RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia

Nature Medicine

Volumn 10, Issue 8, 2004, Pages 816-820

  Xia, Haibin ^a,b   Mao, Qinwen ^a,b   Eliason, Steven L ^a,b   Harper, Scott Q ^a,b   Martins, Inês H ^a,b   Orr, Harry T ^c,d   Paulson, Henry L ^b   Yang, Linda ^e   Kotin, Robert M ^e   Davidson, Beverly L ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; CALBINDIN; COMPLEMENTARY DNA; MUTANT PROTEIN; PARVOVIRUS VECTOR; POLYGLUTAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INCLUSION; CONTROLLED STUDY; GENE MUTATION; GENE SILENCING; HUNTINGTON CHOREA; MOTOR COORDINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PURKINJE CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SPINOCEREBELLAR DEGENERATION; WESTERN BLOTTING;

ADENOVIRIDAE; ANIMALS; BLOTTING, NORTHERN; BRAIN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GLUTAMINE; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PLASMIDS; PSYCHOMOTOR PERFORMANCE; PURKINJE CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SPINOCEREBELLAR ATAXIAS; TRANSDUCTION, GENETIC;

ADENO-ASSOCIATED VIRUS; ANIMALIA; PARVOVIRUS;

EID: 4043057946     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1076     Document Type: Article

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