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Volumn 10, Issue 2, 2005, Pages 1946-1960

Application of RNAi to cancer research and therapy

Author keywords

Cancer; miRNAs; Review; RNAi; shRNAs; siRNAs

Indexed keywords

RNA;

EID: 17244380208     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/1670     Document Type: Review
Times cited : (26)

References (155)
  • 1
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B. & K. W. Kinzler: Cancer genes and the pathways they control. Nat Med 10 (8), 789-799 (2004)
    • (2004) Nat Med , vol.10 , Issue.8 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 2
    • 0036561908 scopus 로고    scopus 로고
    • Modelling the molecular circuitry of cancer
    • Hahn W. C. & R. A. Weinberg: Modelling the molecular circuitry of cancer. Nat Rev Cancer 2 (5), 331-341 (2002)
    • (2002) Nat Rev Cancer , vol.2 , Issue.5 , pp. 331-341
    • Hahn, W.C.1    Weinberg, R.A.2
  • 3
    • 0037158901 scopus 로고    scopus 로고
    • Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi)
    • Wilda M, U. Fuchs, W. Wossmann & A. Borkhardt: Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene 21 (37), 5716-5724 (2002)
    • (2002) Oncogene , vol.21 , Issue.37 , pp. 5716-5724
    • Wilda, M.1    Fuchs, U.2    Wossmann, W.3    Borkhardt, A.4
  • 4
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D. & R. A. Weinberg: The hallmarks of cancer. Cell 100 (1), 57-70 (2000)
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 0036779999 scopus 로고    scopus 로고
    • RNA-mediated gene regulation system: Now and the future
    • Yin J.Q. & Y. Wan: RNA-mediated gene regulation system: now and the future. Int J Mol Med 10 (4), 355-365 (2002)
    • (2002) Int J Mol Med , vol.10 , Issue.4 , pp. 355-365
    • Yin, J.Q.1    Wan, Y.2
  • 7
    • 3242677639 scopus 로고    scopus 로고
    • siRNAs: Applications in functional genomics and potential as therapeutics
    • Dorsett Y. & T. Tuschl: siRNAs: applications in functional genomics and potential as therapeutics. Nat Rev Drug Discov 3 (4), 318-329 (2004)
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.4 , pp. 318-329
    • Dorsett, Y.1    Tuschl, T.2
  • 8
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel D. P: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116 (2), 281-297 (2004)
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 9
    • 0035281741 scopus 로고    scopus 로고
    • RNA interference - 2001
    • Sharp P. A: RNA interference - 2001. Genes Dev 15 (5), 485-490 (2001)
    • (2001) Genes Dev , vol.15 , Issue.5 , pp. 485-490
    • Sharp, P.A.1
  • 10
    • 17244367104 scopus 로고    scopus 로고
    • RNAi, a new therapeutic strategy against viral infection
    • Tan F. L. & J. Q. Yin: RNAi, a new therapeutic strategy against viral infection. Cell Res 14 (6), 460-6 (2004)
    • (2004) Cell Res , vol.14 , Issue.6 , pp. 460-466
    • Tan, F.L.1    Yin, J.Q.2
  • 11
    • 0037686295 scopus 로고    scopus 로고
    • Killing the messenger: Short RNAs that silence gene expression
    • Dykxhoorn D. M, C. D. Novina & P. A. Sharp: Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Bio 4 (6), 457-467 (2003)
    • (2003) Nat Rev Mol Cell Bio , vol.4 , Issue.6 , pp. 457-467
    • Dykxhoorn, D.M.1    Novina, C.D.2    Sharp, P.A.3
  • 12
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, S. Xu, M. K. Montgomery, S. A. Kostas, S. E. Driver & C. C. Mello: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (6669), 806-811 (1998)
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 13
    • 0025134418 scopus 로고
    • Altered gene expression in plants due to trans interactions between homologous genes
    • Jorgensen R: Altered gene expression in plants due to trans interactions between homologous genes. Trends Biotechnol 8 (12), 340-344 (1990)
    • (1990) Trends Biotechnol , vol.8 , Issue.12 , pp. 340-344
    • Jorgensen, R.1
  • 15
    • 0036899212 scopus 로고    scopus 로고
    • RNAi and related mechanisms and their potential use for therapy
    • Agami R: RNAi and related mechanisms and their potential use for therapy. Curr Opin Chem Bio 6 (6), 829-834 (2002)
    • (2002) Curr Opin Chem Bio , vol.6 , Issue.6 , pp. 829-834
    • Agami, R.1
  • 16
    • 0142259345 scopus 로고    scopus 로고
    • New tools for functional mammalian cancer genetics
    • Brummelkamp T. R. & R. Bernards: New tools for functional mammalian cancer genetics. Nat Rev Cancer 3 (10), 781-789 (2003)
    • (2003) Nat Rev Cancer , vol.3 , Issue.10 , pp. 781-789
    • Brummelkamp, T.R.1    Bernards, R.2
  • 17
    • 13844300854 scopus 로고    scopus 로고
    • Induction of tumor cell apoptosis and chemosensitization by antisense strategies
    • Rieber M. & M. Strasberg-Rieber: Induction of tumor cell apoptosis and chemosensitization by antisense strategies. Methods Mol Med 106, 205-214 (2005)
    • (2005) Methods Mol Med , vol.106 , pp. 205-214
    • Rieber, M.1    Strasberg-Rieber, M.2
  • 18
    • 16544368128 scopus 로고    scopus 로고
    • Antisense therapy in clinical oncology: Preclinical and clinical experiences
    • Tamm I: Antisense therapy in clinical oncology: preclinical and clinical experiences. Methods Mol Med 106, 113-34 (2005)
    • (2005) Methods Mol Med , vol.106 , pp. 113-134
    • Tamm, I.1
  • 20
    • 10044261960 scopus 로고    scopus 로고
    • Ribozyme- and deoxyribozyme-strategies for medical applications
    • Schubert S. & J. Kurreck: Ribozyme- and deoxyribozyme-strategies for medical applications. Curr Drug Target 5 (8), 667-681 (2004)
    • (2004) Curr Drug Target , vol.5 , Issue.8 , pp. 667-681
    • Schubert, S.1    Kurreck, J.2
  • 21
    • 13844272635 scopus 로고    scopus 로고
    • Synthetic hammerhead ribozymes as therapeutic tools to control disease genes
    • Citti L, and G. Rainaldi: Synthetic hammerhead ribozymes as therapeutic tools to control disease genes. Curr Gene Ther 5 (1), 11-24 (2005)
    • (2005) Curr Gene Ther , vol.5 , Issue.1 , pp. 11-24
    • Citti, L.1    Rainaldi, G.2
  • 22
    • 0034839007 scopus 로고    scopus 로고
    • Ribozyme gene therapy: Applications for molecular medicine
    • Lewin A. S. & W. W. Hauswirth: Ribozyme gene therapy: applications for molecular medicine. Trends Mol Med May7 (5), 221-228 (2001)
    • (2001) Trends Mol Med May , vol.7 , Issue.5 , pp. 221-228
    • Lewin, A.S.1    Hauswirth, W.W.2
  • 23
    • 0034960390 scopus 로고    scopus 로고
    • Chemistry and biochemistry of 2′,5′-oligoadenylate-based antisense strategy
    • Adah S. A, S. F. Bayly, H. Cramer, R. H. Silverman & P. F. Torrence: Chemistry and biochemistry of 2′,5′-oligoadenylate-based antisense strategy. Curr Med Chem 8 (10), 1189-212 (2001)
    • (2001) Curr Med Chem , vol.8 , Issue.10 , pp. 1189-1212
    • Adah, S.A.1    Bayly, S.F.2    Cramer, H.3    Silverman, R.H.4    Torrence, P.F.5
  • 24
    • 0842332285 scopus 로고    scopus 로고
    • Potent inhibition of respiratory syncytial virus by combination treatment with 2-5A antisense and ribavirin
    • Xu Z, M. Kuang, J. R. Okicki, H. Cramer & N. Chaudhary: Potent inhibition of respiratory syncytial virus by combination treatment with 2-5A antisense and ribavirin. Antiviral Res 61 (3), 195-206 (2004)
    • (2004) Antiviral Res , vol.61 , Issue.3 , pp. 195-206
    • Xu, Z.1    Kuang, M.2    Okicki, J.R.3    Cramer, H.4    Chaudhary, N.5
  • 25
    • 0242526935 scopus 로고    scopus 로고
    • RNA interference: On the road to an alternate therapeutic strategy!
    • Dave R. S. & R. J. Pomerantz: RNA interference: on the road to an alternate therapeutic strategy! Rev Med Virol 13 (6), 373-385 (2003)
    • (2003) Rev Med Virol , vol.13 , Issue.6 , pp. 373-385
    • Dave, R.S.1    Pomerantz, R.J.2
  • 26
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir S. M, W. Lendeckel & T. Tuschl: RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 15 (2), 188-200 (2001)
    • (2001) Genes Dev , vol.15 , Issue.2 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 27
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir S. M, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber & T. Tuschl: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (6836), 494-498 (2001)
    • (2001) Nature , vol.411 , Issue.6836 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 28
    • 3142615372 scopus 로고    scopus 로고
    • The RNAi revolution
    • Novina C. D. & P. A. Sharp: The RNAi revolution. Nature 430 (696), 161-164 (2004)
    • (2004) Nature , vol.430 , Issue.696 , pp. 161-164
    • Novina, C.D.1    Sharp, P.A.2
  • 31
    • 1842715778 scopus 로고    scopus 로고
    • Dicers at RISC; the mechanism of RNAi
    • Tijsterman M. & R. H. Plasterk: Dicers at RISC; the mechanism of RNAi. Cell 117 (1), 1-3 (2004)
    • (2004) Cell , vol.117 , Issue.1 , pp. 1-3
    • Tijsterman, M.1    Plasterk, R.H.2
  • 32
    • 1442360415 scopus 로고    scopus 로고
    • RNase III enzymes and the initiation of gene silencing
    • Carmell M. A. & G. J. Hannon: RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Bio 11 (3), 214-218 (2004)
    • (2004) Nat Struct Mol Bio , vol.11 , Issue.3 , pp. 214-218
    • Carmell, M.A.1    Hannon, G.J.2
  • 33
    • 3142613181 scopus 로고    scopus 로고
    • Single processing center models for human Dicer and bacterial RNase III
    • Zhang H, F. A. Kolb, L. Jaskiewicz, E. Westhof & W. Filipowicz: Single processing center models for human Dicer and bacterial RNase III. Cell 118 (1), 57-68 (2004)
    • (2004) Cell , vol.118 , Issue.1 , pp. 57-68
    • Zhang, H.1    Kolb, F.A.2    Jaskiewicz, L.3    Westhof, E.4    Filipowicz, W.5
  • 34
    • 2442495329 scopus 로고    scopus 로고
    • RISC is a 5′ phosphomonoester-producing RNA endonuclease
    • Martinez J. & T. Tuschl: RISC is a 5′ phosphomonoester- producing RNA endonuclease. Genes Dev 18 (9), 975-980 (2004)
    • (2004) Genes Dev , vol.18 , Issue.9 , pp. 975-980
    • Martinez, J.1    Tuschl, T.2
  • 35
    • 11244279683 scopus 로고    scopus 로고
    • Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity
    • Parker J. S, S. M. Roe & D. Barford: Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J. 23 (24), 4727-37 (2004)
    • (2004) EMBO J , vol.23 , Issue.24 , pp. 4727-4737
    • Parker, J.S.1    Roe, S.M.2    Barford, D.3
  • 36
    • 5144225452 scopus 로고    scopus 로고
    • Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity
    • Rand T. A, K. Ginalski, N. V. Grishin & X. Wang: Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc Natl Acad Sci U S A 101 (40), 14385-14389 (2004)
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.40 , pp. 14385-14389
    • Rand, T.A.1    Ginalski, K.2    Grishin, N.V.3    Wang, X.4
  • 37
    • 9144224451 scopus 로고    scopus 로고
    • Processing of primary microRNAs by the Microprocessor complex
    • Denli A. M, B. B. Tops, R. H. Plasterk, R. F. Ketting & G. J. Hannon: Processing of primary microRNAs by the Microprocessor complex. Nature 432 (7014), 231-235 (2004)
    • (2004) Nature , vol.432 , Issue.7014 , pp. 231-235
    • Denli, A.M.1    Tops, B.B.2    Plasterk, R.H.3    Ketting, R.F.4    Hannon, G.J.5
  • 38
    • 4444226150 scopus 로고    scopus 로고
    • Molecular biology. Argonaute journeys into the heart of RISC
    • Sontheimer E. J. & R. W. Carthew: Molecular biology. Argonaute journeys into the heart of RISC. Science 305 (5689), 1409-1410 (2004)
    • (2004) Science , vol.305 , Issue.5689 , pp. 1409-1410
    • Sontheimer, E.J.1    Carthew, R.W.2
  • 40
    • 4444302947 scopus 로고    scopus 로고
    • Crystal structure of Argonaute and its implications for RISC slicer activity
    • Song J. J, S. K. Smith, G. J. Hannon & L. Joshua-Tor: Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305 (5689), 1434-1437 (2004)
    • (2004) Science , vol.305 , Issue.5689 , pp. 1434-1437
    • Song, J.J.1    Smith, S.K.2    Hannon, G.J.3    Joshua-Tor, L.4
  • 41
    • 3142729150 scopus 로고    scopus 로고
    • Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
    • Okamura K, A. Ishizuka, H. Siomi & M. C. Siomi: Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev 18 (14), 1655-1666 (2004)
    • (2004) Genes Dev , vol.18 , Issue.14 , pp. 1655-1666
    • Okamura, K.1    Ishizuka, A.2    Siomi, H.3    Siomi, M.C.4
  • 42
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • Vi R, Y. Qin, I. G. Macara & B. R. Cullen: Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 17 (24), 3011-3016 (2003)
    • (2003) Genes Dev , vol.17 , Issue.24 , pp. 3011-3016
    • Vi, R.1    Qin, Y.2    Macara, I.G.3    Cullen, B.R.4
  • 43
    • 4444230672 scopus 로고    scopus 로고
    • Structural requirements for pre-microRNA binding and nuclear export by Exportin 5
    • Zeng Y. & B. R. Cullen: Structural requirements for pre-microRNA binding and nuclear export by Exportin 5. Nucleic Acids Res 32 (16), 4776-4785 (2004)
    • (2004) Nucleic Acids Res , vol.32 , Issue.16 , pp. 4776-4785
    • Zeng, Y.1    Cullen, B.R.2
  • 44
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V: The functions of animal microRNAs. Nature 431 (7006), 350-355 (2004)
    • (2004) Nature , vol.431 , Issue.7006 , pp. 350-355
    • Ambros, V.1
  • 45
    • 4744357297 scopus 로고    scopus 로고
    • Structural features of microRNA (miRNA) precursors and their relevance to miRNA biogenesis and small interfering RNA/short hairpin RNA design
    • Krol J, K. Sobczak, U. Wilczynska, M. Drath, A. Jasinska, D. Kaczynska & W. J. Krzyzosiak: Structural features of microRNA (miRNA) precursors and their relevance to miRNA biogenesis and small interfering RNA/short hairpin RNA design. J Biol Chem 279 (40), 42230-42239 (2004)
    • (2004) J Biol Chem , vol.279 , Issue.40 , pp. 42230-42239
    • Krol, J.1    Sobczak, K.2    Wilczynska, U.3    Drath, M.4    Jasinska, A.5    Kaczynska, D.6    Krzyzosiak, W.J.7
  • 46
    • 0037009364 scopus 로고    scopus 로고
    • MicroRNA maturation: Stepwise processing and subcellular localization
    • Lee Y, K. Jeon, J. T. Lee, S. Kim & V. N. Kim: MicroRNA maturation: stepwise processing and subcellular localization. EMBO J 21 (17), 4663-4670 (2002)
    • (2002) EMBO J , vol.21 , Issue.17 , pp. 4663-4670
    • Lee, Y.1    Jeon, K.2    Lee, J.T.3    Kim, S.4    Kim, V.N.5
  • 47
    • 0036544755 scopus 로고    scopus 로고
    • MicroRNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation
    • Lai E. C: MicroRNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet 30 (4), 363-364 (2002)
    • (2002) Nat Genet , vol.30 , Issue.4 , pp. 363-364
    • Lai, E.C.1
  • 48
    • 0037443089 scopus 로고    scopus 로고
    • siRNAs can function as miRNAs
    • Doench J. G, C. P. Petersen & P. A Sharp: siRNAs can function as miRNAs. Genes Dev 17 (4), 438-442 (2003)
    • (2003) Genes Dev , vol.17 , Issue.4 , pp. 438-442
    • Doench, J.G.1    Petersen, C.P.2    Sharp, P.A.3
  • 49
    • 1542297345 scopus 로고    scopus 로고
    • Computational identification of microRNA targets
    • Rajewsky N. & N. D. Socci: Computational identification of microRNA targets. Dev Biol 267 (2), 529-535 (2004)
    • (2004) Dev Biol , vol.267 , Issue.2 , pp. 529-535
    • Rajewsky, N.1    Socci, N.D.2
  • 50
    • 0037782493 scopus 로고    scopus 로고
    • MicroRNAs: At the root of plant development?
    • Bartel B. & D. P. Barrel: MicroRNAs: at the root of plant development? Plant Physiol 132 (2), 709-717 (2003)
    • (2003) Plant Physiol , vol.132 , Issue.2 , pp. 709-717
    • Bartel, B.1    Barrel, D.P.2
  • 51
    • 7944235943 scopus 로고    scopus 로고
    • RNAi in functional genomics
    • Scherr M. & M. Eder: RNAi in functional genomics. Curr Opin Mol Ther 6 (2), 129-135 (2004)
    • (2004) Curr Opin Mol Ther , vol.6 , Issue.2 , pp. 129-135
    • Scherr, M.1    Eder, M.2
  • 52
    • 1842427153 scopus 로고    scopus 로고
    • Use of siRNAs to prevent and treat influenza virus infection
    • Ge Q, H. N. Eisen & J. Chen: Use of siRNAs to prevent and treat influenza virus infection. Virus Res 102 (1), 37-42 (2004)
    • (2004) Virus Res , vol.102 , Issue.1 , pp. 37-42
    • Ge, Q.1    Eisen, H.N.2    Chen, J.3
  • 54
    • 0037062949 scopus 로고    scopus 로고
    • The chemical repertoire of natural ribozymes
    • Doudna J. A. & T. R. Cech: The chemical repertoire of natural ribozymes. Nature 418, 222-228 (2002)
    • (2002) Nature , vol.418 , pp. 222-228
    • Doudna, J.A.1    Cech, T.R.2
  • 55
    • 0037046160 scopus 로고    scopus 로고
    • Lipid-mediated introduction of peptide nucleic acids into cells
    • Braasch D. A. & D. R. Corey: Lipid-mediated introduction of peptide nucleic acids into cells. Biochemistry 41, 4503-4510 (2002)
    • (2002) Biochemistry , vol.41 , pp. 4503-4510
    • Braasch, D.A.1    Corey, D.R.2
  • 56
    • 0037086052 scopus 로고    scopus 로고
    • Morpholino oligos: Making sense of antisense?
    • Heasman J: Morpholino oligos: making sense of antisense? Dev Biol 234, 209-214 (2002)
    • (2002) Dev Biol , vol.234 , pp. 209-214
    • Heasman, J.1
  • 58
    • 0346728473 scopus 로고    scopus 로고
    • Systematic genome-wide screens of gene function
    • Carpenter A. E. & D. M. Sabatini: Systematic genome-wide screens of gene function. Nat Rev Genet 5 (1), 11-22 (2004)
    • (2004) Nat Rev Genet , vol.5 , Issue.1 , pp. 11-22
    • Carpenter, A.E.1    Sabatini, D.M.2
  • 59
    • 0036726313 scopus 로고    scopus 로고
    • Stable suppression of tumorigenicity by virus-mediated RNA interference
    • Brummelkamp T. R, R. Bernards & R. Agami: Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2 (3), 243-247 (2002)
    • (2002) Cancer Cell , vol.2 , Issue.3 , pp. 243-247
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 60
    • 0141706705 scopus 로고    scopus 로고
    • SiRNA agents inhibit oncogene expression and attenuate human tumor cell growth
    • Yin J.Q, J. Gao, R. Shao, W.N. Tian, J. Wang & Y. Wan: SiRNA agents inhibit oncogene expression and attenuate human tumor cell growth. J Exp Ther Onc. 3 (4):194-204 (2003)
    • (2003) J Exp Ther Onc , vol.3 , Issue.4 , pp. 194-204
    • Yin, J.Q.1    Gao, J.2    Shao, R.3    Tian, W.N.4    Wang, J.5    Wan, Y.6
  • 62
    • 0348133602 scopus 로고    scopus 로고
    • In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNA
    • Yoshinouchi M, T. Yamada, M. Kizaki, J. Fen, T. Koseki, Y. Ikeda, T. Nishihara & K. Yamato: In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNA. Mol The 8 (5), 762-768 (2003).
    • (2003) Mol The , vol.8 , Issue.5 , pp. 762-768
    • Yoshinouchi, M.1    Yamada, T.2    Kizaki, M.3    Fen, J.4    Koseki, T.5    Ikeda, Y.6    Nishihara, T.7    Yamato, K.8
  • 63
    • 0141730323 scopus 로고    scopus 로고
    • siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells
    • Butz K, T. Ristriani, A. Hengstermann, C. Denk, M. Scheffner & F. Hoppe-Seyler: siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells. Oncogene. 22 (38), 5938-5945 (2003)
    • (2003) Oncogene , vol.22 , Issue.38 , pp. 5938-5945
    • Butz, K.1    Ristriani, T.2    Hengstermann, A.3    Denk, C.4    Scheffner, M.5    Hoppe-Seyler, F.6
  • 64
    • 0141706827 scopus 로고    scopus 로고
    • Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway
    • Dimova D. K, O. Stevaux, M. V. Frolov & N. J. Dyson: Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev 17 (18), 2308-2320 (2003)
    • (2003) Genes Dev , vol.17 , Issue.18 , pp. 2308-2320
    • Dimova, D.K.1    Stevaux, O.2    Frolov, M.V.3    Dyson, N.J.4
  • 65
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancer A, L. A. Lindsey-Boltz, K. Unsal-Kaccmaz & S. Linn: Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73, 39-85 (2004)
    • (2004) Annu Rev Biochem , vol.73 , pp. 39-85
    • Sancer, A.1    Lindsey-Boltz, L.A.2    Unsal-Kaccmaz, K.3    Linn, S.4
  • 66
    • 0037112508 scopus 로고    scopus 로고
    • Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation
    • Peng Y, Q. Zhang, H. Nagasawa, R. Okayasu, H. L. Liber, & J. S. Bedford: Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation. Cancer Res. 62 (22), 6400-6404 (2002)
    • (2002) Cancer Res , vol.62 , Issue.22 , pp. 6400-6404
    • Peng, Y.1    Zhang, Q.2    Nagasawa, H.3    Okayasu, R.4    Liber, H.L.5    Bedford, J.S.6
  • 67
    • 0037271497 scopus 로고    scopus 로고
    • Caenorhabditis elegans Ce-rdh-1/rad-51 functions after double-strand break formation of meiotic recombination
    • Takanami T, A. Mori, H. Takahashi, S. Horiuchi & A. Higashitani: Caenorhabditis elegans Ce-rdh-1/rad-51 functions after double-strand break formation of meiotic recombination. Chromosome Res 11 (2), 125-135 (2003)
    • (2003) Chromosome Res , vol.11 , Issue.2 , pp. 125-135
    • Takanami, T.1    Mori, A.2    Takahashi, H.3    Horiuchi, S.4    Higashitani, A.5
  • 68
    • 0036185784 scopus 로고    scopus 로고
    • Roles for Caenorhabditis elegans rad-51 in meiosis and in resistance to ionizing radiation during development
    • Rinaldo C, P. Bazzicalupo, S. Ederle, M. Milliard & A. La Volpe: Roles for Caenorhabditis elegans rad-51 in meiosis and in resistance to ionizing radiation during development. Genetics 160 (2), 471-479 (2002)
    • (2002) Genetics , vol.160 , Issue.2 , pp. 471-479
    • Rinaldo, C.1    Bazzicalupo, P.2    Ederle, S.3    Milliard, M.4    La Volpe, A.5
  • 69
    • 0038369994 scopus 로고    scopus 로고
    • Functional genomic analysis of apoptotic DNA degradation in C. elegans
    • Parrish J. Z. & D. Xue: Functional genomic analysis of apoptotic DNA degradation in C. elegans. Mol Cell 11 (4), 987-996 (2003)
    • (2003) Mol Cell , vol.11 , Issue.4 , pp. 987-996
    • Parrish, J.Z.1    Xue, D.2
  • 70
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • Lau N. C, L. P. Lim, E. G. Weinstein & D. P. Bartel: An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294 (5543), 858-862 (2001)
    • (2001) Science , vol.294 , Issue.5543 , pp. 858-862
    • Lau, N.C.1    Lim, L.P.2    Weinstein, E.G.3    Bartel, D.P.4
  • 71
    • 1842576658 scopus 로고    scopus 로고
    • The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways
    • Pichierri P. & F. Rosselli: The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. EMBO J 23 (5), 1178-1187 (2004).
    • (2004) EMBO J , vol.23 , Issue.5 , pp. 1178-1187
    • Pichierri, P.1    Rosselli, F.2
  • 72
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: Diversity and escape mechanisms
    • Friedl P. & K. Wolf: Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3 (5), 362-374 (2003).
    • (2003) Nat Rev Cancer , vol.3 , Issue.5 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 73
    • 0042941765 scopus 로고    scopus 로고
    • Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro
    • Chen Y, G. Stamatoyannopoulos & C. Z. Song: Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Res 63 (16), 4801-4804 (2003)
    • (2003) Cancer Res , vol.63 , Issue.16 , pp. 4801-4804
    • Chen, Y.1    Stamatoyannopoulos, G.2    Song, C.Z.3
  • 74
    • 2942718949 scopus 로고    scopus 로고
    • Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis
    • Lakka S. S, C. S. Gondi, N. Yanamandra, W. C. Olivero, D. H Dinh, M. Gujrati & J.S. Rao: Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. Oncogene 23 (27), 4681-4689 (2004)
    • (2004) Oncogene , vol.23 , Issue.27 , pp. 4681-4689
    • Lakka, S.S.1    Gondi, C.S.2    Yanamandra, N.3    Olivero, W.C.4    Dinh, D.H.5    Gujrati, M.6    Rao, J.S.7
  • 75
    • 0038408486 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion
    • Liu L. T, H. C. Chang, L. C. Chiang & W. C. Hung: Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. Cancer Res 63 (12), 3069-3072 (2003)
    • (2003) Cancer Res , vol.63 , Issue.12 , pp. 3069-3072
    • Liu, L.T.1    Chang, H.C.2    Chiang, L.C.3    Hung, W.C.4
  • 76
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G. & L. E. Benjamin: Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3 (6), 401-410 (2003)
    • (2003) Nat Rev Cancer , vol.3 , Issue.6 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 77
    • 7244253411 scopus 로고    scopus 로고
    • Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1
    • Niu Q, C. Perruzzi, D. Voskas, J. Lawler, D. J. Dumont & L. E. Benjamin: Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1. Cancer Biol Ther 3 (4), 402-405 (2004)
    • (2004) Cancer Biol Ther , vol.3 , Issue.4 , pp. 402-405
    • Niu, Q.1    Perruzzi, C.2    Voskas, D.3    Lawler, J.4    Dumont, D.J.5    Benjamin, L.E.6
  • 78
    • 0038013875 scopus 로고    scopus 로고
    • Senescence, apoptosis and therapy - Cutting the lifelines of cancer
    • Schmitt C. A: Senescence, apoptosis and therapy - cutting the lifelines of cancer. Nat Rev Cancer 3 (4), 286-295 (2003)
    • (2003) Nat Rev Cancer , vol.3 , Issue.4 , pp. 286-295
    • Schmitt, C.A.1
  • 79
    • 0344873763 scopus 로고    scopus 로고
    • Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene
    • Crnkovic-Mertens I, F. Hoppe-Seyler & K. Butz: Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene. Oncogene 22 (51), 8330-8336 (2003)
    • (2003) Oncogene , vol.22 , Issue.51 , pp. 8330-8336
    • Crnkovic-Mertens, I.1    Hoppe-Seyler, F.2    Butz, K.3
  • 80
    • 2342538514 scopus 로고    scopus 로고
    • Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells
    • Lima R. T, L. M. Martins, J. E. Guimaraes, C. Sambade & M. H. Vasconcelos: Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells. Cancer Gene Ther 11 (5), 309-316 (2004)
    • (2004) Cancer Gene Ther , vol.11 , Issue.5 , pp. 309-316
    • Lima, R.T.1    Martins, L.M.2    Guimaraes, J.E.3    Sambade, C.4    Vasconcelos, M.H.5
  • 81
    • 0141688283 scopus 로고    scopus 로고
    • Adoptive-cell-transfer therapy for the treatment of patients with cancer
    • Dudley M. E. & S. A. Rosenberg: Adoptive-cell-transfer therapy for the treatment of patients with cancer. Nat Rev Cancer 3 (9), 666-675 (2003)
    • (2003) Nat Rev Cancer , vol.3 , Issue.9 , pp. 666-675
    • Dudley, M.E.1    Rosenberg, S.A.2
  • 83
    • 2342647439 scopus 로고    scopus 로고
    • PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3
    • Remy I, A. Montmarquette & S. W. Michnick: PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3. Nat Cell Biol 6 (4), 358-365 (2004)
    • (2004) Nat Cell Biol , vol.6 , Issue.4 , pp. 358-365
    • Remy, I.1    Montmarquette, A.2    Michnick, S.W.3
  • 84
    • 2342436459 scopus 로고    scopus 로고
    • The Akt pathway: Molecular targets for anti-cancer drug development
    • Mitsiades C. S, N. Mitsiades & M. Koutsilieris: The Akt pathway: molecular targets for anti-cancer drug development. Curr Cancer Drug Targets 4 (3), 235-256 (2004)
    • (2004) Curr Cancer Drug Targets , vol.4 , Issue.3 , pp. 235-256
    • Mitsiades, C.S.1    Mitsiades, N.2    Koutsilieris, M.3
  • 85
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman M. M, T. Fojo & S. E. Bates: Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2 (1), 48-58 (2002)
    • (2002) Nat Rev Cancer , vol.2 , Issue.1 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 86
    • 0037526598 scopus 로고    scopus 로고
    • Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi)
    • Nieth C, A. Priebsch, A. Stege & H. Lage: Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi). FEBS Lett 545 (2-3), 144-150 (2003)
    • (2003) FEBS Lett , vol.545 , Issue.2-3 , pp. 144-150
    • Nieth, C.1    Priebsch, A.2    Stege, A.3    Lage, H.4
  • 87
    • 4243068680 scopus 로고    scopus 로고
    • Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1
    • Yague E, C. F. Higgins & S. Raguz: Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1. Gene Ther 11 (14), 1170-1174 (2004)
    • (2004) Gene Ther , vol.11 , Issue.14 , pp. 1170-1174
    • Yague, E.1    Higgins, C.F.2    Raguz, S.3
  • 88
    • 2342613652 scopus 로고    scopus 로고
    • The proteasome: A suitable antineoplastic target
    • Adams J: The proteasome: a suitable antineoplastic target. Nat Rev Cancer 4 (5), 349-360 (2004)
    • (2004) Nat Rev Cancer , vol.4 , Issue.5 , pp. 349-360
    • Adams, J.1
  • 89
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti M. A. & P. J. Houghton: The TOR pathway: a target for cancer therapy. Nat Rev Cancer 4 (5), 335-348 (2004)
    • (2004) Nat Rev Cancer , vol.4 , Issue.5 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 90
    • 0037470952 scopus 로고    scopus 로고
    • Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
    • Lum L, S. Yao, B. Mozer, A. Rovescalli, D. Von Kessler, M. Nirenberg & P. A. Beachy: Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science 299 (5615), 2039-2045 (2003)
    • (2003) Science , vol.299 , Issue.5615 , pp. 2039-2045
    • Lum, L.1    Yao, S.2    Mozer, B.3    Rovescalli, A.4    Von Kessler, D.5    Nirenberg, M.6    Beachy, P.A.7
  • 95
    • 2942738996 scopus 로고    scopus 로고
    • The Hedgehog response network: Sensors, switches, and routers
    • Lum L. & P. A. Beachy: The Hedgehog response network: sensors, switches, and routers. Science 304 (5678), 1755-1759 (2004)
    • (2004) Science , vol.304 , Issue.5678 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 97
    • 0037610810 scopus 로고    scopus 로고
    • Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes
    • Suyama E, H. Kawasaki, M. Nakajima & K. Taira: Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes. Proc Natl Acad Sci U S A 100 (10), 5616-5621 (2003)
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.10 , pp. 5616-5621
    • Suyama, E.1    Kawasaki, H.2    Nakajima, M.3    Taira, K.4
  • 98
    • 0034676457 scopus 로고    scopus 로고
    • Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
    • Fraser A. G, R. S. Kamath, P. Zipperlen, M. Martinez-Campos, M. Sohrmann & J. Ahringer: Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408 (6810), 325-330 (2000)
    • (2000) Nature , vol.408 , Issue.6810 , pp. 325-330
    • Fraser, A.G.1    Kamath, R.S.2    Zipperlen, P.3    Martinez-Campos, M.4    Sohrmann, M.5    Ahringer, J.6
  • 100
    • 0037228016 scopus 로고    scopus 로고
    • A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
    • Lee S. S, R. Y. Lee, A. G. Fraser, R. S. Kamath, J. Ahringer & G. Ruvkun: A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33 (1), 40-48 (2003)
    • (2003) Nat Genet , vol.33 , Issue.1 , pp. 40-48
    • Lee, S.S.1    Lee, R.Y.2    Fraser, A.G.3    Kamath, R.S.4    Ahringer, J.5    Ruvkun, G.6
  • 102
    • 0042467554 scopus 로고    scopus 로고
    • Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
    • Brummelkamp T. R, S. M. Nijman, A. M. Dirac & R. Bernards: Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature 424 (6950), 797-801 (2003)
    • (2003) Nature , vol.424 , Issue.6950 , pp. 797-801
    • Brummelkamp, T.R.1    Nijman, S.M.2    Dirac, A.M.3    Bernards, R.4
  • 103
    • 0141750434 scopus 로고    scopus 로고
    • Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening
    • Aza-Blanc P, C. L. Cooper, K. Wagner, S. Batalov, Q. L. Deveraux & M. P. Cooke: Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. Mol Cell 12 (3), 627-637 (2003)
    • (2003) Mol Cell , vol.12 , Issue.3 , pp. 627-637
    • Aza-Blanc, P.1    Cooper, C.L.2    Wagner, K.3    Batalov, S.4    Deveraux, Q.L.5    Cooke, M.P.6
  • 104
    • 0037417136 scopus 로고    scopus 로고
    • Identification of NF-kappa B-regulated genes induced by TNFalpha utilizing expression profiling and RNA interference
    • Zhou A, S. Scoggin, R. B. Gaynor & N. S. Williams: Identification of NF-kappa B-regulated genes induced by TNFalpha utilizing expression profiling and RNA interference. Oncogene 22 (13), 2054-2064 (2003)
    • (2003) Oncogene , vol.22 , Issue.13 , pp. 2054-2064
    • Zhou, A.1    Scoggin, S.2    Gaynor, R.B.3    Williams, N.S.4
  • 106
    • 0029804246 scopus 로고    scopus 로고
    • Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy
    • Shoemaker D. D, D. A. Lashkari, D. Morris, M. Mittmann & R. W. Davis: Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy. Nat Gene 14 (4), 450-456 (1996)
    • (1996) Nat Gene , vol.14 , Issue.4 , pp. 450-456
    • Shoemaker, D.D.1    Lashkari, D.A.2    Morris, D.3    Mittmann, M.4    Davis, R.W.5
  • 107
    • 0036653097 scopus 로고    scopus 로고
    • RNA interference: The new somatic cell genetics?
    • Paddison P. J. & G. J. Hannon: RNA interference: the new somatic cell genetics? Cancer Cell 2 (1), 17-23 (2002)
    • (2002) Cancer Cell , vol.2 , Issue.1 , pp. 17-23
    • Paddison, P.J.1    Hannon, G.J.2
  • 108
    • 1842505022 scopus 로고    scopus 로고
    • RNA interference: Human genes hit the big screen
    • Fraser A: RNA interference: human genes hit the big screen. Nature 428 (6981), 375-378 (2004)
    • (2004) Nature , vol.428 , Issue.6981 , pp. 375-378
    • Fraser, A.1
  • 114
    • 0346727383 scopus 로고    scopus 로고
    • High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma
    • Metzler M, M. Wilda, K. Busch, S. Viehmann & A. Borkhardt: High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Concer 39 (2), 167-169 (2004)
    • (2004) Genes Chromosomes Concer , vol.39 , Issue.2 , pp. 167-169
    • Metzler, M.1    Wilda, M.2    Busch, K.3    Viehmann, S.4    Borkhardt, A.5
  • 117
    • 0037737975 scopus 로고    scopus 로고
    • MicroRNAs and other tiny endogenous RNAs in C. elegans
    • Ambros V, R. C. Lee, A. Lavanway, P. T. Williams & D. Jewell: MicroRNAs and other tiny endogenous RNAs in C. elegans. Curr Biol 13 (10), 807-818 (2003)
    • (2003) Curr Biol , vol.13 , Issue.10 , pp. 807-818
    • Ambros, V.1    Lee, R.C.2    Lavanway, A.3    Williams, P.T.4    Jewell, D.5
  • 120
    • 1642366133 scopus 로고    scopus 로고
    • A MicroRNA as a Translational Repressor of APETALA2 in Arabidopsis Flower Development
    • Chen X. M: A MicroRNA as a Translational Repressor of APETALA2 in Arabidopsis Flower Development. Science 303 (5666), 2022-2025 (2004)
    • (2004) Science , vol.303 , Issue.5666 , pp. 2022-2025
    • Chen, X.M.1
  • 124
    • 0038419800 scopus 로고    scopus 로고
    • Induction of an interferon response by RNAi vectors in mammalian cells
    • Bridge A. J, S. Pebernard, A. Ducraux, A. L. Nicoulaz & R. Iggo. Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet 34 (3), 263-264 (2003)
    • (2003) Nat Genet , vol.34 , Issue.3 , pp. 263-264
    • Bridge, A.J.1    Pebernard, S.2    Ducraux, A.3    Nicoulaz, A.L.4    Iggo, R.5
  • 125
    • 0347623204 scopus 로고    scopus 로고
    • Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)
    • Persengiev S. P, X. C. Zhu and M. R. Green: Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA 10 (1), 12-18 (2004)
    • (2004) RNA , vol.10 , Issue.1 , pp. 12-18
    • Persengiev, S.P.1    Zhu, X.C.2    Green, M.R.3
  • 126
    • 4243754537 scopus 로고    scopus 로고
    • Confirming specificity of RNAi in mammalian cells
    • Lassus P, J. Rodriguez & Y. Lazebnik, Confirming specificity of RNAi in mammalian cells. Sci STKE (147), PL13 (2002)
    • (2002) Sci STKE , Issue.147
    • Lassus, P.1    Rodriguez, J.2    Lazebnik, Y.3
  • 127
    • 17244367865 scopus 로고    scopus 로고
    • A rapid and sensitive assay for quantification of siRNA efficiency and specificity
    • Smart N, P. J. Scambler & P. R. Riley. A rapid and sensitive assay for quantification of siRNA efficiency and specificity. Biol Proced Online. 7, 1-7 (2005)
    • (2005) Biol Proced Online , vol.7 , pp. 1-7
    • Smart, N.1    Scambler, P.J.2    Riley, P.R.3
  • 128
    • 17244377075 scopus 로고    scopus 로고
    • Direct comparison of the specificity of gene silencing using antisense and RNAi
    • Epub ahead of print
    • Bilanges B, & D. Stokoe: Direct comparison of the specificity of gene silencing using antisense and RNAi. Biochem J. [Epub ahead of print] (2005)
    • (2005) Biochem J
    • Bilanges, B.1    Stokoe, D.2
  • 129
    • 11344255740 scopus 로고    scopus 로고
    • Defining and assaying RNAi in mammalian cells
    • Huppi K, S. E. Martin, & N. J. Caplen: Defining and assaying RNAi in mammalian cells. Mol Cell 17 (1), 1-10 (2005)
    • (2005) Mol Cell , vol.17 , Issue.1 , pp. 1-10
    • Huppi, K.1    Martin, S.E.2    Caplen, N.J.3
  • 130
    • 0036351317 scopus 로고    scopus 로고
    • Analysis of gene function in somatic mammalian cells using small interfering RNAs
    • S. M. Elbashir, J. Harborth, K. Weber & T. Tuschl: Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 26 (2), 199-213 (2002)
    • (2002) Methods , vol.26 , Issue.2 , pp. 199-213
    • Elbashir, S.M.1    Harborth, J.2    Weber, K.3    Tuschl, T.4
  • 133
    • 24344500241 scopus 로고    scopus 로고
    • Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing
    • Harborth J, S. M. Elbashir, K. Vandenburgh, H. Manninga, S. A. Scaringe, K. Weber & T. Tuschl: Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense Nucleic Acid Drug Dev 13 (2), 83-105 (2003)
    • (2003) Antisense Nucleic Acid Drug Dev , vol.13 , Issue.2 , pp. 83-105
    • Harborth, J.1    Elbashir, S.M.2    Vandenburgh, K.3    Manninga, H.4    Scaringe, S.A.5    Weber, K.6    Tuschl, T.7
  • 134
    • 0037440005 scopus 로고    scopus 로고
    • Tolerance for mutations and chemical modifications in a siRNA
    • Amarzguioui M, T. Holen, E. Babaie & H. Prydz: Tolerance for mutations and chemical modifications in a siRNA. Nucleic Acids Res 31 (2), 589-595 (2003)
    • (2003) Nucleic Acids Res , vol.31 , Issue.2 , pp. 589-595
    • Amarzguioui, M.1    Holen, T.2    Babaie, E.3    Prydz, H.4
  • 136
    • 0037107034 scopus 로고    scopus 로고
    • Applications of transfected cell microarrays in high-throughput drug discovery
    • Bailey S. N, R. Z. Wu & D. M. Sabatini: Applications of transfected cell microarrays in high-throughput drug discovery. Drug Discov Today 7 (18 Suppl), S113-1118 (2002)
    • (2002) Drug Discov Today , vol.7 , Issue.18 SUPPL.
    • Bailey, S.N.1    Wu, R.Z.2    Sabatini, D.M.3
  • 138
    • 2342513372 scopus 로고    scopus 로고
    • RNA interference microarrays: High-throughput loss-of-function genetics in mammalian cells
    • Silva J. M, H. Mizuno, A. Brady, R. Lucito & G. J. Hannon: RNA interference microarrays: high-throughput loss-of-function genetics in mammalian cells. Proc Natl Acad Sci U S A 101 (17), 6548-6552 (2004)
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.17 , pp. 6548-6552
    • Silva, J.M.1    Mizuno, H.2    Brady, A.3    Lucito, R.4    Hannon, G.J.5
  • 139
    • 0141958108 scopus 로고    scopus 로고
    • Ultra high quality uHTS
    • Macarron R: Ultra high quality uHTS. Drug Discov Today 8 (20), 923 (2003)
    • (2003) Drug Discov Today , vol.8 , Issue.20 , pp. 923
    • Macarron, R.1
  • 140
    • 2442482366 scopus 로고    scopus 로고
    • Miniaturized, ultra-high throughput screening of tyrosine kinases using homogeneous, competitive fluorescence immunoassays
    • Beasley R. L, P. M. McCoy, T. L. Walker & D. A. Dunn: Miniaturized, ultra-high throughput screening of tyrosine kinases using homogeneous, competitive fluorescence immunoassays. Assay Drug Dev Technol 2 (2), 141-151 (2004)
    • (2004) Assay Drug Dev Technol , vol.2 , Issue.2 , pp. 141-151
    • Beasley, R.L.1    McCoy, P.M.2    Walker, T.L.3    Dunn, D.A.4
  • 141
    • 0344395644 scopus 로고    scopus 로고
    • RNAi reveals doublecortin is required for radial migration in rat neocortex
    • Bai J, R. L. Ramos, J. B. Ackman, A. M. Thomas, R. V. Lee & J. J. LoTurco: RNAi reveals doublecortin is required for radial migration in rat neocortex. Nat Neurosci 6 (12), 1277-1283 (2003)
    • (2003) Nat Neurosci , vol.6 , Issue.12 , pp. 1277-1283
    • Bai, J.1    Ramos, R.L.2    Ackman, J.B.3    Thomas, A.M.4    Lee, R.V.5    LoTurco, J.J.6
  • 142
    • 0347089037 scopus 로고    scopus 로고
    • Electroporation and RNA interference in the rodent retina in vivo and in vitro
    • Matsuda T. & C. L. Cepko: Electroporation and RNA interference in the rodent retina in vivo and in vitro. Proc Natl Acad Sci U S A 101 (1), 16-22 (2004)
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.1 , pp. 16-22
    • Matsuda, T.1    Cepko, C.L.2
  • 143
    • 0346216853 scopus 로고    scopus 로고
    • Local gene knockdown in the brain using viral-mediated RNA interference
    • Hommel J. D, R. M. Sears, D. Georgescu, D. L. Simmons & R. J. DiLeone: Local gene knockdown in the brain using viral-mediated RNA interference. Nat Med 9 (12), 1539-1544 (2003)
    • (2003) Nat Med , vol.9 , Issue.12 , pp. 1539-1544
    • Hommel, J.D.1    Sears, R.M.2    Georgescu, D.3    Simmons, D.L.4    Dileone, R.J.5
  • 145
    • 0036727416 scopus 로고    scopus 로고
    • Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
    • Lewis D. L, J. E. Hagstrom, A. G. Loomis, J. A. Wolff & H. Herweijer: Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet 32 (1), 107-108 (2002)
    • (2002) Nat Genet , vol.32 , Issue.1 , pp. 107-108
    • Lewis, D.L.1    Hagstrom, J.E.2    Loomis, A.G.3    Wolff, J.A.4    Herweijer, H.5
  • 146
    • 0141790842 scopus 로고    scopus 로고
    • Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571)
    • Wohlbold L, H. van der Kuip, C. Miething, H. P. Vornlocher, C. Knabbe, J. Duyster & W. E.Aulitzky: Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571). Blood 102 (6), 2236-2239 (2003)
    • (2003) Blood , vol.102 , Issue.6 , pp. 2236-2239
    • Wohlbold, L.1    Van Der Kuip, H.2    Miething, C.3    Vornlocher, H.P.4    Knabbe, C.5    Duyster, J.6    Aulitzky, W.E.7
  • 147
    • 1542599043 scopus 로고    scopus 로고
    • Mouse models of human breast cancer
    • Cardiff R. D: Mouse models of human breast cancer. Comp Med 53 (3), 250-253 (2003)
    • (2003) Comp Med , vol.53 , Issue.3 , pp. 250-253
    • Cardiff, R.D.1
  • 149
    • 0037107886 scopus 로고    scopus 로고
    • RNAi: Gene-silencing in therapeutic intervention
    • Shuey D. J, D. E. McCallus, T. Giordano: RNAi: gene-silencing in therapeutic intervention. Drug Discov Today. 7 (20), 1040-1046 (2002)
    • (2002) Drug Discov Today , vol.7 , Issue.20 , pp. 1040-1046
    • Shuey, D.J.1    McCallus, D.E.2    Giordano, T.3
  • 151
    • 0038157142 scopus 로고    scopus 로고
    • Xpd/Ercc2 regulates CAK activity and mitotic progression
    • Chen J, S. Larochelle, X. Li & B. Suter: Xpd/Ercc2 regulates CAK activity and mitotic progression. Nature 424(6945), 228-232(2003)
    • (2003) Nature , vol.424 , Issue.6945 , pp. 228-232
    • Chen, J.1    Larochelle, S.2    Li, X.3    Suter, B.4
  • 152
    • 0037446068 scopus 로고    scopus 로고
    • Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells
    • Nagy P, D.J. Arndt-Jovin & T.M. Jovin: Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells. Exp Cell Res 285(1), 39-49(2003)
    • (2003) Exp Cell Res , vol.285 , Issue.1 , pp. 39-49
    • Nagy, P.1    Arndt-Jovin, D.J.2    Jovin, T.M.3
  • 153
    • 1342308035 scopus 로고    scopus 로고
    • Specific inhibition of gene expression and transactivation functions of hepatitis B virus X protein and c-myc by small interfering RNAs
    • Hung L. & V. Kumar: Specific inhibition of gene expression and transactivation functions of hepatitis B virus X protein and c-myc by small interfering RNAs. FEBS Lett 560(1-3), 210-214(2004)
    • (2004) FEBS Lett , vol.560 , Issue.1-3 , pp. 210-214
    • Hung, L.1    Kumar, V.2
  • 155
    • 0042349229 scopus 로고    scopus 로고
    • ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility
    • Vial E, E. Sahai & C.J. Marshall: ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. Cancer Cell 4(1), 67-79(2003)
    • (2003) Cancer Cell , vol.4 , Issue.1 , pp. 67-79
    • Vial, E.1    Sahai, E.2    Marshall, C.J.3


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