The Saccharomyces cerevisiae mre11 (ts) allele confers a separation of DNA repair and telomere maintenance functions

Genetics

Volumn 155, Issue 2, 2000, Pages 569-576

  Chamankhah, Mahmood ^a   Fontanie, Treena ^a   Xiao, Wei ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DNA REPAIR; GENE FUNCTION; GENE MUTATION; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; TELOMERE;

ALLELES; AMINO ACID SEQUENCE; DNA REPAIR; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; FUNGAL PROTEINS; GENES, FUNGAL; MOLECULAR SEQUENCE DATA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TELOMERE;

EID: 0034047829     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. AJIMURA, M., S. H. LEEM and H. OGAWA, 1993 Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae. Genetics 133: 51-66.
2. AUSUBEL R. M. R. M., R. BRENT, R. E. KINGSTON, D. D. MOORE, J. G. SEIDMAN et al., 1991 Current Protocols in Mulecular Biology. John Wiley & Sons, New York.
3. BARTEL, P. L., and S. FIELDS, 1995 Analyzing protein-protein interactions using two-hybrid system. Methods Enzymol. 254: 241-263.
4. BOULTON, S. J., S. P. JACKSON, 1998 Components of the Kudependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17: 1819-1828.
5. CHAMANKHAH, M., and W. XIAO, 1998 Molecular cloning and genetic characterization of the Saccharomyces cerevisiae NGSI/MREII gene. Curr. Genet. 34: 368-374.
6. CHAMANKHAH, M., and W. XIAO, 1999 Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance. Nucleic Acids Res. 27: 2072-2079.
7. CHRISTIANSON, T. W., R. S. SIKORSKI, M. DANTE, J. H. SHERO and P. HIETER, 1992 Multifunctional yeast high-copy-number shuttle vectors. Gene 110: 119-122.
8. DIONNE, I., and R.J. WELLINGER, 1998 Processing of telomeric DNA ends requires the passage of a replication fork. Nucleic Acids Res. 26: 5365-5371.
9. DONG, Z., Q. ZHONG and P. L. CHEN, 1999 The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage. J. Biol. Chem. 274: 19513-19516.
10. ESTOJAK, J., R. BRENT and E. A. GOLEMIS, 1995 Correlation of two-hybrid affinity data with in vitro measurements. Mol. Cell. Biol. 15: 5820-5829.
11. FURUSE, M., Y. NAGASE, H. TSUBOUCHI, K. MURAKAMI-MUROFUSHI, T. SHIBATA et al., 1998 Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO J. 17: 6412-6425.
12. GIETZ, R. D., and A. SUGINO, 1988 New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74: 527-534.
13. GOEDECKE, W., M. EIJPE, H. H. OFFENBERG, M. VAN AALDEREN and C. HEYTING, 1999 mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis. Nat. Genet. 23: 194-198.
14. GUARENTE, L., 1983 Yeast promoter and lacZ fusions designed to study expression of cloned genes in yeast. Methods Enzymol. 101: 181-191.
15. HABER, J. E., 1998 The many interfaces of Mre11. Cell 95: 583-580.
16. HILL, J., K. A. DONALD, D. E. GRIFFITHS and G. DONALD, 1991 DMSO-enhanced whole cell yeast transformation. Nucleic Acids Res. 19: 5791.
17. JOHZUKA, K., and H. OGAWA, 1995 Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Genetics 139: 1521-1532.
18. KAISER, C., S. MICHAELIS and A. MITCHELL, 1994 Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Gold Spring Harbor, NY.
19. MOREAU, S., J. R. FERGUSON and L. S. SYMINGTON, 1999 The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell. Biol. 19: 556-566.
20. NAIRZ, K., and F. KLEIN, 1997 mre11S-a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis. Genes Dev. 11: 2272-2290.
21. NUGENT, C. I., G. BOSCO, L. O. ROSS, S. K. EVANS, A. P. SALINGER et al., 1998 Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr. Biol. 8: 657-660.
22. OGAVVA, H., K. JOHZUKA, T. NAKAGAWA, S. H. LEEM and A. H. HAGIHARA, 1995 Functions of the yeast meiotic rerombiantion genes, MRE11 and MRE2. Adv. Biophys. 31: 67-76.
23. PARENTEAU, J., and R. J. WELLINGER, 1999 Accumulation of single-stranded DNA and destabilisation of telomeric repeats in yeast imitant strains earning a deletion of RAD27. Mol. Cell. Biol. 19: 4143-4152.
24. PAULL, T. T., and M. GELLERT, 1998 The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks. Mol. Cell 1: 969-979.
25. PAULL, T. T., and M. GELLART, 1999 Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev. 13: 1276-1288.
26. QIU, J., Y. QIAN, V. CHEN, M. X. GUAN and B. SHEN, 1999 Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance. J. Biol. Chem. 274: 17893-17900.
27. SAMBROOK, J., E. F. FRITSCH and T. MANIATIS, 1989 Molecular Cloning: A Laboratory Manual, Ed. 2. Cold Spring Harbor Laboratory Press, Gold Spring Harbor, NY.
28. SHARPLES, G. J., and D. R. LEACH, 1995 Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast. Mol. Microbiol. 17: 1215-1217.
29. TSUBOUCHI, H., and H. OGAWA, 1998 A novel mre11 mutation impairs processing of double-stand breaks of DNA during both mitosis and meiosis. Mol. Cell. Biol. 18: 260-268.
30. USUI, T., T. OHTA, H. OSHIUMI, J. TOMIZAWA, H. OGAWA et al., 1998 Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95: 705-716.
31. WAILMSLEY, R. M., and T. D. PETES, 1985 Genetic control of chromosome length in yeast. Proc. Natl. Acad. Sci. USA 82: 506-510.
32. XIAO, W., B. L. CHOW and L. RATHGEBER, 1996 The repair of DNA methylation damage in Saccharomyces cerevisiae. Curr. Genet. 30: 461-468.