-
1
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 391:1998;806-811.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
2
-
-
0034609759
-
Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos
-
Yang D., Lu H., Erickson J.W. Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos. Curr Biol. 10:2000;1191-1200.
-
(2000)
Curr Biol
, vol.10
, pp. 1191-1200
-
-
Yang, D.1
Lu, H.2
Erickson, J.W.3
-
3
-
-
0034737298
-
RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
-
Zamore P.D., Tuschl T., Sharp P.A., Bartel D.P. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 101:2000;25-33.
-
(2000)
Cell
, vol.101
, pp. 25-33
-
-
Zamore, P.D.1
Tuschl, T.2
Sharp, P.A.3
Bartel, D.P.4
-
4
-
-
0034673638
-
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
-
Hammond S.M., Bernstein E., Beach D., Hannon G.J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature. 404:2000;293-296.
-
(2000)
Nature
, vol.404
, pp. 293-296
-
-
Hammond, S.M.1
Bernstein, E.2
Beach, D.3
Hannon, G.J.4
-
5
-
-
0033634682
-
Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference
-
Parrish S., Fleenor J., Xu S., Mello C., Fire A. Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference. Mol Cell. 6:2000;1077-1087.
-
(2000)
Mol Cell
, vol.6
, pp. 1077-1087
-
-
Parrish, S.1
Fleenor, J.2
Xu, S.3
Mello, C.4
Fire, A.5
-
6
-
-
0030835456
-
Cosuppression in Drosophila: Gene silencing of alcohol dehydrogenase by white-Adh transgenes is polycomb dependent
-
Pal-Bhadra M., Bhadra U., Birchler J.A. Cosuppression in Drosophila: gene silencing of alcohol dehydrogenase by white-Adh transgenes is polycomb dependent. Cell. 90:1997;479-490.
-
(1997)
Cell
, vol.90
, pp. 479-490
-
-
Pal-Bhadra, M.1
Bhadra, U.2
Birchler, J.A.3
-
7
-
-
0036184188
-
RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila
-
Pal-Bhadra M., Bhadra U., Birchler J.A. RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol Cell. 9:2002;315-327.
-
(2002)
Mol Cell
, vol.9
, pp. 315-327
-
-
Pal-Bhadra, M.1
Bhadra, U.2
Birchler, J.A.3
-
8
-
-
0032717319
-
The rde-1 gene, RNA interference, and transposon silencing in C. elegans
-
Tabara H., Sarkissian M., Kelly W.G., Fleenor J., Grishok A., Timmons L., Fire A., Mello C.C. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell. 99:1999;123-132.
-
(1999)
Cell
, vol.99
, pp. 123-132
-
-
Tabara, H.1
Sarkissian, M.2
Kelly, W.G.3
Fleenor, J.4
Grishok, A.5
Timmons, L.6
Fire, A.7
Mello, C.C.8
-
9
-
-
0028031830
-
RNA-directed de novo methylation of genomic sequences in plants
-
Wassenegger M., Heimes S., Riedel L., Sanger H.L. RNA-directed de novo methylation of genomic sequences in plants. Cell. 76:1994;567-576.
-
(1994)
Cell
, vol.76
, pp. 567-576
-
-
Wassenegger, M.1
Heimes, S.2
Riedel, L.3
Sanger, H.L.4
-
10
-
-
0034596989
-
Transcriptional silencing and promoter methylation triggered by double-stranded RNA
-
Mette M.F., Aufsatz W., van der Winden J., Matzke M.A., Matzke A.J. Transcriptional silencing and promoter methylation triggered by double-stranded RNA. EMBO J. 19:2000;5194-5201.
-
(2000)
EMBO J
, vol.19
, pp. 5194-5201
-
-
Mette, M.F.1
Aufsatz, W.2
Van der Winden, J.3
Matzke, M.A.4
Matzke, A.J.5
-
11
-
-
0033572284
-
The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
-
Olsen P.H., Ambros V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol. 216:1999;671-680.
-
(1999)
Dev Biol
, vol.216
, pp. 671-680
-
-
Olsen, P.H.1
Ambros, V.2
-
12
-
-
0037145031
-
Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena
-
published on-line August 14; 10.1016/S0092867402009091.The authors show that before chromosomal rearrangements, a process that occurs during the development of somatic macronucleus in ciliates, small RNAs are generated. They identify a gene, TWI1, which is a homologue to piwi that is required for the chromosomal rearrangements and for the existence of these small RNAs in the cells. From their observations, they propose that the small RNAs function to guide the chromosomal rearrangements by a process similar to RNAi
-
Mochizuki K, Fine NA, Fujisawa T, Gorovsky MA: Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena. Cell 2002, published on-line August 14; 10.1016/S0092867402009091.The authors show that before chromosomal rearrangements, a process that occurs during the development of somatic macronucleus in ciliates, small RNAs are generated. They identify a gene, TWI1, which is a homologue to piwi that is required for the chromosomal rearrangements and for the existence of these small RNAs in the cells. From their observations, they propose that the small RNAs function to guide the chromosomal rearrangements by a process similar to RNAi.
-
(2002)
Cell
-
-
Mochizuki, K.1
Fine, N.A.2
Fujisawa, T.3
Gorovsky, M.A.4
-
13
-
-
0035905766
-
Role for a bidentate ribonuclease in the initiation step of RNA interference
-
Bernstein E., Caudy A.A., Hammond S.M., Hannon G.J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature. 409:2001;363-366.
-
(2001)
Nature
, vol.409
, pp. 363-366
-
-
Bernstein, E.1
Caudy, A.A.2
Hammond, S.M.3
Hannon, G.J.4
-
14
-
-
0035863097
-
RNA interference is mediated by 21- and 22-nucleotide RNAs
-
Elbashir S.M., Lendeckel W., Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15:2001;188-200.
-
(2001)
Genes Dev
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
15
-
-
17844364875
-
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
-
Grishok A., Pasquinelli A.E., Conte D., Li N., Parrish S., Ha I., Baillie D.L., Fire A., Ruvkun G., Mello C.C. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 106:2001;23-34.
-
(2001)
Cell
, vol.106
, pp. 23-34
-
-
Grishok, A.1
Pasquinelli, A.E.2
Conte, D.3
Li, N.4
Parrish, S.5
Ha, I.6
Baillie, D.L.7
Fire, A.8
Ruvkun, G.9
Mello, C.C.10
-
16
-
-
0035887005
-
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
-
Ketting R.F., Fischer S.E., Bernstein E., Sijen T., Hannon G.J., Plasterk R.H. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15:2001;2654-2659.
-
(2001)
Genes Dev
, vol.15
, pp. 2654-2659
-
-
Ketting, R.F.1
Fischer, S.E.2
Bernstein, E.3
Sijen, T.4
Hannon, G.J.5
Plasterk, R.H.6
-
17
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
In this paper, the authors uncover a way to silence genes in mammalian cells by RNAi. By transfecting siRNAs into cells, they could avoid the toxic effects of long dsRNAs in mammalian cells yet specifically suppress up to 90% of the expression of several genes
-
Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498. In this paper, the authors uncover a way to silence genes in mammalian cells by RNAi. By transfecting siRNAs into cells, they could avoid the toxic effects of long dsRNAs in mammalian cells yet specifically suppress up to 90% of the expression of several genes.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
18
-
-
0035694237
-
Identification of essential genes in cultured mammalian cells using small interfering RNAs
-
Harborth J., Elbashir S.M., Bechert K., Tuschl T., Weber K. Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci. 114:2001;4557-4565.
-
(2001)
J Cell Sci
, vol.114
, pp. 4557-4565
-
-
Harborth, J.1
Elbashir, S.M.2
Bechert, K.3
Tuschl, T.4
Weber, K.5
-
19
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp T.R., Bernards R., Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science. 296:2002;550-553.
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
20
-
-
0037089135
-
Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor
-
Holen T., Amarzguioui M., Wiiger M.T., Babaie E., Prydz H. Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor. Nucleic Acids Res. 30:2002;1757-1766.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 1757-1766
-
-
Holen, T.1
Amarzguioui, M.2
Wiiger, M.T.3
Babaie, E.4
Prydz, H.5
-
21
-
-
0034708122
-
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
-
Reinhart B.J., Slack F.J., Basson M., Pasquinelli A.E., Bettinger J.C., Rougvie A.E., Horvitz H.R., Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 403:2000;901-906.
-
(2000)
Nature
, vol.403
, pp. 901-906
-
-
Reinhart, B.J.1
Slack, F.J.2
Basson, M.3
Pasquinelli, A.E.4
Bettinger, J.C.5
Rougvie, A.E.6
Horvitz, H.R.7
Ruvkun, G.8
-
22
-
-
0033634943
-
The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor
-
Slack F.J., Basson M., Liu Z., Ambros V., Horvitz H.R., Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell. 5:2000;659-669.
-
(2000)
Mol Cell
, vol.5
, pp. 659-669
-
-
Slack, F.J.1
Basson, M.2
Liu, Z.3
Ambros, V.4
Horvitz, H.R.5
Ruvkun, G.6
-
23
-
-
0027751663
-
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
-
Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:1993;843-854.
-
(1993)
Cell
, vol.75
, pp. 843-854
-
-
Lee, R.C.1
Feinbaum, R.L.2
Ambros, V.3
-
24
-
-
0027730383
-
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
-
Wightman B., Ha I., Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 75:1993;855-862.
-
(1993)
Cell
, vol.75
, pp. 855-862
-
-
Wightman, B.1
Ha, I.2
Ruvkun, G.3
-
25
-
-
0030970775
-
The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA
-
Moss E.G., Lee R.C., Ambros V. The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell. 88:1997;637-646.
-
(1997)
Cell
, vol.88
, pp. 637-646
-
-
Moss, E.G.1
Lee, R.C.2
Ambros, V.3
-
26
-
-
0035966319
-
MicroRNAs: Tiny regulators with great potential
-
Ambros V. MicroRNAs: tiny regulators with great potential. Cell. 107:2001;823-826.
-
(2001)
Cell
, vol.107
, pp. 823-826
-
-
Ambros, V.1
-
27
-
-
0035800521
-
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
-
Hutvagner G., McLachlan J., Pasquinelli A.E., Balint E., Tuschl T., Zamore P.D. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 293:2001;834-838.
-
(2001)
Science
, vol.293
, pp. 834-838
-
-
Hutvagner, G.1
McLachlan, J.2
Pasquinelli, A.E.3
Balint, E.4
Tuschl, T.5
Zamore, P.D.6
-
28
-
-
0035955366
-
An extensive class of small RNAs in Caenorhabditis elegans
-
Lee R.C., Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science. 294:2001;862-864.
-
(2001)
Science
, vol.294
, pp. 862-864
-
-
Lee, R.C.1
Ambros, V.2
-
29
-
-
0035955361
-
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
-
Lau N.C., Lim L.P., Weinstein E.G., Bartel D.P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science. 294:2001;858-862.
-
(2001)
Science
, vol.294
, pp. 858-862
-
-
Lau, N.C.1
Lim, L.P.2
Weinstein, E.G.3
Bartel, D.P.4
-
30
-
-
0035955374
-
Identification of novel genes coding for small expressed RNAs
-
Lagos-Quintana M., Rauhut R., Lendeckel W., Tuschl T. Identification of novel genes coding for small expressed RNAs. Science. 294:2001;853-858.
-
(2001)
Science
, vol.294
, pp. 853-858
-
-
Lagos-Quintana, M.1
Rauhut, R.2
Lendeckel, W.3
Tuschl, T.4
-
31
-
-
85031359603
-
A microRNA in a multiple-turnover RNAi enzyme complex, Science
-
In their report, the authors look at the human stRNA that is the let-7 paralog. Surprisingly, they find that the human let-7 RNA naturally enters the RNAi pathway, resulting in mRNA destruction. The authors suggest that the mechanism of RNA silencing (mRNA destruction or translational inhibition) depends on the degree of sequence complementarity between a miRNA and its RNA target
-
Hutvagner G., Zamore P.D. A microRNA in a multiple-turnover RNAi enzyme complex, Science. published on-line August ; .1126/science.1073827. 1:2002;10. In their report, the authors look at the human stRNA that is the let-7 paralog. Surprisingly, they find that the human let-7 RNA naturally enters the RNAi pathway, resulting in mRNA destruction. The authors suggest that the mechanism of RNA silencing (mRNA destruction or translational inhibition) depends on the degree of sequence complementarity between a miRNA and its RNA target.
-
(2002)
Published on-line August ; .1126/science.1073827
, vol.1
, pp. 10
-
-
Hutvagner, G.1
Zamore, P.D.2
-
32
-
-
0037197803
-
Identification of tissue-specific microRNAs from mouse
-
Lagos-Quintana M., Rauhut R., Yalcin A., Meyer J., Lendeckel W., Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr Biol. 12:2002;735-739.
-
(2002)
Curr Biol
, vol.12
, pp. 735-739
-
-
Lagos-Quintana, M.1
Rauhut, R.2
Yalcin, A.3
Meyer, J.4
Lendeckel, W.5
Tuschl, T.6
-
33
-
-
0036645146
-
MicroRNAs in plants
-
Reinhart B.J., Weinstein E.G., Rhoades M.W., Bartel B., Bartel D.P. MicroRNAs in plants. Genes Dev. 16:2002;1616-1626.
-
(2002)
Genes Dev
, vol.16
, pp. 1616-1626
-
-
Reinhart, B.J.1
Weinstein, E.G.2
Rhoades, M.W.3
Bartel, B.4
Bartel, D.P.5
-
34
-
-
0036544755
-
Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation
-
Lai E.C. Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet. 30:2002;363-364.
-
(2002)
Nat Genet
, vol.30
, pp. 363-364
-
-
Lai, E.C.1
-
35
-
-
0037162702
-
Prediction of plant microRNA targets
-
In this theoretical paper, the authors identify in plants mRNAs with evolutionary conserved sequences complementarity to miRNAs. The majority of the target mRNAs are transcription factors involved in developmental and differentiation processes. This paper suggests that miRNAs can function as siRNAs in plants
-
Rhoades M.W., Reinhart B.J., Bartel D.P. Prediction of plant microRNA targets. Cell. 110:2002;513. In this theoretical paper, the authors identify in plants mRNAs with evolutionary conserved sequences complementarity to miRNAs. The majority of the target mRNAs are transcription factors involved in developmental and differentiation processes. This paper suggests that miRNAs can function as siRNAs in plants.
-
(2002)
Cell
, vol.110
, pp. 513
-
-
Rhoades, M.W.1
Reinhart, B.J.2
Bartel, D.P.3
-
36
-
-
0036294527
-
Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells
-
Zeng Y., Wagner E.J., Cullen B.R. Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol Cell. 9:2002;1327-1333.
-
(2002)
Mol Cell
, vol.9
, pp. 1327-1333
-
-
Zeng, Y.1
Wagner, E.J.2
Cullen, B.R.3
-
37
-
-
0036273940
-
Gene silencing using micro-RNA designed hairpins
-
McManus M.T., Petersen C.P., Haines B.B., Chen J., Sharp P.A. Gene silencing using micro-RNA designed hairpins. RNA. 8:2002;842-850.
-
(2002)
RNA
, vol.8
, pp. 842-850
-
-
McManus, M.T.1
Petersen, C.P.2
Haines, B.B.3
Chen, J.4
Sharp, P.A.5
-
38
-
-
0037192490
-
Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1
-
Winston W.M., Molodowitch C., Hunter C.P. Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1. Science. 295:2002;2456-2459.
-
(2002)
Science
, vol.295
, pp. 2456-2459
-
-
Winston, W.M.1
Molodowitch, C.2
Hunter, C.P.3
-
39
-
-
0035900651
-
On the role of RNA amplification in dsRNA-triggered gene silencing
-
Sijen T., Fleenor J., Simmer F., Thijssen K.L., Parrish S., Timmons L., Plasterk R.H., Fire A. On the role of RNA amplification in dsRNA-triggered gene silencing. Cell. 107:2001;465-476.
-
(2001)
Cell
, vol.107
, pp. 465-476
-
-
Sijen, T.1
Fleenor, J.2
Simmer, F.3
Thijssen, K.L.4
Parrish, S.5
Timmons, L.6
Plasterk, R.H.7
Fire, A.8
-
40
-
-
0036066508
-
SiRNA-directed inhibition of HIV-1 infection
-
The authors demonstrate that siRNAs may have potential for therapeutic intervention in HIV. They used siRNAs to inhibit HIV production by targeting the HIV Gag gene or CD4, the cellular receptor for HIV
-
Novina C.D., Murray M.F., Dykxhoorn D.M., Beresford P.J., Riess J., Lee S.K., Collman R.G., Lieberman J., Shankar P., Sharp P.A. siRNA-directed inhibition of HIV-1 infection. Nat Med. 8:2002;681-686. The authors demonstrate that siRNAs may have potential for therapeutic intervention in HIV. They used siRNAs to inhibit HIV production by targeting the HIV Gag gene or CD4, the cellular receptor for HIV.
-
(2002)
Nat Med
, vol.8
, pp. 681-686
-
-
Novina, C.D.1
Murray, M.F.2
Dykxhoorn, D.M.3
Beresford, P.J.4
Riess, J.5
Lee, S.K.6
Collman, R.G.7
Lieberman, J.8
Shankar, P.9
Sharp, P.A.10
-
41
-
-
0037173613
-
Short interfering RNA confers intracellular antiviral immunity in human cells
-
In this paper, the authors have pre-treated cells with siRNAs designed against the poliovirus genome. This treatment protected the cells from viral replication. The antiviral effect was highly effective and sequence specific. A virus that was resistant to the treatment was also mutated in the target recognition site of the siRNAs
-
Gitlin L., Karelsky S., Andino R. Short interfering RNA confers intracellular antiviral immunity in human cells. Nature. 418:2002;430-434. In this paper, the authors have pre-treated cells with siRNAs designed against the poliovirus genome. This treatment protected the cells from viral replication. The antiviral effect was highly effective and sequence specific. A virus that was resistant to the treatment was also mutated in the target recognition site of the siRNAs.
-
(2002)
Nature
, vol.418
, pp. 430-434
-
-
Gitlin, L.1
Karelsky, S.2
Andino, R.3
-
42
-
-
0037173610
-
Modulation of HIV-1 replication by RNA interference
-
Using synthetic siRNAs, the authors demonstrated efficient inhibition of HIV infection. Although the HIV genomic RNA exists in a nucleoprotein complex, it was still open to siRNA-mediated degradation
-
Jacque J.M., Triques K., Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature. 418:2002;435-438. Using synthetic siRNAs, the authors demonstrated efficient inhibition of HIV infection. Although the HIV genomic RNA exists in a nucleoprotein complex, it was still open to siRNA-mediated degradation.
-
(2002)
Nature
, vol.418
, pp. 435-438
-
-
Jacque, J.M.1
Triques, K.2
Stevenson, M.3
-
43
-
-
0036653097
-
RNA interference: The new somatic cell genetics?
-
Paddison P.J., Hannon G.J. RNA interference: the new somatic cell genetics? Cancer Cell. 2:2002;17-23.
-
(2002)
Cancer Cell
, vol.2
, pp. 17-23
-
-
Paddison, P.J.1
Hannon, G.J.2
-
44
-
-
0037089589
-
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
-
Paddison P.J., Caudy A.A., Bernstein E., Hannon G.J., Conklin D.S. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 16:2002;948-958.
-
(2002)
Genes Dev
, vol.16
, pp. 948-958
-
-
Paddison, P.J.1
Caudy, A.A.2
Bernstein, E.3
Hannon, G.J.4
Conklin, D.S.5
-
45
-
-
0036726313
-
Stable suppression of tumorigenicity by virus-mediated RNA interference
-
V12 led to loss of anchorage-independent growth and tumorigenicity. The authors indicate that viral delivery of small interfering RNAs can be applied for tumor-specific gene therapy
-
V12 led to loss of anchorage-independent growth and tumorigenicity. The authors indicate that viral delivery of small interfering RNAs can be applied for tumor-specific gene therapy.
-
(2002)
Cancer Cell
, vol.2
, pp. 243-247
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
46
-
-
0037197914
-
RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells
-
Yu J.Y., DeRuiter S.L., Turner D.L. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci USA. 99:2002;6047-6052.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 6047-6052
-
-
Yu, J.Y.1
DeRuiter, S.L.2
Turner, D.L.3
-
47
-
-
0037117550
-
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells
-
Sui G., Soohoo C., Affar el B., Gay F., Shi Y., Forrester W.C. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA. 99:2002;5515-5520.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 5515-5520
-
-
Sui, G.1
Soohoo, C.2
Affar el, B.3
Gay, F.4
Shi, Y.5
Forrester, W.C.6
-
48
-
-
0036256430
-
Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells
-
Lee N.S., Dohjima T., Bauer G., Li H., Li M.J., Ehsani A., Salvaterra P., Rossi J. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol. 20:2002;500-505.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 500-505
-
-
Lee, N.S.1
Dohjima, T.2
Bauer, G.3
Li, H.4
Li, M.J.5
Ehsani, A.6
Salvaterra, P.7
Rossi, J.8
-
49
-
-
0036245628
-
U6 promoter driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells
-
Miyagishi M., Taira K. U6 promoter driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol. 20:2002;497-500.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 497-500
-
-
Miyagishi, M.1
Taira, K.2
-
50
-
-
0036251639
-
Effective expression of small interfering RNA in human cells
-
Paul C.P., Good P.D., Winer I., Engelke D.R. Effective expression of small interfering RNA in human cells. Nat Biotechnol. 20:2002;505-508.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 505-508
-
-
Paul, C.P.1
Good, P.D.2
Winer, I.3
Engelke, D.R.4
-
51
-
-
0037158901
-
Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi)
-
Wilda M., Fuchs U., Wossmann W., Borkhardt A. Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene. 21:2002;5716-5724.
-
(2002)
Oncogene
, vol.21
, pp. 5716-5724
-
-
Wilda, M.1
Fuchs, U.2
Wossmann, W.3
Borkhardt, A.4
-
52
-
-
0036727416
-
Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
-
Here a method was developed for efficient in vivo induction of RNAi in organs of postnatal mice. The authors injected a large volume of physiological solution containing siRNAs into the tail vein of postnatal mice. This resulted in specific and efficient inhibition of gene expression in several organs
-
Lewis D.L., Hagstrom J.E., Loomis A.G., Wolff J.A., Herweijer H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet. 32:2002;107-108. Here a method was developed for efficient in vivo induction of RNAi in organs of postnatal mice. The authors injected a large volume of physiological solution containing siRNAs into the tail vein of postnatal mice. This resulted in specific and efficient inhibition of gene expression in several organs.
-
(2002)
Nat Genet
, vol.32
, pp. 107-108
-
-
Lewis, D.L.1
Hagstrom, J.E.2
Loomis, A.G.3
Wolff, J.A.4
Herweijer, H.5
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