메뉴 건너뛰기




Volumn 285, Issue 1, 2003, Pages 39-49

Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells

Author keywords

EGF receptor; ErbB1; Inhibition of proliferation; RNA interference

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GREEN FLUORESCENT PROTEIN; MESSENGER RNA;

EID: 0037446068     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4827(02)00050-2     Document Type: Article
Times cited : (101)

References (50)
  • 2
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
    • Yarden Y. The EGFR family and its ligands in human cancer signalling mechanisms and therapeutic opportunities . Eur. J. Cancer. 37:(Suppl. 4):2001;S3-S8.
    • (2001) Eur. J. Cancer , vol.37 , Issue.SUPPL. 4
    • Yarden, Y.1
  • 3
    • 0029814271 scopus 로고    scopus 로고
    • A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
    • Tzahar E., Waterman H., Chen X., Levkowitz G., Karunagaran D., Lavi S., Ratzkin B.J., Yarden Y. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol. Cell Biol. 16:1996;5276-5287.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 5276-5287
    • Tzahar, E.1    Waterman, H.2    Chen, X.3    Levkowitz, G.4    Karunagaran, D.5    Lavi, S.6    Ratzkin, B.J.7    Yarden, Y.8
  • 4
    • 0035476803 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells
    • Moasser M.M., Basso A., Averbuch S.D., Rosen N. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 61:2001;7184-7188.
    • (2001) Cancer Res. , vol.61 , pp. 7184-7188
    • Moasser, M.M.1    Basso, A.2    Averbuch, S.D.3    Rosen, N.4
  • 5
    • 0036490442 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors in cancer therapy
    • Shawver L.K., Slamon D., Ullrich A. Tyrosine kinase inhibitors in cancer therapy. Cancer Cell. 1:2002;117-123.
    • (2002) Cancer Cell , vol.1 , pp. 117-123
    • Shawver, L.K.1    Slamon, D.2    Ullrich, A.3
  • 6
    • 0032127350 scopus 로고    scopus 로고
    • Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
    • Baselga J., Norton L., Albanell J., Kim Y.M., Mendelsohn J. Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res. 58:1998;2825-2831.
    • (1998) Cancer Res. , vol.58 , pp. 2825-2831
    • Baselga, J.1    Norton, L.2    Albanell, J.3    Kim, Y.M.4    Mendelsohn, J.5
  • 7
    • 0034864020 scopus 로고    scopus 로고
    • Phase I and II clinical trials of trastuzumab
    • Baselga J. Phase I and II clinical trials of trastuzumab. Ann. Oncol. 12:(Suppl. 1):2001;S49-S55.
    • (2001) Ann. Oncol. , vol.12 , Issue.SUPPL. 1
    • Baselga, J.1
  • 8
    • 0031903646 scopus 로고    scopus 로고
    • Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
    • Pegram M.D., Lipton A., Hayes D.F., Weber B.L., Baselga J.M., Tripathy D., Baly D., Baughman S.A., Twaddell T., Glaspy J.A., Slamon D.J. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J. Clin. Oncol. 16:1998;2659-2671.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2659-2671
    • Pegram, M.D.1    Lipton, A.2    Hayes, D.F.3    Weber, B.L.4    Baselga, J.M.5    Tripathy, D.6    Baly, D.7    Baughman, S.A.8    Twaddell, T.9    Glaspy, J.A.10    Slamon, D.J.11
  • 9
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon D.S., Brandt R., Ciardiello F., Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19:1995;183-232.
    • (1995) Crit. Rev. Oncol. Hematol. , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3    Normanno, N.4
  • 10
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn J., Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene. 19:2000;6550-6565.
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 12
    • 0034068319 scopus 로고    scopus 로고
    • Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • Ciardiello F., Caputo R., Bianco R., Damiano V., Pomatico G., De Placido S., Bianco A.R., Tortora G. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin. Cancer Res. 6:2000;2053-2063.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2053-2063
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3    Damiano, V.4    Pomatico, G.5    De Placido, S.6    Bianco, A.R.7    Tortora, G.8
  • 13
    • 0034779291 scopus 로고    scopus 로고
    • The EGFR as a target for anticancer therapy - Focus on cetuximab
    • Baselga J. The EGFR as a target for anticancer therapy - focus on cetuximab. Eur. J. Cancer. 37:(Suppl. 4):2001;S16-S22.
    • (2001) Eur. J. Cancer , vol.37 , Issue.SUPPL. 4
    • Baselga, J.1
  • 14
    • 0037012036 scopus 로고    scopus 로고
    • Differential sensitivity of cancer cells to inhibitors of the epidermal growth factor receptor family
    • Bishop P.C., Myers T., Robey R., Fry D.W., Liu E.T., Blagosklonny M.V., Bates S.E. Differential sensitivity of cancer cells to inhibitors of the epidermal growth factor receptor family. Oncogene. 21:2002;119-127.
    • (2002) Oncogene , vol.21 , pp. 119-127
    • Bishop, P.C.1    Myers, T.2    Robey, R.3    Fry, D.W.4    Liu, E.T.5    Blagosklonny, M.V.6    Bates, S.E.7
  • 15
    • 0032891108 scopus 로고    scopus 로고
    • Transfection of anti-sense complementary DNA of human epidermal-growth-factor receptor attenuates the proliferation of human non-small-cell-lung-cancer cells
    • Fang K., Chen M.H. Transfection of anti-sense complementary DNA of human epidermal-growth-factor receptor attenuates the proliferation of human non-small-cell-lung-cancer cells. Int. J. Cancer. 81:1999;471-478.
    • (1999) Int. J. Cancer , vol.81 , pp. 471-478
    • Fang, K.1    Chen, M.H.2
  • 16
    • 0033834587 scopus 로고    scopus 로고
    • Suppression of gene expression by targeted disruption of messenger RNA: Available options and current strategies
    • Jen K.Y., Gewirtz A.M. Suppression of gene expression by targeted disruption of messenger RNA available options and current strategies . Stem Cells. 18:2000;307-319.
    • (2000) Stem Cells , vol.18 , pp. 307-319
    • Jen, K.Y.1    Gewirtz, A.M.2
  • 17
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 18
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp T.R., Bernards R., Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science. 296:2002;550-553.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 19
    • 0036245628 scopus 로고    scopus 로고
    • U6 promoter driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells
    • Miyagishi M., Taira K. U6 promoter driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nat. Biotechnol. 20:2002;497-500.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 497-500
    • Miyagishi, M.1    Taira, K.2
  • 20
    • 0021804944 scopus 로고
    • MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF
    • Filmus J., Pollak M.N., Cailleau R., Buick R.N. MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF. Biochem. Biophys. Res. Commun. 128:1985;898-905.
    • (1985) Biochem. Biophys. Res. Commun. , vol.128 , pp. 898-905
    • Filmus, J.1    Pollak, M.N.2    Cailleau, R.3    Buick, R.N.4
  • 21
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I., Migliorati G., Pagliacci M.C., Grignani F., Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods. 139:1991;271-279.
    • (1991) J. Immunol. Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 23
    • 0031779831 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT in vitro
    • Kehlenbach R.H., Dickmanns A., Gerace L. Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT in vitro. J. Cell Biol. 141:1998;863-874.
    • (1998) J. Cell Biol. , vol.141 , pp. 863-874
    • Kehlenbach, R.H.1    Dickmanns, A.2    Gerace, L.3
  • 24
    • 0033119241 scopus 로고    scopus 로고
    • Comparison of fixation protocols for adherent cultured cells applied to a GFP fusion protein of the epidermal growth factor receptor
    • Brock R., Hamelers I.H., Jovin T.M. Comparison of fixation protocols for adherent cultured cells applied to a GFP fusion protein of the epidermal growth factor receptor. Cytometry. 35:1999;353-362.
    • (1999) Cytometry , vol.35 , pp. 353-362
    • Brock, R.1    Hamelers, I.H.2    Jovin, T.M.3
  • 25
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 103:2000;211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 26
    • 0034758726 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors-ZD1839 (Iressa)
    • Arteaga C.L., Johnson D.H. Tyrosine kinase inhibitors-ZD1839 (Iressa). Curr. Opin. Oncol. 13:2001;491-498.
    • (2001) Curr. Opin. Oncol. , vol.13 , pp. 491-498
    • Arteaga, C.L.1    Johnson, D.H.2
  • 27
    • 0032697492 scopus 로고    scopus 로고
    • Signaling pathways and structural domains required for phosphorylation of EMSI/cortactin
    • Campbell D.H., Sutherland R.L., Daly R.J. Signaling pathways and structural domains required for phosphorylation of EMSI/cortactin. Cancer Res. 59:1999;5376-5385.
    • (1999) Cancer Res. , vol.59 , pp. 5376-5385
    • Campbell, D.H.1    Sutherland, R.L.2    Daly, R.J.3
  • 28
    • 0034090402 scopus 로고    scopus 로고
    • Epidermal growth factor induces cell cycle arrest and apoptosis of squamous carcinoma cells through reduction of cell adhesion
    • Cao L., Yao Y., Lee V., Kiani C., Spaner D., Lin Z., Zhang Y., Adams M.E., Yang B.B. Epidermal growth factor induces cell cycle arrest and apoptosis of squamous carcinoma cells through reduction of cell adhesion. J. Cell Biochem. 77:2000;569-583.
    • (2000) J. Cell Biochem. , vol.77 , pp. 569-583
    • Cao, L.1    Yao, Y.2    Lee, V.3    Kiani, C.4    Spaner, D.5    Lin, Z.6    Zhang, Y.7    Adams, M.E.8    Yang, B.B.9
  • 29
    • 0032479156 scopus 로고    scopus 로고
    • High-affinity binding of epidermal growth factor (EGF) to EGF receptor is disrupted by overexpression of mutant dynamin (K44A)
    • Ringerike T., Stang E., Johannessen L.E., Sandnes D., Levy F.O., Madshus I.H. High-affinity binding of epidermal growth factor (EGF) to EGF receptor is disrupted by overexpression of mutant dynamin (K44A). J. Biol. Chem. 273:1998;16639-16642.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16639-16642
    • Ringerike, T.1    Stang, E.2    Johannessen, L.E.3    Sandnes, D.4    Levy, F.O.5    Madshus, I.H.6
  • 30
    • 0029912203 scopus 로고    scopus 로고
    • All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired
    • Baulida J., Kraus M.H., Alimandi M., Di Fiore P.P., Carpenter G. All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J. Biol. Chem. 271:1996;5251-5257.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5251-5257
    • Baulida, J.1    Kraus, M.H.2    Alimandi, M.3    Di Fiore, P.P.4    Carpenter, G.5
  • 33
    • 37049185280 scopus 로고
    • Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells
    • Merlino G.T., Xu Y.H., Ishii S., Clark A.J., Semba K., Toyoshima K., Yamamoto T., Pastan I. Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science. 224:1984;417-419.
    • (1984) Science , vol.224 , pp. 417-419
    • Merlino, G.T.1    Xu, Y.H.2    Ishii, S.3    Clark, A.J.4    Semba, K.5    Toyoshima, K.6    Yamamoto, T.7    Pastan, I.8
  • 34
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 391:1998;806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 35
    • 0033014064 scopus 로고    scopus 로고
    • Activation-dependent clustering of the erbB2 receptor tyrosine kinase detected by scanning near-field optical microscopy
    • Nagy P., Jenei A., Kirsch A.K., Szöllösi J., Damjanovich S., Jovin T.M. Activation-dependent clustering of the erbB2 receptor tyrosine kinase detected by scanning near-field optical microscopy. J. Cell. Sci. 112:1999;1733-1741.
    • (1999) J. Cell. Sci. , vol.112 , pp. 1733-1741
    • Nagy, P.1    Jenei, A.2    Kirsch, A.K.3    Szöllösi, J.4    Damjanovich, S.5    Jovin, T.M.6
  • 36
    • 0034915134 scopus 로고    scopus 로고
    • Heterogeneity of signal transduction at the subcellular level: Microsphere-based focal EGF receptor activation and stimulation of Shc translocation
    • Brock R., Jovin T.M. Heterogeneity of signal transduction at the subcellular level microsphere-based focal EGF receptor activation and stimulation of Shc translocation . J. Cell Sci. 114:2001;2437-2447.
    • (2001) J. Cell Sci. , vol.114 , pp. 2437-2447
    • Brock, R.1    Jovin, T.M.2
  • 37
    • 0034711405 scopus 로고    scopus 로고
    • Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane
    • Verveer P.J., Wouters F.S., Reynolds A.R., Bastiaens P.I. Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane. Science. 290:2000;1567-1570.
    • (2000) Science , vol.290 , pp. 1567-1570
    • Verveer, P.J.1    Wouters, F.S.2    Reynolds, A.R.3    Bastiaens, P.I.4
  • 38
    • 0036500994 scopus 로고    scopus 로고
    • Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum
    • Haj F.G., Verveer P.J., Squire A., Neel B.G., Bastiaens P.I. Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum. Science. 295:2002;1708-1711.
    • (2002) Science , vol.295 , pp. 1708-1711
    • Haj, F.G.1    Verveer, P.J.2    Squire, A.3    Neel, B.G.4    Bastiaens, P.I.5
  • 39
    • 0029790351 scopus 로고    scopus 로고
    • Ultrasensitivity in the mitogen-activated protein kinase cascade
    • Huang C.Y., Ferrell J.E. Jr. Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA. 93:1996;10078-10083.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10078-10083
    • Huang, C.Y.1    Ferrell J.E., Jr.2
  • 40
    • 0034629485 scopus 로고    scopus 로고
    • Reversible G1 arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires upregulation of p27KIP1 independent of MAPK activity
    • Busse D., Doughty R.S., Ramsey T.T., Russell W.E., Price J.O., Flanagan W.M., Shawver L.K., Arteaga C.L. Reversible G1 arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires upregulation of p27KIP1 independent of MAPK activity. J. Biol. Chem. 275:2000;6987-6995.
    • (2000) J. Biol. Chem. , vol.275 , pp. 6987-6995
    • Busse, D.1    Doughty, R.S.2    Ramsey, T.T.3    Russell, W.E.4    Price, J.O.5    Flanagan, W.M.6    Shawver, L.K.7    Arteaga, C.L.8
  • 41
    • 0034038282 scopus 로고    scopus 로고
    • Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity
    • Liu B., Fang M., Schmidt M., Lu Y., Mende Isohn J., Fan Z. Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. Br. J. Cancer. 82:2000;1991-1999.
    • (2000) Br. J. Cancer , vol.82 , pp. 1991-1999
    • Liu, B.1    Fang, M.2    Schmidt, M.3    Lu, Y.4    Mende Isohn, J.5    Fan, Z.6
  • 42
    • 0031817827 scopus 로고    scopus 로고
    • EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5
    • Modjtahedi H., Affleck K., Stubberfield C., Dean C. EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5. Int. J. Oncol. 13:1998;335-342.
    • (1998) Int. J. Oncol. , vol.13 , pp. 335-342
    • Modjtahedi, H.1    Affleck, K.2    Stubberfield, C.3    Dean, C.4
  • 43
    • 0034754136 scopus 로고    scopus 로고
    • Epidermal growth factor receptor biology (IMC-C225)
    • Kim E.S., Khuri F.R., Herbst R.S. Epidermal growth factor receptor biology (IMC-C225). Curr. Opin. Oncol. 13:2001;506-513.
    • (2001) Curr. Opin. Oncol. , vol.13 , pp. 506-513
    • Kim, E.S.1    Khuri, F.R.2    Herbst, R.S.3
  • 44
    • 0035418622 scopus 로고    scopus 로고
    • Activated extracellular signal-regulated kinases: Association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments
    • Albanell J., Codony-Servat J., Rojo F., Del Campo J.M., Sauleda S., Anido J., Raspall G., Giralt J., Rosello J., Nicholson R.I., Mendelsohn J., Baselga J. Activated extracellular signal-regulated kinases association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments . Cancer Res. 61:2001;6500-6510.
    • (2001) Cancer Res. , vol.61 , pp. 6500-6510
    • Albanell, J.1    Codony-Servat, J.2    Rojo, F.3    Del Campo, J.M.4    Sauleda, S.5    Anido, J.6    Raspall, G.7    Giralt, J.8    Rosello, J.9    Nicholson, R.I.10    Mendelsohn, J.11    Baselga, J.12
  • 45
    • 0025053348 scopus 로고
    • EGF receptor activities in mammalian development
    • Adamson E.D. EGF receptor activities in mammalian development. Mol. Reprod. Dev. 27:1990;16-22.
    • (1990) Mol. Reprod. Dev. , vol.27 , pp. 16-22
    • Adamson, E.D.1
  • 47
    • 0037106377 scopus 로고    scopus 로고
    • Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: Results of a phase I trial
    • Herbst R.S., Maddox A.M., Rothenberg M.L., Small E.J., Rubin E.H., Baselga J., Rojo F., Hong W.K., Swaisland H., Averbuch S.D., Ochs J., LoRusso P.M. Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors results of a phase I trial . J. Clin. Oncol. 20:2002;3815-3825.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3815-3825
    • Herbst, R.S.1    Maddox, A.M.2    Rothenberg, M.L.3    Small, E.J.4    Rubin, E.H.5    Baselga, J.6    Rojo, F.7    Hong, W.K.8    Swaisland, H.9    Averbuch, S.D.10    Ochs, J.11    LoRusso, P.M.12
  • 48
    • 0034489914 scopus 로고    scopus 로고
    • Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
    • Sirotnak F.M., Zakowski M.F., Miller V.A., Scher H.I., Kris M.G. Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clin. Cancer Res. 6:2000;4885-4892.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4885-4892
    • Sirotnak, F.M.1    Zakowski, M.F.2    Miller, V.A.3    Scher, H.I.4    Kris, M.G.5
  • 49
    • 0037123639 scopus 로고    scopus 로고
    • RNA-dependent RNA polymerases, viruses, and RNA silencing
    • Ahlquist P. RNA-dependent RNA polymerases, viruses, and RNA silencing. Science. 296:2002;1270-1273.
    • (2002) Science , vol.296 , pp. 1270-1273
    • Ahlquist, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.