Reversion of transcriptional repression of Sp1 by 5 aza-2′ deoxycytidine restores TGF-β type II receptor expression in the pancreatic cancer cell line MIA PaCa-2

Cancer Research

Volumn 61, Issue 16, 2001, Pages 6239-6247

  Venkatasubbarao, K ^a   Ammanamanchi, S ^a   Brattain, M G ^a   Mimari, D ^a   Freeman, J W ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CHLORAMPHENICOL ACETYLTRANSFERASE; COMPLEMENTARY DNA; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL GROWTH; CLONOGENESIS; CONTROLLED STUDY; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

ANTIBIOTICS, ANTINEOPLASTIC; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; CELL DIVISION; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DNA MODIFICATION METHYLASES; DNA, COMPLEMENTARY; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; HUMANS; PANCREATIC NEOPLASMS; PLICAMYCIN; PROMOTER REGIONS (GENETICS); RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 0035881295     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. The transforming growth factor-βs
2. TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights
3. TGF-β signal transduction
4. The role for transforming growth factor-β (TGF-β) in human cancer
5. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase
6. TGF β signals through a heteromeric protein kinase receptor complex
7. Cloning of a TGF β type I receptor that forms a heteromeric complex with the TGF β type II receptor
8. A transforming growth factor β type I receptor that signals to activate gene expression
9. Expression cloning and characterization of the TGF-β type III receptor
10. Molecular cloning and characterization of the human and porcine transforming growth factor-β type III receptors
11. β glycan presents ligand to the TGF β signaling receptor
12. The transforming growth factor β receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand
13. Loss of receptors for transforming growth factor β in human T-cell malignancies
14. Genetic changes in the transforming growth factor β TGF-β type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-β
15. Expression of transforming growth factor β type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells
16. The type II transforming growth factor-β receptor as a tumor-suppressor gene
17. Growth inhibition by transforming growth factor β TGF-β type I is restored in TGF-β-resistant hepatoma cells after expression of TGF-β receptor type II cDNA
18. Expression of transforming growth factor β type II receptor reduces tumorigenicity in human gastric cancer cells
19. Overexpression of transforming growth factor TGF β1 type II receptor restores TGF-β1 sensitivity and signaling in human prostate cancer cells
20. Demonstration that mutation of the type II transforming growth factor β receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells
21. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
22. A transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability
23. Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer
24. Expression of a dominant-negative mutant TGF-β type II receptor in transgenic mice reveals essential roles for TGF-β in regulation of growth and differentiation in the exocrine pancreas
25. Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development
26. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
27. DPC4/SMAD4 gene alterations in human cancer, and their functional implications
28. Progress in cancer genetics: Lessons from pancreatic cancer
29. DPC4 gene in various tumor types
30. Genetic alterations of the transforming growth factor β receptor genes in pancreatic and biliary adenocarcinomas
31. Novel mutations in the polyadenine tract of the transforming growth factor β type II receptor gene are found in a subpopulation of human pancreatic adenocarcinomas
32. Mutation analysis of the transforming growth factor β type II receptor in sporadic human cancers of the pancreas, liver, and breast
33. Differential expression of transforming growth factor β receptors in human pancreatic adenocarcinoma
34. Structure and expression of the promoter for the human type II transforming growth factor-β receptor
35. Characterization of the promoter region of the human transforming growth factor-β type II receptor gene
36. A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming growth factor-β type II receptor
37. Increased tumorigenicity in the human pancreatic cell line MIA PaCa-2 is associated with an aberrant regulation of an IGF-1 autocrine loop and lack of expression of the TGF-β type II receptor
38. waf1 expression and growth inhibition by transforming growth factor β involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells
39. Restoration of TGF-β receptor type II in pancreatic cancer cell line MIA PaCa-2 caused increased sensitivity to ionizing radiation
40. DNA methylation errors and cancer
41. Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines
42. Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo
43. Sp1 is required for the early response of α2(I) collagen to transforming growth factor-β1
44. Altered transcription control is responsible for the increased level of proliferation-associated P120 in rapidly growing breast carcinoma
45. Induction of transforming growth factor-β receptor type II expression in estrogen receptor-positive breast cancer cells through SP1 activation by 5-aza-2′-deoxycytidine
46. Stimulation of human insulin receptor gene expression by retinoblastoma gene product
47. Regulation of transforming growth factor-β type II receptor expression in human breast cancer MCF-7 cells by vitamin D3 and its analogues
48. Contextual effects of transforming growth factor β on the tumorigenicity of human colon carcinoma cells
49. Alterations in DNA methylation: A fundamental aspect of neoplasia
50. Hypermethylation of tumor suppressor genes in cancer
51. Cancer epigenetics comes of age
52. Cytosine methylation and human cancer
53. Transcription from TATA-less promoters: Dihydrofolate reductase as a model
54. Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes
55. Tumor necrosis factor-α regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells
56. Regulation of tissue factor gene expression in human endometrium by transcription factors Sp1 and Sp3