Fragments of ATM which have dominant-negative or complementing activity

Molecular and Cellular Biology

Volumn 17, Issue 4, 1997, Pages 2020-2029

  Morgan, Susan E ^a   Lovly, Christine ^a   Pandita, Tej K ^b   Shiloh, Yosef ^c   Kastan, Michael B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b College of Physicians and Surgeons ^*  (United States)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; DNA FRAGMENT; LEUCINE ZIPPER PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; ATAXIA TELANGIECTASIA; BLAST TRANSFORMATION; CELL AGING; CELL CYCLE; CHROMOSOME BREAKAGE; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; PRIORITY JOURNAL; PROTEIN DOMAIN; RADIOSENSITIVITY; SIGNAL TRANSDUCTION;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0030969423     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.4.2020     Document Type: Article

References (65)

1. Al-Khodairy, F., E. Fotou, K. S. Sheldrick, D. J. F. Griffiths, A. R. Lehmann, and A. M. Carr. 1994. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. Mol. Biol. Cell 5:147-160.
2. Allen, J. B., Z. Zhou, W. Siede, E. C. Friedberg, and S. J. Elledge. 1994. The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 8:2401-2415.
3. Beamish, H., K. K. Khanna, and M. F. Lavin. 1994. Ionizing radiation and cell cycle progression in ataxia telangiectasia. Radiat. Res. 138:S130-S133.
4. Brown, E. J., M. W. Albers, T. B. Shin, K. Ichikawa, C. T. Keith, W. S. Lane, and S. L. Schreiber. 1994. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369:756-758.
5. Byrd, P. J., C. M. McConville, P. Cooper, J. Parkhill, T. Stankovic, G. M. McGuire, J. A. Thick, and A. M. R. Taylor. 1996. Mutations revealed by sequencing the 5-prime half of the gene for ataxia-telangiectasia. Hum. Mol. Genet. 5:145-149.
6. Canman, C. E., A. C. Wolff, C. Chen, A. J. Fornace, and M. B. Kastan. 1994. The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia. Cancer Res. 54:5054-5058.
7. Chen, P., A. A. Girjes, K. Hobson, H. Beamish, K. K. Khanna, A. Farrell, M. Gatei, B. Teale, M. Buchwald, R. Legerski, and M. F. Lavin. 1996. Genetic complementation of radiation response by 3′ untranslated regions (UTR) of RNA. Int. J. Radiat. Biol. 69:385-395.
8. Dang, C. V., M. McGuire, M. Buckmire, and W. M. F. Lee. 1989. Involvement of the "leucine zipper" region in the oligomerization and transforming activity of human c-myc protein. Nature 337:664-666.
9. Dhand, R., I. Hiles, G. Panayotou, S. Roche, M. J. Fry, I. Gout, N. F. Totty, O. Truong, P. Vicendo, K. Yonezawa, M. Kasuga, S. A. Courtneidge, and M. D. Waterfield. 1994. PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO J. 13:522-533.
10. Enoch, T., and C. Norbury. 1995. Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. Trends Biochem. Sci. 20:426-430.
11. Freund, G. G., J. G. Wittig, and R. A. Mooney. 1995. The PI3-kinase serine kinase phosphorylates its p85 subunit and IRS-1 in PI3-kinase/IRS-1 complexes. Biochem. Biophys. Res. Commun. 206:272-278.
12. Gatti, R. A., E. Boder, H. V. Vinters, R. S. Sparkes, A. Norman, and K. Lange. 1991. Ataxia-telangeictasia: an interdisciplinary approach to pathogenesis. Medicine 70:99-117.
13. Gibbas, L. M., and L. G. Jackson. 1985. A new hypotonic solution for cytogenetic analysis of leukemic bone marrow cells. Karyogram 11:91-92.
14. Gilad, S., R. Khosravi, D. Shkedy, T. Uziel, Y. Ziv, K. Savitsky, G. Rotman, S. Smith, L. Chessa, T. J. Jorgensen, R. Harnik, M. Frydman, O. Sanal, S. Portnoi, Z. Goldwicz, N. G. J. Jaspers, R. A. Gatti, G. Lenoir, M. F. Lavin, K. Tatsumi, R. D. Wegner, Y. Shiloh, and A. Bar-Shira. 1996. Predominance of null mutations in ataxia-telangiectasia. Hum. Mol. Genet. 5:433-439.
15. Gottlieb, T. M., and S. P. Jackson. 1993. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72:131-142.
16. Granger-Schnarr, M., E. Benusiglio, M. Schnarr, and P. Sassone-Corsi. 1992. Transformation and transactivation suppressor activity of the c-Jun leucine zipper fused to a bacterial repressor. Proc. Natl. Acad. Sci. USA 89:4236-4239.
17. Greenwell, P. W., S. L. Krommal, S. E. Porter, J. Gassenhuber, B. Obermaier, and T. D. Petes. 1995. Tel1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82:823-829.
18. Hanks, S. K., A. M. Quinn, and T. Hunter. 1988. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241:42-52.
19. Hari, K. L., A. Santerre, J. J. Sekelsky, K. S. McKim, J. B. Boyd, and R. S. Hawley. 1995. The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell 82:815-821.
20. Harnden, D. G. 1994. The nature of ataxia-telangiectasia: problems and perspectives. Int. J. Radiat. Biol. 66:S13-19.
21. Hartley, K. O., D. Gell, G. C. M. Smith, H. Zhang, N. Divecha, M. A. Connelly, A. Admon, S. P. Lees-Miller, C. W. Anderson, and S. P. Jackson. 1995. DNA-dependent protein kinase catalytic subunit - a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82:849-856.
22. Hecht, F., and B. K. Hecht. 1990. Cancer in ataxia-telangiectasia patients. Cancer Genet. Cytogenet. 46:9-19.
23. Heitman, J., N. R. Movva, and M. N. Hall. 1991. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253:905-909.
24. Helliwell, S. B., P. Wagner, J. Kunz, M. Deuter-Reinhard, R. Henriquez, and M. N. Hall. 1994. TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol. Biol. Cell 5:105-118.
25. Hiles, I. D., M. Otsu, S. Volinia, M. J. Fry, I. Gout, R. Dhand, G. Panayotou, F. Ruiz-Larrea, A. Thompson, H. F. Totty, J. J. Hsuan, S. A. Courtneidge, P. J. Parker, and M. Waterfield. 1992. Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell 70:419-429.
26. Houldsworth, J., and M. F. Lavin. 1980. Effect of ionizing radiation on DNA synthesis in ataxia-telangiectasia cells. Nucleic Acids Res. 8:3709-3720.
27. Kastan, M. B., Q. Zhan, W. S. El-Deiry, F. Carrier, T. Jacks, W. V. Walsh, B. S. Plunkett, B. Vogelstein, and A. J. Fornace Jr. 1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71:587-597.
28. Kato, J., M. Matsuoka, D. K. Strom, and C. J. Sherr. 1994. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol. Cell. Biol. 14:2713-2721.
29. Khanna, K. K., and M. F. Lavin. 1993. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene 8:3307-3312.
30. Kobayashi, Y., B. Tycko, A. L. Soreng, and J. Sklar. 1991. Transrearrangements between antigen receptor genes in normal human lymphoid tissues and in ataxia telangiectasia. J. Immunol. 147:3201-3209.
31. Kuerbitz, S. J., B. S. Plunkett, W. V. Walsh, and M. B. Kastan. 1992. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA 89:7491-7495.
32. Kunz, J., R. Henriquez, U. Schneider, M. Deuter-Reinhard, N. R. Movva, and M. N. Hall. 1993. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73: 585-596.
33. Larner, J. M., H. Lee, and J. L. Hamlin. 1994. Radiation effects on DNA synthesis in a defined chromosomal replicon. Mol. Cell. Biol. 14:1901-1908.
34. Lipkowitz, S., M. H. Stern, and I. R. Kirsh. 1990. Hybrid T cell receptor genes formed by interlocus recombination in normal and ataxia-telangiectasia lymphocytes. J. Exp. Med. 172:409-118.
35. Lydall, D., and T. Weinert. 1995. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 270:1488-1491.
36. McKinnon, P. J. 1987. Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Progress in the elucidation of the underlying biochemical defect. Hum. Genet. 75:197-208.
37. Meyn, M. S. 1993. High spontaneous intrachromosomal recombination rates in ataxia-telangiectasia. Science 260:1327-1330.
38. Meyn, M. S., J. M. Lu-Kuo, and L. B. Herring. 1993. Expression cloning of multiple human cDNAs that complement the phenotypic defects of ataxia-telangiectasia group D fibroblasts. Am. J. Hum. Genet. 53:1206-1216.
39. Miller, A. D., D. G. Miller, J. G. Victor, and C. M. Lynch. 1993. Use of retroviral vectors for gene transfer and expression. Methods Enzymol. 217: 581-599.
40. Morgenstern, J. P., and H. Land. 1990. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18:3587-3596.
41. Morrow, D. M., D. A. Tagle, Y. Shiloh, F. S. Collins, and P. Hieter. 1995. TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82:831-840.
42. Nagasawa, H., S. A. Latt, M. E. Lalande, and J. B. Little. 1985. Effects of X-irradiation on cell-cycle progression, induction of chromosomal aberrations and cell killing in ataxia-telangiectasia (AT) fibroblasts. Mutat. Res. 148:71-82.
43. Painter, R. B., and B. R. Young. 1980. Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc. Natl. Acad. Sci. USA 77:7315-7317.
44. Pandita, T. K., S. Pathak, and C. R. Geard. 1995. Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells. Cytogenet. Cell Genet. 71:86-93.
45. Pandita, T. K., and C. R. Geard. 1996. Chromosome aberrations in human fibroblasts induced by monoenergetic neutrons. 1. Relative biological effectiveness. Radiat. Res. 145:730-739.
46. Pandita, T. K., E. J. Hall, T. K. Hei, M. A. Piatyszek, W. E. Wright, C. Q. Piao, R. K. Pandita, J. C. Willey, R. C. Geard, M. B. Kastan, and J. W. Shay. 1996. Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles stimulating radon progeny. Oncogene 13:1423-1430.
47. Pandita, T. K., and W. N. Hittelman. 1992. The contribution of DNA and chromosome repair deficiencies to the radiosensitivity of ataxia-telangiectasia. Radiat. Res. 131:214-223.
48. Paules, R. S., E. N. Levedakou, S. J. Wilson, C. L. Innes, N. Rhodes, T. D. Tlsty, D. A. Galloway, L. A. Donehower, M. A. Tainsky, and W. K. Kaufmann. 1995. Defective G2 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res. 55:1763-1773.
49. Sabatini, D. M., H. Erdjument-Bromage, M. Lui, P. Tempst, and S. H. Snyder. 1994. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78: 35-43.
50. Sabers, C. J., M. M. Martin, G. J. Brunn, J. M. Williams, F. J. Dumont, G. Wiederrecht, and R. T. Abraham. 1995. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J. Biol. Chem. 270:815-822.
51. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
52. Sanchez, Y., B. A. Desany, W. J. Jones, Q. Liu, B. Wang, and S. J. Elledge. 1996. Regulation of Rad53 by the ATM-like kinases Mec1 and Tel1 in yeast cell cycle checkpoint pathways. Science 271:357-360.
53. Savitsky, K., A. Bar-Shira, S. Gilad, G. Rotman, Y. Ziv, L. Vanagaite, D. A. Tagle, S. Smith, T. Uziel, S. Sfez, M. Ashkenazi, I. Pecker, M. Frydman, R. Harnik, S. R. Patanjali, A. Simmons, G. A. Clines, A. Sartiel, R. A. Gatti, L. Chessa, O. Sanal, M. F. Lavin, N. G. J. Jaspers, A. M. R. Taylor, C. F. Arlett, T. Miki, S. M. Weissman, M. Lovett, F. S. Collins, and Y. Shiloh. 1995. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268:1749-1753.
54. Savitsky, K., S. Sfez, D. A. Tagle, A. Sartiel, F. S. Collins, Y. Shiloh, and G. Rotman. 1995. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum. Mol. Genet. 4:2025-2032.
55. Shiloh, Y. 1995. Ataxia-telangiectasia: closer to unraveling the mystery. Eur. J. Hum. Genet. 3:116-138.
56. Stan, R., M. M. McLaughlin, R. Cafferkey, R. K. Johnson, M. Rosenberg, and G. P. Livi. 1994. Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue. J. Biol. Chem. 269:32027-32030.
57. Sun, Z., D. S. Fay, F. Marini, M. Foiani, and D. F. Stern. 1996. Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev. 10:395-406.
58. Swift, M., D. Morrell, R. B. Massey, and C. L. Chase. 1991. Incidence of cancer in 161 families affected by ataxia-telangiectasia. N. Engl. J. Med. 325:1831-1836.
59. Swift, M., P. J. Reitnauer, D. Morrell, and C. L. Chase. 1987. Breast and other cancers in families affected by ataxia-telangeictasia. N. Engl. J. Med. 316:1289-1294.
60. Taccioli, G. E., T. M. Gottlieb, T. Blunt, A. Priestley, J. Demengeot, R. Mizuta, A. R. Lehmann, F. W. Alt, S. P. Jackson, and P. A. Jeggo. 1994. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265:1442-1445.
61. Tanti, J. F., T. Gremeaux, E. Van Obberghen, and Y. LeMarchand-Brustel. 1994. Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase. Biochem. J. 304:17-21.
62. Tuteja, N., M. Meyer, K. K. Reddy, J. R. Falck, R. Aneja, A. Parra, D. J. Burns, L. M. Ballas, and L. C. Cantley. 1994. Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. J. Biol. Chem. 269:32358-32367.
63. Weinert, T. A., G. L. Kiser, and L. H. Hartwell. 1994. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8:652-665.
64. Yao, K.-S., M. Clayton, and P. J. O'Dwyer. 1995. Apoptosis in human adenocarcinoma HT29 cells induced by exposure to hypoxia. J. Natl. Cancer Inst. 87:117-122.
65. Ziv, Y., A. Bar-Shira, T. J. Jorgensen, P. S. Russell, A. Sartiel, T. B. Shows, R. L. Eddy, M. Buchwald, R. Legerski, R. T. Schimke, et al. 1995. Human cDNA clones that modify radiomimetic sensitivity of ataxia-telangiectasia (group A) cells. Somatic Cell Mol. Genet. 21:99-111.