Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

Oncogene

Volumn 18, Issue 28, 1999, Pages 4047-4054

  Chaturvedi, Priya ^a   Eng, Wai K ^a   Zhu, Yuan ^a   Mattern, Michael R ^a   Mishra, Rubin ^a   Hurle, Mark R ^a   Zhang, Xiaolong ^a   Annan, Roland S ^a   Lu, Quinn ^a   Faucette, Leo F ^a   Scott, Gilbert F ^a   Li, Xiaotong ^a   Carr, Steven A ^a   Johnson, Randall K ^a   Winkler, James D ^a   Zhou, Bin Bing S ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

radiation; ATM; cdc25C; Chk2; Hydroxyurea; Topotecan

Indexed keywords

DNA TOPOISOMERASE INHIBITOR; HYDROXYUREA; PHOSPHOTRANSFERASE; SERINE; TOPOTECAN;

ARTICLE; ATAXIA TELANGIECTASIA; CELL CYCLE PARAMETERS; DNA DAMAGE; DNA FLANKING REGION; DNA REPLICATION; ENZYME PHOSPHORYLATION; GAMMA RADIATION; GENETIC COMPLEMENTATION; HUMAN; MAMMAL; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

ALKYLATING AGENTS; ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; CELLS, CULTURED; CLONING, MOLECULAR; DNA DAMAGE; DNA REPAIR; DNA TOPOISOMERASES, TYPE I; DNA, COMPLEMENTARY; DNA, FUNGAL; DNA-BINDING PROTEINS; ENZYME INHIBITORS; FUNGAL PROTEINS; GAMMA RAYS; GENETIC COMPLEMENTATION TEST; HUMANS; HYDROXYUREA; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RAS-GRF1; RATS; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; TOPOTECAN; TUMOR SUPPRESSOR PROTEINS;

ATAXIA; ATAXIA TELANGIECTASIA; MAMMALIA; RODENTIA; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

EID: 0033566082     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202925     Document Type: Article

References (39)

1. Allen JB, Zhou Z, Siede W, Friedberg EC and Elledge SJ. (1994). Genes Dev., 8, 2401-2415.
2. Barlow C, Hirotsune S, Paylor R, Liyanage M, Eckhaus M, Collins F, Shiloh Y, Crowley JN, Ried T, Tagle D and Wynshaw-Boris A. (1996). Cell, 86, 159-171.
3. Biemann K. (1990). In: McCloskey JA. (ed.). Methods in Enzymology, Vol 193, Academic Press. New York: pp. 886-887.
4. Bentley NJ, Holtzman DA, Flaggs G, Keegan KS, DeMaggio A, Ford JC, Hoekstra M and Carr AM. (1996). EMBO J., 15, 6641-6651.
5. Blasina A, Van de Weyer I, Laus MC, Luyten WHML, Parker AE and McGowan CH. (1999). Curr. Biol., 9, 1-10.
6. Boddy MN, Furnari B, Mondesert O and Russell P. (1998). Science, 280, 909-912.
7. Carr SA, Huddleston MJ and Annan RS. (1996). Anal. Biochem., 239, 180-192.
8. Cimprich KA, Shin TB, Keith CT and Schreiber SL. (1996). Proc. Natl. Acad. Sci. USA, 93, 2850-2855.
9. Elledge SJ. (1996). Science, 274, 1664-1672.
10. Hartwell LH and Weinert TA. (1989). Science, 246, 629-634.
11. Hofmann K and Bucher P. (1995). Trends Biochem Sci., 20, 347-349.
12. Huang M, Zhou Z and Elledge SJ. (1998). Cell, 94, 595-605.
13. Kastan MB, Zhou Q. El-Diery WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace Jr AJ. (1992). Cell, 71, 587-597.
14. Keegan KS, Holtzman DA, Plug AW, Christenson ER, Brainerd EE, Flaggs G, Bentley NJ, Taylor EM, Meyn MS, Moss SB, Carr AM, Ashley T, Hockstra MF. (1996). Genes Dev., 10, 2423-2437.
15. Kingsbury WD, Boehm JC, Jakas DR, Holden KG, Hecht SM, Gallagher G, Caranfa MJ, McCabe FL, Faucette LF, Johnson RK and Hertzberg RP. (1991). J. Med. Chem., 34, 98-107.
16. Lindsay HD, Griffiths DJF, Edwards RJ, Christensen PU, Murray JM, Osman F, Walworth N and Carr AM. (1998). Genes Dev., 12, 382-395.
17. Matsuoka S, Huang M and Elledge SJ. (1998). Science, 282, 1893-1897.
18. Maundrell K. (1990). J. Biol. Chem., 265, 10857-10864.
19. Murakami H and Okayama H. (1995). Nature, 374, 817-819.
20. Murray AW. (1995). Curr. Opin. Genet. Dev., 5, 5-11.
21. Paulovich AG and Hartwell LH. (1995). Cell, 82, 841-847.
22. Painter RB and Young BR. (1980). Proc. Natl. Acad. Sci. USA, 77, 7315-7317.
23. Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS and Piwnica-Worms H. (1997). Science, 277, 1501-1505.
24. Ryan AJ, Squires S, Strutt HL, Evans A, Johnson RT. (1994). Carcinogenesis, 15, 823-828.
25. Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B and Elledge SJ. (1996). Science, 271, 357-360.
26. Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H and Elledge SJ. (1997). Science, 277, 1497-1501.
27. Santocanale C and Diffley JFX. (1998). Nature, 395, 615-617.
28. Savitsky K, Bar-shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, Tagle DA, Smith S, Uziel T, Sfez S, Ashkenazi LP, Frydman M, Harnik R, Sankhavaram RP, Simmons A, Clines GA, Sartiel A, Gatti RA, Chessa L, Sanal O, Lavin MF, Jaspers NGJ, Taylor MR, Arlett CF, Miki T, Weissman SM, Lovett M, Collins F and Shiloh Y. (1995). Nature, 268, 1749-1753.
29. Scudiero DA, Shoemaker RH, Pauli KD, Monks A, Tierney S, Nofziger TH, Currens MJ, Seniff D and Boyd MR. (1988). Cancer Res., 48, 4827-4834.
30. Shirahige K, Hori Y, Shiraishi K, Yamashita M, Takahashi K, Obuse C, Tsurimoto T and Yoshikawa H. (1998). Nature, 395, 618-621.
31. Sun Z, Fay DS, Marini F, Foiani M and Stern DF. (1996). Genes Dev., 10, 395-406.
32. Sun Z, Hsiao J, Fay DS and Stern DF. (1998). Science, 281, 272-274.
33. Walworth N, Davey S and Beach D. (1993). Nature, 363, 368-371.
34. Walworth N and Bernard R. (1996). Science, 271, 353-356.
35. Weichselbaum RR, Nove J and Little JB. (1978). Nature, 271, 261-262.
36. Weinert TA, Kiser GL and Hartwell LH. (1994). Genes Dev., 8, 652-665.
37. Zeng Y, Forbes KC, Wu Z, Moreno S, Piwnica-Worms H and Enoch T. (1998). Nature, 395, 507-510.
38. Zhang X, Herring CJ, Romano PR, Szczepanowska J, Breska H, Hinnebusch and Qin J. (1998). Anal Chem., 70, 2050-2059.
39. Ziv Y, Bar-Shira A, Pecker I, Russell P Jorgensen TJ, Tsarfate I and Shiloh Y. (1997). Oncogene, 15, 159-167.