Meiotic telomere distribution and sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice

Molecular and Cellular Biology

Volumn 20, Issue 20, 2000, Pages 7773-7783

  Scherthan, H ^a   Jerratsch, M ^a   Dhar, S ^a   Wang, Y A ^a   Goff, S P ^a   Pandita, T K ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; HISTONE H1; MUTANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA TELANGIECTASIA; CONTROLLED STUDY; DNA DAMAGE; GENE MUTATION; MEIOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SERTOLI CELL; SPERMATID; SPERMATOGENESIS; TELOMERE;

ANIMAL; ATAXIA TELANGIECTASIA; CELL NUCLEUS; CHROMATIN; FLUORESCENT DYES; GENE DELETION; GENES, P53; HETEROCHROMATIN; HISTONES; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MEIOSIS; MICE; MICE, KNOCKOUT; NUCLEAR MATRIX; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SERTOLI CELLS; SPERMATOCYTES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TELOMERE; VIMENTIN;

EID: 0033800840     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.20.7773-7783.2000     Document Type: Article

References (100)

1. RecA-like proteins arc components of early meiotic nodules in Lilly
2. Patterns of keratins 8, 18 and 19 during gonadal differentiation in the mouse: Sex- and time-dependent expression of keratin 19
3. Intermediate filaments in Sertoli cells
4. A model for the structure of chromatin in mammalian sperm
5. Atm-deficient mice: A paradigm of ataxia telangiectasia
6. Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles
7. Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I
8. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
9. The Schizosaccharomyces pombe rad3 checkpoint gene
10. The distribution pattern of cytokeratin and vimentin immunoreactivity in testicular biopsies of infertile men
11. DNA repair at the level of the gene
12. Multiple ATM-dependent pathways: An explanation for pleiotropy
13. The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
14. A reassessment of Y chromosome behaviour in germ cells and Sertoli cells of the mouse as revealed by in situ hybridisation
15. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
16. The product of the ATM gene is a 370 kDa nuclear phosphoprotein
17. Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl
18. Nuclear compartments and gene regulation
19. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
20. Ending up with the right partner
21. The cytology of telomeres
22. Co-expression of cytokeratin and vimentin filaments in rete testis and epididymis: An immunohistochemical study. Virchows Arch
23. Expression of the mouse testicular histone gene H1t during spermatogenesis
24. Differential expression of the c-Abl proto-oncogene and the homeo box-containing gene Hox 1.4 during mouse spermatogenesis
25. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
26. Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
27. Rad52 associates with RPA and functions with rad55 and rad57 to assemble meiotic recombination complexes
28. Characterization of ATM expression, localization, associated DNA-dependent protein kinase activity
29. Alterations of cell cycle kinetics and vimentin expression in asynchronous, TPA-treated MPC-11 mouse plasmacytoma cells
30. Crossing over in the male mouse as analyzed by recombination nodules and bars
31. Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA
32. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
33. Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice
34. Histone H1 dephosphorylation is mediated through a radiation-induced signal transduction pathway dependent on ATM
35. Interphase chromosome arrangement in Sertoli cells of adult mice
36. Nucleolar transcriptional activity in mouse Sertoli cells is dependent on centromere arrangement
37. Abnormal peripheral lymphocyte function in c-abl mutant mice
38. The nature of ataxia-telangiectasia: Problems and perspectives
39. Arrangement of centromeres in mouse cells
40. Targeting double-strand breaks to replicating DNA identifies a subpathway of DSB repair that is defective in ataxia-telangiectasia cells
41. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
42. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes
43. PIK-related kinases: DNA repair, recombination, cell cycle checkpoint
44. Mammalian spermatogenesis in vivo and in vitro: A partnership of spermatogenic and somatic cell lineages
45. Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase
46. Meiotic chromosome metabolism: One view
47. The cytogenetics of ataxia telangiectasia
48. The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases
49. A cytological and cytoskeletal comparison of Sertoli cells without germ cell and those with germ cells using the W/WV mutant mouse
50. The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes
51. Eighth international workshop on ataxia-telangiectasia (ATW8)
52. The initiation of meiotic chromosome pairing: The cytological view
53. Structure, subnuclear distribution, nuclear matrix association of the mammalian telomeric complex
54. A meiotic recombination checkpoint controlled by mitotic checkpoint genes
55. Proteins of the meiotic cell nucleus
56. Ataxia-telangiectasia and cellular responses to DNA damage
57. Histones H1 and H4 of surface-spread meiotic chromosomes
58. The association of ATR protein with mouse meiotic chromosome cores
59. The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
60. The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis
61. Chromosome end association, telomeres and telomerase activity in ataxia telangiectasia cells
62. Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with a-particles simulating radon progeny
63. Atm inactivation results in aberrant telomere clustering during meiotic prophase
64. Transient coexpression of cytokeratin and vimentin in differentiating rat Sertoli cells
65. Cell interactions during the seminiferous epithelial cycle
66. ATM and RPA in meiotic chromosome synapsis and recombination
67. Changes in protein composition of meiotic nodules during mammalian meiosis
68. Haploid expression of a unique c-Abl transcript in the mouse male germ line
69. Telomeres and telomerase: Broad effects on cell growth
70. Telomere-mediated chromosome pairing during meiosis in budding yeast
71. Meiotic chromosomes: It takes two to tango
72. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
73. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
74. Localization of SCP2 and SCP3 protein molecules within synaptonemal complexes of the rat
75. Chromosome behavior in earliest meiotic prophase
76. Methodology of non isotopic in situ-hybridization in paraffin embedded tissue sections
77. Centromere and telomere movement during early prophase of mouse and man are associated with the onset of chromosome pairing
78. Interactions between ATM protein and c-Abl in response to DNA damage
79. Ataxia-telangiectasia: Closer to unraveling the mystery
80. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
81. Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombination
82. Influence of ATM function on telomere metabolism
83. Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment
84. DNA nicks and increased sensitivity of DNA to fluorescence in situ end labeling during functional spermiogenesis
85. Meiosis in the foetal mouse ovary
86. Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation
87. RAD51 and DMC1 form mixed complexes associated with mouse meiotic chromosome cores and synaptonemal complexes
88. Localization of RecA-like recombination proteins on chromosomes of the lily at various meiotic stages
89. Bouquet formation in budding yeast: Initiation of recombination is not required for meiotic telomere clustering
90. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
91. Cell-cycle signaling: Arm displays its many talents
92. Atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
93. Sequence organization and cytological localization of the minor satellite of mouse
94. Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints
95. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, thymic lymphoma
96. Dual roles of ATM in the cellular response to radiation and in cell growth control
97. Saccharomyces telomeres: Function, structure and replication
98. The leptotene-zygotene transition of meiosis