메뉴 건너뛰기




Volumn 26, Issue 8, 2005, Pages 897-907

Molecular basis of ataxia telangiectasia and related diseases

Author keywords

Ataxia telangiectasia; cdc genes; DNA damage; DNA repair; Phosphotransferases

Indexed keywords

ATM PROTEIN; DNA DEPENDENT PROTEIN KINASE; DNA DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; KU ANTIGEN; MRE11 PROTEIN; MRN PROTEIN COMPLEX; NIBRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE LIKE PROTEIN KINASE; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN KINASE; RAD50 PROTEIN; UNCLASSIFIED DRUG;

EID: 23844433614     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2005.00165.x     Document Type: Review
Times cited : (44)

References (157)
  • 1
    • 0014164020 scopus 로고
    • Ataxia telangiectasia. Neoplasia, untoward response to x-irradiation, and tuberous sclerosis
    • Gotoff SP, Amirmokri E, Liebner EJ. Ataxia telangiectasia. Neoplasia, untoward response to x-irradiation, and tuberous sclerosis. Am J Dis Child 1967; 114: 617-25.
    • (1967) Am J Dis Child , vol.114 , pp. 617-625
    • Gotoff, S.P.1    Amirmokri, E.2    Liebner, E.J.3
  • 3
    • 0024313378 scopus 로고
    • Radioresistant DNA synthesis and human genetic diseases
    • Young BR, Painter RB. Radioresistant DNA synthesis and human genetic diseases. Hum Genet 1989; 82: 113-7.
    • (1989) Hum Genet , vol.82 , pp. 113-117
    • Young, B.R.1    Painter, R.B.2
  • 4
    • 0028200107 scopus 로고
    • Radiosensitivity of ataxia-telangiectasia, X-linked agammaglobulinemia, and related syndromes using a modified colony survival assay
    • Huo YK, Wang Z, Hong JH, Chessa L, McBride WH, Perlman SL, et al. Radiosensitivity of ataxia-telangiectasia, X-linked agammaglobulinemia, and related syndromes using a modified colony survival assay. Cancer Res 1994; 54: 2544-7.
    • (1994) Cancer Res , vol.54 , pp. 2544-2547
    • Huo, Y.K.1    Wang, Z.2    Hong, J.H.3    Chessa, L.4    McBride, W.H.5    Perlman, S.L.6
  • 5
    • 0036085557 scopus 로고    scopus 로고
    • Early diagnosis of ataxia-telangiectasia using radiosensitivity testing
    • Sun X, Becker-Catania SG, Chun HH, Hwang MJ, Huo Y, Wang Z, et al. Early diagnosis of ataxia-telangiectasia using radiosensitivity testing. J Pediatr 2002; 140: 724-31.
    • (2002) J Pediatr , vol.140 , pp. 724-731
    • Sun, X.1    Becker-Catania, S.G.2    Chun, H.H.3    Hwang, M.J.4    Huo, Y.5    Wang, Z.6
  • 6
    • 78651043982 scopus 로고
    • Ataxia-telangiectasia: A familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary infection
    • Boder E, Sedgwick RP. Ataxia-telangiectasia: a familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary infection. Pediatrics 1958; 21: 526-54.
    • (1958) Pediatrics , vol.21 , pp. 526-554
    • Boder, E.1    Sedgwick, R.P.2
  • 7
    • 0022292043 scopus 로고
    • Ataxia-telangiectasia: An overview
    • Boder E. Ataxia-telangiectasia: an overview. Kroc Found Ser 1985; 19: 1-63.
    • (1985) Kroc Found Ser , vol.19 , pp. 1-63
    • Boder, E.1
  • 9
    • 0242405169 scopus 로고    scopus 로고
    • Ataxia-telangiectasia
    • Vogelstein B, Kinzler KW, editors. New York: Mc Graw-Hill
    • Gatti RA. Ataxia-telangiectasia. In: Vogelstein B, Kinzler KW, editors. The Genetic Basis of Human Cancer. New York: Mc Graw-Hill; 2002. p 239-65.
    • (2002) The Genetic Basis of Human Cancer , pp. 239-265
    • Gatti, R.A.1
  • 10
    • 3242876404 scopus 로고    scopus 로고
    • Ataxia-telangiectasia, an evolving phenotype
    • Chun HH, Gatti RA. Ataxia-telangiectasia, an evolving phenotype. DNA Repair (Amst) 2004; 3: 1187-96.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1187-1196
    • Chun, H.H.1    Gatti, R.A.2
  • 12
    • 2142691766 scopus 로고    scopus 로고
    • ATM: Ready, set, go
    • Shiloh Y. ATM: ready, set, go. Cell Cycle 2003; 2: 116-7.
    • (2003) Cell Cycle , vol.2 , pp. 116-117
    • Shiloh, Y.1
  • 13
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • 3 Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003; 3: 155-68.
    • (2003) Nat Rev Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 14
    • 0030933152 scopus 로고    scopus 로고
    • The genetic defect in ataxia-telangiectasia
    • Lavin MF, Shiloh Y. The genetic defect in ataxia-telangiectasia. Annu Rev Immunol 1997; 15: 177-202.
    • (1997) Annu Rev Immunol , vol.15 , pp. 177-202
    • Lavin, M.F.1    Shiloh, Y.2
  • 16
    • 0029021663 scopus 로고
    • Discovery of at gene sparks biomedical research bonanza
    • Nowak R. Discovery of AT gene sparks biomedical research bonanza. Science 1995; 268: 1700-1.
    • (1995) Science , vol.268 , pp. 1700-1701
    • Nowak, R.1
  • 18
    • 0026409331 scopus 로고
    • Incidence of cancer in 161 families affected by ataxia-telangiectasia
    • Swift M, Morrell D, Massey RB, Chase CL. Incidence of cancer in 161 families affected by ataxia-telangiectasia. N Engl J Med 1991; 325: 1831-6.
    • (1991) N Engl J Med , vol.325 , pp. 1831-1836
    • Swift, M.1    Morrell, D.2    Massey, R.B.3    Chase, C.L.4
  • 19
    • 0023244806 scopus 로고
    • Breast and other cancers in families with ataxia-telangiectasia
    • Swift M, Reitnauer PJ, Morrell D, Chase CL. Breast and other cancers in families with ataxia-telangiectasia. N Engl J Med 1987; 316: 1289-94.
    • (1987) N Engl J Med , vol.316 , pp. 1289-1294
    • Swift, M.1    Reitnauer, P.J.2    Morrell, D.3    Chase, C.L.4
  • 21
    • 0344062639 scopus 로고    scopus 로고
    • Improved diagnostic testing for ataxia-telangiectasia by immunoblotting of nuclear lysates for ATM protein expression
    • Chun HH, Sun X, Nahas SA, Teraoka S, Lai CH, Concannon P, et al. Improved diagnostic testing for ataxia-telangiectasia by immunoblotting of nuclear lysates for ATM protein expression. Mol Genet Metab 2003; 80: 437-43.
    • (2003) Mol Genet Metab , vol.80 , pp. 437-443
    • Chun, H.H.1    Sun, X.2    Nahas, S.A.3    Teraoka, S.4    Lai, C.H.5    Concannon, P.6
  • 22
    • 0027340235 scopus 로고
    • A G→A substitution in an HNF I binding site in the human alpha-fetoprotein gene is associated with hereditary persistence of alpha-fetoprotein (HPAFP)
    • McVey JH, Michaelides K, Hansen LP, Ferguson-Smith M, Tilghman S, Krumlauf R, et al. A G→A substitution in an HNF I binding site in the human alpha-fetoprotein gene is associated with hereditary persistence of alpha-fetoprotein (HPAFP). Hum Mol Genet 1993; 2: 379-84.
    • (1993) Hum Mol Genet , vol.2 , pp. 379-384
    • McVey, J.H.1    Michaelides, K.2    Hansen, L.P.3    Ferguson-Smith, M.4    Tilghman, S.5    Krumlauf, R.6
  • 25
    • 0032076190 scopus 로고    scopus 로고
    • Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
    • Varon R, Vissinga C, Platzer M, Cerosaletti KM, Chrzanowska KH, Saar K, et al. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 1998; 93: 467-76.
    • (1998) Cell , vol.93 , pp. 467-476
    • Varon, R.1    Vissinga, C.2    Platzer, M.3    Cerosaletti, K.M.4    Chrzanowska, K.H.5    Saar, K.6
  • 26
    • 10744230604 scopus 로고    scopus 로고
    • Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2
    • Moreira MC, Klur S, Watanabe M, Nemeth AH, Le Ber I, Moniz JC, et al. Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2. Nat Genet 2004; 36: 225-7.
    • (2004) Nat Genet , vol.36 , pp. 225-227
    • Moreira, M.C.1    Klur, S.2    Watanabe, M.3    Nemeth, A.H.4    Le Ber, I.5    Moniz, J.C.6
  • 27
    • 3242889151 scopus 로고    scopus 로고
    • Ataxia-telangiectasia-like disorder (ATLD) - Its clinical presentation and molecular basis
    • Taylor AM, Groom A, Byrd PJ. Ataxia-telangiectasia-like disorder (ATLD) - its clinical presentation and molecular basis. DNA Repair (Amst) 2004; 3: 1219-25.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1219-1225
    • Taylor, A.M.1    Groom, A.2    Byrd, P.J.3
  • 28
    • 0034790947 scopus 로고    scopus 로고
    • Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene
    • Date H, Onodera O, Tanaka H, Iwabuchi K, Uekawa K, Igarashi S, et al. Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene. Nat Genet 2001; 29: 184-8.
    • (2001) Nat Genet , vol.29 , pp. 184-188
    • Date, H.1    Onodera, O.2    Tanaka, H.3    Iwabuchi, K.4    Uekawa, K.5    Igarashi, S.6
  • 29
    • 0033544724 scopus 로고    scopus 로고
    • The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
    • Stewart GS, Maser RS, Stankovic T, Bressan DA, Kaplan MI, Jaspers NG, et al. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 1999; 99: 577-87.
    • (1999) Cell , vol.99 , pp. 577-587
    • Stewart, G.S.1    Maser, R.S.2    Stankovic, T.3    Bressan, D.A.4    Kaplan, M.I.5    Jaspers, N.G.6
  • 30
    • 0029882106 scopus 로고    scopus 로고
    • Ataxia without telangiectasia masquerading as benign hereditary chorea
    • Klein C, Wenning GK, Quinn NP, Marsden CD. Ataxia without telangiectasia masquerading as benign hereditary chorea. Mov Disord 1996; 11: 217-20.
    • (1996) Mov Disord , vol.11 , pp. 217-220
    • Klein, C.1    Wenning, G.K.2    Quinn, N.P.3    Marsden, C.D.4
  • 31
    • 0027512319 scopus 로고
    • A family showing no evidence of linkage between the ataxia telangiectasia gene and chromosome 11q22-23
    • Hernandez D, McConville CM, Stacey M, Woods CG, Brown MM, Shutt P, et al. A family showing no evidence of linkage between the ataxia telangiectasia gene and chromosome 11q22-23. J Med Genet 1993; 30: 135-40.
    • (1993) J Med Genet , vol.30 , pp. 135-140
    • Hernandez, D.1    McConville, C.M.2    Stacey, M.3    Woods, C.G.4    Brown, M.M.5    Shutt, P.6
  • 32
    • 0036276388 scopus 로고    scopus 로고
    • The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling
    • D'Amours D, Jackson SP. The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Nat Rev Mol Cell Biol 2002; 3: 317-27.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 317-327
    • D'Amours, D.1    Jackson, S.P.2
  • 33
    • 0034020464 scopus 로고    scopus 로고
    • The Mre11 complex and ATM: Collaborating to navigate S phase
    • Petrini JH. The Mre11 complex and ATM: collaborating to navigate S phase. Curr Opin Cell Biol 2000; 12: 293-6.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 293-296
    • Petrini, J.H.1
  • 34
  • 35
    • 0032834595 scopus 로고    scopus 로고
    • Impaired IgG antibody production to pneumococcal polysaccharides in patients with ataxia-telangiectasia
    • Sanal O, Ersoy F, Yel L, Tezcan I, Metin A, Ozyurek H, et al. Impaired IgG antibody production to pneumococcal polysaccharides in patients with ataxia-telangiectasia. J Clin Immunol 1999; 19: 326-34.
    • (1999) J Clin Immunol , vol.19 , pp. 326-334
    • Sanal, O.1    Ersoy, F.2    Yel, L.3    Tezcan, I.4    Metin, A.5    Ozyurek, H.6
  • 36
    • 0035184902 scopus 로고    scopus 로고
    • The inherited basis of human radiosensitivity
    • Gatti RA. The inherited basis of human radiosensitivity. Acta Oncol 2001; 40: 702-11.
    • (2001) Acta Oncol , vol.40 , pp. 702-711
    • Gatti, R.A.1
  • 40
    • 2642528031 scopus 로고    scopus 로고
    • DNA damage-induced activation of ATM and ATM-dependent signaling pathways
    • Kurz EU, Lees-Miller SP. DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair (Amst) 2004; 3: 889-900.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 889-900
    • Kurz, E.U.1    Lees-Miller, S.P.2
  • 42
    • 0037115935 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability
    • Tauchi H, Matsuura S, Kobayashi J, Sakamoto S, Komatsu K. Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability. Oncogene 2002; 21: 8967-80.
    • (2002) Oncogene , vol.21 , pp. 8967-8980
    • Tauchi, H.1    Matsuura, S.2    Kobayashi, J.3    Sakamoto, S.4    Komatsu, K.5
  • 45
    • 0029057336 scopus 로고
    • A single ataxia telangiectasia gene with a product similar to PI-3 kinase
    • Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 1995; 268: 1749-53.
    • (1995) Science , vol.268 , pp. 1749-1753
    • Savitsky, K.1    Bar-Shira, A.2    Gilad, S.3    Rotman, G.4    Ziv, Y.5    Vanagaite, L.6
  • 46
    • 0028827312 scopus 로고
    • The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
    • Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, Collins FS, et al. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum Mol Genet 1995; 4: 2025-32.
    • (1995) Hum Mol Genet , vol.4 , pp. 2025-2032
    • Savitsky, K.1    Sfez, S.2    Tagle, D.A.3    Ziv, Y.4    Sartiel, A.5    Collins, F.S.6
  • 48
    • 0033909670 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: Phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity
    • Becker-Catania SG, Chen G, Hwang MJ, Wang Z, Sun X, Sanal O, et al. Ataxia-telangiectasia: phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity. Mol Genet Metab 2000; 70: 122-33.
    • (2000) Mol Genet Metab , vol.70 , pp. 122-133
    • Becker-Catania, S.G.1    Chen, G.2    Hwang, M.J.3    Wang, Z.4    Sun, X.5    Sanal, O.6
  • 49
    • 17344362697 scopus 로고    scopus 로고
    • ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: Expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer
    • Stankovic T, Kidd AM, Sutcliffe A, McGuire GM, Robinson P, Weber P, et al. ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer. Am J Hum Genet 1998; 62: 334-45.
    • (1998) Am J Hum Genet , vol.62 , pp. 334-345
    • Stankovic, T.1    Kidd, A.M.2    Sutcliffe, A.3    McGuire, G.M.4    Robinson, P.5    Weber, P.6
  • 50
    • 0035839431 scopus 로고    scopus 로고
    • Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T→G mutations, showing a less severe phenotype
    • Stewart GS, Last JI, Stankovic T, Haites N, Kidd AM, Byrd PJ, et al. Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T→G mutations, showing a less severe phenotype. J Biol Chem 2001; 276: 30 133-41.
    • (2001) J Biol Chem , vol.276 , pp. 30133-30141
    • Stewart, G.S.1    Last, J.I.2    Stankovic, T.3    Haites, N.4    Kidd, A.M.5    Byrd, P.J.6
  • 52
    • 0642317018 scopus 로고    scopus 로고
    • The role of ATM and ATR in DNA damage-induced cell cycle control
    • Goodarzi AA, Block WD, Lees-Miller SP. The role of ATM and ATR in DNA damage-induced cell cycle control. Prog Cell Cycle Res 2003; 5: 393-411.
    • (2003) Prog Cell Cycle Res , vol.5 , pp. 393-411
    • Goodarzi, A.A.1    Block, W.D.2    Lees-Miller, S.P.3
  • 54
    • 0033621392 scopus 로고    scopus 로고
    • Substrate specificities and identification of putative substrates of ATM kinase family members
    • Kim ST, Lim DS, Canman CE, Kastan MB. Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem 1999; 274: 37 538-43.
    • (1999) J Biol Chem , vol.274 , pp. 37538-37543
    • Kim, S.T.1    Lim, D.S.2    Canman, C.E.3    Kastan, M.B.4
  • 55
    • 0034725592 scopus 로고    scopus 로고
    • Utilization of oriented peptide libraries to identify substrate motifs selected by ATM
    • O'Neill T, Dwyer AJ, Ziv Y, Chan DW, Lees-Miller SP, Abraham RH, et al. Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. J Biol Chem 2000; 275: 22 719-27.
    • (2000) J Biol Chem , vol.275 , pp. 22719-22727
    • O'Neill, T.1    Dwyer, A.J.2    Ziv, Y.3    Chan, D.W.4    Lees-Miller, S.P.5    Abraham, R.H.6
  • 57
    • 0037462453 scopus 로고    scopus 로고
    • The ATRs, ATMs, and TORs are giant HEAT repeat proteins
    • Perry J, Kleckner N. The ATRs, ATMs, and TORs are giant HEAT repeat proteins. Cell 2003; 112: 151-5.
    • (2003) Cell , vol.112 , pp. 151-155
    • Perry, J.1    Kleckner, N.2
  • 58
    • 20144362478 scopus 로고    scopus 로고
    • The solution structure of the FATC domain of the protein kinase TOR suggests a role for redox-dependent structural and cellular stability
    • Dames SA, Mulet JM, Rathgeb-Szabo K, Hall MN, Grzesiek S. The solution structure of the FATC domain of the protein kinase TOR suggests a role for redox-dependent structural and cellular stability. J Biol Chem 2005; 280: 20558-64
    • (2005) J Biol Chem , vol.280 , pp. 20558-20564
    • Dames, S.A.1    Mulet, J.M.2    Rathgeb-Szabo, K.3    Hall, M.N.4    Grzesiek, S.5
  • 60
    • 0033560796 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase
    • Smith GC, Jackson SP. The DNA-dependent protein kinase. Genes Dev 1999; 13: 916-34.
    • (1999) Genes Dev , vol.13 , pp. 916-934
    • Smith, G.C.1    Jackson, S.P.2
  • 61
    • 0037159220 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation
    • Merkle D, Douglas P, Moorhead GB, Leonenko Z, Yu Y, Cramb D, et al. The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Biochemistry 2002; 41: 12 706-14.
    • (2002) Biochemistry , vol.41 , pp. 12706-12714
    • Merkle, D.1    Douglas, P.2    Moorhead, G.B.3    Leonenko, Z.4    Yu, Y.5    Cramb, D.6
  • 62
    • 0030746109 scopus 로고    scopus 로고
    • Interaction of DNA-dependent protein kinase with DNA and with Ku: Biochemical and atomic-force microscopy studies
    • Yaneva M, Kowalewski T, Lieber MR. Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies. EMBO J 1997; 16: 5098-112.
    • (1997) EMBO J , vol.16 , pp. 5098-5112
    • Yaneva, M.1    Kowalewski, T.2    Lieber, M.R.3
  • 63
    • 0038339042 scopus 로고    scopus 로고
    • Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an ATM-like domain to clamp around double-stranded DNA
    • Llorca O, Rivera-Calzada A, Grantham J, Willison KR. Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an ATM-like domain to clamp around double-stranded DNA. Oncogene 2003; 22: 3867-74.
    • (2003) Oncogene , vol.22 , pp. 3867-3874
    • Llorca, O.1    Rivera-Calzada, A.2    Grantham, J.3    Willison, K.R.4
  • 64
    • 0032508608 scopus 로고    scopus 로고
    • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    • Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 1998; 281: 1677-9.
    • (1998) Science , vol.281 , pp. 1677-1679
    • Canman, C.E.1    Lim, D.S.2    Cimprich, K.A.3    Taya, Y.4    Tamai, K.5    Sakaguchi, K.6
  • 65
    • 0032508504 scopus 로고    scopus 로고
    • Enhanced phosphorylation of p53 by ATM in response to DNA damage
    • Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998; 281: 1674-7.
    • (1998) Science , vol.281 , pp. 1674-1677
    • Banin, S.1    Moyal, L.2    Shieh, S.3    Taya, Y.4    Anderson, C.W.5    Chessa, L.6
  • 66
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR, 3rd, et al. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 1998; 93: 477-86.
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    Le Beau, M.5    Yates III, J.R.6
  • 68
    • 3242892589 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome: Clinical manifestation of defective response to DNA double-strand breaks
    • Digweed M, Sperling K. Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks. DNA Repair (Amst) 2004; 3: 1207-17.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1207-1217
    • Digweed, M.1    Sperling, K.2
  • 69
    • 0030749867 scopus 로고    scopus 로고
    • Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
    • Xiao Y, Weaver DT. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res 1997; 25: 2985-91.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2985-2991
    • Xiao, Y.1    Weaver, D.T.2
  • 70
    • 0242610857 scopus 로고    scopus 로고
    • Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis
    • Dumon-Jones V, Frappart PO, Tong WM, Sajithlal G, Hulla W, Schmid G, et al. Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis. Cancer Res 2003; 63: 7263-9.
    • (2003) Cancer Res , vol.63 , pp. 7263-7269
    • Dumon-Jones, V.1    Frappart, P.O.2    Tong, W.M.3    Sajithlal, G.4    Hulla, W.5    Schmid, G.6
  • 71
    • 0035936554 scopus 로고    scopus 로고
    • Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
    • Zhu J, Petersen S, Tessarollo L, Nussenzweig A. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr Biol 2001; 11: 105-9.
    • (2001) Curr Biol , vol.11 , pp. 105-109
    • Zhu, J.1    Petersen, S.2    Tessarollo, L.3    Nussenzweig, A.4
  • 72
    • 0033594904 scopus 로고    scopus 로고
    • Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
    • Luo G, Yao MS, Bender CF, Mills M, Bladl AR, Bradley A, et al. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci USA 1999; 96: 7376-81.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7376-7381
    • Luo, G.1    Yao, M.S.2    Bender, C.F.3    Mills, M.4    Bladl, A.R.5    Bradley, A.6
  • 74
    • 0032576565 scopus 로고    scopus 로고
    • Isolation of hMRE11B: Failure to complement yeast mre11 defects due to species-specific protein interactions
    • Chamankhah M, Wei YF, Xiao W. Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions. Gene 1998; 225: 107-16.
    • (1998) Gene , vol.225 , pp. 107-116
    • Chamankhah, M.1    Wei, Y.F.2    Xiao, W.3
  • 75
    • 0028857690 scopus 로고
    • Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast
    • Sharples GJ, Leach DR. Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast. Mol Microbiol 1995; 17: 1215-7.
    • (1995) Mol Microbiol , vol.17 , pp. 1215-1217
    • Sharples, G.J.1    Leach, D.R.2
  • 76
    • 0032567108 scopus 로고    scopus 로고
    • Complex formation and functional versatility of Mre11 of budding yeast in recombination
    • Usui T, Ohta T, Oshiumi H, Tomizawa J, Ogawa H, Ogawa T. Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 1998; 95: 705-16.
    • (1998) Cell , vol.95 , pp. 705-716
    • Usui, T.1    Ohta, T.2    Oshiumi, H.3    Tomizawa, J.4    Ogawa, H.5    Ogawa, T.6
  • 77
    • 0033562839 scopus 로고    scopus 로고
    • Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance
    • Chamankhah M, Xiao W. Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance. Nucleic Acids Res 1999; 27: 2072-9.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2072-2079
    • Chamankhah, M.1    Xiao, W.2
  • 78
    • 0035813227 scopus 로고    scopus 로고
    • Structure of the Rad50 × Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy
    • Anderson DE, Trujillo KM, Sung P, Erickson HP. Structure of the Rad50 × Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy. J Biol Chem 2001; 276: 37 027-33.
    • (2001) J Biol Chem , vol.276 , pp. 37027-37033
    • Anderson, D.E.1    Trujillo, K.M.2    Sung, P.3    Erickson, H.P.4
  • 79
    • 0035906860 scopus 로고    scopus 로고
    • Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase
    • Hopfner KP, Karcher A, Craig L, Woo TT, Carney JP, Tainer JA. Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell 2001; 105: 473-85.
    • (2001) Cell , vol.105 , pp. 473-485
    • Hopfner, K.P.1    Karcher, A.2    Craig, L.3    Woo, T.T.4    Carney, J.P.5    Tainer, J.A.6
  • 81
    • 0032555480 scopus 로고    scopus 로고
    • Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
    • Trujillo KM, Yuan SS, Lee EY, Sung P. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J Biol Chem 1998; 273: 21447-50.
    • (1998) J Biol Chem , vol.273 , pp. 21447-21450
    • Trujillo, K.M.1    Yuan, S.S.2    Lee, E.Y.3    Sung, P.4
  • 82
    • 0032085295 scopus 로고    scopus 로고
    • The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks
    • Paull TT, Gellert M. The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks. Mol Cell 1998; 1: 969-79.
    • (1998) Mol Cell , vol.1 , pp. 969-979
    • Paull, T.T.1    Gellert, M.2
  • 83
    • 0033563229 scopus 로고    scopus 로고
    • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
    • Paull TT, Gellert M. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev 1999; 13: 1276-88.
    • (1999) Genes Dev , vol.13 , pp. 1276-1288
    • Paull, T.T.1    Gellert, M.2
  • 84
    • 0032931844 scopus 로고    scopus 로고
    • The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
    • Moreau S, Ferguson JR, Symington LS. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol Cell Biol 1999; 19: 556-66.
    • (1999) Mol Cell Biol , vol.19 , pp. 556-566
    • Moreau, S.1    Ferguson, J.R.2    Symington, L.S.3
  • 85
    • 0032567041 scopus 로고    scopus 로고
    • The many interfaces of Mre11
    • Haber JE. The many interfaces of Mre11. Cell 1998; 95: 583-6.
    • (1998) Cell , vol.95 , pp. 583-586
    • Haber, J.E.1
  • 86
    • 0036900120 scopus 로고    scopus 로고
    • Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair
    • Symington LS. Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev 2002; 66: 630-70.
    • (2002) Microbiol Mol Biol Rev , vol.66 , pp. 630-670
    • Symington, L.S.1
  • 87
    • 0033537926 scopus 로고    scopus 로고
    • Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes
    • Anderson RA, Boronenkov IV, Doughman SD, Kunz J, Loijens JC. Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes. J Biol Chem 1999; 274: 9907-10.
    • (1999) J Biol Chem , vol.274 , pp. 9907-9910
    • Anderson, R.A.1    Boronenkov, I.V.2    Doughman, S.D.3    Kunz, J.4    Loijens, J.C.5
  • 88
    • 0033969444 scopus 로고    scopus 로고
    • The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity
    • Kunz J, Wilson MP, Kisseleva M, Hurley JH, Majerus PW, Anderson RA. The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell 2000; 5: 1-11.
    • (2000) Mol Cell , vol.5 , pp. 1-11
    • Kunz, J.1    Wilson, M.P.2    Kisseleva, M.3    Hurley, J.H.4    Majerus, P.W.5    Anderson, R.A.6
  • 89
    • 0033538496 scopus 로고    scopus 로고
    • The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage
    • Dong Z, Zhong Q, Chen PL. The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage. J Biol Chem 1999; 274: 19513-6.
    • (1999) J Biol Chem , vol.274 , pp. 19513-19516
    • Dong, Z.1    Zhong, Q.2    Chen, P.L.3
  • 90
    • 0033603360 scopus 로고    scopus 로고
    • Polyphosphoinositides inhibit the interaction of vinculin with actin filaments
    • Steimle PA, Hoffert JD, Adey NB, Craig SW. Polyphosphoinositides inhibit the interaction of vinculin with actin filaments. J Biol Chem 1999; 274: 18414-20.
    • (1999) J Biol Chem , vol.274 , pp. 18414-18420
    • Steimle, P.A.1    Hoffert, J.D.2    Adey, N.B.3    Craig, S.W.4
  • 91
    • 0028212415 scopus 로고
    • Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae
    • Ivanov EL, Sugawara N, White CI, Fabre F, Haber JE. Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae. Mol Cell Biol 1994; 14: 3414-25.
    • (1994) Mol Cell Biol , vol.14 , pp. 3414-3425
    • Ivanov, E.L.1    Sugawara, N.2    White, C.I.3    Fabre, F.4    Haber, J.E.5
  • 92
    • 0028914077 scopus 로고
    • Interaction of Mre11 and Rad50: Two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae
    • Johzuka K, Ogawa H. Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Genetics 1995; 139: 1521-32.
    • (1995) Genetics , vol.139 , pp. 1521-1532
    • Johzuka, K.1    Ogawa, H.2
  • 93
    • 0034047829 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae mre11(ts) allele confers a separation of DNA repair and telomere maintenance functions
    • Chamankhah M, Fontanie T, Xiao W. The Saccharomyces cerevisiae mre11(ts) allele confers a separation of DNA repair and telomere maintenance functions. Genetics 2000; 155: 569-76.
    • (2000) Genetics , vol.155 , pp. 569-576
    • Chamankhah, M.1    Fontanie, T.2    Xiao, W.3
  • 94
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck J, Coates J, Jackson SP. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005; 434: 605-11.
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 96
    • 0037086702 scopus 로고    scopus 로고
    • Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
    • Kang J, Bronson RT, Xu Y. Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J 2002; 21: 1447-55.
    • (2002) EMBO J , vol.21 , pp. 1447-1455
    • Kang, J.1    Bronson, R.T.2    Xu, Y.3
  • 97
    • 0034665121 scopus 로고    scopus 로고
    • Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage
    • Chen J. Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. Cancer Res 2000; 60: 5037-9.
    • (2000) Cancer Res , vol.60 , pp. 5037-5039
    • Chen, J.1
  • 98
    • 0034644220 scopus 로고    scopus 로고
    • Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
    • Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, et al. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 2000; 406: 210-5.
    • (2000) Nature , vol.406 , pp. 210-215
    • Li, S.1    Ting, N.S.2    Zheng, L.3    Chen, P.L.4    Ziv, Y.5    Shiloh, Y.6
  • 100
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003; 421: 499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 101
    • 1042301303 scopus 로고    scopus 로고
    • Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation
    • Ali A, Zhang J, Bao S, Liu I, Otterness D, Dean NM, et al. Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. Genes Dev 2004; 18: 249-54.
    • (2004) Genes Dev , vol.18 , pp. 249-254
    • Ali, A.1    Zhang, J.2    Bao, S.3    Liu, I.4    Otterness, D.5    Dean, N.M.6
  • 102
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999; 146: 905-16.
    • (1999) J Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 104
    • 0034713393 scopus 로고    scopus 로고
    • Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
    • Zhao S, Weng YC, Yuan SS, Lin YT, Hsu HC, Lin SC, et al. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature 2000; 405: 473-7.
    • (2000) Nature , vol.405 , pp. 473-477
    • Zhao, S.1    Weng, Y.C.2    Yuan, S.S.3    Lin, Y.T.4    Hsu, H.C.5    Lin, S.C.6
  • 105
    • 0036500555 scopus 로고    scopus 로고
    • Involvement of the cohesin protein, Smc1, in ATM-dependent and independent responses to DNA damage
    • Kim ST, Xu B, Kastan MB. Involvement of the cohesin protein, Smc1, in ATM-dependent and independent responses to DNA damage. Genes Dev 2002; 16: 560-70.
    • (2002) Genes Dev , vol.16 , pp. 560-570
    • Kim, S.T.1    Xu, B.2    Kastan, M.B.3
  • 106
    • 0036500690 scopus 로고    scopus 로고
    • SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
    • Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev 2002; 16: 571-82.
    • (2002) Genes Dev , vol.16 , pp. 571-582
    • Yazdi, P.T.1    Wang, Y.2    Zhao, S.3    Patel, N.4    Lee, E.Y.5    Qin, J.6
  • 107
    • 4544281398 scopus 로고    scopus 로고
    • Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
    • Lisby M, Barlow JH, Burgess RC, Rothstein R. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 2004; 118: 699-713.
    • (2004) Cell , vol.118 , pp. 699-713
    • Lisby, M.1    Barlow, J.H.2    Burgess, R.C.3    Rothstein, R.4
  • 108
    • 0029088371 scopus 로고
    • TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
    • Greenwell PW, Kronmal SL, Porter SE, Gassenhuber J, Obermaier B, Petes TD. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 1995; 82: 823-9.
    • (1995) Cell , vol.82 , pp. 823-829
    • Greenwell, P.W.1    Kronmal, S.L.2    Porter, S.E.3    Gassenhuber, J.4    Obermaier, B.5    Petes, T.D.6
  • 109
    • 0029150855 scopus 로고
    • TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1
    • Morrow DM, Tagle DA, Shiloh Y, Collins FS, Hieter P. TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 1995; 82: 831-40.
    • (1995) Cell , vol.82 , pp. 831-840
    • Morrow, D.M.1    Tagle, D.A.2    Shiloh, Y.3    Collins, F.S.4    Hieter, P.5
  • 111
    • 17644409069 scopus 로고    scopus 로고
    • ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
    • Lee JH, Paull TT. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 2005; 308: 551-4.
    • (2005) Science , vol.308 , pp. 551-554
    • Lee, J.H.1    Paull, T.T.2
  • 112
    • 0346059615 scopus 로고    scopus 로고
    • 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage
    • Mochan TA, Venere M, DiTullio RA, Jr, Halazonetis TD. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res 2003; 63: 8586-91.
    • (2003) Cancer Res , vol.63 , pp. 8586-8591
    • Mochan, T.A.1    Venere, M.2    DiTullio Jr., R.A.3    Halazonetis, T.D.4
  • 116
    • 0037468232 scopus 로고    scopus 로고
    • MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
    • Lou Z, Minter-Dykhouse K, Wu X, Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 2003; 421: 957-61.
    • (2003) Nature , vol.421 , pp. 957-961
    • Lou, Z.1    Minter-Dykhouse, K.2    Wu, X.3    Chen, J.4
  • 117
    • 0037458608 scopus 로고    scopus 로고
    • NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response
    • Shang YL, Bodero AJ, Chen PL. NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response. J Biol Chem 2003; 278: 6323-9.
    • (2003) J Biol Chem , vol.278 , pp. 6323-6329
    • Shang, Y.L.1    Bodero, A.J.2    Chen, P.L.3
  • 118
    • 0037424296 scopus 로고    scopus 로고
    • NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways
    • Xu X, Stern DF. NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways. J Biol Chem 2003; 278: 8795-803.
    • (2003) J Biol Chem , vol.278 , pp. 8795-8803
    • Xu, X.1    Stern, D.F.2
  • 119
    • 0038391226 scopus 로고    scopus 로고
    • NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage
    • Peng A, Chen PL. NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage. J Biol Chem 2003; 278: 8873-6.
    • (2003) J Biol Chem , vol.278 , pp. 8873-8876
    • Peng, A.1    Chen, P.L.2
  • 121
    • 0036902410 scopus 로고    scopus 로고
    • 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
    • DiTullio RA, Jr, Mochan TA, Venere M, Bartkova J, Sehested M, Bartek J, et al. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol 2002; 4: 998-1002.
    • (2002) Nat Cell Biol , vol.4 , pp. 998-1002
    • DiTullio Jr., R.A.1    Mochan, T.A.2    Venere, M.3    Bartkova, J.4    Sehested, M.5    Bartek, J.6
  • 122
    • 0037378527 scopus 로고    scopus 로고
    • p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
    • Ward IM, Minn K, van Deursen J, Chen J. p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol 2003; 23: 2556-63.
    • (2003) Mol Cell Biol , vol.23 , pp. 2556-2563
    • Ward, I.M.1    Minn, K.2    Van Deursen, J.3    Chen, J.4
  • 123
    • 0037772381 scopus 로고    scopus 로고
    • Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability
    • Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, et al. Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem 2003; 278: 14 971-7.
    • (2003) J Biol Chem , vol.278 , pp. 14971-14977
    • Morales, J.C.1    Xia, Z.2    Lu, T.3    Aldrich, M.B.4    Wang, B.5    Rosales, C.6
  • 124
    • 0029156599 scopus 로고
    • DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
    • Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, et al. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 1995; 82: 849-56.
    • (1995) Cell , vol.82 , pp. 849-856
    • Hartley, K.O.1    Gell, D.2    Smith, G.C.3    Zhang, H.4    Divecha, N.5    Connelly, M.A.6
  • 125
    • 0037106180 scopus 로고    scopus 로고
    • Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    • Chan DW, Chen BP, Prithivirajsingh S, Kurimasa A, Story MD, Qin J, et al. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev 2002; 16: 2333-8.
    • (2002) Genes Dev , vol.16 , pp. 2333-2338
    • Chan, D.W.1    Chen, B.P.2    Prithivirajsingh, S.3    Kurimasa, A.4    Story, M.D.5    Qin, J.6
  • 127
    • 0028960511 scopus 로고
    • Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation
    • Blunt T, Finnie NJ, Taccioli GE, Smith GC, Demengeot J, Gottlieb TM, et al. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 1995; 80: 813-23.
    • (1995) Cell , vol.80 , pp. 813-823
    • Blunt, T.1    Finnie, N.J.2    Taccioli, G.E.3    Smith, G.C.4    Demengeot, J.5    Gottlieb, T.M.6
  • 128
    • 0024540013 scopus 로고
    • Chromosome instability syndromes
    • Cohen MM, Levy HP. Chromosome instability syndromes. Adv Hum Genet 1989; 18: 43-149, 365-171.
    • (1989) Adv Hum Genet , vol.18 , pp. 43-149
    • Cohen, M.M.1    Levy, H.P.2
  • 129
    • 0033104498 scopus 로고    scopus 로고
    • Structure of DNA-dependent protein kinase: Implications for its regulation by DNA
    • Leuther KK, Hammarsten O, Kornberg RD, Chu G. Structure of DNA-dependent protein kinase: implications for its regulation by DNA. EMBO J 1999; 18: 1114-23.
    • (1999) EMBO J , vol.18 , pp. 1114-1123
    • Leuther, K.K.1    Hammarsten, O.2    Kornberg, R.D.3    Chu, G.4
  • 130
  • 131
    • 13844253934 scopus 로고    scopus 로고
    • Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs)
    • Rivera-Calzada A, Maman JP, Spagnolo L, Pearl LH, Llorca O. Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Structure (Camb) 2005; 13: 243-55.
    • (2005) Structure (Camb) , vol.13 , pp. 243-255
    • Rivera-Calzada, A.1    Maman, J.P.2    Spagnolo, L.3    Pearl, L.H.4    Llorca, O.5
  • 132
    • 3242886503 scopus 로고    scopus 로고
    • Role of DNA-PK in the cellular response to DNA double-strand breaks
    • Burma S, Chen DJ. Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair (Amst) 2004; 3: 909-18.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 909-918
    • Burma, S.1    Chen, D.J.2
  • 133
    • 1642458360 scopus 로고    scopus 로고
    • Microhomology-dependent end joining and repair of transposon-induced DNA hairpins by host factors in Saccharomyces cerevisiae
    • Yu J, Marshall K, Yamaguchi M, Haber JE, Weil CF. Microhomology-dependent end joining and repair of transposon-induced DNA hairpins by host factors in Saccharomyces cerevisiae. Mol Cell Biol 2004; 24: 1351-64.
    • (2004) Mol Cell Biol , vol.24 , pp. 1351-1364
    • Yu, J.1    Marshall, K.2    Yamaguchi, M.3    Haber, J.E.4    Weil, C.F.5
  • 134
    • 0028013486 scopus 로고
    • Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events
    • Kramer KM, Brock JA, Bloom K, Moore JK, Haber JE. Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events. Mol Cell Biol 1994; 14: 1293-301.
    • (1994) Mol Cell Biol , vol.14 , pp. 1293-1301
    • Kramer, K.M.1    Brock, J.A.2    Bloom, K.3    Moore, J.K.4    Haber, J.E.5
  • 135
    • 0034733497 scopus 로고    scopus 로고
    • Tying up loose ends: Nonhomologous end-joining in Saccharomyces cerevisiae
    • Lewis LK, Resnick MA. Tying up loose ends: nonhomologous end-joining in Saccharomyces cerevisiae. Mutat Res 2000; 451: 71-89.
    • (2000) Mutat Res , vol.451 , pp. 71-89
    • Lewis, L.K.1    Resnick, M.A.2
  • 136
    • 0029976325 scopus 로고    scopus 로고
    • Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae
    • Moore JK, Haber JE. Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mo Cell Biol 1996; 16: 2164-73.
    • (1996) Mo Cell Biol , vol.16 , pp. 2164-2173
    • Moore, J.K.1    Haber, J.E.2
  • 137
    • 0032536861 scopus 로고    scopus 로고
    • Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
    • Boulton SJ, Jackson SP. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J 1998; 17: 1819-28.
    • (1998) EMBO J , vol.17 , pp. 1819-1828
    • Boulton, S.J.1    Jackson, S.P.2
  • 138
    • 0032554797 scopus 로고    scopus 로고
    • Telomere maintenance is dependent on activities required for end repair of double-strand breaks
    • Nugent CI, Bosco G, Ross LO, Evans SK, Salinger AP, Moore JK, et al. Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr Biol 1998; 8: 657-60.
    • (1998) Curr Biol , vol.8 , pp. 657-660
    • Nugent, C.I.1    Bosco, G.2    Ross, L.O.3    Evans, S.K.4    Salinger, A.P.5    Moore, J.K.6
  • 139
    • 0036864626 scopus 로고    scopus 로고
    • Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination
    • Frank-Vaillant M, Marcand S. Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination. Mol Cell 2002; 10: 1189-99.
    • (2002) Mol Cell , vol.10 , pp. 1189-1199
    • Frank-Vaillant, M.1    Marcand, S.2
  • 140
    • 0033612287 scopus 로고    scopus 로고
    • Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
    • Martin SG, Laroche T, Suka N, Grunstein M, Gasser SM. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 1999; 97: 621-33.
    • (1999) Cell , vol.97 , pp. 621-633
    • Martin, S.G.1    Laroche, T.2    Suka, N.3    Grunstein, M.4    Gasser, S.M.5
  • 141
    • 0035930342 scopus 로고    scopus 로고
    • Promotion of Dn14-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes
    • Chen L, Trujillo K, Ramos W, Sung P, Tomkinson AE. Promotion of Dn14-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. Mol Cell 2001; 8: 1105-15.
    • (2001) Mol Cell , vol.8 , pp. 1105-1115
    • Chen, L.1    Trujillo, K.2    Ramos, W.3    Sung, P.4    Tomkinson, A.E.5
  • 142
    • 0034628617 scopus 로고    scopus 로고
    • Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks
    • Teo SH, Jackson SP. Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks. Curr Biol 2000; 10: 165-8.
    • (2000) Curr Biol , vol.10 , pp. 165-168
    • Teo, S.H.1    Jackson, S.P.2
  • 143
    • 0035941021 scopus 로고    scopus 로고
    • ATR and ATRIP: Partners in checkpoint signaling
    • Cortez D, Guntuku S, Qin J, Elledge SJ. ATR and ATRIP: partners in checkpoint signaling. Science 2001; 294: 1713-6.
    • (2001) Science , vol.294 , pp. 1713-1716
    • Cortez, D.1    Guntuku, S.2    Qin, J.3    Elledge, S.J.4
  • 144
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003; 300: 1542-8.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 145
    • 0032076127 scopus 로고    scopus 로고
    • Yeast Ku as a regulator of chromosomal DNA end structure
    • Gravel S, Larrivee M, Labrecque P, Wellinger RJ. Yeast Ku as a regulator of chromosomal DNA end structure. Science 1998; 280: 741-4.
    • (1998) Science , vol.280 , pp. 741-744
    • Gravel, S.1    Larrivee, M.2    Labrecque, P.3    Wellinger, R.J.4
  • 147
    • 0031180154 scopus 로고    scopus 로고
    • Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae
    • Kironmai KM, Muniyappa K. Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae. Genes Cells 1997; 2: 443-55.
    • (1997) Genes Cells , vol.2 , pp. 443-455
    • Kironmai, K.M.1    Muniyappa, K.2
  • 148
    • 0035852742 scopus 로고    scopus 로고
    • RAD50 function is essential for telomere maintenance in Arabidopsis
    • Gallego ME, White CI. RAD50 function is essential for telomere maintenance in Arabidopsis. Proc Natl Acad Sci USA 2001; 98: 1711-6.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1711-1716
    • Gallego, M.E.1    White, C.I.2
  • 149
    • 0033168094 scopus 로고    scopus 로고
    • The role of Schizosaccharomyces pombe Rad32, the Mre11 homologue, and other DNA damage response proteins in non-homologous end joining and telomere length maintenance
    • Wilson S, Warr N, Taylor DL, Watts FZ. The role of Schizosaccharomyces pombe Rad32, the Mre11 homologue, and other DNA damage response proteins in non-homologous end joining and telomere length maintenance. Nucleic Acids Res 1999; 27: 2655-61.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2655-2661
    • Wilson, S.1    Warr, N.2    Taylor, D.L.3    Watts, F.Z.4
  • 150
    • 0041470140 scopus 로고    scopus 로고
    • Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance
    • Ueno M, Nakazaki T, Akamatsu Y, Watanabe K, Tomita K, Lindsay HD, et al. Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance. Mol Cell Biol 2003; 23: 6553-63.
    • (2003) Mol Cell Biol , vol.23 , pp. 6553-6563
    • Ueno, M.1    Nakazaki, T.2    Akamatsu, Y.3    Watanabe, K.4    Tomita, K.5    Lindsay, H.D.6
  • 151
    • 0034013797 scopus 로고    scopus 로고
    • The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast
    • Ritchie KB, Petes TD. The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 2000; 155: 475-9.
    • (2000) Genetics , vol.155 , pp. 475-479
    • Ritchie, K.B.1    Petes, T.D.2
  • 152
    • 0037716757 scopus 로고    scopus 로고
    • Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining
    • Chan SW, Blackburn EH. Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Mol Cell 2003; 11: 1379-87.
    • (2003) Mol Cell , vol.11 , pp. 1379-1387
    • Chan, S.W.1    Blackburn, E.H.2
  • 153
    • 0034964498 scopus 로고    scopus 로고
    • A DNA damage response pathway controlled by Tel1 and the Mre11 complex
    • Usui T, Ogawa H, Petrini JH. A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol Cell 2001; 7: 1255-66.
    • (2001) Mol Cell , vol.7 , pp. 1255-1266
    • Usui, T.1    Ogawa, H.2    Petrini, J.H.3
  • 154
    • 0030565541 scopus 로고    scopus 로고
    • Reduced telomere length in ataxia-telangiectasia fibroblasts
    • Xia SJ, Shammas MA, Shmookler Reis RJ. Reduced telomere length in ataxia-telangiectasia fibroblasts. Mutat Res 1996; 364: 1-11.
    • (1996) Mutat Res , vol.364 , pp. 1-11
    • Xia, S.J.1    Shammas, M.A.2    Shmookler Reis, R.J.3
  • 155
    • 0035282711 scopus 로고    scopus 로고
    • Extra-chromosomal telomeric DNA in cells from Atm(-/-) mice and patients with ataxia-telangiectasia
    • Hande MP, Balajee AS, Tchirkov A, Wynshaw-Boris A, Lansdorp PM. Extra-chromosomal telomeric DNA in cells from Atm(-/-) mice and patients with ataxia-telangiectasia. Hum Mol Genet 2001; 10: 519-28.
    • (2001) Hum Mol Genet , vol.10 , pp. 519-528
    • Hande, M.P.1    Balajee, A.S.2    Tchirkov, A.3    Wynshaw-Boris, A.4    Lansdorp, P.M.5
  • 156
    • 0033853835 scopus 로고    scopus 로고
    • Influence of ATM function on interactions between telomeres and nuclear matrix
    • Pandita TK, Dhar S. Influence of ATM function on interactions between telomeres and nuclear matrix. Radiat Res 2000; 154: 133-9.
    • (2000) Radiat Res , vol.154 , pp. 133-139
    • Pandita, T.K.1    Dhar, S.2
  • 157
    • 0037421896 scopus 로고    scopus 로고
    • Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
    • Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, et al. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 2003; 421: 643-8.
    • (2003) Nature , vol.421 , pp. 643-648
    • Wong, K.K.1    Maser, R.S.2    Bachoo, R.M.3    Menon, J.4    Carrasco, D.R.5    Gu, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.