr. Relat. Cancer 8, 83-96 (2001).
    • (2001) Endocr. Relat. Cancer , vol.8 , pp. 83-96
    • Kuan, C.T.1    Wikstrand, C.J.2    Bigner, D.D.3
  • 35
    • 0029127042 scopus 로고
    • Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
    • Bellacosa, A. et al. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int. J. Cancer 64, 280-285 (1995).
    • (1995) Int. J. Cancer , vol.64 , pp. 280-285
    • Bellacosa, A.1
  • 36
    • 0035835824 scopus 로고    scopus 로고
    • PTEN: Life as a tumor suppressor
    • Simpson, L. & Parsons, R. PTEN: life as a tumor suppressor. Exp. Cell Res. 264, 29-41 (2001).
    • (2001) Exp. Cell Res. , vol.264 , pp. 29-41
    • Simpson, L.1    Parsons, R.2
  • 37
    • 0034722890 scopus 로고    scopus 로고
    • Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies
    • Sebti, S. M. & Hamilton, A. D. Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies. Oncogene 19, 6584-6593 (2000).
    • (2000) Oncogene , vol.19 , pp. 6584-6593
    • Sebti, S.M.1    Hamilton, A.D.2
  • 38
    • 0036667388 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors: Promises and realities
    • Cox, A. D. & Der, C. J. Farnesyltransferase inhibitors: promises and realities. Curr. Opin. Pharmacol. 2, 388-393 (2002).
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 388-393
    • Cox, A.D.1    Der, C.J.2
  • 39
    • 0029150669 scopus 로고
    • Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
    • Kohl, N. E. et al. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nature Med. 1, 792-797 (1995). The study that launched massive interest in farnesyltransferase inhibitors as tumour therapeutic drugs aimed at RAS. Unfortunately, the activity turned out to be selective for HRAS, an isoform that is only very rarely activated in human tumours.
    • (1995) Nature Med. , vol.1 , pp. 792-797
    • Kohl, N.E.1
  • 40
    • 0035893740 scopus 로고    scopus 로고
    • Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models
    • Lobell, R. B. et al. Evaluation of farnesyl: protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. Cancer Res. 61, 8758-8768 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 8758-8768
    • Lobell, R.B.1
  • 41
    • 0035523359 scopus 로고    scopus 로고
    • Actin' up: RhoB in cancer and apoptosis
    • Prendergast, G. C. Actin' up: RhoB in cancer and apoptosis. Nature Rev. Cancer 1, 162-168 (2001).
    • (2001) Nature Rev. Cancer , vol.1 , pp. 162-168
    • Prendergast, G.C.1
  • 43
    • 0036489947 scopus 로고    scopus 로고
    • Current progress on farnesyl protein transferase inhibitors
    • Singh, S. B. & Lingham, R. B. Current progress on farnesyl protein transferase inhibitors. Curr. Opin Drug Discov. Devel. 5, 225-244 (2002).
    • (2002) Curr. Opin Drug Discov. Devel. , vol.5 , pp. 225-244
    • Singh, S.B.1    Lingham, R.B.2
  • 44
    • 0012446889 scopus 로고    scopus 로고
    • Efficacy of the farnesyl transferase inhibitor, ZARNESTRATM (R115777), in chronic myeloid leukemia and other other hematological malignancies
    • Cortes, J. E. et al. Efficacy of the farnesyl transferase inhibitor, ZARNESTRATM (R115777), in chronic myeloid leukemia and other other hematological malignancies. Blood 31, 31 (2002).
    • (2002) Blood , vol.31 , pp. 31
    • Cortes, J.E.1
  • 45
    • 0034722899 scopus 로고    scopus 로고
    • Potential roles of antisense technology in cancer chemotherapy
    • Crooke, S. T. Potential roles of antisense technology in cancer chemotherapy. Oncogene 19, 6651-6659 (2000).
    • (2000) Oncogene , vol.19 , pp. 6651-6659
    • Crooke, S.T.1
  • 46
    • 0025868669 scopus 로고
    • Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA
    • Mukhopadhyay, T., Tainsky, M., Cavender, A. C. & Roth, J. A. Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA. Cancer Res. 51, 1744-1748 (1991).
    • (1991) Cancer Res. , vol.51 , pp. 1744-1748
    • Mukhopadhyay, T.1    Tainsky, M.2    Cavender, A.C.3    Roth, J.A.4
  • 47
    • 0029903628 scopus 로고    scopus 로고
    • Antisense oligonuclectides demonstrate a dominant role of c-Ki-RAS proteins in regulating the proliferation of diploid human fibroblasts
    • Chen, G., Oh, S., Monia, B. P. & Stacey, D. W. Antisense oligonuclectides demonstrate a dominant role of c-Ki-RAS proteins in regulating the proliferation of diploid human fibroblasts. J. Biol. Chem. 271, 28259-28265 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 28259-28265
    • Chen, G.1    Oh, S.2    Monia, B.P.3    Stacey, D.W.4
  • 48
    • 0029977448 scopus 로고    scopus 로고
    • Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase
    • Monia, B. P., Johnston, J. F., Geiger, T., Muller, M. & Fabbro, D. Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase. Nature Med. 2, 668-675 (1996)
    • (1996) Nature Med. , vol.2 , pp. 668-675
    • Monia, B.P.1    Johnston, J.F.2    Geiger, T.3    Muller, M.4    Fabbro, D.5
  • 49
    • 17744378364 scopus 로고    scopus 로고
    • MEK kinase activity is not necessary for Raf-1 function
    • Hüser, M. et al. MEK kinase activity is not necessary for Raf-1 function. EMBO J. 20, 1940-1951 (2001).
    • (2001) EMBO J. , vol.20 , pp. 1940-1951
    • Hüser, M.1
  • 50
    • 0034783583 scopus 로고    scopus 로고
    • Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer. A European Organization for Research and Treatment of Cancer (EORTC) Early Clinical Studies Group report
    • Coudert, B. et al. Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer. A European Organization for Research and Treatment of Cancer (EORTC) Early Clinical Studies Group report. Eur. J. Cancer 37, 2194-2198 (2001).
    • (2001) Eur. J. Cancer , vol.37 , pp. 2194-2198
    • Coudert, B.1
  • 51
    • 0036467568 scopus 로고    scopus 로고
    • Rational therapeutic intervention in cancer: Kinases as drug targets
    • Sawyers, C. L. Rational therapeutic intervention in cancer: kinases as drug targets. Curr. Opin. Genet. Dev. 12, 111-115 (2002).
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 111-115
    • Sawyers, C.L.1
  • 52
    • 0033590636 scopus 로고    scopus 로고
    • Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
    • Hoshino, R. et al. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene 18, 813-822 (1999).
    • (1999) Oncogene , vol.18 , pp. 813-822
    • Hoshino, R.1
  • 54
    • 14444279192 scopus 로고    scopus 로고
    • Identification of a novel inhibitor of mitogen-activated protein kinase kinase
    • Favata, M. F. et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273, 18623-18632 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 18623-18632
    • Favata, M.F.1
  • 55
    • 0034722894 scopus 로고    scopus 로고
    • Development of anticancer drugs targeting the MAP kinase pathway
    • Sebolt-Leopold, J. S. Development of anticancer drugs targeting the MAP kinase pathway. Oncogene 19, 6594-6599 (2000).
    • (2000) Oncogene , vol.19 , pp. 6594-6599
    • Sebolt-Leopold, J.S.1
  • 56
    • 0032984348 scopus 로고    scopus 로고
    • Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
    • Sebolt-Leopold, J. S. et al. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nature Med. 5, 810-816 (1999).
    • (1999) Nature Med. , vol.5 , pp. 810-816
    • Sebolt-Leopold, J.S.1
  • 58
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002).
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1
  • 60
    • 0034697962 scopus 로고    scopus 로고
    • The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development
    • Sibilia, M. et al. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development Cell 102, 211-220 (2000). An elegant transgenic mouse study showing that the ability of activated endogenous RAS protein to promote tumour formation is dependent on the activity of EGFR, indicating the importance of autocrine EGF signalling in RAS transformation.
    • (2000) Cell , vol.102 , pp. 211-220
    • Sibilia, M.1
  • 61
    • 0036667385 scopus 로고    scopus 로고
    • Protein tyrosine kinase inhibitors: New treatment modalities?
    • Fabbro, D., Parkinson, D. & Matter, A. Protein tyrosine kinase inhibitors: new treatment modalities? Curr. Opin. Pharmacol. 2, 374-381 (2002).
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 374-381
    • Fabbro, D.1    Parkinson, D.2    Matter, A.3
  • 62
    • 0036667387 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors
    • Wakeling, A. E. Epidermal growth factor receptor tyrosine kinase inhibitors. Curr. Opin. Pharmacol. 2, 382-387 (2002).
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 382-387
    • Wakeling, A.E.1
  • 63
    • 0036214044 scopus 로고    scopus 로고
    • The ErbB receptor family: A therapeutic target for cancer
    • de Bono, J. S. & Rowinsky, E. K. The ErbB receptor family: a therapeutic target for cancer. Trends Mol. Med. 8, S19-S26 (2002).
    • (2002) Trends Mol. Med. , vol.8
    • De Bono, J.S.1    Rowinsky, E.K.2
  • 64
    • 0036016095 scopus 로고    scopus 로고
    • ZD1839: Targeting the epidermal growth factor receptor in cancer therapy
    • Herbst, R. S. ZD1839: targeting the epidermal growth factor receptor in cancer therapy. Expert Opin. Investig. Drugs 11, 837-849 (2002).
    • (2002) Expert Opin. Investig. Drugs , vol.11 , pp. 837-849
    • Herbst, R.S.1
  • 65
    • 0035398631 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    • Hidalgo, M. et al. Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J. Clin. Oncol. 19, 3267-3279 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3267-3279
    • Hidalgo, M.1
  • 66
    • 0035871383 scopus 로고    scopus 로고
    • Analysis of the transcriptional program induced by Raf in epithelial cells
    • Schulze, A., Lehmann, K., Jeffedes, H. B., McMahon, M. & Downward, J. Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev. 15, 981-994 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 981-994
    • Schulze, A.1    Lehmann, K.2    Jeffedes, H.B.3    McMahon, M.4    Downward, J.5
  • 67
    • 0036500831 scopus 로고    scopus 로고
    • Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: A new paradigm for cancer therapy
    • Herbst, R. S. & Shin, D. M. Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer 94, 1593-1611 (2002).
    • (2002) Cancer , vol.94 , pp. 1593-1611
    • Herbst, R.S.1    Shin, D.M.2
  • 68
    • 0035398021 scopus 로고    scopus 로고
    • Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer
    • Robert, F. et al. Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. J. Clin. Oncol. 19, 3234-3243 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3234-3243
    • Robert, F.1
  • 69
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon, D. J. et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344, 783-792 (2001). The results of the Phase III trials with trastuzumab (Herceptin) that showed it to be an effective treatment for metastatic breast cancer with amplification of ERBB2.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 783-792
    • Slamon, D.J.1
  • 70
    • 0029023438 scopus 로고
    • Tyrosine phosphorylation of Shc proteins and formation of Shc/Grb2 complex correlate to the transformation of NIH3T3 cells mediated by the point-mutation activated neu
    • Xie, Y., Li, K. & Hung, M. C. Tyrosine phosphorylation of Shc proteins and formation of Shc/Grb2 complex correlate to the transformation of NIH3T3 cells mediated by the point-mutation activated neu. Oncogene 10, 2409-2413 (1995).
    • (1995) Oncogene , vol.10 , pp. 2409-2413
    • Xie, Y.1    Li, K.2    Hung, M.C.3
  • 71
    • 0037151034 scopus 로고    scopus 로고
    • Mechanism of 17-β-estradiol-induced Erk1/2 activation in breast cancer cells: A role for HER2 and PKC-δ
    • Keshamouni, V. G., Mattingly, R. R. & Reddy, K. B. Mechanism of 17-β-estradiol-induced Erk1/2 activation in breast cancer cells: A role for HER2 and PKC-δ. J. Biol. Chem. 277, 22558-22565 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 22558-22565
    • Keshamouni, V.G.1    Mattingly, R.R.2    Reddy, K.B.3
  • 72
    • 0035017385 scopus 로고    scopus 로고
    • Successful induction of immune responses against mutant ras in melanoma patients using intradermal injection of peptides and GM-CSF as adjuvant
    • Hunger, R. E. et al. Successful induction of immune responses against mutant ras in melanoma patients using intradermal injection of peptides and GM-CSF as adjuvant. Exp. Dermatol. 10, 161-167 (2001).
    • (2001) Exp. Dermatol. , vol.10 , pp. 161-167
    • Hunger, R.E.1
  • 73
    • 0037072302 scopus 로고    scopus 로고
    • Toward a PKB inhibitor: Modification of a selective PKA inhibitor by rational design
    • Reuveni, H. et al. Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design. Biochemistry 41, 10304-10314 (2002).
    • (2002) Biochemistry , vol.41 , pp. 10304-10314
    • Reuveni, H.1
  • 74
    • 0036132907 scopus 로고    scopus 로고
    • Absence of CAAX endoprotease Rce 1: Effects on cell growth and transformation
    • Bergo, M. O. et al. Absence of CAAX endoprotease Rce 1: effects on cell growth and transformation. Mol. Cell. Biol. 22, 171-181 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 171-181
    • Bergo, M.O.1
  • 76
    • 0032445969 scopus 로고    scopus 로고
    • RNA aptamers that specifically bind to the Ras-binding domain of c-Raf-1
    • Kimoto, M., Sakamoto, K., Shirouzu, M., Mirao, I. & Yokoyama, S. RNA aptamers that specifically bind to the Ras-binding domain of c-Raf-1. FEBS Lett. 441, 322-326 (1998).
    • (1998) FEBS Lett. , vol.441 , pp. 322-326
    • Kimoto, M.1    Sakamoto, K.2    Shirouzu, M.3    Mirao, I.4    Yokoyama, S.5
  • 77
    • 0037195142 scopus 로고    scopus 로고
    • Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells
    • Kato-Stankiewicz, J. et al. Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells. Proc. Natl Acad. Sci. USA 99, 14398-14403 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14398-14403
    • Kato-Stankiewicz, J.1
  • 78
    • 0033535950 scopus 로고    scopus 로고
    • Guanosine triphopshatase stimulation of oncogenic Ras mutants
    • Ahmadian, M. R. et al. Guanosine triphopshatase stimulation of oncogenic Ras mutants. Proc. Natl Acad. Sci. USA 96, 7065-7070 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7065-7070
    • Ahmadian, M.R.1
  • 79
    • 0034722888 scopus 로고    scopus 로고
    • The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
    • Hidalgo, M. & Rowinsky, E. K. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 19, 6680-6686 (2000).
    • (2000) Oncogene , vol.19 , pp. 6680-6686
    • Hidalgo, M.1    Rowinsky, E.K.2
  • 80
    • 0036219609 scopus 로고    scopus 로고
    • Hsp9O inhibitors as novel cancer chemotherapeutic agents
    • Neckers, L. Hsp9O inhibitors as novel cancer chemotherapeutic agents. Trends Mol. Med. 8, S55-S61 (2002).
    • (2002) Trends Mol. Med. , vol.8
    • Neckers, L.1
  • 81
    • 0034722898 scopus 로고    scopus 로고
    • Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment
    • Zucker, S., Cao, J. & Chen, W. T. Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment. Oncogene 19, 6642-6650 (2000).
    • (2000) Oncogene , vol.19 , pp. 6642-6650
    • Zucker, S.1    Cao, J.2    Chen, W.T.3
  • 82
    • 0035525207 scopus 로고    scopus 로고
    • Angiogenesis inhibition in solid tumors
    • Rosen, L. S. Angiogenesis inhibition in solid tumors. Cancer J. 7 (Suppl. 3), S120-S128 (2001).
    • (2001) Cancer J. , vol.7 , Issue.SUPPL. 3
    • Rosen, L.S.1
  • 84
  • 85
    • 0026504147 scopus 로고
    • Social controls on cell survival and cell death
    • Raff, M. C. Social controls on cell survival and cell death. Nature 356, 397-400 (1992).
    • (1992) Nature , vol.356 , pp. 397-400
    • Raff, M.C.1
  • 86
    • 0035132538 scopus 로고    scopus 로고
    • Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
    • End, D. W. et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 61, 131-137 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 131-137
    • End, D.W.1
  • 87
    • 0035886842 scopus 로고    scopus 로고
    • Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor
    • Rose, W. C. et al. Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor. Cancer Res. 61, 7507-7517 (2001). References 86 and 87 describe preclinical data on two of the leading farnesyltransferase inhibitors. The significant effects that are seen in these model systems are probably not due to targeting RAS, and it remains unclear whether they can be replicated in the clinic.
    • (2001) Cancer Res. , vol.61 , pp. 7507-7517
    • Rose, W.C.1


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