Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA

Oncogene

Volumn 22, Issue 25, 2003, Pages 3867-3874

  Llorca, O ^a,b   Rivera Calzada, A ^b   Grantham, J ^a   Willison, K R ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

ATM; DNA repair; Electron microscopy reconstruction

Indexed keywords

ATM PROTEIN; AVIDIN; BRCA1 PROTEIN; CHECKPOINT KINASE 2; DOUBLE STRANDED DNA; HISTONE H2AX; PROTEIN; PROTEIN KINASE; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; ATAXIA TELANGIECTASIA; ATM GENE; CANCER SUSCEPTIBILITY; CELL CYCLE; DEGENERATIVE DISEASE; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; ELECTRON MICROSCOPY; ENZYME ACTIVATION; HUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; SYNDROME; THREE DIMENSIONAL IMAGING; TUMOR SUPPRESSOR GENE;

AVIDIN; CELL CYCLE PROTEINS; DNA; DNA DAMAGE; DNA-BINDING PROTEINS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MACROMOLECULAR SUBSTANCES; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0038339042     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206649     Document Type: Article

References (30)

1. Abraham RT. (2001). Genes Dev., 15, 2177-2196.
2. Andegeko Y, Moyal L, Mittelman L, Tsarfaty I, Shiloh Y and Rotman G. (2001). J. Biol. Chem., 276, 38224-38230.
3. Bakkenist CJ and Kastan MB. (2003). Nature, 421, 499-506.
4. Burma S, Chen BP, Murphy M, Kurimasa A and Chen DJ. (2001). J. Biol. Chem., 276, 42462-42467.
5. Concannon P. (2002). Nat. Genet., 32, 89-90.
6. Chiu CY, Cary RB, Chen DJ, Peterson SR and Stewart PL. (1998). J. Mol. Biol., 284, 1075-1081.
7. Durocher D and Jackson SP. (2001). Curr. Opin. Cell Biol., 13, 225-231.
8. Ellison V and Stillman B. (2001). Cell, 106, 655-660.
9. Frank J, Radermacher M, Penczek P, Zhu J, Li Y, Ladjadj M and Leith A. (1996). J. Struct. Biol., 116, 190-199.
10. Kastan MB and Dae-sik L. (2000). Nat. Rev. Mol. Cell. Biol., 1, 179-186.
11. Keegan KS, Holtzman DA, Plug AW, Chnstenson ER, Brainerd EE and Flaggs G et al. (1996). Genes Dev., 10, 2423-2437.
12. Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, Taya Y, Gabrielli B, Chan D, Lees-Miller SP and Lavin MF. (1998). Nat. Genet., 20, 398-400.
13. Leuther KK, Hammarsten O, Kornberg R and Chu G. (1999). EMBO J., 18, 1114-1123.
14. Llorca O, Marco S, Carrascosa JL and Valpuesta JM. (1997). J. Struct. Biol., 118, 31-42.
15. Llorca O, Martin-Benito J, Grantham J, Ritco-Vonsovici M, Willison KR, Carrascosa JL and Valpuesta JM. (2001). EMBO J., 20, 4065-4075.
16. Llorca O, McCormack EA, Hynes G, Grantham J, Cordell J, Carrascosa JL, Willison KR, Fernandez JJ and Valpuesta JM. (1999). Nature, 402, 693-696.
17. Marabini R, Masegosa IM, SanMartin MC, Marco S, Fernandez JJ, De la Fraga LG, Vaquerizo C and Carazo JM. (1996). J. Struct. Biol., 116, 237-240.
18. Meijers-Heijboer H et al. (2002). Nat. Genet., 31, 55-59.
19. Perry J and Kleckner N. (2003). Cell, 112, 151-155.
20. Rhodes N, Gilmer TM and Lansing TJ. (2001). Protein Expression Purification, 22, 462-466.
21. Rosano C, Arosio P and Bolognesi M. (1999). Biomol. Eng., 16, 5-12.
22. Rouse J and Jackson SP. (2002). Mol. Cell, 9, 857-869.
23. Scott S, Bendix R, Chen P, Clark R, Dork T and Lavin MF. (2002). Proc. Natl. Acad. Sci. USA, 99, 925-930.
24. Smith GCM, Cary RB, Lakin ND, Hann BC, Teo S-H, Chen DJ and Jackson SP. (1999). Proc. Natl. Acad. Sci. USA, 96, 11134-11139.
25. Spring K, Ahangari F, Scott SP, Waring P, Purdie DM, Chen PC, Hourigan K, Ramsay J, McKinnon PJ, Swift M and Lavin MF. (2002). Nat. Genet., 32, 185-190.
26. Stroud JC, Lopez-Rodriguez C, Rao A and Chen L. (2002). Nat. Struct. Biol., 9, 90-94.
27. Suzuki K, Kodama S and Watanabe M. (1999). J. Biol. Chem., 274, 25571-25575.
28. VanLoop MS, Alexandrov A, Yu X, Cozzarelli MR and Egelman EH. (2002). Curr. Biol, 12, 472-476.
29. Walker JR, Corpina RA and Goldberg J. (2001). Nature, 412, 607-613.
30. Yaneva M, Kowalewski T and Lieber MR. (1997). EMBO J., 16, 5098-5112.