Altering telomere structure allows telomerase to act in yeast lacking ATM kinases

Current Biology

Volumn 11, Issue 16, 2001, Pages 1240-1250

  Chan, Simon W L ^a   Chang, Jennifer ^a   Prescott, John ^a   Blackburn, Elizabeth H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0035928740     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00391-8     Document Type: Article

References (48)

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6. Telomerase in yeast
7. Reverse transcriptase motifs in the catalytic subunit of telomerase
8. Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity
9. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues
10. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae
11. The DNA damage response: Putting checkpoints in perspective
12. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
13. TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1
14. Accelerated telomere shortening in ataxia telangiectasia
15. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
16. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
17. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
18. Sequence-specific DNA primer effects on telomerase polymerization activity
19. Purification of telomerase from Euplotes aediculatus: Requirement of a primer 3′ overhang
20. Mutational analysis defines a C-terminal tail domain of RAP1 essential for telomeric silencing in Saccharomyces cerevisiae
21. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
22. Rap1 protein regulates telomere turnover in yeast
23. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
24. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae
25. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process
26. Circular rDNA replicons persist in Tetrahymena thermophila transformants synthesizing GGGGTC telomeric repeats
27. Runaway telomere elongation caused by telomerase RNA gene mutations
28. Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast
29. Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres
30. The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast
31. The many interfaces of Mre11
32. Characterization of double-strand break-induced recombination: Homology requirements and single-stranded DNA formation
33. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
34. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
35. Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway
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37. Progressive cis-inhibition of telomerase upon telomere elongation
38. Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo
39. Block in anaphase chromosome separation caused by a telomerase template mutation
40. Template boundary in a yeast telomerase specified by RNA structure
41. Use of a selection technique to identify the diversity of binding sites for the yeast RAP1 transcription factor
42. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
43. Designer deletion strains derived from Saccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications
44. A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae
45. Targeting, disruption, replacement, and allele rescue: Integrative DNA transformation in yeast
46. High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier
47. Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro