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Volumn 5, Issue 16, 2003, Pages

A multifaceted role for ATM in genome maintenance

Author keywords

A T; ataxia telangiectasia; ATM; cancer; DNA damage; neurodegeneration; signal transduction

Indexed keywords

ATM PROTEIN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

EID: 1842515632     PISSN: 14623994     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1462399403006318     Document Type: Review
Times cited : (44)

References (152)
  • 1
    • 0028596368 scopus 로고
    • The nature of ataxia-telangiectasia: Problems and perspectives
    • PubMed: 95138611
    • Harnden, D.G. (1994) The nature of ataxia-telangiectasia: problems and perspectives. Int J Radiat Biol 66, S13-19, PubMed: 95138611
    • (1994) Int J Radiat Biol , vol.66
    • Harnden, D.G.1
  • 2
    • 0029002103 scopus 로고
    • Ataxia-telangiectasia: Closer to unraveling the mystery
    • PubMed: 96018070
    • Shiloh, Y. (1995) Ataxia-telangiectasia: closer to unraveling the mystery. Eur J Hum Genet 3, 116-138, PubMed: 96018070
    • (1995) Eur J Hum Genet , vol.3 , pp. 116-138
    • Shiloh, Y.1
  • 3
    • 0037148403 scopus 로고    scopus 로고
    • ATM function and telomere stability
    • DOI 10.1038/sj/onc/1205060
    • Pandita, T.K. (2002) ATM function and telomere stability. Oncogene 21, 611-618, PubMed: 21839807 (Pubitemid 34146261)
    • (2002) Oncogene , vol.21 , Issue.4 REV. ISSUE 1 , pp. 611-618
    • Pandita, T.K.1
  • 4
    • 0022406075 scopus 로고
    • Altered cellular morphology and microfilament array in ataxia-telangiectasia fibroblasts
    • McKinnon, P.J. and Burgoyne, L.A. (1985) Altered cellular morphology and microfilament array in ataxia-telangiectasia fibroblasts. Eur J Cell Biol 39, 161-166, PubMed: 86108391 (Pubitemid 16206686)
    • (1985) European Journal of Cell Biology , vol.39 , Issue.1 , pp. 161-166
    • McKinnon, P.J.1    Burgoyne, L.A.2
  • 5
    • 0028980925 scopus 로고
    • Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells
    • PubMed: 95330979
    • Pandita, T.K, Pathak, S. and Geard, C.R. (1995) Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells. Cytogenet Cell Genet 71, 86-93, PubMed: 95330979
    • (1995) Cytogenet Cell Genet , vol.71 , pp. 86-93
    • Pandita, T.K.1    Pathak, S.2    Geard, C.R.3
  • 8
    • 0032850745 scopus 로고    scopus 로고
    • Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment
    • Smilenov, L.B., Dhar, S. and Pandita, T.K. (1999) Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment. Mol Cell Biol 19, 6963-6971, PubMed: 99421978 (Pubitemid 29441878)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.10 , pp. 6963-6971
    • Smilenov, L.B.1    Dhar, S.2    Pandita, T.K.3
  • 10
    • 0033853835 scopus 로고    scopus 로고
    • Influence of ATM function on interactions between telomeres and nuclear matrix
    • Pandita, T.K. and Dhar, S. (2000) Influence of ATM function on interactions between telomeres and nuclear matrix. Radiat Res 154, 133-139, PubMed: 20392517 (Pubitemid 30612911)
    • (2000) Radiation Research , vol.154 , Issue.2 , pp. 133-139
    • Pandita, T.K.1    Dhar, S.2
  • 11
    • 0033800840 scopus 로고    scopus 로고
    • Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm-and Atm-p53-deficient mice
    • PubMed: 20459278
    • Scherthan, H. et al. (2000) Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm-and Atm-p53-deficient mice. Mol Cell Biol 20, 7773-7783, PubMed: 20459278
    • (2000) Mol Cell Biol , vol.20 , pp. 7773-7783
    • Scherthan, H.1
  • 13
    • 0029057336 scopus 로고
    • A single ataxia telangiectasia gene with a product similar to PI-3 kinase
    • PubMed: 95312868
    • Savitsky, K. et al. (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753, PubMed: 95312868
    • (1995) Science , vol.268 , pp. 1749-1753
    • Savitsky, K.1
  • 14
    • 0029925097 scopus 로고    scopus 로고
    • A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23
    • PubMed: 96301396
    • Savitsky, K. et al. (1996) A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. Genomics 33, 199-206, PubMed: 96301396
    • (1996) Genomics , vol.33 , pp. 199-206
    • Savitsky, K.1
  • 15
    • 0028827312 scopus 로고
    • The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
    • PubMed: 96154672
    • Savitsky, K. et al. (1995) The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum Mol Genet 4, 2025-2032, PubMed: 96154672
    • (1995) Hum Mol Genet , vol.4 , pp. 2025-2032
    • Savitsky, K.1
  • 16
    • 0029807481 scopus 로고    scopus 로고
    • A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: Amino acid sequence, structure and expression studies
    • DOI 10.1093/hmg/5.11.1785
    • Byrd, P.J. et al. (1996) A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies. Hum Mol Genet 5, 1785-1791, PubMed: 97081764 (Pubitemid 26372415)
    • (1996) Human Molecular Genetics , vol.5 , Issue.11 , pp. 1785-1791
    • Byrd, P.J.1    Cooper, P.R.2    Stankovic, T.3    Kullar, H.S.4    Watts, G.D.J.5    Robinson, P.J.6    Taylor, A.M.R.7
  • 17
    • 0030977349 scopus 로고    scopus 로고
    • Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family
    • DOI 10.1016/S0959-437X(97)80125-6
    • Hoekstra, M.F. (1997) Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family. Curr Opin Genet Dev 7, 170-175, PubMed: 97277111 (Pubitemid 27206754)
    • (1997) Current Opinion in Genetics and Development , vol.7 , Issue.2 , pp. 170-175
    • Hoekstra, M.F.1
  • 19
    • 0032555458 scopus 로고    scopus 로고
    • Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development
    • DOI 10.1016/S0304-3940(98)00576-X, PII S030439409800576X
    • Oka, A. and Takashima, S. (1998) Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development. Neurosci Lett 252, 195-198, PubMed: 98410710 (Pubitemid 28400341)
    • (1998) Neuroscience Letters , vol.252 , Issue.3 , pp. 195-198
    • Oka, A.1    Takashima, S.2
  • 21
    • 0034576494 scopus 로고    scopus 로고
    • The many substrates and functions of ATM
    • PubMed: 21146994
    • Kastan, M.B. and Lim, D.S. (2000) The many substrates and functions of ATM. Nat Rev Mol Cell Biol 1, 179-186, PubMed: 21146994
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 179-186
    • Kastan, M.B.1    Lim, D.S.2
  • 23
    • 0031663617 scopus 로고    scopus 로고
    • ATM: From gene to function
    • DOI 10.1093/hmg/7.10.1555
    • Rotman, G. and Shiloh, Y. (1998) ATM: from gene to function. Hum Mol Genet 7, 1555-1563, PubMed: 98407936 (Pubitemid 28464032)
    • (1998) Human Molecular Genetics , vol.7 , Issue.10 , pp. 1555-1563
    • Rotman, G.1    Shiloh, Y.2
  • 25
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: Preventing an identity crisis
    • DOI 10.1126/science.274.5293.1664
    • Elledge, S.J. (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1672, PubMed: 97094361 (Pubitemid 26414889)
    • (1996) Science , vol.274 , Issue.5293 , pp. 1664-1672
    • Elledge, S.J.1
  • 26
    • 0028880649 scopus 로고
    • Ataxia-telangiectasia and cellular responses to DNA damage
    • PubMed: 96105008
    • Meyn, M.S. (1995) Ataxia-telangiectasia and cellular responses to DNA damage. Cancer Res 55, 5991-6001, PubMed: 96105008
    • (1995) Cancer Res , vol.55 , pp. 5991-6001
    • Meyn, M.S.1
  • 27
    • 0030910037 scopus 로고    scopus 로고
    • P53 and ATM: Cell cycle, cell death, and cancer
    • Morgan, S.E. and Kastan, M.B. (1997) p53 and ATM: cell cycle, cell death, and cancer. Adv Cancer Res 71, 1-25, PubMed: 97266058 (Pubitemid 27197755)
    • (1997) Advances in Cancer Research , vol.71 , pp. 1-25
    • Morgan, S.E.1    Kastan, M.B.2
  • 28
    • 0026496885 scopus 로고
    • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
    • PubMed: 93046658
    • Kastan, M.B. et al. (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587-597, PubMed: 93046658
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.B.1
  • 30
    • 0033598754 scopus 로고    scopus 로고
    • Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
    • PubMed: 20040627
    • Chehab, N.H. et al. (1999) Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci USA 96, 13777-13782, PubMed: 20040627
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13777-13782
    • Chehab, N.H.1
  • 31
    • 0033118933 scopus 로고    scopus 로고
    • DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
    • Shieh, S.Y., Taya, Y. and Prives, C. (1999) DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. Embo J 18, 1815-1823, PubMed: 99219860 (Pubitemid 29158525)
    • (1999) EMBO Journal , vol.18 , Issue.7 , pp. 1815-1823
    • Shieh, S.-Y.1    Taya, Y.2    Prives, C.3
  • 32
    • 0036724625 scopus 로고    scopus 로고
    • Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
    • PubMed: 22179714
    • Hirao, A. et al. (2002) Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol 22, 6521-6532, PubMed: 22179714
    • (2002) Mol Cell Biol , vol.22 , pp. 6521-6532
    • Hirao, A.1
  • 33
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    • PubMed: 20139418
    • Shieh, S.Y. et al. (2000) The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 14, 289-300, PubMed: 20139418
    • (2000) Genes Dev , vol.14 , pp. 289-300
    • Shieh, S.Y.1
  • 34
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • Giaccia, A.J. and Kastan, M.B. (1998) The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev 12, 2973-2983, PubMed: 98438444 (Pubitemid 28469299)
    • (1998) Genes and Development , vol.12 , Issue.19 , pp. 2973-2983
    • Giaccia, A.J.1    Kastan, M.B.2
  • 37
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • DOI 10.1016/S0092-8674(00)81175-7
    • Carney, J.P. et al. (1998) The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93, 477-486, PubMed: 98250063 (Pubitemid 28232091)
    • (1998) Cell , vol.93 , Issue.3 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    Le Beau, M.5    Yates III, J.R.6    Hays, L.7    Morgan, W.F.8    Petrini, J.H.J.9
  • 39
    • 0033563229 scopus 로고    scopus 로고
    • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
    • Paull, T.T. and Gellert, M. (1999) Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev 13, 1276-1288, PubMed: 99276558 (Pubitemid 29250195)
    • (1999) Genes and Development , vol.13 , Issue.10 , pp. 1276-1288
    • Paull, T.T.1    Gellert, M.2
  • 40
    • 0034611728 scopus 로고    scopus 로고
    • ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
    • PubMed: 20227312
    • Lim, D.S. et al. (2000) ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404, 613-617, PubMed: 20227312
    • (2000) Nature , vol.404 , pp. 613-617
    • Lim, D.S.1
  • 44
    • 0034798285 scopus 로고    scopus 로고
    • ATM: Genome stability, neuronal development, and cancer cross paths
    • DOI 10.1016/S0065-230X(01)83007-4
    • Shiloh, Y. and Kastan, M.B. (2001) ATM: genome stability, neuronal development, and cancer cross paths. Adv Cancer Res 83, 209-254, PubMed: 21521819 (Pubitemid 32959266)
    • (2001) Advances in Cancer Research , vol.83 , pp. 209-254
    • Shiloh, Y.1    Kastan, M.B.2
  • 45
    • 0029085781 scopus 로고
    • A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage
    • PubMed: 95401274
    • Paulovich, A.G. and Hartwell, L.H. (1995) A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell 82, 841-847, PubMed: 95401274
    • (1995) Cell , vol.82 , pp. 841-847
    • Paulovich, A.G.1    Hartwell, L.H.2
  • 48
    • 0036500555 scopus 로고    scopus 로고
    • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
    • DOI 10.1101/gad.970602
    • Kim, S.T., Xu, B. and Kastan, M.B. (2002) Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev 16, 560-570, PubMed: 21866463 (Pubitemid 34212489)
    • (2002) Genes and Development , vol.16 , Issue.5 , pp. 560-570
    • Kim, S.-T.1    Xu, B.2    Kastan, M.B.3
  • 49
    • 0036500690 scopus 로고    scopus 로고
    • SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
    • DOI 10.1101/gad.970702
    • Yazdi, P.T. et al. (2002) SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev 16, 571-582, PubMed: 21866464 (Pubitemid 34212490)
    • (2002) Genes and Development , vol.16 , Issue.5 , pp. 571-582
    • Yazdi, P.T.1    Wang, Y.2    Zhao, S.3    Patel, N.4    Lee, E.Y.-H.P.5    Qin, J.6
  • 50
    • 0036146085 scopus 로고    scopus 로고
    • 2/M checkpoints are induced by ionizing irradiation
    • DOI 10.1128/MCB.22.4.1049-1059.2002
    • Xu, B. et al. (2002) Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 22, 1049-1059, PubMed: 21668979 (Pubitemid 34094842)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.4 , pp. 1049-1059
    • Xu, B.1    Kim, S.-T.2    Lim, D.-S.3    Kastan, M.B.4
  • 51
    • 0032484084 scopus 로고    scopus 로고
    • Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    • Matsuoka, S., Huang, M. and Elledge, S.J. (1998) Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282, 1893-1897, PubMed: 99055399 (Pubitemid 28555269)
    • (1998) Science , vol.282 , Issue.5395 , pp. 1893-1897
    • Matsuoka, S.1    Huang, M.2    Elledge, S.J.3
  • 54
    • 0035810054 scopus 로고    scopus 로고
    • Regulation of the G2/M transition by p53
    • DOI 10.1038/sj.onc.1204252
    • Taylor, W.R. and Stark, G.R. (2001) Regulation of the G2/M transition by p53. Oncogene 20, 1803-1815, PubMed: 21214584 (Pubitemid 32458690)
    • (2001) Oncogene , vol.20 , Issue.15 , pp. 1803-1815
    • Taylor, W.R.1    Stark, G.R.2
  • 55
    • 0035913162 scopus 로고    scopus 로고
    • Cdc25B activity is regulated by 14-3-3
    • DOI 10.1038/sj.onc.1204574
    • Forrest, A. and Gabrielli, B. (2001) Cdc25B activity is regulated by 14-3-3. Oncogene 20, 4393-4401, PubMed: 21359859 (Pubitemid 32726881)
    • (2001) Oncogene , vol.20 , Issue.32 , pp. 4393-4401
    • Forrest, A.1    Gabrielli, B.2
  • 56
    • 0030611095 scopus 로고    scopus 로고
    • Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
    • PubMed: 97426626
    • Peng, C.Y. et al. (1997) Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501-1505, PubMed: 97426626
    • (1997) Science , vol.277 , pp. 1501-1505
    • Peng, C.Y.1
  • 57
    • 0033106326 scopus 로고    scopus 로고
    • 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
    • DOI 10.1016/S1097-2765(00)80466-9
    • Xu, X. et al. (1999) Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell 3, 389-395, PubMed: 99214854 (Pubitemid 29290679)
    • (1999) Molecular Cell , vol.3 , Issue.3 , pp. 389-395
    • Xu, X.1    Weaver, Z.2    Linke, S.P.3    Li, C.4    Gotay, J.5    Wang, X.-W.6    Harris, C.C.7    Ried, T.8    Deng, C.-X.9
  • 58
    • 0035032649 scopus 로고    scopus 로고
    • 2-phase checkpoints after ionizing irradiation
    • DOI 10.1128/MCB.21.10.3445-3450.2001
    • Xu, B., Kim, S. and Kastan, M.B. (2001) Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol 21, 3445-3450, PubMed: 21214383 (Pubitemid 32381780)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.10 , pp. 3445-3450
    • Xu, B.1    Kim, S.-T.2    Kastan, M.B.3
  • 59
    • 0036510163 scopus 로고    scopus 로고
    • BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
    • PubMed: 21918578
    • Yarden, R.I. et al. (2002) BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet 30, 285-289, PubMed: 21918578
    • (2002) Nat Genet , vol.30 , pp. 285-289
    • Yarden, R.I.1
  • 60
    • 0034650582 scopus 로고    scopus 로고
    • Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice
    • Bishop, A.J. et al. (2000) Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice. Cancer Res 60, 395-399, PubMed: 20129055 (Pubitemid 30070768)
    • (2000) Cancer Research , vol.60 , Issue.2 , pp. 395-399
    • Bishop, A.J.R.1    Barlow, C.2    Wynshaw-Boris, A.J.3    Schiestl, R.H.4
  • 61
    • 0030048511 scopus 로고    scopus 로고
    • High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines
    • PubMed: 96224036
    • Luo, C.M. et al. (1996) High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines. J Biol Chem 271, 4497-4503, PubMed: 96224036
    • (1996) J Biol Chem , vol.271 , pp. 4497-4503
    • Luo, C.M.1
  • 62
    • 0026663777 scopus 로고
    • Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells
    • PubMed: 92220950
    • Pandita, T.K. and Hittelman, W.N. (1992) Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells. Radiat Res 130, 94-103, PubMed: 92220950
    • (1992) Radiat Res , vol.130 , pp. 94-103
    • Pandita, T.K.1    Hittelman, W.N.2
  • 63
    • 0026733077 scopus 로고
    • The contribution of DNA and chromosome repair deficiencies to the radiosensitivity of ataxia-telangiectasia
    • PubMed: 92350894
    • Pandita, T.K. and Hittelman, W.N. (1992) The contribution of DNA and chromosome repair deficiencies to the radiosensitivity of ataxia-telangiectasia. Radiat Res 131, 214-223, PubMed: 92350894
    • (1992) Radiat Res , vol.131 , pp. 214-223
    • Pandita, T.K.1    Hittelman, W.N.2
  • 64
    • 0028228994 scopus 로고
    • Effect of chromosome size on aberration levels caused by gamma radiation as detected by fluorescence in situ hybridization
    • Pandita, T.K. et al. (1994) Effect of chromosome size on aberration levels caused by gamma radiation as detected by fluorescence in situ hybridization. Cytogenet Cell Genet 67, 94-101, PubMed: 94313899 (Pubitemid 24213855)
    • (1994) Cytogenetics and Cell Genetics , vol.67 , Issue.2 , pp. 94-101
    • Pandita, T.K.1    Gregoire, V.2    Dhingra, K.3    Hittelman, W.N.4
  • 65
    • 0024495171 scopus 로고
    • Kinetics of chromatid aberrations in G2 ataxia-telangiectasia cells exposed to X-rays and ara A
    • Mozdarani, H. and Bryant, P.E. (1989) Kinetics of chromatid aberrations in G2 ataxia-telangiectasia cells exposed to X-rays and ara A. Int J Radiat Biol 55, 71-84, PubMed: 89094138 (Pubitemid 19036809)
    • (1989) International Journal of Radiation Biology , vol.55 , Issue.1 , pp. 71-84
    • Mozdarani, H.1    Bryant, P.E.2
  • 67
    • 0031697988 scopus 로고    scopus 로고
    • Characterization of ATM expression, localization, and associated DNA- dependent protein kinase activity
    • Gately, D.P. et al. (1998) Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity. Mol Biol Cell 9, 2361-2374, PubMed: 98395041 (Pubitemid 28425881)
    • (1998) Molecular Biology of the Cell , vol.9 , Issue.9 , pp. 2361-2374
    • Gately, D.P.1    Hittle, J.C.2    Chan, G.K.T.3    Yen, T.J.4
  • 68
    • 0033603601 scopus 로고    scopus 로고
    • Histone H1 dephosphorylation is mediated through a radiation-induced signal transduction pathway dependent on ATM
    • PubMed: 99303642
    • Guo, C.Y. et al. (1999) Histone H1 dephosphorylation is mediated through a radiation-induced signal transduction pathway dependent on ATM. J Biol Chem 274, 18715-18720, PubMed: 99303642
    • (1999) J Biol Chem , vol.274 , pp. 18715-18720
    • Guo, C.Y.1
  • 69
    • 0033615547 scopus 로고    scopus 로고
    • Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase
    • PubMed: 20002626
    • Kim, G.D. et al. (1999) Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase. J Biol Chem 274, 31127-31130, PubMed: 20002626
    • (1999) J Biol Chem , vol.274 , pp. 31127-31130
    • Kim, G.D.1
  • 70
    • 0035930342 scopus 로고    scopus 로고
    • Promotion of Dnl4-Catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes
    • DOI 10.1016/S1097-2765(01)00388-4
    • Chen, L. et al. (2001) Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. Mol Cell 8, 1105-1115, PubMed: 21617596 (Pubitemid 34031812)
    • (2001) Molecular Cell , vol.8 , Issue.5 , pp. 1105-1115
    • Chen, L.1    Trujillo, K.2    Ramos, W.3    Sung, P.4    Tomkinson, A.E.5
  • 71
    • 0032528066 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae LIF1: A function involved in DNA double-strand break repair related to mammalian XRCC4
    • DOI 10.1093/emboj/17.14.4188
    • Herrmann, G., Lindahl, T. and Schar, P. (1998) Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4. Embo J 17, 4188-4198, PubMed: 98336207 (Pubitemid 28334002)
    • (1998) EMBO Journal , vol.17 , Issue.14 , pp. 4188-4198
    • Herrmann, G.1    Lindahl, T.2    Schar, P.3
  • 72
    • 0030749258 scopus 로고    scopus 로고
    • A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks
    • Schar, P. et al. (1997) A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks. Genes Dev 11, 1912-1924, PubMed: 97415316 (Pubitemid 27332979)
    • (1997) Genes and Development , vol.11 , Issue.15 , pp. 1912-1924
    • Schar, P.1    Herrmann, G.2    Daly, G.3    Lindahl, T.4
  • 73
    • 0030849085 scopus 로고    scopus 로고
    • Identification of saccharomyces cerevisiae DNA ligase IV: Involvement in DNA double-strand break repair
    • DOI 10.1093/emboj/16.15.4788
    • Teo, S.H. and Jackson, S.P. (1997) Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair. Embo J 16, 4788-4795, PubMed: 97447583 (Pubitemid 27326616)
    • (1997) EMBO Journal , vol.16 , Issue.15 , pp. 4788-4795
    • Teo, S.-H.1    Jackson, S.P.2
  • 74
    • 0033168094 scopus 로고    scopus 로고
    • The role of Schizosaccharomyces pombe Rad32, the Mre11 homologue, and other DNA damage response proteins in non-homologous end joining and telomere length maintenance
    • DOI 10.1093/nar/27.13.2655
    • Wilson, S. et al. (1999) The role of Schizosaccharomyces pombe Rad32, the Mre11 homologue, and other DNA damage response proteins in non-homologous end joining and telomere length maintenance. Nucleic Acids Res 27, 2655-2661, PubMed: 99303825 (Pubitemid 29306563)
    • (1999) Nucleic Acids Research , vol.27 , Issue.13 , pp. 2655-2661
    • Wilson, S.1    Warr, N.2    Taylor, D.L.3    Watts, F.Z.4
  • 75
    • 0035895504 scopus 로고    scopus 로고
    • Human DNA repair genes
    • DOI 10.1126/science.1056154
    • Wood, R.D. et al. (2001) Human DNA repair genes. Science 291, 1284-1289, PubMed: 21108349 (Pubitemid 32173086)
    • (2001) Science , vol.291 , Issue.5507 , pp. 1284-1289
    • Wood, R.D.1    Mitchell, M.2    Sgouros, J.3    Lindahl, T.4
  • 76
    • 0037155703 scopus 로고    scopus 로고
    • Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    • DOI 10.1016/S0092-8674(02)00671-2
    • Ma, Y. et al. (2002) Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108, 781-794, PubMed: 21952476 (Pubitemid 34327530)
    • (2002) Cell , vol.108 , Issue.6 , pp. 781-794
    • Ma, Y.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 79
    • 0034031137 scopus 로고    scopus 로고
    • DNA double strand break repair in mammalian cells
    • DOI 10.1016/S0959-437X(00)00069-1
    • Karran, P. (2000) DNA double strand break repair in mammalian cells. Curr Opin Genet Dev 10, 144-150, PubMed: 20218811 (Pubitemid 30182246)
    • (2000) Current Opinion in Genetics and Development , vol.10 , Issue.2 , pp. 144-150
    • Karran, P.1
  • 80
    • 0032536861 scopus 로고    scopus 로고
    • Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
    • DOI 10.1093/emboj/17.6.1819
    • Boulton, S.J. and Jackson, S.P. (1998) Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. Embo J 17, 1819-1828, PubMed: 98169398 (Pubitemid 28119135)
    • (1998) EMBO Journal , vol.17 , Issue.6 , pp. 1819-1828
    • Boulton, S.J.1    Jackson, S.P.2
  • 81
    • 0029836924 scopus 로고    scopus 로고
    • New vectors for combinatorial deletions in yeast chromosomes and for gap-repair cloning using 'split-marker' recombination
    • DOI 10.1002/(SICI)1097-0061 (199611)12:14<1439:: AID-YEA37>3.0. CO;2-O
    • Fairhead, C. et al. (1996) New vectors for combinatorial deletions in yeast chromosomes and for gap-repair cloning using 'split-marker' recombination. Yeast 12, 1439-1457, PubMed: 97103773 (Pubitemid 26393225)
    • (1996) Yeast , vol.12 , Issue.14 , pp. 1439-1457
    • Fairhead, C.1    Llorente, B.2    Denis, F.3    Soler, M.4    Dujon, B.5
  • 82
    • 0035889233 scopus 로고    scopus 로고
    • NEHJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the Ligase IV pathway
    • DOI 10.1101/gad.206801
    • Frank-Vaillant, M. and Marcand, S. (2001) NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway. Genes Dev 15, 3005-3012, PubMed: 21567938 (Pubitemid 33078950)
    • (2001) Genes and Development , vol.15 , Issue.22 , pp. 3005-3012
    • Frank-Vaillant, M.1    Marcand, S.2
  • 83
    • 0033565609 scopus 로고    scopus 로고
    • Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths
    • DOI 10.1016/S0960-9822(99)80339-X
    • Lee, S.E. et al. (1999) Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths. Curr Biol 9, 767-770, PubMed: 99350623 (Pubitemid 29350858)
    • (1999) Current Biology , vol.9 , Issue.14 , pp. 767-770
    • Lee, S.E.1    Paques, F.2    Sylvan, J.3    Haber, J.E.4
  • 84
    • 0031896912 scopus 로고    scopus 로고
    • Requirement for end-joining and checkpoint functions, but not RAD52- mediated recombination, after EcoRI endonuclease cleavage of Saccharomyces cerevisiae DNA
    • Lewis, L.K., Kirchner, J.M. and Resnick, M.A. (1998) Requirement for end-joining and checkpoint functions, but not RAD52-mediated recombination, after EcoRI endonuclease cleavage of Saccharomyces cerevisiae DNA. Mol Cell Biol 18, 1891-1902, PubMed: 98187609 (Pubitemid 28152637)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.4 , pp. 1891-1902
    • Lewis, L.K.1    Kirchner, J.M.2    Resnick, M.A.3
  • 85
    • 0033551662 scopus 로고    scopus 로고
    • Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway
    • PubMed: 99367496
    • Wilson, T.E. and Lieber, M.R. (1999) Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway. J Biol Chem 274, 23599-23609, PubMed: 99367496
    • (1999) J Biol Chem , vol.274 , pp. 23599-23609
    • Wilson, T.E.1    Lieber, M.R.2
  • 86
    • 0035899933 scopus 로고    scopus 로고
    • Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast
    • DOI 10.1016/S0960-9822(01)00488-2
    • Kegel, A., Sjostrand, J.O. and Astrom, S.U. (2001) Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast. Curr Biol 11, 1611-1617, PubMed: 21534323 (Pubitemid 32978528)
    • (2001) Current Biology , vol.11 , Issue.20 , pp. 1611-1617
    • Kegel, A.1    Sjostrand, J.O.O.2    Astrom, S.U.3
  • 87
    • 0032530658 scopus 로고    scopus 로고
    • Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
    • DOI 10.1093/emboj/17.18.5497
    • Takata, M. et al. (1998) Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. Embo J 17, 5497-5508, PubMed: 98409553 (Pubitemid 28427063)
    • (1998) EMBO Journal , vol.17 , Issue.18 , pp. 5497-5508
    • Takata, M.1    Sasaki, M.S.2    Sonoda, E.3    Morrison, C.4    Hashimoto, M.5    Utsumi, H.6    Yamaguchi-Iwai, Y.7    Shinohara, A.8    Takeda, S.9
  • 88
    • 0034668060 scopus 로고    scopus 로고
    • Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm
    • PubMed: 20496893
    • Lee, Y. et al. (2000) Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Genes Dev 14, 2576-2580, PubMed: 20496893
    • (2000) Genes Dev , vol.14 , pp. 2576-2580
    • Lee, Y.1
  • 90
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • DOI 10.1038/85798
    • Khanna, K.K. and Jackson, S.P. (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 27, 247-254, PubMed: 21135082 (Pubitemid 32201842)
    • (2001) Nature Genetics , vol.27 , Issue.3 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 92
    • 0032516654 scopus 로고    scopus 로고
    • BRCA1 required for transcription-coupled repair of oxidative DNA damage
    • Gowen, L.C. et al. (1998) BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science 281, 1009-1012, PubMed: 98369178 (Pubitemid 28399254)
    • (1998) Science , vol.281 , Issue.5379 , pp. 1009-1012
    • Gowen, L.C.1    Avrutskaya, A.V.2    Latour, A.M.3    Koller, B.H.4    Leadon, S.A.5
  • 93
    • 0033213392 scopus 로고    scopus 로고
    • Brca1 controls homology-directed DNA repair
    • DOI 10.1016/S1097-2765(00)80202-6
    • Moynahan, M.E. et al. (1999) Brca1 controls homology-directed DNA repair. Mol Cell 4, 511-518, PubMed: 20017049 (Pubitemid 29531131)
    • (1999) Molecular Cell , vol.4 , Issue.4 , pp. 511-518
    • Moynahan, M.E.1    Chiu, J.W.2    Koller, B.H.3    Jasint, M.4
  • 95
    • 0035951809 scopus 로고    scopus 로고
    • Characterization of tumor-associated Chk2 mutations
    • PubMed: 21264758
    • Wu, X., Webster, S.R. and Chen, J. (2001) Characterization of tumor-associated Chk2 mutations. J Biol Chem 276, 2971-2974, PubMed: 21264758
    • (2001) J Biol Chem , vol.276 , pp. 2971-2974
    • Wu, X.1    Webster, S.R.2    Chen, J.3
  • 96
    • 0034644220 scopus 로고    scopus 로고
    • Functional link of BRCA1 and ataxia telangiectasia gone product in DNA damage response
    • DOI 10.1038/35018134
    • Li, S. et al. (2000) Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 406, 210-215, PubMed: 20365735 (Pubitemid 30469007)
    • (2000) Nature , vol.406 , Issue.6792 , pp. 210-215
    • Li, S.1    Ting, N.S.Y.2    Zheng, L.3    Chen, P.-L.4    Ziv, Y.5    Shiloh, Y.6    Lee, E.Y.-H.P.7    Lee, W.-H.8
  • 97
    • 0342561644 scopus 로고    scopus 로고
    • Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
    • PubMed: 20347725
    • Zhu, X.D. et al. (2000) Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet 25, 347-352, PubMed: 20347725
    • (2000) Nat Genet , vol.25 , pp. 347-352
    • Zhu, X.D.1
  • 98
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • Blackburn, E.H. (1991) Structure and function of telomeres. Nature 350, 569-573, PubMed: 91204051 (Pubitemid 21912269)
    • (1991) Nature , vol.350 , Issue.6319 , pp. 569-573
    • Blackburn, E.H.1
  • 99
    • 0035928740 scopus 로고    scopus 로고
    • Altering telomere structure allows telomerase to act in yeast lacking ATM kinases
    • DOI 10.1016/S0960-9822(01)00391-8
    • Chan, S.W. et al. (2001) Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr Biol 11, 1240-1250, PubMed: 21417174 (Pubitemid 32774080)
    • (2001) Current Biology , vol.11 , Issue.16 , pp. 1240-1250
    • Chan, S.W.L.1    Chang, J.2    Prescott, J.3    Blackburn, E.H.4
  • 100
    • 0035851090 scopus 로고    scopus 로고
    • Nuclear retention of ATM at sites of DNA double strand breaks
    • PubMed: 21474284
    • Andegeko, Y. et al. (2001) Nuclear retention of ATM at sites of DNA double strand breaks. J Biol Chem 276, 38224-38230, PubMed: 21474284
    • (2001) J Biol Chem , vol.276 , pp. 38224-38230
    • Andegeko, Y.1
  • 101
    • 0035800767 scopus 로고    scopus 로고
    • Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks
    • PubMed: 21369915
    • Kishi, S. et al. (2001) Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J Biol Chem 276, 29282-29291, PubMed: 21369915
    • (2001) J Biol Chem , vol.276 , pp. 29282-29291
    • Kishi, S.1
  • 102
    • 0036510540 scopus 로고    scopus 로고
    • 2/M checkpoint defect of ataxia-telangiectasia cells
    • DOI 10.1074/jbc.M111365200
    • Kishi, S. and Lu, K.P. (2002) A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells. J Biol Chem 277, 7420-7429, PubMed: 21850661 (Pubitemid 34953139)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.9 , pp. 7420-7429
    • Kishi, S.1    Lu, K.P.2
  • 103
    • 0033605145 scopus 로고    scopus 로고
    • P53-and ATM-dependent apoptosis induced by telomeres lacking TRF2
    • PubMed: 99157118
    • Karlseder, J. et al. (1999) p53-and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283, 1321-1325, PubMed: 99157118
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1
  • 104
    • 0032558998 scopus 로고    scopus 로고
    • Structure and function of the core histone N-termini: More than meets the eye
    • DOI 10.1021/bi982409v
    • Hansen, J.C., Tse, C. and Wolffe, A.P. (1998) Structure and function of the core histone N-termini: more than meets the eye. Biochemistry 37, 17637-17641, PubMed: 99119190 (Pubitemid 29023917)
    • (1998) Biochemistry , vol.37 , Issue.51 , pp. 17637-17641
    • Hansen, J.C.1    Tse, C.2    Wolffe, A.P.3
  • 105
    • 0034757212 scopus 로고    scopus 로고
    • The role of ATM in telomere structure and function
    • Pandita, T.K. (2001) The role of ATM in telomere structure and function. Radiat Res 156, 642-647, PubMed: 21491093 (Pubitemid 33027542)
    • (2001) Radiation Research , vol.156 , Issue.5 , pp. 642-647
    • Pandita, T.K.1
  • 107
    • 0027298713 scopus 로고
    • Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites
    • DOI 10.1006/jmbi.1993.1283
    • Gilson, E. et al. (1993) Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites. J Mol Biol 231, 293-310, PubMed: 93287103 (Pubitemid 23188254)
    • (1993) Journal of Molecular Biology , vol.231 , Issue.2 , pp. 293-310
    • Gilson, E.1    Roberge, M.2    Giraldo, R.3    Rhodes, D.4    Gasser, S.M.5
  • 108
    • 0028102668 scopus 로고
    • Mammalian meiotic recombination: A reexamination
    • Ashley, T. (1994) Mammalian meiotic recombination: a reexamination. Hum Genet 94, 587-593, PubMed: 95080765 (Pubitemid 24351514)
    • (1994) Human Genetics , vol.94 , Issue.6 , pp. 587-593
    • Ashley, T.1
  • 109
    • 0017380785 scopus 로고
    • Development of the synaptonemal complex and the 'recombination nodules' during meiotic prophase in the seven bivalents of the fungus Sordaria macrospora Auersw
    • Zickler, D. (1977) Development of the synaptonemal complex and the recombination nodules during meiotic prophase in the seven bivalents of the fungus Sordaria macrospora Auersw. Chromosoma 61, 289-316, PubMed: 77224706 (Pubitemid 8126273)
    • (1977) Chromosoma , vol.61 , Issue.4 , pp. 289-316
    • Zickler, D.1
  • 110
    • 0019272334 scopus 로고
    • Mechanics of meiosis
    • Rasmussen, S.W. and Holm, P.B. (1980) Mechanics of meiosis. Hereditas 93, 187-216, PubMed: 81069269 (Pubitemid 11162231)
    • (1980) Hereditas , vol.93 , Issue.2 , pp. 187-216
    • Rasmussen, S.W.1    Holm, P.B.2
  • 111
    • 0021751950 scopus 로고
    • Synaptonemal complex-associated centromeres and recombination nodules in plant meiocytes prepared by an improved surface-spreading technique
    • DOI 10.1016/0014-4827(84)90219-2
    • Albini, S.M. and Jones, G.H. (1984) Synaptonemal complex-associated centromeres and recombination nodules in plant meiocytes prepared by an improved surface-spreading technique. Exp Cell Res 155, 588-592, PubMed: 85051651 (Pubitemid 15216654)
    • (1984) Experimental Cell Research , vol.155 , Issue.2 , pp. 588-592
    • Albini, S.M.1    Jones, G.H.2
  • 112
    • 0026784331 scopus 로고
    • Meiotic chromosome condensation and pairing in Saccharomyces cerevisiae studied by chromosome painting
    • PubMed: 93048363
    • Scherthan, H. et al. (1992) Meiotic chromosome condensation and pairing in Saccharomyces cerevisiae studied by chromosome painting. Chromosoma 101, 590-595, PubMed: 93048363
    • (1992) Chromosoma , vol.101 , pp. 590-595
    • Scherthan, H.1
  • 113
    • 0032529177 scopus 로고    scopus 로고
    • Telomere-mediated chromosome pairing during meiosis in budding yeast
    • Rockmill, B. and Roeder, G.S. (1998) Telomere-mediated chromosome pairing during meiosis in budding yeast. Genes Dev 12, 2574-2586, PubMed: 98382509 (Pubitemid 28406959)
    • (1998) Genes and Development , vol.12 , Issue.16 , pp. 2574-2586
    • Rockmill, B.1    Roeder, G.S.2
  • 114
    • 0000470365 scopus 로고
    • Moens, P.B., ed. Academic Press, Orlando, FL
    • Fussell, C.P. (1987) In Meiosis (Moens, P.B., ed.), pp. 275-299, Academic Press, Orlando, FL
    • (1987) Meiosis , pp. 275-299
    • Fussell, C.P.1
  • 115
    • 0000369119 scopus 로고
    • Blackburn, E.H.and Grieder, C.W., eds Cold Spring Harbor Press, New York
    • Dernburg, A.F. et al. (1995) In Telomeres (Blackburn, E.H.and Grieder, C.W., eds), pp. 295-338, Cold Spring Harbor Press, New York
    • (1995) Telomeres , pp. 295-338
    • Dernburg, A.F.1
  • 116
    • 0017365714 scopus 로고
    • Premeiotic and early meiotic stages in the pollen mother cells of Eremurus and in human embryonic oocytes
    • DOI 10.1007/BF00393963
    • Therman, E. and Sarto, G.E. (1977) Premeiotic and early meiotic stages in the pollen mother cells of Eremurus and in human embryonic oocytes. Hum Genet 35, 137-151, PubMed: 77139706 (Pubitemid 8031293)
    • (1977) Human Genetics , vol.35 , Issue.2 , pp. 137-151
    • Therman, E.1    Sarto, G.E.2
  • 117
    • 0025607289 scopus 로고
    • The initiation of meiotic chromosome pairing: The cytological view
    • PubMed: 91200651
    • Loidl, J. (1990) The initiation of meiotic chromosome pairing: the cytological view. Genome 33, 759-778, PubMed: 91200651
    • (1990) Genome , vol.33 , pp. 759-778
    • Loidl, J.1
  • 122
    • 0033533612 scopus 로고    scopus 로고
    • 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
    • PubMed: 99452264
    • Chan, T.A. et al. (1999) 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 401, 616-620, PubMed: 99452264
    • (1999) Nature , vol.401 , pp. 616-620
    • Chan, T.A.1
  • 123
    • 0031149850 scopus 로고    scopus 로고
    • The protein kinase KSR interacts with 14-3-3 protein and Raf
    • Xing, H., Kornfeld, K. and Muslin, A.J. (1997) The protein kinase KSR interacts with 14-3-3 protein and Raf. Curr Biol 7, 294-300, PubMed: 97277256 (Pubitemid 27195605)
    • (1997) Current Biology , vol.7 , Issue.5 , pp. 294-300
    • Xing, H.1    Kornfeld, K.2    Muslin, A.J.3
  • 124
    • 0034729189 scopus 로고    scopus 로고
    • Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes
    • PubMed: 20293208
    • Dellambra, E. et al. (2000) Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes. J Cell Biol 149, 1117-1130, PubMed: 20293208
    • (2000) J Cell Biol , vol.149 , pp. 1117-1130
    • Dellambra, E.1
  • 125
    • 0033806120 scopus 로고    scopus 로고
    • Inactivation of 14-3-3sigma influences telomere behavior and ionizing radiation-induced chromosomal instability
    • PubMed: 20459277
    • Dhar, S. et al. (2000) Inactivation of 14-3-3sigma influences telomere behavior and ionizing radiation-induced chromosomal instability. Mol Cell Biol 20, 7764-7772, PubMed: 20459277
    • (2000) Mol Cell Biol , vol.20 , pp. 7764-7772
    • Dhar, S.1
  • 126
    • 0035913157 scopus 로고    scopus 로고
    • Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress
    • DOI 10.1038/sj.onc.1204509
    • Gage, B.M. et al. (2001) Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress. Oncogene 20, 4291-4297, PubMed: 21359848 (Pubitemid 32726870)
    • (2001) Oncogene , vol.20 , Issue.32 , pp. 4291-4297
    • Gage, B.M.1    Alroy, D.2    Shin, C.Y.3    Ponomareva, O.N.4    Dhar, S.5    Sharma, G.G.6    Pandita, T.K.7    Thayer, M.J.8    Turker, M.S.9
  • 127
    • 0030807476 scopus 로고    scopus 로고
    • Identification of defective illegitimate recombinational repair of oxidatively-induced DNA double-strand breaks in ataxia-telangiectasia cells
    • DOI 10.1016/S0921-8777(97)00021-9, PII S0921877797000219
    • Dar, M.E., Winters, T.A. and Jorgensen, T.J. (1997) Identification of defective illegitimate recombinational repair of oxidatively-induced DNA double-strand breaks in ataxia-telangiectasia cells. Mutat Res 384, 169-179, PubMed: 97471672 (Pubitemid 27394242)
    • (1997) Mutation Research - DNA Repair , vol.384 , Issue.3 , pp. 169-179
    • Dar, M.E.1    Winters, T.A.2    Jorgensen, T.J.3
  • 128
    • 0030071035 scopus 로고    scopus 로고
    • Elevation of interferon β-inducible proteins in ataxia telangiectasia cells
    • Siddoo-Atwal, C., Haas, A.L. and Rosin, M.P. (1996) Elevation of interferon beta-inducible proteins in ataxia telangiectasia cells. Cancer Res 56, 443-447, PubMed: 96147247 (Pubitemid 26048598)
    • (1996) Cancer Research , vol.56 , Issue.3 , pp. 443-447
    • Siddoo-Atwal, C.1    Haas, A.L.2    Rosin, M.P.3
  • 129
    • 0035905742 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: Chronic activation of damage-responsive functions is reduced by α-lipoic acid
    • DOI 10.1038/sj.onc.1204111
    • Gatei, M. et al. (2001) Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid. Oncogene 20, 289-294, PubMed: 21214419 (Pubitemid 32142317)
    • (2001) Oncogene , vol.20 , Issue.3 , pp. 289-294
    • Gatei, M.1    Shkedy, D.2    Khanna, K.K.3    Uziel, T.4    Shiloh, Y.5    Pandita, T.K.6    Lavin, M.F.7    Rotman, G.8
  • 132
    • 0036792811 scopus 로고    scopus 로고
    • ATM gene regulates oxygen-glucose deprivation-induced nuclear factor-kappaB DNA-binding activity and downstream apoptotic cascade in mouse cerebrovascular endothelial cells
    • PubMed: 22251401
    • Yin, K.J. et al. (2002) ATM gene regulates oxygen-glucose deprivation-induced nuclear factor-kappaB DNA-binding activity and downstream apoptotic cascade in mouse cerebrovascular endothelial cells. Stroke 33, 2471-2477, PubMed: 22251401
    • (2002) Stroke , vol.33 , pp. 2471-2477
    • Yin, K.J.1
  • 134
    • 0028588643 scopus 로고
    • Clinical and genetic features of ataxia-telangiectasia
    • PubMed: 95138621
    • Bundey, S. (1994) Clinical and genetic features of ataxia-telangiectasia. Int J Radiat Biol 66, S23-29, PubMed: 95138621
    • (1994) Int J Radiat Biol , vol.66
    • Bundey, S.1
  • 136
    • 0001086904 scopus 로고
    • Vinken, P.J. and Bruyn, G.W., eds North-Holland, Amsterdam
    • Sedgwick, R.P. and Boder, E. (1972) In Handbook of Clinical Neurology (Vinken, P.J. and Bruyn, G.W., eds), pp. 267-339, North-Holland, Amsterdam
    • (1972) Handbook of Clinical Neurology , pp. 267-339
    • Sedgwick, R.P.1    Boder, E.2
  • 137
    • 0022992181 scopus 로고
    • The incidence and gene frequency of Ataxia-telangiectasia in the United States
    • Swift, M. et al. (1986) The incidence and gene frequency of ataxia-telangiectasia in the United States. Am J Hum Genet 39, 573-583, PubMed: 87073434 (Pubitemid 17071140)
    • (1986) American Journal of Human Genetics , vol.39 , Issue.5 , pp. 573-583
    • Swift, M.1    Morrell, D.2    Cromartie, E.3
  • 138
    • 0021096730 scopus 로고
    • Cancer and cardiac deaths in obligatory ataxia-telangiectasia heterozygotes
    • PubMed: 83190986
    • Swift, M. and Chase, C. (1983) Cancer and cardiac deaths in obligatory ataxia-telangiectasia heterozygotes. Lancet 1, 1049-1050, PubMed: 83190986
    • (1983) Lancet , vol.1 , pp. 1049-1050
    • Swift, M.1    Chase, C.2
  • 139
    • 0031029676 scopus 로고    scopus 로고
    • Heterozygous ATM mutations do not contribute to early onset of breast cancer
    • PubMed: 97207655
    • FitzGerald, M.G. et al. (1997) Heterozygous ATM mutations do not contribute to early onset of breast cancer. Nat Genet 15, 307-310, PubMed: 97207655
    • (1997) Nat Genet , vol.15 , pp. 307-310
    • Fitzgerald, M.G.1
  • 141
    • 0035425350 scopus 로고    scopus 로고
    • Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history
    • DOI 10.1002/1097-0142 (20010801)92:3<479:: AID-CNCR1346>3.0.CO;2-G
    • Teraoka, S.N. et al. (2001) Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history. Cancer 92, 479-487, PubMed: 21395916 (Pubitemid 32735182)
    • (2001) Cancer , vol.92 , Issue.3 , pp. 479-487
    • Teraoka, S.N.1    Malone, K.E.2    Doody, D.R.3    Suter, N.M.4    Ostrander, E.A.5    Daling, J.R.6    Concannon, P.7
  • 144
    • 0028761632 scopus 로고
    • Ionizing radiation, breast cancer, and ataxia-telangiectasia
    • PubMed: 95018332
    • Swift, M. (1994) Ionizing radiation, breast cancer, and ataxia-telangiectasia. J Natl Cancer Inst 86, 1571-1572, PubMed: 95018332
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1571-1572
    • Swift, M.1
  • 145
    • 0028966306 scopus 로고
    • Cancer mortality and low doses of ionising radiation
    • PubMed: 95124088
    • Swift, M. (1995) Cancer mortality and low doses of ionising radiation. Lancet 345, 253, PubMed: 95124088
    • (1995) Lancet , vol.345 , pp. 253
    • Swift, M.1
  • 146
    • 0027991848 scopus 로고
    • Increased initial levels of chromosome damage and heterogeneous chromosome repair in ataxia telangiectasia heterozygote cells
    • DOI 10.1016/0027-5107(94)90004-3
    • Pandita, T.K. and Hittelman, W.N. (1994) Increased initial levels of chromosome damage and heterogeneous chromosome repair in ataxia telangiectasia heterozygote cells. Mutat Res 310, 1-13, PubMed: 95021343 (Pubitemid 24302715)
    • (1994) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol.310 , Issue.1 , pp. 1-13
    • Pandita, T.K.1    Hittelman, W.N.2
  • 148
    • 0031738103 scopus 로고    scopus 로고
    • A preliminary report: Frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy
    • PubMed: 99070250
    • Hall, E.J. et al. (1998) A preliminary report: frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy. Cancer J Sci Am 4, 385-389, PubMed: 99070250
    • (1998) Cancer J Sci Am , vol.4 , pp. 385-389
    • Hall, E.J.1
  • 149
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • DOI 10.1038/nature01368
    • Bakkenist, C.J. and Kastan, M.B. (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506, PubMed: 22444791 (Pubitemid 36168436)
    • (2003) Nature , vol.421 , Issue.6922 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 150
    • 84867562855 scopus 로고    scopus 로고
    • ATP activates ATM in vitro: Importance of autophosphorylation
    • Kozlov, S. et al. (2003) ATP activates ATM in vitro: importance of autophosphorylation. J Biol Chem 6, 6
    • (2003) J Biol Chem , vol.6 , pp. 6
    • Kozlov, S.1


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