Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history

Cancer

Volumn 92, Issue 3, 2001, Pages 479-487

  Teraoka, Sharon N ^a   Malone, Kathleen E ^b   Doody, David R ^c   Suter, Nicola M ^b   Ostrander, Elaine A ^d   Daling, Janet R ^b   Concannon, Patrick ^a  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Ataxia telangiectasia; Breast carcinoma; DNA double strand break repair; Missense mutations

Indexed keywords

ATM PROTEIN;

ADULT; ARTICLE; BREAST CARCINOMA; CANCER DIAGNOSIS; CONTROLLED STUDY; DISEASE COURSE; FAMILY HISTORY; FEMALE; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MISSENSE MUTATION; PRIORITY JOURNAL;

ADULT; AGE OF ONSET; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; EXONS; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENETIC MARKERS; HUMANS; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RISK FACTORS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0035425350     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20010801)92:3<479::AID-CNCR1346>3.0.CO;2-G     Document Type: Article

References (52)

1. Ataxia-telangiectasia
2. Ataxia-telangiectasia and cellular responses to DNA damage
3. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
4. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
5. Interaction between ATM protein and c-Abl in response to DNA damage
6. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
7. Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks
8. ATM-dependent phosphorylation of nibrin in response to radiation exposure
9. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
10. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
11. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
12. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
13. The incidence and gene frequency of ataxia-telangiectasia in the United States
14. Cancer risks in A-T heterozygotes
15. Heterozygous ATM mutations do not contribute to early onset of breast cancer
16. Breast and other cancers in families with ataxia-telangiectasia
17. Cancers in 44 families with ataxia-telangiectasia
18. Incidence of cancer in 161 families affected by ataxia-telangiectasia
19. Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer
20. Cancer in homozygotes and heterozygotes of ataxia-telangiectasia and xeroderma pigmentosum in Britain
21. ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: Expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer
22. Risk of breast cancer and other cancers in heterozygotes for ataxia-telangiectasia
23. Breast cancer and other cancers in Norwegian families with ataxia-telangiectasia
24. Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia
25. Biallelic mutations in the ATM gene in T-prolymphocytic leukemia
26. ATM is usually rearranged in T-cell prolymphocytic leukaemia
27. Inactivation of the ATM gene in T-cell prolymphocytic leukemias
28. Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia
29. ATM mutations in B-cell chronic lymphocytic leukemia
30. Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia
31. Mantle cell lymphoma is characterized by inactivation of the ATM gene
32. The ATM gene and susceptibility to breast cancer: Analysis of 38 breast tumors reveals no evidence for mutation
33. ATM mutations in cancer families
34. The role of ataxia-telangiectasia heterozygotes in familial breast cancer
35. No evidence for constitutional ATM mutation in breast/gastric cancer families
36. ATM-heterozygous germline mutations contribute to breast cancer-susceptibility
37. AT-tributable risks?
38. Cancer risk in ATM heterozygotes: A model of phenotypic and mechanistic differences between missense and truncating mutations
39. Risk of breast cancer among young women: Relationship to induced abortion
40. Oral contraceptives and breast cancer risk among younger women
41. BRCA1 mutations in a population-based sample of young women with breast cancer
42. BRCA1 mutations and breast cancer in the general population: Nalyses in women before age 35 years and in women before age 45 years with first-degree family history
43. Frequency of BRCA1/BRCA2 mutations in a population-based sample of young breast carcinoma cases
44. Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene
45. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
46. Scanning by DOVAM-S detects all unique sequence changes in blinded analyses: Evidence that the scanning conditions are generic
47. Exon-scanning mutation analysis of the ATM gene in patients with ataxia-telangiectasia
48. Predominance of null mutations in ataxia-telangiectasia
49. Diversity of ATM gene mutations detected in patients with ataxia-telangiectasia
50. Ataxia-telangiectasia: Identification and detection of founder-effect mutations in the ATM gene in ethnic populations
51. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of a berrant DNA structures
52. Mutations at the ataxia-telangiectasia locus and clinical phenotypes of A-T patients