Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer

Nature Genetics

Volumn 32, Issue 1, 2002, Pages 185-190

  Spring, Kevin ^a   Ahangari, Farida ^a   Scott, Shaun P ^a   Waring, Paul ^b   Purdie, David M ^a   Chen, Philip C ^a   Hourigan, Kevin ^c   Ramsay, Jonathan ^a   McKinnon, Peter J ^d   Swift, Michael ^e   Lavin, Martin F ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

^c 'Alexandra'   (Australia)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e PACE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; COMPLEMENTARY DNA;

ANIMAL MODEL; ARTICLE; ATAXIA TELANGIECTASIA; BREAST CANCER; CANCER SUSCEPTIBILITY; CHROMOSOME ABERRATION; CONTROLLED STUDY; GENE MUTATION; HISTOLOGY; HUMAN; HUMAN CELL; LEUKEMIA; LYMPHOMA; MOUSE; NONHUMAN; OVARY TUMOR; PRIORITY JOURNAL; RADIOSENSITIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SARCOMA; TERATOMA;

ANIMALIA;

EID: 0036727417     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng958     Document Type: Article

References (30)

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5. Cancer in patients with ataxia-telangiectasia and in their relatives in the Nordic countries
6. Molecular genotyping shows that ataxiatelangiectasia heterozygotes are predisposed to breast cancer
7. Heterozygous ATM mutations do not contribute to early onset of breast cancer
8. Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer
9. Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history
10. Spectrum of ATM gene mutations in a hospital-based series of unselected breast cancer patients
11. Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype
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18. Identification of ataxia-telangiectasia heterozygotes, a cancer prone population
19. Cellular hypersensitivity to chronic γ-radiation in cultured fibroblasts from ataxia-telangiectasia heterozygotes
20. Isolation of full-length ATM cDNA and correction of the ataxiatelangiectasia cellular phenotype
21. Dominant negative ATM mutations in breast cancer families
22. An allelic variant at the ATM locus is implicated in breast cancer susceptibility
23. Ataxia-telangiectasia: Phenotype/genotype studies of ATM protein expression, mutations and radiosensitivity
24. Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia
25. Predominance of null mutations in ataxia-telangiectasia
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27. ATM phosphorylates p95/nbsl in an S-phase checkpoint pathway
28. Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer
29. Atm haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice
30. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53