Analysis of TGF-β type I receptor for mutations and polymorphisms in head and neck cancers

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 479, Issue 1-2, 2001, Pages 131-139

  Knobloch, Thomas J ^a   Lynch, Melanie A ^a   Song, Huijuan ^a   Degroff, Valerie L ^a   Casto, Bruce C ^a   Adams, Elizabeth M ^a   Alam, Kiswar Y ^a   Lang, James C ^b,c   Schuller, David E ^b,c   Weghorst, Christopher M ^a,c  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Cold SSCP; Polymorphisms; Squamous cell carcinoma; T R I(6A); Transforming growth factor

Indexed keywords

ADENINE; CYTOSINE; GUANINE; NUCLEOTIDE; RECEPTOR SUBTYPE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ALLELE; ARTICLE; BASE PAIRING; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; EXON; GENE DELETION; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; GENETIC POLYMORPHISM; GENOTYPE; GROWTH INHIBITION; HEAD CANCER; HUMAN; HUMAN TISSUE; INTRON; NECK CANCER; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR GENE; SINGLE STRAND CONFORMATION POLYMORPHISM; SQUAMOUS CELL CARCINOMA;

ACTIVIN RECEPTORS, TYPE I; ALLELES; CARCINOMA, SQUAMOUS CELL; DNA MUTATIONAL ANALYSIS; EXONS; GENE DELETION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEAD AND NECK NEOPLASMS; HETEROZYGOTE; HOMOZYGOTE; HUMANS; INTRONS; MICROSATELLITE REPEATS; MUTATION; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA;

EID: 0035828188     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00157-9     Document Type: Article

References (39)

1. Transforming growth factors
2. Transforming growth factor-beta 2: cDNA cloning and sequence analysis
3. A new type of transforming growth factor-beta, TGF-beta 3
4. Transforming growth factor-beta
5. The transforming growth factor-β family
6. Complementation between kinase-defective and activation-defective TGF-β receptors reveals a novel form of receptor co-operativity essential for signaling
7. Cloning of a TGF-β type I receptor that forms a heteromeric complex with the TGF-β type II receptor
8. Mechanism of activation of the TGF-β receptor
9. A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity
10. Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta
11. MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signaling
12. Transforming growth factor-β-induced phosphorylation of SMAD3 is required for growth inhibition and transcriptional induction in epithelial cells
13. Human type II receptor for bone morphogenetic proteins (BMPs): Extension of the two-kinase receptor model to the BMPs
14. Mechanism of TGF-β receptor inhibition by FKBP12
15. ras farnesyltransferase α-subunit in TGF-β and activin signaling
16. Signal transduction by transforming growth factor-beta: A co-operative paradigm with extensive negative regulation
17. Tumor suppressor activity of the TGF-beta pathway in human cancers
18. Resistance to inhibition of cell growth by transforming growth factor-β and its role in oncogenesis
19. Receptors for transforming growth factor-β
20. Mutation analysis of the transforming growth factor-β type II receptor in human cell lines resistant to growth inhibition by transforming growth factor-β
21. A transforming growth factor-β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability
22. Missense mutations in the transforming growth factor-β type II receptor in human head and neck squamous cell carcinoma cells
23. Mutation and downregulation of the transforming growth factor-β type II receptor gene in primary squamous cell carcinomas of the head and neck
24. Mutational analysis of the transforming growth factor-β type II receptor gene in human ovarian carcinoma
25. Reduced expression of transforming growth factor-beta type I receptor contributes to the malignancy of human colon carcinoma cells
26. Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition
27. Genetic changes in transforming growth factor-β (TGF-β) receptor type I gene correlates with insensitivity to TGF-β1 in human prostate cancer cells
28. Frequent mutations in transforming growth factor-β (TGF-β) receptor I (TβR-I) and II (TβR-II) genes in cervical carcinoma
29. Type I transforming growth factor-beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyadenine tract
30. TβR-I(6A) is a candidate tumor susceptibility allele
31. Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene
32. Genomic structure of the transforming growth factor-β type II receptor gene and its mutations in hereditary non-polyposis colorectal cancers
33. An improved PCR method for walking in uncloned genomic DNA
34. Cold SSCP: A simple, rapid and non-radioactive method for optimized single strand conformation polymorphism analyses
35. The megaprimer method of site-directed mutagenesis
36. Cloning and genomic organization of the human transforming growth factor-β type I receptor gene
37. RNA splicing junctions of different classes of eukaryotes: Sequence statistics and functional implications in expression
38. The genomic structure of gene encoding the human transforming growth factor-β type II receptor TGF-β RII
39. Decreased expression of transforming growth factor-beta receptors on head and neck squamous cell carcinoma tumor cells